Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              19     869
XP_006718908                                                           19     869
XP_005271621                                                           19     869
XP_006718907                                                           19     869
XP_006718906                                                           19     869
XP_005271619                                                           19     869
XP_005271618                                                           19     869
NP_001095896                                                           17    3301
NP_055661                                                              17    3301
XP_005251177                                                           17    3301
XP_005263921                                                           17    3301
XP_005263920                                                           17    3301
XP_005263919                                                           17    3301
NP_000250                                                              16    5631
NP_001135967                                                           16    5631
XP_005254459                                                           16    5631
XP_005254458                                                           16    5631
XP_005254457                                                           16    5631
XP_005254456                                                           16    5631
XP_005254455                                                           16    5631
XP_005254454                                                           16    5631
NP_006531                                                              16    7355
NP_006013                                                              16    7355
NP_904358                                                              16    7355
NP_001230726                                                           16    7355
NP_001230727                                                           16    7355
NP_775922                                                              16    7355
XP_006719950                                                           16    7355
XP_005251190                                                           16    7355
XP_005251188                                                           16    7355
XP_005251189                                                           16    7355
XP_005251187                                                           16    7355
XP_005251186                                                           16    7355
XP_005251185                                                           16    7355
XP_005247977                                                           16    7355
NP_055594                                                              16    7355
NP_001137359                                                           15    9605
NP_001127810                                                           15    9605
NP_009150                                                              15    9605
NP_004279                                                              15    9605
NP_004227                                                              15    9605
NP_064632                                                              15    9605
XP_006723600                                                           15    9605
XP_006723599                                                           15    9605
XP_005273260                                                           15    9605
XP_005273259                                                           15    9605
XP_005273258                                                           15    9605
NP_001127809                                                           15    9605
NP_060689                                                              15    9605
>NP_000042
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ILKQMIKQL 9
            ILKQMIK+L
Sbjct: 2311 ILKQMIKKL 2319
>XP_006718908
          Length = 1708

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILKQMIKQL 9
           ILKQMIK+L
Sbjct: 963 ILKQMIKKL 971
>XP_005271621
          Length = 2708

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ILKQMIKQL 9
            ILKQMIK+L
Sbjct: 1963 ILKQMIKKL 1971
>XP_006718907
          Length = 3050

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ILKQMIKQL 9
            ILKQMIK+L
Sbjct: 2305 ILKQMIKKL 2313
>XP_006718906
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ILKQMIKQL 9
            ILKQMIK+L
Sbjct: 2311 ILKQMIKKL 2319
>XP_005271619
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ILKQMIKQL 9
            ILKQMIK+L
Sbjct: 2311 ILKQMIKKL 2319
>XP_005271618
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ILKQMIKQL 9
            ILKQMIK+L
Sbjct: 2311 ILKQMIKKL 2319
>NP_001095896
          Length = 1140

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LKQMIKQL 9
           LKQMIK L
Sbjct: 967 LKQMIKDL 974
>NP_055661
          Length = 1159

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ILKQMIKQL 9
           ILK+M KQ+
Sbjct: 423 ILKEMFKQM 431
>XP_005251177
          Length = 1011

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ILKQMIKQL 9
           ILK+M KQ+
Sbjct: 275 ILKEMFKQM 283
>XP_005263921
          Length = 1147

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LKQMIKQL 9
           LKQMIK L
Sbjct: 974 LKQMIKDL 981
>XP_005263920
          Length = 1155

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LKQMIKQL 9
           LKQMIK L
Sbjct: 982 LKQMIKDL 989
>XP_005263919
          Length = 1162

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LKQMIKQL 9
           LKQMIK L
Sbjct: 989 LKQMIKDL 996
>NP_000250
          Length = 1855

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    ILKQMIKQL 9
            ++KQ++KQ+
Sbjct: 1684 LIKQVVKQM 1692
>NP_001135967
          Length = 1828

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    ILKQMIKQL 9
            ++KQ++KQ+
Sbjct: 1657 LIKQVVKQM 1665
>XP_005254459
          Length = 1825

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    ILKQMIKQL 9
            ++KQ++KQ+
Sbjct: 1654 LIKQVVKQM 1662
>XP_005254458
          Length = 1852

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    ILKQMIKQL 9
            ++KQ++KQ+
Sbjct: 1681 LIKQVVKQM 1689
>XP_005254457
          Length = 1853

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    ILKQMIKQL 9
            ++KQ++KQ+
Sbjct: 1682 LIKQVVKQM 1690
>XP_005254456
          Length = 1877

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    ILKQMIKQL 9
            ++KQ++KQ+
Sbjct: 1706 LIKQVVKQM 1714
>XP_005254455
          Length = 1880

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    ILKQMIKQL 9
            ++KQ++KQ+
Sbjct: 1709 LIKQVVKQM 1717
>XP_005254454
          Length = 1880

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    ILKQMIKQL 9
            ++KQ++KQ+
Sbjct: 1709 LIKQVVKQM 1717
>NP_006531
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ILKQMIKQL 9
          ILK+ +KQ+
Sbjct: 72 ILKETVKQI 80
>NP_006013
          Length = 144

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ILKQMIKQL 9
          +LK+ IK+L
Sbjct: 76 VLKEQIKEL 84
>NP_904358
          Length = 1073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ILKQMIKQL 9
            +LK+ IK+L
Sbjct: 1005 VLKEQIKEL 1013
>NP_001230726
          Length = 86

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ILKQMIKQL 9
          +LK+ IK+L
Sbjct: 18 VLKEQIKEL 26
>NP_001230727
          Length = 86

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ILKQMIKQL 9
          +LK+ IK+L
Sbjct: 18 VLKEQIKEL 26
>NP_775922
          Length = 6996

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ILKQMIKQL 9
            ILK+M+K +
Sbjct: 1202 ILKEMLKDI 1210
>XP_006719950
          Length = 1073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ILKQMIKQL 9
            +LK+ IK+L
Sbjct: 1005 VLKEQIKEL 1013
>XP_005251190
          Length = 1395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ILKQMIKQL 9
          ILK+ +KQ+
Sbjct: 72 ILKETVKQI 80
>XP_005251188
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ILKQMIKQL 9
          ILK+ +KQ+
Sbjct: 72 ILKETVKQI 80
>XP_005251189
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ILKQMIKQL 9
          ILK+ +KQ+
Sbjct: 72 ILKETVKQI 80
>XP_005251187
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ILKQMIKQL 9
          ILK+ +KQ+
Sbjct: 72 ILKETVKQI 80
>XP_005251186
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ILKQMIKQL 9
          ILK+ +KQ+
Sbjct: 72 ILKETVKQI 80
>XP_005251185
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ILKQMIKQL 9
          ILK+ +KQ+
Sbjct: 72 ILKETVKQI 80
>XP_005247977
          Length = 756

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ILKQMIKQL 9
           +LK+ IK+L
Sbjct: 687 VLKEQIKEL 695
>NP_055594
          Length = 780

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ILKQMIKQL 9
           +LK+ IK+L
Sbjct: 711 VLKEQIKEL 719
>NP_001137359
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  LKQMIK 7
          LKQMIK
Sbjct: 72 LKQMIK 77
>NP_001127810
          Length = 169

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ILKQMIKQL 9
          ILK+ +K+L
Sbjct: 85 ILKEKVKEL 93
>NP_009150
          Length = 148

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ILKQMIKQL 9
          ILK+ +K+L
Sbjct: 64 ILKEKVKEL 72
>NP_004279
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ILKQMIKQ 8
           +LKQ +KQ
Sbjct: 180 VLKQTLKQ 187
>NP_004227
          Length = 443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  LKQMIK 7
          LKQMIK
Sbjct: 72 LKQMIK 77
>NP_064632
          Length = 647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LKQMIKQL 9
           LKQM+K L
Sbjct: 309 LKQMMKTL 316
>XP_006723600
          Length = 137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ILKQMIKQL 9
          ILK+ +K+L
Sbjct: 85 ILKEKVKEL 93
>XP_006723599
          Length = 148

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ILKQMIKQL 9
          ILK+ +K+L
Sbjct: 64 ILKEKVKEL 72
>XP_005273260
          Length = 647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LKQMIKQL 9
           LKQM+K L
Sbjct: 309 LKQMMKTL 316
>XP_005273259
          Length = 647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LKQMIKQL 9
           LKQM+K L
Sbjct: 309 LKQMMKTL 316
>XP_005273258
          Length = 647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LKQMIKQL 9
           LKQM+K L
Sbjct: 309 LKQMMKTL 316
>NP_001127809
          Length = 148

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ILKQMIKQL 9
          ILK+ +K+L
Sbjct: 64 ILKEKVKEL 72
>NP_060689
          Length = 849

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKQMIKQL 9
           LKQ+IK++
Sbjct: 357 LKQLIKKM 364
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.147    0.344 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 360,090
Number of extensions: 969
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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