Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001005172                                                           18    1935
NP_001005171                                                           18    1935
NP_001005169                                                           17    3301
NP_001005170                                                           17    3301
NP_060421                                                              17    4312
NP_001164554                                                           17    4312
NP_060221                                                              17    4312
NP_001157851                                                           17    4312
XP_005263761                                                           17    4312
XP_006712688                                                           17    4312
NP_001128504                                                           16    5631
NP_115557                                                              16    5631
NP_001367                                                              16    7355
NP_001269461                                                           16    7355
NP_056154                                                              16    7355
NP_001182325                                                           16    7355
NP_997625                                                              16    7355
NP_001032241                                                           16    7355
NP_001269460                                                           16    7355
NP_005729                                                              16    7355
NP_055906                                                              16    7355
NP_001184154                                                           16    7355
NP_852107                                                              16    7355
NP_001001479                                                           16    7355
XP_006723822                                                           16    7355
XP_006721207                                                           16    7355
XP_006720146                                                           16    7355
XP_005267508                                                           16    7355
NP_001004747                                                           16    7355
NP_112217                                                              16    7355
NP_001004477                                                           16    7355
NP_001153699                                                           15    9605
NP_079413                                                              15    9605
NP_055087                                                              15    9605
NP_060445                                                              15    9605
NP_001274750                                                           15    9605
NP_001274751                                                           15    9605
NP_001274752                                                           15    9605
NP_775733                                                              15    9605
NP_055746                                                              15    9605
XP_006723153                                                           15    9605
XP_005258727                                                           15    9605
XP_005258726                                                           15    9605
XP_006720764                                                           15    9605
XP_005254752                                                           15    9605
XP_006720763                                                           15    9605
XP_006720762                                                           15    9605
XP_005254751                                                           15    9605
XP_005254194                                                           15    9605
XP_005268242                                                           15    9605
XP_005268241                                                           15    9605
XP_005270390                                                           15    9605
XP_006711823                                                           15    9605
NP_733843                                                              15    9605
>NP_001005172
          Length = 314

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HILIVRLSC 9
           H+ +VRL+C
Sbjct: 183 HMAVVRLAC 191
>NP_001005171
          Length = 314

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HILIVRLSC 9
           H+ +VRL+C
Sbjct: 183 HMAVVRLAC 191
>NP_001005169
          Length = 324

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HILIVRLSC 9
           HI + RL+C
Sbjct: 185 HIALARLAC 193
>NP_001005170
          Length = 350

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HILIVRLSC 9
           HI + RL+C
Sbjct: 211 HIALARLAC 219
>NP_060421
          Length = 866

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   HILIVRL 7
           H+L+VRL
Sbjct: 365 HVLVVRL 371
>NP_001164554
          Length = 764

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   HILIVRL 7
           H+L+VRL
Sbjct: 263 HVLVVRL 269
>NP_060221
          Length = 837

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   HILIVRL 7
           H+L+VRL
Sbjct: 336 HVLVVRL 342
>NP_001157851
          Length = 183

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HILIVRLSC 9
           H+L+  LSC
Sbjct: 120 HLLLTGLSC 128
>XP_005263761
          Length = 530

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  HILIVRL 7
          H+L+VRL
Sbjct: 29 HVLVVRL 35
>XP_006712688
          Length = 559

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  HILIVRL 7
          H+L+VRL
Sbjct: 58 HVLVVRL 64
>NP_001128504
          Length = 152

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  LIVRLSC 9
          L++R+SC
Sbjct: 53 LVIRISC 59
>NP_115557
          Length = 152

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  LIVRLSC 9
          L++R+SC
Sbjct: 53 LVIRISC 59
>NP_001367
          Length = 4646

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    IVRLSC 9
            +VRLSC
Sbjct: 3935 VVRLSC 3940
>NP_001269461
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HILIVRLSC 9
           H+LI  LSC
Sbjct: 506 HMLIHGLSC 514
>NP_056154
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HILIVRLSC 9
           H+LI  LSC
Sbjct: 506 HMLIHGLSC 514
>NP_001182325
          Length = 200

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  HILIVRLSC 9
          HI+I+ L C
Sbjct: 22 HIVILGLDC 30
>NP_997625
          Length = 200

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  HILIVRLSC 9
          HI+I+ L C
Sbjct: 22 HIVILGLDC 30
>NP_001032241
          Length = 200

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  HILIVRLSC 9
          HI+I+ L C
Sbjct: 22 HIVILGLDC 30
>NP_001269460
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HILIVRLSC 9
           H+LI  LSC
Sbjct: 506 HMLIHGLSC 514
>NP_005729
          Length = 200

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  HILIVRLSC 9
          HI+I+ L C
Sbjct: 22 HIVILGLDC 30
>NP_055906
          Length = 1720

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   HILIVRL 7
           H+L++RL
Sbjct: 419 HLLVIRL 425
>NP_001184154
          Length = 208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ILIVRLSC 9
           I +VR+SC
Sbjct: 103 IFLVRVSC 110
>NP_852107
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HILIVRLSC 9
           H+LI  LSC
Sbjct: 506 HMLIHGLSC 514
>NP_001001479
          Length = 350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  HILIVRLSC 9
          H+L+  L+C
Sbjct: 86 HMLVAALAC 94
>XP_006723822
          Length = 1111

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HILIVRLSC 9
           H+LI  LSC
Sbjct: 515 HMLIHGLSC 523
>XP_006721207
          Length = 159

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ILIVRLSC 9
          I +VR+SC
Sbjct: 54 IFLVRVSC 61
>XP_006720146
          Length = 1226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   HILIVRL 7
           H+L++RL
Sbjct: 419 HLLVIRL 425
>XP_005267508
          Length = 1773

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   HILIVRL 7
           H+L++RL
Sbjct: 419 HLLVIRL 425
>NP_001004747
          Length = 340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ILIVRLSC 9
           ILIV +SC
Sbjct: 241 ILIVLISC 248
>NP_112217
          Length = 1594

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   HILIVRL 7
           HI++VRL
Sbjct: 292 HIVVVRL 298
>NP_001004477
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   ILIVRLSC 9
           + ++RLSC
Sbjct: 198 LAVIRLSC 205
>NP_001153699
          Length = 2330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    HILIVRLSC 9
            H+L V L C
Sbjct: 1003 HLLYVYLDC 1011
>NP_079413
          Length = 2443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    HILIVRLSC 9
            H+L V L C
Sbjct: 1003 HLLYVYLDC 1011
>NP_055087
          Length = 1686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   HILIVRL 7
           HI IVRL
Sbjct: 288 HITIVRL 294
>NP_060445
          Length = 591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HILIVRLSC 9
           HIL + +SC
Sbjct: 469 HILEILVSC 477
>NP_001274750
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HILIVRLSC 9
           HIL + +SC
Sbjct: 355 HILEILVSC 363
>NP_001274751
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HILIVRLSC 9
           HIL + +SC
Sbjct: 355 HILEILVSC 363
>NP_001274752
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HILIVRLSC 9
           HIL + +SC
Sbjct: 355 HILEILVSC 363
>NP_775733
          Length = 1251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IVRLSC 9
           +VRLSC
Sbjct: 899 LVRLSC 904
>NP_055746
          Length = 881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HILIVRLSC 9
           H L  RLSC
Sbjct: 318 HALRPRLSC 326
>XP_006723153
          Length = 754

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HILIVRLSC 9
           H L  RLSC
Sbjct: 191 HALRPRLSC 199
>XP_005258727
          Length = 881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HILIVRLSC 9
           H L  RLSC
Sbjct: 318 HALRPRLSC 326
>XP_005258726
          Length = 881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HILIVRLSC 9
           H L  RLSC
Sbjct: 318 HALRPRLSC 326
>XP_006720764
          Length = 1584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    HILIVRLSC 9
            H+L V L C
Sbjct: 1003 HLLYVYLDC 1011
>XP_005254752
          Length = 2357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HILIVRLSC 9
           H+L V L C
Sbjct: 917 HLLYVYLDC 925
>XP_006720763
          Length = 2395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    HILIVRLSC 9
            H+L V L C
Sbjct: 1003 HLLYVYLDC 1011
>XP_006720762
          Length = 2397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    HILIVRLSC 9
            H+L V L C
Sbjct: 1003 HLLYVYLDC 1011
>XP_005254751
          Length = 2407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    HILIVRLSC 9
            H+L V L C
Sbjct: 1003 HLLYVYLDC 1011
>XP_005254194
          Length = 1689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   HILIVRL 7
           HI IVRL
Sbjct: 288 HITIVRL 294
>XP_005268242
          Length = 1285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IVRLSC 9
           +VRLSC
Sbjct: 933 LVRLSC 938
>XP_005268241
          Length = 1300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IVRLSC 9
           +VRLSC
Sbjct: 948 LVRLSC 953
>XP_005270390
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LIVRLSC 9
           LI+R++C
Sbjct: 245 LIIRMNC 251
>XP_006711823
          Length = 592

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LIVRLSC 9
           LI+R++C
Sbjct: 248 LIIRMNC 254
>NP_733843
          Length = 592

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LIVRLSC 9
           LI+R++C
Sbjct: 248 LIIRMNC 254
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.350    0.155    0.516 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 437,310
Number of extensions: 974
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.8 bits)
S2: 28 (15.4 bits)

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