Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_060678                                                              17    2528
XP_005245359                                                           17    2528
NP_001265546                                                           17    3301
NP_001265545                                                           17    3301
NP_004327                                                              17    3301
NP_005426                                                              17    4312
NP_002652                                                              17    4312
XP_006726519                                                           17    4312
XP_006716191                                                           17    4312
XP_006716190                                                           17    4312
NP_001166176                                                           16    5631
NP_001036024                                                           16    5631
NP_001409                                                              16    5631
NP_006173                                                              16    5631
NP_001014796                                                           16    5631
NP_001257448                                                           16    5631
NP_004681                                                              16    5631
XP_006715666                                                           16    5631
XP_006711408                                                           16    5631
XP_006711407                                                           16    5631
XP_005245278                                                           16    5631
NP_001004308                                                           16    5631
NP_000073                                                              16    7355
NP_001007234                                                           16    7355
NP_001277214                                                           16    7355
NP_036363                                                              16    7355
NP_001007258                                                           16    7355
NP_056950                                                              16    7355
XP_005246055                                                           16    7355
XP_006710943                                                           16    7355
XP_006710942                                                           16    7355
XP_006710941                                                           16    7355
XP_005246054                                                           16    7355
XP_005246053                                                           16    7355
XP_006710940                                                           16    7355
XP_005246052                                                           16    7355
XP_005246051                                                           16    7355
XP_005246050                                                           16    7355
XP_005246049                                                           16    7355
NP_001127835                                                           15    9605
NP_510966                                                              15    9605
NP_001156909                                                           15    9605
NP_149106                                                              15    9605
NP_001156908                                                           15    9605
NP_001277697                                                           15    9605
NP_001775                                                              15    9605
NP_001156907                                                           15    9605
NP_001020331                                                           15    9605
NP_036595                                                              15    9605
NP_110394                                                              15    9605
NP_055437                                                              15    9605
XP_005260229                                                           15    9605
XP_005260228                                                           15    9605
XP_005260227                                                           15    9605
XP_006719381                                                           15    9605
XP_006719380                                                           15    9605
XP_005253620                                                           15    9605
XP_006717358                                                           15    9605
XP_005252305                                                           15    9605
XP_005252303                                                           15    9605
XP_006717357                                                           15    9605
XP_005252304                                                           15    9605
XP_005252302                                                           15    9605
XP_005252301                                                           15    9605
XP_005252300                                                           15    9605
NP_001123614                                                           15    9605
>NP_060678
          Length = 386

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   IKSEVNPAM 9
           +K+E+NP++
Sbjct: 207 VKNEINPSL 215
>XP_005245359
          Length = 394

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   IKSEVNPAM 9
           +K+E+NP++
Sbjct: 207 VKNEINPSL 215
>NP_001265546
          Length = 1028

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KSEVNPA 8
           +SEVNPA
Sbjct: 317 RSEVNPA 323
>NP_001265545
          Length = 1065

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KSEVNPA 8
           +SEVNPA
Sbjct: 297 RSEVNPA 303
>NP_004327
          Length = 1085

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KSEVNPA 8
           +SEVNPA
Sbjct: 317 RSEVNPA 323
>NP_005426
          Length = 1597

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KSEVNPAM 9
           KSEV+P M
Sbjct: 916 KSEVSPGM 923
>NP_002652
          Length = 1265

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SEVNPAM 9
           SE+NP+M
Sbjct: 763 SEINPSM 769
>XP_006726519
          Length = 1493

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KSEVNPAM 9
           KSEV+P M
Sbjct: 897 KSEVSPGM 904
>XP_006716191
          Length = 1543

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KSEVNPAM 9
           KSEV+P M
Sbjct: 916 KSEVSPGM 923
>XP_006716190
          Length = 1597

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KSEVNPAM 9
           KSEV+P M
Sbjct: 916 KSEVSPGM 923
>NP_001166176
          Length = 907

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   IKSEVNP 7
           I SEVNP
Sbjct: 780 ISSEVNP 786
>NP_001036024
          Length = 869

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   IKSEVNP 7
           I SEVNP
Sbjct: 742 ISSEVNP 748
>NP_001409
          Length = 907

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   IKSEVNP 7
           I SEVNP
Sbjct: 780 ISSEVNP 786
>NP_006173
          Length = 855

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  KSEVNPAM 9
          K++VNPA+
Sbjct: 22 KAQVNPAI 29
>NP_001014796
          Length = 855

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  KSEVNPAM 9
          K++VNPA+
Sbjct: 22 KAQVNPAI 29
>NP_001257448
          Length = 690

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SEVNP M
Sbjct: 99  SEVNPQM 105
>NP_004681
          Length = 1130

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SEVNP M
Sbjct: 99  SEVNPQM 105
>XP_006715666
          Length = 886

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SEVNP M
Sbjct: 99  SEVNPQM 105
>XP_006711408
          Length = 571

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  KSEVNPAM 9
          K++VNPA+
Sbjct: 34 KAQVNPAI 41
>XP_006711407
          Length = 855

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  KSEVNPAM 9
          K++VNPA+
Sbjct: 22 KAQVNPAI 29
>XP_005245278
          Length = 867

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  KSEVNPAM 9
          K++VNPA+
Sbjct: 34 KAQVNPAI 41
>NP_001004308
          Length = 310

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KSEVNPAM 9
           K E+NP M
Sbjct: 141 KQEINPLM 148
>NP_000073
          Length = 396

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KSEVNPA 8
           KS++NPA
Sbjct: 378 KSQLNPA 384
>NP_001007234
          Length = 338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KSEVNPA 8
           KS++NPA
Sbjct: 320 KSQLNPA 326
>NP_001277214
          Length = 243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KSEVNPA 8
           KS++NPA
Sbjct: 225 KSQLNPA 231
>NP_036363
          Length = 1718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SEV PAM
Sbjct: 335 SEVTPAM 341
>NP_001007258
          Length = 1481

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SEV PAM
Sbjct: 134 SEVTPAM 140
>NP_056950
          Length = 1682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SEV PAM
Sbjct: 335 SEVTPAM 341
>XP_005246055
          Length = 1481

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SEV PAM
Sbjct: 134 SEVTPAM 140
>XP_006710943
          Length = 1517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SEV PAM
Sbjct: 134 SEVTPAM 140
>XP_006710942
          Length = 1517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SEV PAM
Sbjct: 134 SEVTPAM 140
>XP_006710941
          Length = 1517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SEV PAM
Sbjct: 134 SEVTPAM 140
>XP_005246054
          Length = 1517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SEV PAM
Sbjct: 134 SEVTPAM 140
>XP_005246053
          Length = 1644

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SEV PAM
Sbjct: 261 SEVTPAM 267
>XP_006710940
          Length = 1682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SEV PAM
Sbjct: 335 SEVTPAM 341
>XP_005246052
          Length = 1692

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SEV PAM
Sbjct: 345 SEVTPAM 351
>XP_005246051
          Length = 1717

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SEV PAM
Sbjct: 334 SEVTPAM 340
>XP_005246050
          Length = 1718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SEV PAM
Sbjct: 335 SEVTPAM 341
>XP_005246049
          Length = 1728

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SEV PAM
Sbjct: 345 SEVTPAM 351
>NP_001127835
          Length = 1227

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IKSEVNPAM 9
           +KSEV P +
Sbjct: 304 LKSEVGPLL 312
>NP_510966
          Length = 835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SE+NP M
Sbjct: 723 SEINPDM 729
>NP_001156909
          Length = 854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IKSEVNP 7
           +KSEV+P
Sbjct: 716 LKSEVSP 722
>NP_149106
          Length = 830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IKSEVNP 7
           +KSEV+P
Sbjct: 692 LKSEVSP 698
>NP_001156908
          Length = 893

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IKSEVNP 7
           +KSEV+P
Sbjct: 755 LKSEVSP 761
>NP_001277697
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IKSEVNP 7
           +KSEV+P
Sbjct: 583 LKSEVSP 589
>NP_001775
          Length = 742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SE+NP M
Sbjct: 630 SEINPDM 636
>NP_001156907
          Length = 893

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IKSEVNP 7
           +KSEV+P
Sbjct: 755 LKSEVSP 761
>NP_001020331
          Length = 786

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SE+NP M
Sbjct: 674 SEINPDM 680
>NP_036595
          Length = 856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EVNPAM 9
           EVNPA+
Sbjct: 393 EVNPAL 398
>NP_110394
          Length = 1439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SEVNPAM 9
           SEVNP++
Sbjct: 187 SEVNPSV 193
>NP_055437
          Length = 786

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IKSEVNPAM 9
           +KS V+PA+
Sbjct: 775 LKSSVDPAI 783
>XP_005260229
          Length = 801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SE+NP M
Sbjct: 689 SEINPDM 695
>XP_005260228
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SE+NP M
Sbjct: 733 SEINPDM 739
>XP_005260227
          Length = 894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SEVNPAM 9
           SE+NP M
Sbjct: 782 SEINPDM 788
>XP_006719381
          Length = 582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EVNPAM 9
           EVNPA+
Sbjct: 119 EVNPAL 124
>XP_006719380
          Length = 685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EVNPAM 9
           EVNPA+
Sbjct: 222 EVNPAL 227
>XP_005253620
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EVNPAM 9
           EVNPA+
Sbjct: 393 EVNPAL 398
>XP_006717358
          Length = 831

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SEVNPAM 9
           SEVNP++
Sbjct: 187 SEVNPSV 193
>XP_005252305
          Length = 1407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SEVNPAM 9
           SEVNP++
Sbjct: 187 SEVNPSV 193
>XP_005252303
          Length = 1439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SEVNPAM 9
           SEVNP++
Sbjct: 187 SEVNPSV 193
>XP_006717357
          Length = 1439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SEVNPAM 9
           SEVNP++
Sbjct: 187 SEVNPSV 193
>XP_005252304
          Length = 1439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SEVNPAM 9
           SEVNP++
Sbjct: 187 SEVNPSV 193
>XP_005252302
          Length = 1439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SEVNPAM 9
           SEVNP++
Sbjct: 187 SEVNPSV 193
>XP_005252301
          Length = 1439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SEVNPAM 9
           SEVNP++
Sbjct: 187 SEVNPSV 193
>XP_005252300
          Length = 1439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SEVNPAM 9
           SEVNP++
Sbjct: 187 SEVNPSV 193
>NP_001123614
          Length = 786

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IKSEVNPAM 9
           +KS V+PA+
Sbjct: 775 LKSSVDPAI 783
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.305    0.119    0.306 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 674,363
Number of extensions: 790
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package