Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245202                                                           19     869
NP_001245200                                                           19     869
NP_001161091                                                           19     869
NP_000240                                                              19     869
NP_001161090                                                           19     869
NP_001161089                                                           19     869
NP_001245203                                                           19     869
XP_005265221                                                           19     869
XP_005265220                                                           19     869
NP_001243000                                                           18    1935
XP_005257603                                                           18    1935
XP_006722058                                                           18    1935
XP_005257602                                                           18    1935
NP_976046                                                              17    4312
NP_073754                                                              17    4312
NP_689777                                                              16    5631
NP_060360                                                              16    5631
NP_056058                                                              16    5631
NP_060647                                                              16    5631
NP_858047                                                              16    5631
NP_001229338                                                           16    5631
NP_001010987                                                           16    5631
NP_073588                                                              16    5631
XP_006716574                                                           16    5631
XP_006716573                                                           16    5631
XP_005250858                                                           16    5631
XP_005250857                                                           16    5631
XP_006714086                                                           16    5631
XP_006714085                                                           16    5631
XP_006714084                                                           16    5631
NP_115642                                                              15    9605
NP_000312                                                              15    9605
NP_001273063                                                           15    9605
NP_068751                                                              15    9605
NP_004721                                                              15    9605
NP_001243231                                                           15    9605
NP_001177962                                                           15    9605
NP_001269114                                                           15    9605
NP_001131140                                                           15    9605
NP_036247                                                              15    9605
NP_075055                                                              15    9605
NP_001161713                                                           15    9605
NP_079113                                                              15    9605
NP_001131139                                                           15    9605
XP_006722904                                                           15    9605
XP_005260077                                                           15    9605
XP_006720759                                                           15    9605
XP_006720758                                                           15    9605
XP_006720757                                                           15    9605
XP_006720756                                                           15    9605
XP_006718333                                                           15    9605
XP_005253109                                                           15    9605
XP_005271978                                                           15    9605
XP_005271977                                                           15    9605
XP_006712014                                                           15    9605
>NP_001245202
          Length = 515

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  HRLVESISL 9
          HRLVES SL
Sbjct: 23 HRLVESTSL 31
>NP_001245200
          Length = 687

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HRLVESISL 9
           HRLVES SL
Sbjct: 264 HRLVESTSL 272
>NP_001161091
          Length = 515

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  HRLVESISL 9
          HRLVES SL
Sbjct: 23 HRLVESTSL 31
>NP_000240
          Length = 756

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HRLVESISL 9
           HRLVES SL
Sbjct: 264 HRLVESTSL 272
>NP_001161090
          Length = 515

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  HRLVESISL 9
          HRLVES SL
Sbjct: 23 HRLVESTSL 31
>NP_001161089
          Length = 658

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HRLVESISL 9
           HRLVES SL
Sbjct: 166 HRLVESTSL 174
>NP_001245203
          Length = 515

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  HRLVESISL 9
          HRLVES SL
Sbjct: 23 HRLVESTSL 31
>XP_005265221
          Length = 515

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  HRLVESISL 9
          HRLVES SL
Sbjct: 23 HRLVESTSL 31
>XP_005265220
          Length = 515

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  HRLVESISL 9
          HRLVES SL
Sbjct: 23 HRLVESTSL 31
>NP_001243000
          Length = 5207

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    RLVESISL 9
            RLVESISL
Sbjct: 2600 RLVESISL 2607
>XP_005257603
          Length = 5256

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    RLVESISL 9
            RLVESISL
Sbjct: 2649 RLVESISL 2656
>XP_006722058
          Length = 5256

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    RLVESISL 9
            RLVESISL
Sbjct: 2649 RLVESISL 2656
>XP_005257602
          Length = 5256

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    RLVESISL 9
            RLVESISL
Sbjct: 2649 RLVESISL 2656
>NP_976046
          Length = 555

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           H L+E +SL
Sbjct: 511 HNLIEQVSL 519
>NP_073754
          Length = 951

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HRLVESIS 8
           HR VES+S
Sbjct: 878 HRKVESVS 885
>NP_689777
          Length = 3997

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           H LVES+ L
Sbjct: 256 HTLVESLKL 264
>NP_060360
          Length = 4022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           H LVES+ L
Sbjct: 256 HTLVESLKL 264
>NP_056058
          Length = 863

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           H LVES+ L
Sbjct: 256 HTLVESLKL 264
>NP_060647
          Length = 1770

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HRLVESISL 9
           H+LV S+S+
Sbjct: 825 HKLVNSVSV 833
>NP_858047
          Length = 415

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           H LVES+ L
Sbjct: 256 HTLVESLKL 264
>NP_001229338
          Length = 876

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           HR  ESISL
Sbjct: 203 HRTNESISL 211
>NP_001010987
          Length = 474

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   RLVESISL 9
           R+VES+SL
Sbjct: 435 RVVESVSL 442
>NP_073588
          Length = 875

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           HR  ESISL
Sbjct: 203 HRTNESISL 211
>XP_006716574
          Length = 968

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           H LVES+ L
Sbjct: 256 HTLVESLKL 264
>XP_006716573
          Length = 1776

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           H LVES+ L
Sbjct: 256 HTLVESLKL 264
>XP_005250858
          Length = 4022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           H LVES+ L
Sbjct: 256 HTLVESLKL 264
>XP_005250857
          Length = 4022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           H LVES+ L
Sbjct: 256 HTLVESLKL 264
>XP_006714086
          Length = 1690

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HRLVESISL 9
           H+LV S+S+
Sbjct: 745 HKLVNSVSV 753
>XP_006714085
          Length = 1690

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HRLVESISL 9
           H+LV S+S+
Sbjct: 745 HKLVNSVSV 753
>XP_006714084
          Length = 1753

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HRLVESISL 9
           H+LV S+S+
Sbjct: 825 HKLVNSVSV 833
>NP_115642
          Length = 1984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           HR+ ES+ L
Sbjct: 356 HRVPESVEL 364
>NP_000312
          Length = 928

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   HRLVESIS 8
           HR++ES++
Sbjct: 555 HRIMESLA 562
>NP_001273063
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HRLVESIS 8
           HRL ES++
Sbjct: 325 HRLKESVA 332
>NP_068751
          Length = 537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HRLVESIS 8
           HRL ES++
Sbjct: 325 HRLKESVA 332
>NP_004721
          Length = 437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           H L+ES+ L
Sbjct: 366 HELIESMPL 374
>NP_001243231
          Length = 404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           H L+ES+ L
Sbjct: 333 HELIESMPL 341
>NP_001177962
          Length = 664

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           HR  ES+SL
Sbjct: 144 HRTNESLSL 152
>NP_001269114
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           H L+ES+ L
Sbjct: 352 HELIESMPL 360
>NP_001131140
          Length = 1982

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HRLVESISL 9
            HR++ES  L
Sbjct: 1066 HRIIESAIL 1074
>NP_036247
          Length = 1982

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HRLVESISL 9
            HR++ES  L
Sbjct: 1066 HRIIESAIL 1074
>NP_075055
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RLVESIS 8
           RLVES+S
Sbjct: 910 RLVESLS 916
>NP_001161713
          Length = 874

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           HR  ES+SL
Sbjct: 221 HRTNESLSL 229
>NP_079113
          Length = 1192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           H L+ESI +
Sbjct: 451 HHLMESIKM 459
>NP_001131139
          Length = 1982

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HRLVESISL 9
            HR++ES  L
Sbjct: 1066 HRIIESAIL 1074
>XP_006722904
          Length = 546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RLVESIS 8
           RLVES+S
Sbjct: 445 RLVESLS 451
>XP_005260077
          Length = 1005

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RLVESIS 8
           RLVES+S
Sbjct: 904 RLVESLS 910
>XP_006720759
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           H L+ESI +
Sbjct: 488 HHLMESIKM 496
>XP_006720758
          Length = 754

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           H L+ESI +
Sbjct: 488 HHLMESIKM 496
>XP_006720757
          Length = 1008

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           H L+ESI +
Sbjct: 267 HHLMESIKM 275
>XP_006720756
          Length = 1229

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           H L+ESI +
Sbjct: 488 HHLMESIKM 496
>XP_006718333
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HRLVESIS 8
           HRL ES++
Sbjct: 215 HRLKESVA 222
>XP_005253109
          Length = 535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HRLVESIS 8
           HRL ES++
Sbjct: 329 HRLKESVA 336
>XP_005271978
          Length = 404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           H L+ES+ L
Sbjct: 333 HELIESMPL 341
>XP_005271977
          Length = 404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           H L+ES+ L
Sbjct: 333 HELIESMPL 341
>XP_006712014
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HRLVESISL 9
           HR  ES+SL
Sbjct: 221 HRTNESLSL 229
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.135    0.343 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 326,919
Number of extensions: 432
Number of successful extensions: 55
Number of sequences better than 10000.0: 55
Number of HSP's gapped: 55
Number of HSP's successfully gapped: 55
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package