Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              20     509
XP_006714104                                                           20     509
XP_005265800                                                           20     509
XP_006714103                                                           20     509
XP_006714102                                                           20     509
NP_001273336                                                           17    2528
NP_689473                                                              17    2528
NP_115984                                                              17    3301
NP_000740                                                              16    5631
NP_077014                                                              16    5631
XP_005255628                                                           16    5631
XP_005255627                                                           16    5631
NP_001192157                                                           15    9605
NP_002950                                                              15    9605
NP_006693                                                              15    9605
NP_001159583                                                           15    9605
NP_001159585                                                           15    9605
NP_001159586                                                           15    9605
NP_001159584                                                           15    9605
NP_795352                                                              15    9605
NP_055429                                                              15    9605
NP_006416                                                              15    9605
XP_005262372                                                           15    9605
XP_005262371                                                           15    9605
XP_005265850                                                           15    9605
XP_006712032                                                           15    9605
XP_006710875                                                           15    9605
XP_005271159                                                           15    9605
XP_005271158                                                           15    9605
XP_005271157                                                           15    9605
XP_005270402                                                           15    9605
XP_005270400                                                           15    9605
XP_006710340                                                           15    9605
XP_005270398                                                           15    9605
XP_006710339                                                           15    9605
XP_006710338                                                           15    9605
>NP_006197
          Length = 1089

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILAQNEDAV 9
           I+AQNEDAV
Sbjct: 394 IVAQNEDAV 402
>XP_006714104
          Length = 832

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILAQNEDAV 9
           I+AQNEDAV
Sbjct: 419 IVAQNEDAV 427
>XP_005265800
          Length = 1089

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILAQNEDAV 9
           I+AQNEDAV
Sbjct: 394 IVAQNEDAV 402
>XP_006714103
          Length = 1111

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILAQNEDAV 9
           I+AQNEDAV
Sbjct: 416 IVAQNEDAV 424
>XP_006714102
          Length = 1114

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILAQNEDAV 9
           I+AQNEDAV
Sbjct: 419 IVAQNEDAV 427
>NP_001273336
          Length = 484

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ILAQNEDAV 9
           +LA+NED V
Sbjct: 164 LLAENEDVV 172
>NP_689473
          Length = 545

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ILAQNEDAV 9
           +LA+NED V
Sbjct: 225 LLAENEDVV 233
>NP_115984
          Length = 817

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LAQNEDAV 9
           LA+NEDA+
Sbjct: 650 LAENEDAL 657
>NP_000740
          Length = 458

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LAQNEDAV 9
          +A+NEDA+
Sbjct: 25 IAENEDAL 32
>NP_077014
          Length = 404

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ILAQNEDAV 9
           ILAQ ED V
Sbjct: 148 ILAQEEDDV 156
>XP_005255628
          Length = 346

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ILAQNEDAV 9
           ILAQ ED V
Sbjct: 148 ILAQEEDDV 156
>XP_005255627
          Length = 424

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ILAQNEDAV 9
           ILAQ ED V
Sbjct: 148 ILAQEEDDV 156
>NP_001192157
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ILAQNEDAV 9
           ILA N+D V
Sbjct: 216 ILAANDDMV 224
>NP_002950
          Length = 831

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ILAQNEDAV 9
           ILA N+D V
Sbjct: 353 ILAANDDMV 361
>NP_006693
          Length = 1327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LAQNEDA 8
           LAQ EDA
Sbjct: 794 LAQQEDA 800
>NP_001159583
          Length = 1375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LAQNEDA 8
           LAQ EDA
Sbjct: 842 LAQQEDA 848
>NP_001159585
          Length = 1327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LAQNEDA 8
           LAQ EDA
Sbjct: 794 LAQQEDA 800
>NP_001159586
          Length = 1365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LAQNEDA 8
           LAQ EDA
Sbjct: 832 LAQQEDA 838
>NP_001159584
          Length = 1300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LAQNEDA 8
           LAQ EDA
Sbjct: 767 LAQQEDA 773
>NP_795352
          Length = 1801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    ILAQNEDAV 9
            +  +NEDAV
Sbjct: 1317 VFIRNEDAV 1325
>NP_055429
          Length = 1843

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    ILAQNEDAV 9
            I   NEDAV
Sbjct: 1675 IFLNNEDAV 1683
>NP_006416
          Length = 586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ILAQNEDAV 9
           +LAQ ED V
Sbjct: 390 LLAQTEDYV 398
>XP_005262372
          Length = 1027

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LAQNEDA 8
          L+QNED+
Sbjct: 21 LSQNEDS 27
>XP_005262371
          Length = 1107

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LAQNEDA 8
           L+QNED+
Sbjct: 101 LSQNEDS 107
>XP_005265850
          Length = 596

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ILAQNEDAV 9
           +LAQ ED V
Sbjct: 400 LLAQTEDYV 408
>XP_006712032
          Length = 1001

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ILAQNEDAV 9
           I   NEDAV
Sbjct: 833 IFLNNEDAV 841
>XP_006710875
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ILAQNEDAV 9
           ILA N+D V
Sbjct: 217 ILAANDDMV 225
>XP_005271159
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ILAQNEDAV 9
           ILA N+D V
Sbjct: 217 ILAANDDMV 225
>XP_005271158
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ILAQNEDAV 9
           ILA N+D V
Sbjct: 217 ILAANDDMV 225
>XP_005271157
          Length = 830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ILAQNEDAV 9
           ILA N+D V
Sbjct: 352 ILAANDDMV 360
>XP_005270402
          Length = 1454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    ILAQNEDAV 9
            +  +NEDAV
Sbjct: 1317 VFIRNEDAV 1325
>XP_005270400
          Length = 1668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    ILAQNEDAV 9
            +  +NEDAV
Sbjct: 1317 VFIRNEDAV 1325
>XP_006710340
          Length = 1815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    ILAQNEDAV 9
            +  +NEDAV
Sbjct: 1317 VFIRNEDAV 1325
>XP_005270398
          Length = 1882

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    ILAQNEDAV 9
            +  +NEDAV
Sbjct: 1317 VFIRNEDAV 1325
>XP_006710339
          Length = 1896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    ILAQNEDAV 9
            +  +NEDAV
Sbjct: 1317 VFIRNEDAV 1325
>XP_006710338
          Length = 1896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    ILAQNEDAV 9
            +  +NEDAV
Sbjct: 1317 VFIRNEDAV 1325
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.126    0.304 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 561,254
Number of extensions: 622
Number of successful extensions: 36
Number of sequences better than 10000.0: 36
Number of HSP's gapped: 36
Number of HSP's successfully gapped: 36
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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