Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              18    1135
NP_001035957                                                           18    1135
XP_006721990                                                           18    1135
XP_006721989                                                           18    1135
XP_005258041                                                           18    1135
XP_006721988                                                           18    1135
XP_006721987                                                           18    1135
XP_006721986                                                           18    1135
XP_005258040                                                           18    1135
XP_006721985                                                           18    1135
NP_002882                                                              18    1482
NP_001139120                                                           18    1482
XP_006720692                                                           18    1482
XP_006720691                                                           18    1482
XP_006720690                                                           18    1482
XP_005254635                                                           18    1482
NP_005224                                                              17    4312
NP_004422                                                              17    4312
XP_005264773                                                           17    4312
XP_005264772                                                           17    4312
XP_005245809                                                           17    4312
XP_005245808                                                           17    4312
NP_001182502                                                           16    7355
NP_001258211                                                           16    7355
NP_085124                                                              16    7355
NP_803187                                                              16    7355
NP_001262                                                              16    7355
NP_775922                                                              16    7355
NP_079421                                                              15    9605
NP_001275558                                                           15    9605
NP_001156                                                              15    9605
NP_892007                                                              15    9605
NP_775819                                                              15    9605
NP_004431                                                              15    9605
XP_005258685                                                           15    9605
XP_005270233                                                           15    9605
XP_005270231                                                           15    9605
XP_005270230                                                           15    9605
XP_005270229                                                           15    9605
XP_005270228                                                           15    9605
XP_006715432                                                           15    9605
XP_005248726                                                           15    9605
>NP_000258
          Length = 2818

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AILDKLIT 9
            AILDKLIT
Sbjct: 1952 AILDKLIT 1959
>NP_001035957
          Length = 2839

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AILDKLIT 9
            AILDKLIT
Sbjct: 1973 AILDKLIT 1980
>XP_006721990
          Length = 2823

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AILDKLIT 9
            AILDKLIT
Sbjct: 1983 AILDKLIT 1990
>XP_006721989
          Length = 2823

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AILDKLIT 9
            AILDKLIT
Sbjct: 1983 AILDKLIT 1990
>XP_005258041
          Length = 2836

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AILDKLIT 9
            AILDKLIT
Sbjct: 1952 AILDKLIT 1959
>XP_006721988
          Length = 2846

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AILDKLIT 9
            AILDKLIT
Sbjct: 1962 AILDKLIT 1969
>XP_006721987
          Length = 2849

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AILDKLIT 9
            AILDKLIT
Sbjct: 1983 AILDKLIT 1990
>XP_006721986
          Length = 2854

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AILDKLIT 9
            AILDKLIT
Sbjct: 1970 AILDKLIT 1977
>XP_005258040
          Length = 2857

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AILDKLIT 9
            AILDKLIT
Sbjct: 1973 AILDKLIT 1980
>XP_006721985
          Length = 2867

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AILDKLIT 9
            AILDKLIT
Sbjct: 1983 AILDKLIT 1990
>NP_002882
          Length = 1273

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   IAILDKLIT 9
           I +LDKLIT
Sbjct: 685 IVVLDKLIT 693
>NP_001139120
          Length = 1257

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   IAILDKLIT 9
           I +LDKLIT
Sbjct: 672 IVVLDKLIT 680
>XP_006720692
          Length = 1270

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   IAILDKLIT 9
           I +LDKLIT
Sbjct: 685 IVVLDKLIT 693
>XP_006720691
          Length = 1182

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   IAILDKLIT 9
           I +LDKLIT
Sbjct: 672 IVVLDKLIT 680
>XP_006720690
          Length = 1245

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   IAILDKLIT 9
           I +LDKLIT
Sbjct: 672 IVVLDKLIT 680
>XP_005254635
          Length = 1280

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   IAILDKLIT 9
           I +LDKLIT
Sbjct: 672 IVVLDKLIT 680
>NP_005224
          Length = 983

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   IAILDKLI 8
           ++ILDKLI
Sbjct: 875 VSILDKLI 882
>NP_004422
          Length = 976

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   IAILDKLI 8
           ++ILDKLI
Sbjct: 868 VSILDKLI 875
>XP_005264773
          Length = 918

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   IAILDKLI 8
           ++ILDKLI
Sbjct: 875 VSILDKLI 882
>XP_005264772
          Length = 982

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   IAILDKLI 8
           ++ILDKLI
Sbjct: 874 VSILDKLI 881
>XP_005245809
          Length = 922

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   IAILDKLI 8
           ++ILDKLI
Sbjct: 814 VSILDKLI 821
>XP_005245808
          Length = 965

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   IAILDKLI 8
           ++ILDKLI
Sbjct: 857 VSILDKLI 864
>NP_001182502
          Length = 1829

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    AILDKLIT 9
            AILD LIT
Sbjct: 1710 AILDYLIT 1717
>NP_001258211
          Length = 1922

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    AILDKLIT 9
            AILD LIT
Sbjct: 1710 AILDYLIT 1717
>NP_085124
          Length = 1922

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    AILDKLIT 9
            AILD LIT
Sbjct: 1710 AILDYLIT 1717
>NP_803187
          Length = 1922

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    AILDKLIT 9
            AILD LIT
Sbjct: 1710 AILDYLIT 1717
>NP_001262
          Length = 1828

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IAILDKLIT 9
           + +LDKL+T
Sbjct: 793 LILLDKLLT 801
>NP_775922
          Length = 6996

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AILDKLIT 9
           AIL+KL+T
Sbjct: 915 AILEKLMT 922
>NP_079421
          Length = 1665

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    IAILDKL 7
            IA+LDK+
Sbjct: 1554 IAVLDKM 1560
>NP_001275558
          Length = 993

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IAILDKLI 8
           + ILDK+I
Sbjct: 882 VGILDKMI 889
>NP_001156
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IAILDKLIT 9
           I ILD L+T
Sbjct: 462 IPILDSLLT 470
>NP_892007
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IAILDKLIT 9
           I ILD L+T
Sbjct: 462 IPILDSLLT 470
>NP_775819
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AILDKLIT 9
           A+LD LIT
Sbjct: 173 ALLDHLIT 180
>NP_004431
          Length = 998

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IAILDKLI 8
           + ILDK+I
Sbjct: 887 VGILDKMI 894
>XP_005258685
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AILDKLIT 9
           A+LD LIT
Sbjct: 165 ALLDHLIT 172
>XP_005270233
          Length = 927

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IAILDKL 7
           IA+LDK+
Sbjct: 816 IAVLDKM 822
>XP_005270231
          Length = 1627

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    IAILDKL 7
            IA+LDK+
Sbjct: 1516 IAVLDKM 1522
>XP_005270230
          Length = 1627

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    IAILDKL 7
            IA+LDK+
Sbjct: 1516 IAVLDKM 1522
>XP_005270229
          Length = 1637

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    IAILDKL 7
            IA+LDK+
Sbjct: 1526 IAVLDKM 1532
>XP_005270228
          Length = 1666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    IAILDKL 7
            IA+LDK+
Sbjct: 1555 IAVLDKM 1561
>XP_006715432
          Length = 610

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IAILDKLI 8
           + ILDK+I
Sbjct: 499 VGILDKMI 506
>XP_005248726
          Length = 994

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IAILDKLI 8
           + ILDK+I
Sbjct: 883 VGILDKMI 890
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.335    0.154    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 441,488
Number of extensions: 737
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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