Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245202                                                           19     869
NP_001245200                                                           19     869
NP_001161091                                                           19     869
NP_000240                                                              19     869
NP_001161090                                                           19     869
NP_001161089                                                           19     869
NP_001245203                                                           19     869
XP_005265221                                                           19     869
XP_005265220                                                           19     869
NP_078831                                                              18    1935
NP_036294                                                              18    1935
NP_689777                                                              16    7355
NP_060360                                                              16    7355
NP_002449                                                              16    7355
NP_056058                                                              16    7355
NP_858047                                                              16    7355
XP_006716574                                                           16    7355
XP_006716573                                                           16    7355
XP_005250858                                                           16    7355
XP_005250857                                                           16    7355
NP_000476                                                              15    9605
NP_061959                                                              15    9605
NP_775760                                                              15    9605
XP_006719530                                                           15    9605
XP_005271456                                                           15    9605
>NP_001245202
          Length = 515

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  HSLVESTSL 9
          H LVESTSL
Sbjct: 23 HRLVESTSL 31
>NP_001245200
          Length = 687

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HSLVESTSL 9
           H LVESTSL
Sbjct: 264 HRLVESTSL 272
>NP_001161091
          Length = 515

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  HSLVESTSL 9
          H LVESTSL
Sbjct: 23 HRLVESTSL 31
>NP_000240
          Length = 756

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HSLVESTSL 9
           H LVESTSL
Sbjct: 264 HRLVESTSL 272
>NP_001161090
          Length = 515

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  HSLVESTSL 9
          H LVESTSL
Sbjct: 23 HRLVESTSL 31
>NP_001161089
          Length = 658

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HSLVESTSL 9
           H LVESTSL
Sbjct: 166 HRLVESTSL 174
>NP_001245203
          Length = 515

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  HSLVESTSL 9
          H LVESTSL
Sbjct: 23 HRLVESTSL 31
>XP_005265221
          Length = 515

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  HSLVESTSL 9
          H LVESTSL
Sbjct: 23 HRLVESTSL 31
>XP_005265220
          Length = 515

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  HSLVESTSL 9
          H LVESTSL
Sbjct: 23 HRLVESTSL 31
>NP_078831
          Length = 533

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   HSLVESTSL 9
           HS+VEST++
Sbjct: 249 HSMVESTAV 257
>NP_036294
          Length = 539

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   HSLVESTSL 9
           HS+VEST++
Sbjct: 255 HSMVESTAV 263
>NP_689777
          Length = 3997

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLVESTSL 9
           H+LVES  L
Sbjct: 256 HTLVESLKL 264
>NP_060360
          Length = 4022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLVESTSL 9
           H+LVES  L
Sbjct: 256 HTLVESLKL 264
>NP_002449
          Length = 5762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   HSLVESTS 8
           H+LV+ST+
Sbjct: 275 HALVDSTA 282
>NP_056058
          Length = 863

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLVESTSL 9
           H+LVES  L
Sbjct: 256 HTLVESLKL 264
>NP_858047
          Length = 415

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLVESTSL 9
           H+LVES  L
Sbjct: 256 HTLVESLKL 264
>XP_006716574
          Length = 968

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLVESTSL 9
           H+LVES  L
Sbjct: 256 HTLVESLKL 264
>XP_006716573
          Length = 1776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLVESTSL 9
           H+LVES  L
Sbjct: 256 HTLVESLKL 264
>XP_005250858
          Length = 4022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLVESTSL 9
           H+LVES  L
Sbjct: 256 HTLVESLKL 264
>XP_005250857
          Length = 4022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLVESTSL 9
           H+LVES  L
Sbjct: 256 HTLVESLKL 264
>NP_000476
          Length = 180

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SLVESTSL 9
           SLVE TSL
Sbjct: 155 SLVELTSL 162
>NP_061959
          Length = 540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SLVESTSL 9
          SLV++TSL
Sbjct: 81 SLVDATSL 88
>NP_775760
          Length = 1585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLVESTSL 9
           HS  EST+L
Sbjct: 486 HSAKESTAL 494
>XP_006719530
          Length = 439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SLVESTSL 9
          SLV++TSL
Sbjct: 81 SLVDATSL 88
>XP_005271456
          Length = 344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HSLVESTSL 9
           H++  STSL
Sbjct: 108 HAMASSTSL 116
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.299    0.110    0.262 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 331,860
Number of extensions: 522
Number of successful extensions: 25
Number of sequences better than 10000.0: 25
Number of HSP's gapped: 25
Number of HSP's successfully gapped: 25
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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