Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005148                                                              20     509
NP_009297                                                              20     509
NP_003172                                                              17    2528
NP_001257413                                                           17    2528
XP_006709992                                                           17    2528
XP_006710191                                                           17    2528
NP_001177369                                                           16    5631
NP_006302                                                              16    5631
XP_005256932                                                           16    5631
XP_006721667                                                           16    5631
XP_005256931                                                           16    5631
XP_005256930                                                           16    5631
XP_006721666                                                           16    5631
XP_005256929                                                           16    5631
XP_005256928                                                           16    5631
XP_006721665                                                           16    5631
XP_005256925                                                           16    5631
XP_005256924                                                           16    5631
XP_006721664                                                           16    5631
XP_005256923                                                           16    5631
NP_116056                                                              16    7355
NP_001124174                                                           16    7355
NP_001116427                                                           16    7355
NP_871626                                                              16    7355
NP_001193583                                                           16    7355
NP_006303                                                              16    7355
NP_001070729                                                           16    7355
NP_037371                                                              16    7355
NP_002709                                                              16    7355
NP_001177376                                                           16    7355
NP_060910                                                              16    7355
XP_006725715                                                           16    7355
XP_006725714                                                           16    7355
XP_006725713                                                           16    7355
XP_006725712                                                           16    7355
XP_006725479                                                           16    7355
XP_006725478                                                           16    7355
XP_006725477                                                           16    7355
XP_006725476                                                           16    7355
XP_005274834                                                           16    7355
XP_006724926                                                           16    7355
XP_005274833                                                           16    7355
XP_005274485                                                           16    7355
XP_006724505                                                           16    7355
XP_005274484                                                           16    7355
XP_006716525                                                           16    7355
XP_006716524                                                           16    7355
XP_006713749                                                           16    7355
NP_001238892                                                           15    9605
NP_001238891                                                           15    9605
NP_002290                                                              15    9605
NP_002356                                                              15    9605
NP_056410                                                              15    9605
NP_001009959                                                           15    9605
NP_065762                                                              15    9605
XP_006725061                                                           15    9605
XP_005274567                                                           15    9605
>NP_005148
          Length = 1130

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IANGAITKG 9
            IA+GAITKG
Sbjct: 1022 IASGAITKG 1030
>NP_009297
          Length = 1149

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IANGAITKG 9
            IA+GAITKG
Sbjct: 1041 IASGAITKG 1049
>NP_003172
          Length = 435

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           ++NGA+T G
Sbjct: 353 VSNGAVTPG 361
>NP_001257413
          Length = 377

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           ++NGA+T G
Sbjct: 295 VSNGAVTPG 303
>XP_006709992
          Length = 1311

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   IANGAITKG 9
           IANG  TKG
Sbjct: 913 IANGDATKG 921
>XP_006710191
          Length = 1582

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IANGAITKG 9
            IANG  TKG
Sbjct: 1296 IANGDATKG 1304
>NP_001177369
          Length = 2337

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GAITKG 9
            GAITKG
Sbjct: 1346 GAITKG 1351
>NP_006302
          Length = 2440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GAITKG 9
            GAITKG
Sbjct: 1330 GAITKG 1335
>XP_005256932
          Length = 2448

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GAITKG 9
            GAITKG
Sbjct: 1414 GAITKG 1419
>XP_006721667
          Length = 2456

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GAITKG 9
            GAITKG
Sbjct: 1346 GAITKG 1351
>XP_005256931
          Length = 2466

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GAITKG 9
            GAITKG
Sbjct: 1356 GAITKG 1361
>XP_005256930
          Length = 2508

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GAITKG 9
            GAITKG
Sbjct: 1398 GAITKG 1403
>XP_006721666
          Length = 2511

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GAITKG 9
            GAITKG
Sbjct: 1414 GAITKG 1419
>XP_005256929
          Length = 2514

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GAITKG 9
            GAITKG
Sbjct: 1404 GAITKG 1409
>XP_005256928
          Length = 2515

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GAITKG 9
            GAITKG
Sbjct: 1405 GAITKG 1410
>XP_006721665
          Length = 2523

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GAITKG 9
            GAITKG
Sbjct: 1413 GAITKG 1418
>XP_005256925
          Length = 2523

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GAITKG 9
            GAITKG
Sbjct: 1413 GAITKG 1418
>XP_005256924
          Length = 2524

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GAITKG 9
            GAITKG
Sbjct: 1414 GAITKG 1419
>XP_006721664
          Length = 2524

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GAITKG 9
            GAITKG
Sbjct: 1414 GAITKG 1419
>XP_005256923
          Length = 2524

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GAITKG 9
            GAITKG
Sbjct: 1414 GAITKG 1419
>NP_116056
          Length = 398

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  IANGAITKG 9
          +AN ++TKG
Sbjct: 86 VANVSLTKG 94
>NP_001124174
          Length = 287

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  IANGAITKG 9
          +AN ++TKG
Sbjct: 86 VANVSLTKG 94
>NP_001116427
          Length = 462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           +AN ++TKG
Sbjct: 150 VANVSLTKG 158
>NP_871626
          Length = 529

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           I +GA+T+G
Sbjct: 318 IFSGAVTRG 326
>NP_001193583
          Length = 2504

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IANGAITKG 9
            +  G+ITKG
Sbjct: 1193 VPGGSITKG 1201
>NP_006303
          Length = 2514

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IANGAITKG 9
            +  G+ITKG
Sbjct: 1203 VPGGSITKG 1211
>NP_001070729
          Length = 2458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IANGAITKG 9
            +  G+ITKG
Sbjct: 1193 VPGGSITKG 1201
>NP_037371
          Length = 575

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           I +GA+T+G
Sbjct: 355 IFSGAVTRG 363
>NP_002709
          Length = 1150

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           I +GA+T+G
Sbjct: 939 IFSGAVTRG 947
>NP_001177376
          Length = 414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           I +GA+T+G
Sbjct: 203 IFSGAVTRG 211
>NP_060910
          Length = 432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  NGAITKG 9
          NGA+T G
Sbjct: 84 NGALTNG 90
>XP_006725715
          Length = 414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           I +GA+T+G
Sbjct: 194 IFSGAVTRG 202
>XP_006725714
          Length = 414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           I +GA+T+G
Sbjct: 194 IFSGAVTRG 202
>XP_006725713
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           I +GA+T+G
Sbjct: 289 IFSGAVTRG 297
>XP_006725712
          Length = 575

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           I +GA+T+G
Sbjct: 355 IFSGAVTRG 363
>XP_006725479
          Length = 414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           I +GA+T+G
Sbjct: 194 IFSGAVTRG 202
>XP_006725478
          Length = 414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           I +GA+T+G
Sbjct: 194 IFSGAVTRG 202
>XP_006725477
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           I +GA+T+G
Sbjct: 289 IFSGAVTRG 297
>XP_006725476
          Length = 575

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           I +GA+T+G
Sbjct: 355 IFSGAVTRG 363
>XP_005274834
          Length = 414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           I +GA+T+G
Sbjct: 194 IFSGAVTRG 202
>XP_006724926
          Length = 414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           I +GA+T+G
Sbjct: 194 IFSGAVTRG 202
>XP_005274833
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           I +GA+T+G
Sbjct: 289 IFSGAVTRG 297
>XP_005274485
          Length = 414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           I +GA+T+G
Sbjct: 194 IFSGAVTRG 202
>XP_006724505
          Length = 414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           I +GA+T+G
Sbjct: 194 IFSGAVTRG 202
>XP_005274484
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           I +GA+T+G
Sbjct: 289 IFSGAVTRG 297
>XP_006716525
          Length = 432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  NGAITKG 9
          NGA+T G
Sbjct: 84 NGALTNG 90
>XP_006716524
          Length = 432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  NGAITKG 9
          NGA+T G
Sbjct: 84 NGALTNG 90
>XP_006713749
          Length = 1150

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IANGAITKG 9
           I +GA+T+G
Sbjct: 939 IFSGAVTRG 947
>NP_001238892
          Length = 791

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ANGAIT 7
           ANGA+T
Sbjct: 129 ANGAVT 134
>NP_001238891
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ANGAIT 7
           ANGA+T
Sbjct: 129 ANGAVT 134
>NP_002290
          Length = 1927

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NGAITKG 9
           NG +TKG
Sbjct: 845 NGFLTKG 851
>NP_002356
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   NGAITKG 9
           NG +T+G
Sbjct: 189 NGTVTRG 195
>NP_056410
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ANGAIT 7
           ANGA+T
Sbjct: 129 ANGAVT 134
>NP_001009959
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  GAITKG 9
          GA+TKG
Sbjct: 64 GALTKG 69
>NP_065762
          Length = 284

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  GAITKG 9
          GA+TKG
Sbjct: 51 GALTKG 56
>XP_006725061
          Length = 904

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ANGAIT 7
           ANGA+T
Sbjct: 129 ANGAVT 134
>XP_005274567
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   NGAITKG 9
           NG +T+G
Sbjct: 189 NGTVTRG 195
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.132    0.357 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 480,830
Number of extensions: 775
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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