Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              18    1135
NP_001263689                                                           18    1135
NP_001119584                                                           18    1135
NP_001119586                                                           18    1135
NP_001263625                                                           18    1135
NP_001119590                                                           18    1135
NP_001263690                                                           18    1135
NP_001119585                                                           18    1135
NP_001263624                                                           18    1135
NP_001119588                                                           18    1135
NP_001119587                                                           18    1135
NP_001119589                                                           18    1135
NP_001263627                                                           18    1135
NP_001263628                                                           18    1135
NP_001263626                                                           18    1135
NP_000224                                                              16    5631
NP_000360                                                              16    5631
XP_005268094                                                           16    5631
XP_005264366                                                           16    5631
XP_006712078                                                           16    5631
NP_001268639                                                           15    9605
NP_001268640                                                           15    9605
NP_001186308                                                           15    9605
NP_056156                                                              15    9605
NP_062873                                                              15    9605
NP_001186307                                                           15    9605
NP_004696                                                              15    9605
NP_062874                                                              15    9605
NP_001003811                                                           15    9605
NP_001268641                                                           15    9605
NP_004184                                                              15    9605
XP_006718114                                                           15    9605
XP_005270318                                                           15    9605
XP_006718113                                                           15    9605
XP_006718112                                                           15    9605
XP_006718111                                                           15    9605
XP_006718110                                                           15    9605
XP_006712451                                                           15    9605
XP_005263965                                                           15    9605
XP_005263964                                                           15    9605
NP_000863                                                              15    9605
NP_112566                                                              15    9605
>NP_000537
          Length = 393

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLEN 9
           ILTIITLE+
Sbjct: 251 ILTIITLED 259
>NP_001263689
          Length = 354

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLEN 9
           ILTIITLE+
Sbjct: 212 ILTIITLED 220
>NP_001119584
          Length = 393

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLEN 9
           ILTIITLE+
Sbjct: 251 ILTIITLED 259
>NP_001119586
          Length = 341

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLEN 9
           ILTIITLE+
Sbjct: 251 ILTIITLED 259
>NP_001263625
          Length = 302

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLEN 9
           ILTIITLE+
Sbjct: 212 ILTIITLED 220
>NP_001119590
          Length = 354

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLEN 9
           ILTIITLE+
Sbjct: 212 ILTIITLED 220
>NP_001263690
          Length = 354

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLEN 9
           ILTIITLE+
Sbjct: 212 ILTIITLED 220
>NP_001119585
          Length = 346

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLEN 9
           ILTIITLE+
Sbjct: 251 ILTIITLED 259
>NP_001263624
          Length = 307

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLEN 9
           ILTIITLE+
Sbjct: 212 ILTIITLED 220
>NP_001119588
          Length = 209

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLEN 9
           ILTIITLE+
Sbjct: 119 ILTIITLED 127
>NP_001119587
          Length = 261

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLEN 9
           ILTIITLE+
Sbjct: 119 ILTIITLED 127
>NP_001119589
          Length = 214

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLEN 9
           ILTIITLE+
Sbjct: 119 ILTIITLED 127
>NP_001263627
          Length = 182

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLEN 9
           ILTIITLE+
Sbjct: 92  ILTIITLED 100
>NP_001263628
          Length = 187

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLEN 9
           ILTIITLE+
Sbjct: 92  ILTIITLED 100
>NP_001263626
          Length = 234

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLEN 9
           ILTIITLE+
Sbjct: 92  ILTIITLED 100
>NP_000224
          Length = 699

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LTIITLE 8
           LT+ITLE
Sbjct: 457 LTVITLE 463
>NP_000360
          Length = 764

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LTIITLE 8
           LT+ITLE
Sbjct: 512 LTVITLE 518
>XP_005268094
          Length = 764

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LTIITLE 8
           LT+ITLE
Sbjct: 512 LTVITLE 518
>XP_005264366
          Length = 380

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LTIITLE 8
           LT+ITLE
Sbjct: 138 LTVITLE 144
>XP_006712078
          Length = 389

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LTIITLE 8
           LT+ITLE
Sbjct: 147 LTVITLE 153
>NP_001268639
          Length = 730

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ILTIITLEN 9
           ILT  TLEN
Sbjct: 481 ILTKSTLEN 489
>NP_001268640
          Length = 717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ILTIITLEN 9
           ILT  TLEN
Sbjct: 468 ILTKSTLEN 476
>NP_001186308
          Length = 1855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ILTIITLEN 9
           ++ IIT+EN
Sbjct: 502 LMEIITVEN 510
>NP_056156
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ILTIITLEN 9
           ILT  TLEN
Sbjct: 492 ILTKSTLEN 500
>NP_062873
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  ILTIITL 7
          ILT+ITL
Sbjct: 87 ILTLITL 93
>NP_001186307
          Length = 1856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ILTIITLEN 9
           ++ IIT+EN
Sbjct: 503 LMEIITVEN 511
>NP_004696
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ILTIITLEN 9
           I+TI+ L+N
Sbjct: 480 IVTIVVLKN 488
>NP_062874
          Length = 432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  ILTIITL 7
          ILT+ITL
Sbjct: 87 ILTLITL 93
>NP_001003811
          Length = 940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IITLEN 9
           IITLEN
Sbjct: 514 IITLEN 519
>NP_001268641
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ILTIITLEN 9
           ILT  TLEN
Sbjct: 356 ILTKSTLEN 364
>NP_004184
          Length = 1859

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ILTIITLEN 9
           ++ IIT+EN
Sbjct: 502 LMEIITVEN 510
>XP_006718114
          Length = 1850

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ILTIITLEN 9
           ++ IIT+EN
Sbjct: 536 LMEIITVEN 544
>XP_005270318
          Length = 1860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ILTIITLEN 9
           ++ IIT+EN
Sbjct: 503 LMEIITVEN 511
>XP_006718113
          Length = 1881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ILTIITLEN 9
           ++ IIT+EN
Sbjct: 536 LMEIITVEN 544
>XP_006718112
          Length = 1889

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ILTIITLEN 9
           ++ IIT+EN
Sbjct: 536 LMEIITVEN 544
>XP_006718111
          Length = 1892

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ILTIITLEN 9
           ++ IIT+EN
Sbjct: 535 LMEIITVEN 543
>XP_006718110
          Length = 1893

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ILTIITLEN 9
           ++ IIT+EN
Sbjct: 536 LMEIITVEN 544
>XP_006712451
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ILTIITLEN 9
           ILT  TLEN
Sbjct: 492 ILTKSTLEN 500
>XP_005263965
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ILTIITLEN 9
           ILT  TLEN
Sbjct: 492 ILTKSTLEN 500
>XP_005263964
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ILTIITLEN 9
           ILT  TLEN
Sbjct: 489 ILTKSTLEN 497
>NP_000863
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  ILTIITL 7
          ILT+ITL
Sbjct: 87 ILTLITL 93
>NP_112566
          Length = 925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IITLEN 9
           IITLEN
Sbjct: 499 IITLEN 504
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.147    0.355 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 405,664
Number of extensions: 791
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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