Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              21     229
XP_005265800                                                           21     229
XP_006714103                                                           21     229
XP_006714102                                                           21     229
NP_056175                                                              17    2528
NP_001188467                                                           17    3301
NP_004033                                                              17    3301
NP_001188468                                                           17    3301
NP_620168                                                              16    5631
NP_079247                                                              16    5631
NP_001007472                                                           16    5631
NP_066003                                                              16    5631
NP_996830                                                              16    5631
NP_996829                                                              16    5631
NP_996828                                                              16    5631
NP_996827                                                              16    5631
NP_001171473                                                           16    5631
XP_006722720                                                           16    5631
XP_006722719                                                           16    5631
XP_006722718                                                           16    5631
XP_006722717                                                           16    5631
XP_005252275                                                           16    5631
NP_001161957                                                           16    7355
NP_001161954                                                           16    7355
NP_001161951                                                           16    7355
NP_001161952                                                           16    7355
NP_073749                                                              16    7355
NP_001161950                                                           16    7355
NP_613258                                                              16    7355
NP_001035248                                                           16    7355
NP_004408                                                              16    7355
NP_001385                                                              16    7355
NP_001171765                                                           16    7355
NP_001171764                                                           16    7355
NP_001073327                                                           16    7355
NP_001171766                                                           16    7355
NP_001171763                                                           16    7355
NP_001171762                                                           16    7355
NP_005747                                                              16    7355
NP_001073328                                                           16    7355
NP_001073329                                                           16    7355
NP_476499                                                              16    7355
NP_004884                                                              16    7355
XP_006724519                                                           16    7355
XP_006724518                                                           16    7355
XP_006724517                                                           16    7355
XP_006724516                                                           16    7355
XP_006724515                                                           16    7355
XP_006724514                                                           16    7355
XP_006724513                                                           16    7355
XP_006724512                                                           16    7355
XP_005253667                                                           16    7355
XP_005253666                                                           16    7355
XP_006716110                                                           16    7355
XP_006716109                                                           16    7355
NP_060120                                                              16    7355
NP_076417                                                              16    7355
NP_001269557                                                           15    9605
NP_000038                                                              15    9605
NP_000342                                                              15    9605
NP_115690                                                              15    9605
NP_055325                                                              15    9605
NP_149015                                                              15    9605
NP_001093146                                                           15    9605
NP_001258807                                                           15    9605
NP_006550                                                              15    9605
XP_005274576                                                           15    9605
XP_005274575                                                           15    9605
XP_006724551                                                           15    9605
XP_005274568                                                           15    9605
XP_006719702                                                           15    9605
XP_006715989                                                           15    9605
NP_001164104                                                           15    9605
NP_001135780                                                           15    9605
>NP_006197
          Length = 1089

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IDMIDDIGI 9
            IDM+DDIGI
Sbjct: 1070 IDMMDDIGI 1078
>XP_005265800
          Length = 1089

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IDMIDDIGI 9
            IDM+DDIGI
Sbjct: 1070 IDMMDDIGI 1078
>XP_006714103
          Length = 1111

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IDMIDDIGI 9
            IDM+DDIGI
Sbjct: 1092 IDMMDDIGI 1100
>XP_006714102
          Length = 1114

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IDMIDDIGI 9
            IDM+DDIGI
Sbjct: 1095 IDMMDDIGI 1103
>NP_056175
          Length = 1042

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IDMIDDIGI 9
           +D IDD+GI
Sbjct: 777 LDPIDDMGI 785
>NP_001188467
          Length = 590

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  MIDDIGI 9
          M+DD+GI
Sbjct: 36 MVDDLGI 42
>NP_004033
          Length = 590

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  MIDDIGI 9
          M+DD+GI
Sbjct: 36 MVDDLGI 42
>NP_001188468
          Length = 590

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  MIDDIGI 9
          M+DD+GI
Sbjct: 36 MVDDLGI 42
>NP_620168
          Length = 1300

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   DMIDDIG 8
           D++DD+G
Sbjct: 200 DLVDDMG 206
>NP_079247
          Length = 1566

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DMIDDI 7
           DM+DDI
Sbjct: 543 DMVDDI 548
>NP_001007472
          Length = 1707

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DMIDDI 7
           DM+DDI
Sbjct: 684 DMVDDI 689
>NP_066003
          Length = 1554

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DMIDDI 7
           DM+DDI
Sbjct: 531 DMVDDI 536
>NP_996830
          Length = 1569

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DMIDDI 7
           DM+DDI
Sbjct: 546 DMVDDI 551
>NP_996829
          Length = 1579

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DMIDDI 7
           DM+DDI
Sbjct: 556 DMVDDI 561
>NP_996828
          Length = 1556

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DMIDDI 7
           DM+DDI
Sbjct: 533 DMVDDI 538
>NP_996827
          Length = 1544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DMIDDI 7
           DM+DDI
Sbjct: 521 DMVDDI 526
>NP_001171473
          Length = 1263

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   DMIDDIG 8
           D++DD+G
Sbjct: 147 DLVDDMG 153
>XP_006722720
          Length = 820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   DMIDDIG 8
           D++DD+G
Sbjct: 200 DLVDDMG 206
>XP_006722719
          Length = 1224

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   DMIDDIG 8
           D++DD+G
Sbjct: 114 DLVDDMG 120
>XP_006722718
          Length = 1310

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   DMIDDIG 8
           D++DD+G
Sbjct: 200 DLVDDMG 206
>XP_006722717
          Length = 1310

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   DMIDDIG 8
           D++DD+G
Sbjct: 200 DLVDDMG 206
>XP_005252275
          Length = 1734

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DMIDDI 7
           DM+DDI
Sbjct: 711 DMVDDI 716
>NP_001161957
          Length = 558

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DMIDDIGI 9
           D+I D+GI
Sbjct: 346 DIIHDVGI 353
>NP_001161954
          Length = 558

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DMIDDIGI 9
           D+I D+GI
Sbjct: 346 DIIHDVGI 353
>NP_001161951
          Length = 558

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DMIDDIGI 9
           D+I D+GI
Sbjct: 346 DIIHDVGI 353
>NP_001161952
          Length = 558

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DMIDDIGI 9
           D+I D+GI
Sbjct: 346 DIIHDVGI 353
>NP_073749
          Length = 558

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DMIDDIGI 9
           D+I D+GI
Sbjct: 346 DIIHDVGI 353
>NP_001161950
          Length = 558

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DMIDDIGI 9
           D+I D+GI
Sbjct: 346 DIIHDVGI 353
>NP_613258
          Length = 372

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IDMIDDIG 8
           ID+ DD+G
Sbjct: 223 IDLKDDLG 230
>NP_001035248
          Length = 371

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IDMIDDIG 8
           ID+ DD+G
Sbjct: 222 IDLKDDLG 229
>NP_004408
          Length = 367

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DMIDDIGI 9
           DM+D +GI
Sbjct: 193 DMLDALGI 200
>NP_001385
          Length = 394

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DMIDDIGI 9
           DM+D +GI
Sbjct: 215 DMLDALGI 222
>NP_001171765
          Length = 993

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IDMIDDIGI 9
           + ++DDIG+
Sbjct: 400 LKVVDDIGL 408
>NP_001171764
          Length = 979

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IDMIDDIGI 9
           + ++DDIG+
Sbjct: 386 LKVVDDIGL 394
>NP_001073327
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IDMIDDIGI 9
           + ++DDIG+
Sbjct: 424 LKVVDDIGL 432
>NP_001171766
          Length = 987

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IDMIDDIGI 9
           + ++DDIG+
Sbjct: 394 LKVVDDIGL 402
>NP_001171763
          Length = 966

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IDMIDDIGI 9
           + ++DDIG+
Sbjct: 424 LKVVDDIGL 432
>NP_001171762
          Length = 1001

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IDMIDDIGI 9
           + ++DDIG+
Sbjct: 408 LKVVDDIGL 416
>NP_005747
          Length = 1014

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IDMIDDIGI 9
           + ++DDIG+
Sbjct: 421 LKVVDDIGL 429
>NP_001073328
          Length = 1003

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IDMIDDIGI 9
           + ++DDIG+
Sbjct: 410 LKVVDDIGL 418
>NP_001073329
          Length = 995

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IDMIDDIGI 9
           + ++DDIG+
Sbjct: 402 LKVVDDIGL 410
>NP_476499
          Length = 303

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DMIDDIGI 9
           DM+D +GI
Sbjct: 124 DMLDALGI 131
>NP_004884
          Length = 371

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IDMIDDIG 8
           ID+ DD+G
Sbjct: 222 IDLKDDLG 229
>XP_006724519
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IDMIDDIGI 9
           + ++DDIG+
Sbjct: 424 LKVVDDIGL 432
>XP_006724518
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IDMIDDIGI 9
           + ++DDIG+
Sbjct: 424 LKVVDDIGL 432
>XP_006724517
          Length = 1025

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IDMIDDIGI 9
           + ++DDIG+
Sbjct: 432 LKVVDDIGL 440
>XP_006724516
          Length = 1031

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IDMIDDIGI 9
           + ++DDIG+
Sbjct: 438 LKVVDDIGL 446
>XP_006724515
          Length = 1039

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IDMIDDIGI 9
           + ++DDIG+
Sbjct: 446 LKVVDDIGL 454
>XP_006724514
          Length = 1041

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IDMIDDIGI 9
           + ++DDIG+
Sbjct: 448 LKVVDDIGL 456
>XP_006724513
          Length = 1052

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IDMIDDIGI 9
           + ++DDIG+
Sbjct: 459 LKVVDDIGL 467
>XP_006724512
          Length = 1055

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IDMIDDIGI 9
           + ++DDIG+
Sbjct: 462 LKVVDDIGL 470
>XP_005253667
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DMIDDIGI 9
           D++D IGI
Sbjct: 368 DLVDRIGI 375
>XP_005253666
          Length = 631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DMIDDIGI 9
           D++D IGI
Sbjct: 368 DLVDRIGI 375
>XP_006716110
          Length = 1141

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    IDMIDD 6
            +DMIDD
Sbjct: 1004 LDMIDD 1009
>XP_006716109
          Length = 1365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    IDMIDD 6
            +DMIDD
Sbjct: 1228 LDMIDD 1233
>NP_060120
          Length = 1098

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   IDMIDD 6
           +DMIDD
Sbjct: 961 LDMIDD 966
>NP_076417
          Length = 672

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DMIDDIGI 9
           D++D IGI
Sbjct: 368 DLVDRIGI 375
>NP_001269557
          Length = 614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  MIDDIGI 9
          M DD+GI
Sbjct: 69 MADDLGI 75
>NP_000038
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  MIDDIGI 9
          M DD+GI
Sbjct: 44 MADDLGI 50
>NP_000342
          Length = 583

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  MIDDIGI 9
          M DD+GI
Sbjct: 33 MADDLGI 39
>NP_115690
          Length = 327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DMIDDIG 8
           DMI+D G
Sbjct: 299 DMIEDAG 305
>NP_055325
          Length = 4935

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    MIDDIG 8
            +IDDIG
Sbjct: 4048 LIDDIG 4053
>NP_149015
          Length = 5142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    MIDDIG 8
            +IDDIG
Sbjct: 4048 LIDDIG 4053
>NP_001093146
          Length = 462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  IDMIDD 6
          ID+IDD
Sbjct: 82 IDLIDD 87
>NP_001258807
          Length = 404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DMIDDI 7
           DM+DDI
Sbjct: 219 DMMDDI 224
>NP_006550
          Length = 443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DMIDDI 7
           DM+DDI
Sbjct: 258 DMMDDI 263
>XP_005274576
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  MIDDIGI 9
          M DD+GI
Sbjct: 44 MADDLGI 50
>XP_005274575
          Length = 598

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  MIDDIGI 9
          M DD+GI
Sbjct: 53 MADDLGI 59
>XP_006724551
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  MIDDIGI 9
          M DD+GI
Sbjct: 40 MADDLGI 46
>XP_005274568
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  MIDDIGI 9
          M DD+GI
Sbjct: 40 MADDLGI 46
>XP_006719702
          Length = 246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DMIDDIG 8
           DMI+D G
Sbjct: 218 DMIEDAG 224
>XP_006715989
          Length = 5148

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    MIDDIG 8
            +IDDIG
Sbjct: 4048 LIDDIG 4053
>NP_001164104
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  IDMIDD 6
          ID+IDD
Sbjct: 82 IDLIDD 87
>NP_001135780
          Length = 2156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   DMIDDIG 8
           D++DD G
Sbjct: 845 DLVDDCG 851
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.166    0.471 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 498,567
Number of extensions: 908
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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