Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245200                                                           18    1135
NP_000240                                                              18    1135
NP_001161089                                                           18    1135
NP_055444                                                              17    2528
NP_006434                                                              17    2528
NP_954653                                                              17    2528
XP_006725174                                                           17    2528
XP_006725173                                                           17    2528
XP_006725172                                                           17    2528
XP_006725171                                                           17    2528
XP_006725170                                                           17    2528
XP_006725169                                                           17    2528
XP_006725168                                                           17    2528
XP_006725167                                                           17    2528
XP_005266099                                                           17    2528
XP_006716304                                                           17    2528
XP_006716303                                                           17    2528
XP_006716302                                                           17    2528
XP_005266098                                                           17    2528
XP_005266097                                                           17    2528
XP_005266096                                                           17    2528
XP_006716301                                                           17    2528
NP_009187                                                              17    3301
NP_002069                                                              17    3301
NP_001166184                                                           17    3301
XP_006718490                                                           17    3301
XP_005265132                                                           17    3301
XP_005265131                                                           17    3301
XP_006713173                                                           17    3301
XP_005265130                                                           17    3301
XP_005265129                                                           17    3301
XP_005265128                                                           17    3301
XP_005265127                                                           17    3301
XP_005265126                                                           17    3301
NP_001138684                                                           17    3301
NP_001138683                                                           17    3301
NP_078925                                                              17    4312
NP_940876                                                              16    5631
XP_005252935                                                           16    5631
NP_005860                                                              16    5631
NP_001099043                                                           16    7355
XP_005276745                                                           16    7355
XP_006724409                                                           16    7355
XP_005261851                                                           16    7355
XP_005261850                                                           16    7355
XP_005260689                                                           16    7355
XP_005275950                                                           16    7355
NP_001138678                                                           16    7355
NP_919431                                                              15    9605
NP_061836                                                              15    9605
NP_115702                                                              15    9605
NP_001138593                                                           15    9605
NP_387505                                                              15    9605
NP_001273270                                                           15    9605
NP_689932                                                              15    9605
NP_001273359                                                           15    9605
NP_620147                                                              15    9605
NP_001273271                                                           15    9605
XP_005261857                                                           15    9605
XP_005261856                                                           15    9605
XP_006724410                                                           15    9605
XP_005261855                                                           15    9605
XP_005261854                                                           15    9605
XP_005261051                                                           15    9605
XP_006719837                                                           15    9605
XP_006713983                                                           15    9605
XP_005272364                                                           15    9605
XP_005272360                                                           15    9605
XP_005272359                                                           15    9605
XP_005272358                                                           15    9605
XP_006710958                                                           15    9605
NP_004601                                                              15    9605
NP_071376                                                              15    9605
>NP_001245200
          Length = 687

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IGREDKTLA 9
           IG EDKTLA
Sbjct: 231 IGCEDKTLA 239
>NP_000240
          Length = 756

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IGREDKTLA 9
           IG EDKTLA
Sbjct: 231 IGCEDKTLA 239
>NP_001161089
          Length = 658

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IGREDKTLA 9
           IG EDKTLA
Sbjct: 133 IGCEDKTLA 141
>NP_055444
          Length = 1344

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           +GRED  LA
Sbjct: 186 VGREDSALA 194
>NP_006434
          Length = 174

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  GREDKTL 8
          GRED+TL
Sbjct: 32 GREDRTL 38
>NP_954653
          Length = 148

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  GREDKTL 8
          GRED+TL
Sbjct: 32 GREDRTL 38
>XP_006725174
          Length = 1306

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           +GRED  LA
Sbjct: 187 VGREDSALA 195
>XP_006725173
          Length = 1328

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           +GRED  LA
Sbjct: 211 VGREDSALA 219
>XP_006725172
          Length = 1329

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           +GRED  LA
Sbjct: 210 VGREDSALA 218
>XP_006725171
          Length = 1330

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           +GRED  LA
Sbjct: 211 VGREDSALA 219
>XP_006725170
          Length = 1345

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           +GRED  LA
Sbjct: 187 VGREDSALA 195
>XP_006725169
          Length = 1368

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           +GRED  LA
Sbjct: 211 VGREDSALA 219
>XP_006725168
          Length = 1368

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           +GRED  LA
Sbjct: 210 VGREDSALA 218
>XP_006725167
          Length = 1369

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           +GRED  LA
Sbjct: 211 VGREDSALA 219
>XP_005266099
          Length = 1306

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           +GRED  LA
Sbjct: 187 VGREDSALA 195
>XP_006716304
          Length = 1328

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           +GRED  LA
Sbjct: 211 VGREDSALA 219
>XP_006716303
          Length = 1329

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           +GRED  LA
Sbjct: 210 VGREDSALA 218
>XP_006716302
          Length = 1330

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           +GRED  LA
Sbjct: 211 VGREDSALA 219
>XP_005266098
          Length = 1345

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           +GRED  LA
Sbjct: 187 VGREDSALA 195
>XP_005266097
          Length = 1368

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           +GRED  LA
Sbjct: 211 VGREDSALA 219
>XP_005266096
          Length = 1368

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           +GRED  LA
Sbjct: 210 VGREDSALA 218
>XP_006716301
          Length = 1369

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           +GRED  LA
Sbjct: 211 VGREDSALA 219
>NP_009187
          Length = 709

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IGREDKTLA 9
           + +EDKTLA
Sbjct: 590 VKKEDKTLA 598
>NP_002069
          Length = 2230

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    IGREDKTLA 9
            +GRE KT+A
Sbjct: 2187 MGRETKTMA 2195
>NP_001166184
          Length = 2243

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    IGREDKTLA 9
            +GRE KT+A
Sbjct: 2202 MGRETKTMA 2210
>XP_006718490
          Length = 635

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IGREDKTLA 9
           + +EDKTLA
Sbjct: 590 VKKEDKTLA 598
>XP_005265132
          Length = 2214

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    IGREDKTLA 9
            +GRE KT+A
Sbjct: 2171 MGRETKTMA 2179
>XP_005265131
          Length = 2245

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    IGREDKTLA 9
            +GRE KT+A
Sbjct: 2202 MGRETKTMA 2210
>XP_006713173
          Length = 2250

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    IGREDKTLA 9
            +GRE KT+A
Sbjct: 2207 MGRETKTMA 2215
>XP_005265130
          Length = 2252

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    IGREDKTLA 9
            +GRE KT+A
Sbjct: 2209 MGRETKTMA 2217
>XP_005265129
          Length = 2269

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    IGREDKTLA 9
            +GRE KT+A
Sbjct: 2226 MGRETKTMA 2234
>XP_005265128
          Length = 2278

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    IGREDKTLA 9
            +GRE KT+A
Sbjct: 2235 MGRETKTMA 2243
>XP_005265127
          Length = 2283

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    IGREDKTLA 9
            +GRE KT+A
Sbjct: 2242 MGRETKTMA 2250
>XP_005265126
          Length = 2285

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    IGREDKTLA 9
            +GRE KT+A
Sbjct: 2242 MGRETKTMA 2250
>NP_001138684
          Length = 565

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IGREDKTLA 9
           + +EDKTLA
Sbjct: 446 VKKEDKTLA 454
>NP_001138683
          Length = 687

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IGREDKTLA 9
           + +EDKTLA
Sbjct: 568 VKKEDKTLA 576
>NP_078925
          Length = 593

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GREDKTL 8
           GRED TL
Sbjct: 382 GREDNTL 388
>NP_940876
          Length = 402

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           I  EDKTLA
Sbjct: 112 IESEDKTLA 120
>XP_005252935
          Length = 402

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           I  EDKTLA
Sbjct: 112 IESEDKTLA 120
>NP_005860
          Length = 472

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   REDKTLA 9
           RED+TLA
Sbjct: 381 REDQTLA 387
>NP_001099043
          Length = 286

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EDKTLA 9
           EDKTLA
Sbjct: 237 EDKTLA 242
>XP_005276745
          Length = 271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GREDKTL 8
           G+ED+TL
Sbjct: 135 GKEDETL 141
>XP_006724409
          Length = 1806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   REDKTLA 9
           RED TLA
Sbjct: 445 REDSTLA 451
>XP_005261851
          Length = 1806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   REDKTLA 9
           RED TLA
Sbjct: 445 REDSTLA 451
>XP_005261850
          Length = 1806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   REDKTLA 9
           RED TLA
Sbjct: 445 REDSTLA 451
>XP_005260689
          Length = 271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GREDKTL 8
           G+ED+TL
Sbjct: 135 GKEDETL 141
>XP_005275950
          Length = 271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GREDKTL 8
           G+ED+TL
Sbjct: 135 GKEDETL 141
>NP_001138678
          Length = 1806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   REDKTLA 9
           RED TLA
Sbjct: 445 REDSTLA 451
>NP_919431
          Length = 1717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  IGREDKTLA 9
          +GRED+  A
Sbjct: 15 LGREDRASA 23
>NP_061836
          Length = 2320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IGREDKTL 8
           IGR+ KTL
Sbjct: 771 IGRKRKTL 778
>NP_115702
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           +G+ D TLA
Sbjct: 102 VGKTDDTLA 110
>NP_001138593
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   GREDKTLA 9
           GRE  TLA
Sbjct: 114 GRESHTLA 121
>NP_387505
          Length = 2269

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IGREDKTL 8
           IGR+ KTL
Sbjct: 771 IGRKRKTL 778
>NP_001273270
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GREDKTL 8
           G+ED TL
Sbjct: 214 GKEDSTL 220
>NP_689932
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GREDKTL 8
           G+ED TL
Sbjct: 241 GKEDSTL 247
>NP_001273359
          Length = 606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GREDKT 7
           GREDK+
Sbjct: 146 GREDKS 151
>NP_620147
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GREDKT 7
           GREDK+
Sbjct: 146 GREDKS 151
>NP_001273271
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GREDKTL 8
           G+ED TL
Sbjct: 205 GKEDSTL 211
>XP_005261857
          Length = 410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  REDKTLA 9
          R+DKTL+
Sbjct: 8  RQDKTLS 14
>XP_005261856
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   REDKTLA 9
           R+DKTL+
Sbjct: 292 RQDKTLS 298
>XP_006724410
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   REDKTLA 9
           R+DKTL+
Sbjct: 292 RQDKTLS 298
>XP_005261855
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   REDKTLA 9
           R+DKTL+
Sbjct: 292 RQDKTLS 298
>XP_005261854
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   REDKTLA 9
           R+DKTL+
Sbjct: 292 RQDKTLS 298
>XP_005261051
          Length = 2242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IGREDKTL 8
           IGR+ KTL
Sbjct: 771 IGRKRKTL 778
>XP_006719837
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GREDKTL 8
           G+ED TL
Sbjct: 205 GKEDSTL 211
>XP_006713983
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  IGREDKTLA 9
          +G+ D TLA
Sbjct: 20 VGKTDDTLA 28
>XP_005272364
          Length = 307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           +G+ D TLA
Sbjct: 102 VGKTDDTLA 110
>XP_005272360
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  IGREDKTLA 9
          +G+ D TLA
Sbjct: 20 VGKTDDTLA 28
>XP_005272359
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  IGREDKTLA 9
          +G+ D TLA
Sbjct: 20 VGKTDDTLA 28
>XP_005272358
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IGREDKTLA 9
           +G+ D TLA
Sbjct: 102 VGKTDDTLA 110
>XP_006710958
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  GREDKT 7
          GREDK+
Sbjct: 20 GREDKS 25
>NP_004601
          Length = 326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  GREDKTLA 9
          GRE  TLA
Sbjct: 87 GRESHTLA 94
>NP_071376
          Length = 1299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IGREDKTLA 9
            +GRED+  A
Sbjct: 1019 LGREDQRFA 1027
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.136    0.354 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 616,494
Number of extensions: 890
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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