Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              20     299
XP_005265800                                                           20     299
XP_006714103                                                           20     299
XP_006714102                                                           20     299
NP_076927                                                              17    4312
NP_115780                                                              17    4312
NP_001007262                                                           17    4312
NP_001007260                                                           17    4312
NP_001243246                                                           17    4312
XP_006724086                                                           17    4312
XP_006724085                                                           17    4312
NP_115781                                                              17    4312
NP_694551                                                              16    5631
NP_061863                                                              16    5631
NP_067646                                                              16    5631
XP_006711541                                                           16    5631
XP_005245460                                                           16    5631
NP_653312                                                              16    7355
NP_005046                                                              16    7355
NP_690051                                                              16    7355
NP_116034                                                              16    7355
NP_006038                                                              16    7355
NP_001012267                                                           16    7355
NP_001185769                                                           16    7355
NP_001185767                                                           16    7355
NP_001186219                                                           16    7355
NP_001273898                                                           16    7355
NP_001273900                                                           16    7355
XP_005253100                                                           16    7355
XP_005253099                                                           16    7355
NP_001001920                                                           16    7355
NP_001439                                                              15    9605
NP_056054                                                              15    9605
NP_001070143                                                           15    9605
NP_001092739                                                           15    9605
NP_003671                                                              15    9605
NP_001273646                                                           15    9605
NP_056298                                                              15    9605
NP_001138876                                                           15    9605
NP_775873                                                              15    9605
NP_060289                                                              15    9605
NP_001273644                                                           15    9605
NP_775802                                                              15    9605
NP_775483                                                              15    9605
NP_055897                                                              15    9605
NP_055789                                                              15    9605
NP_001139588                                                           15    9605
NP_055966                                                              15    9605
XP_006726297                                                           15    9605
XP_006726296                                                           15    9605
XP_006726295                                                           15    9605
XP_006722726                                                           15    9605
XP_006722725                                                           15    9605
XP_005259841                                                           15    9605
XP_005259840                                                           15    9605
XP_006719585                                                           15    9605
XP_006719584                                                           15    9605
XP_005269101                                                           15    9605
XP_006719583                                                           15    9605
XP_006717878                                                           15    9605
XP_005269804                                                           15    9605
XP_005269803                                                           15    9605
XP_005269802                                                           15    9605
XP_005269801                                                           15    9605
XP_005252487                                                           15    9605
XP_005252486                                                           15    9605
XP_005252485                                                           15    9605
XP_005252484                                                           15    9605
XP_005252483                                                           15    9605
XP_005251906                                                           15    9605
XP_005251905                                                           15    9605
XP_005251904                                                           15    9605
XP_005249754                                                           15    9605
XP_005249753                                                           15    9605
NP_066385                                                              15    9605
>NP_006197
          Length = 1089

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HDSIYVSKG 9
           HDS YVSKG
Sbjct: 845 HDSNYVSKG 853
>XP_005265800
          Length = 1089

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HDSIYVSKG 9
           HDS YVSKG
Sbjct: 845 HDSNYVSKG 853
>XP_006714103
          Length = 1111

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HDSIYVSKG 9
           HDS YVSKG
Sbjct: 867 HDSNYVSKG 875
>XP_006714102
          Length = 1114

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HDSIYVSKG 9
           HDS YVSKG
Sbjct: 870 HDSNYVSKG 878
>NP_076927
          Length = 454

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HDSIYVSKG 9
           H S+YV +G
Sbjct: 185 HHSVYVREG 193
>NP_115780
          Length = 327

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  HDSIYVSKG 9
          H S+YV +G
Sbjct: 58 HHSVYVREG 66
>NP_001007262
          Length = 283

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HDSIYVSKG 9
           H  +YVS+G
Sbjct: 269 HACVYVSRG 277
>NP_001007260
          Length = 307

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HDSIYVSKG 9
           H  +YVS+G
Sbjct: 293 HACVYVSRG 301
>NP_001243246
          Length = 453

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HDSIYVSKG 9
           H S+YV +G
Sbjct: 185 HHSVYVREG 193
>XP_006724086
          Length = 324

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HDSIYVSKG 9
           H  +YVS+G
Sbjct: 310 HACVYVSRG 318
>XP_006724085
          Length = 338

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HDSIYVSKG 9
           H  +YVS+G
Sbjct: 310 HACVYVSRG 318
>NP_115781
          Length = 344

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HDSIYVSKG 9
           H S+YV +G
Sbjct: 185 HHSVYVREG 193
>NP_694551
          Length = 534

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SIYVSKG 9
           SIYVS+G
Sbjct: 417 SIYVSEG 423
>NP_061863
          Length = 380

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HDSIYVSKG 9
           HDS+ + KG
Sbjct: 191 HDSLKLQKG 199
>NP_067646
          Length = 568

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HDSIYVSKG 9
           HD IYV  G
Sbjct: 328 HDRIYVIGG 336
>XP_006711541
          Length = 509

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HDSIYVSKG 9
           HD IYV  G
Sbjct: 366 HDRIYVIGG 374
>XP_005245460
          Length = 606

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HDSIYVSKG 9
           HD IYV  G
Sbjct: 366 HDRIYVIGG 374
>NP_653312
          Length = 558

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HDSIYVSKG 9
           HD IYV  G
Sbjct: 415 HDVIYVIGG 423
>NP_005046
          Length = 412

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DSIYVSKG 9
           +SIY SKG
Sbjct: 333 ESIYRSKG 340
>NP_690051
          Length = 932

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DSIYVSKG 9
           DSIY++ G
Sbjct: 458 DSIYIAYG 465
>NP_116034
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DSIYVSKG 9
           +SIY SKG
Sbjct: 274 ESIYRSKG 281
>NP_006038
          Length = 932

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DSIYVSKG 9
           DSIY++ G
Sbjct: 458 DSIYIAYG 465
>NP_001012267
          Length = 288

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   DSIYVSKG 9
           D++Y+S+G
Sbjct: 193 DAVYLSEG 200
>NP_001185769
          Length = 932

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DSIYVSKG 9
           DSIY++ G
Sbjct: 458 DSIYIAYG 465
>NP_001185767
          Length = 932

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DSIYVSKG 9
           DSIY++ G
Sbjct: 458 DSIYIAYG 465
>NP_001186219
          Length = 558

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HDSIYVSKG 9
           HD IYV  G
Sbjct: 415 HDVIYVIGG 423
>NP_001273898
          Length = 176

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  DSIYVSKG 9
          D++Y+S+G
Sbjct: 81 DAVYLSEG 88
>NP_001273900
          Length = 115

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  DSIYVSKG 9
          D++Y+S+G
Sbjct: 20 DAVYLSEG 27
>XP_005253100
          Length = 371

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DSIYVSKG 9
           +SIY SKG
Sbjct: 292 ESIYRSKG 299
>XP_005253099
          Length = 394

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DSIYVSKG 9
           +SIY SKG
Sbjct: 315 ESIYRSKG 322
>NP_001001920
          Length = 370

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DSIYVSK 8
           DS+YV+K
Sbjct: 137 DSLYVTK 143
>NP_001439
          Length = 556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  IYVSKG 9
          +YVSKG
Sbjct: 36 LYVSKG 41
>NP_056054
          Length = 1186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HDSIYVSKG 9
           H +IY +KG
Sbjct: 950 HPTIYHAKG 958
>NP_001070143
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HDSIYVSKG 9
           HD++ + KG
Sbjct: 108 HDNLQLKKG 116
>NP_001092739
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HDSIYVSKG 9
           HD++ + KG
Sbjct: 108 HDNLQLKKG 116
>NP_003671
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DSIYVSK 8
           DS+YV K
Sbjct: 385 DSLYVEK 391
>NP_001273646
          Length = 1238

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HDSIYVSKG 9
            H +IY +KG
Sbjct: 1002 HPTIYHAKG 1010
>NP_056298
          Length = 623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   HDSIYV 6
           HD IYV
Sbjct: 428 HDCIYV 433
>NP_001138876
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  HDSIYVSKG 9
          HD++ + KG
Sbjct: 76 HDNLQLKKG 84
>NP_775873
          Length = 1576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    HDSIYV 6
            HD++YV
Sbjct: 1454 HDALYV 1459
>NP_060289
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   HDSIYV 6
           HD +YV
Sbjct: 303 HDKVYV 308
>NP_001273644
          Length = 1278

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HDSIYVSKG 9
            H +IY +KG
Sbjct: 1042 HPTIYHAKG 1050
>NP_775802
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HDSIYVSKG 9
           HD++ + KG
Sbjct: 140 HDNLQLQKG 148
>NP_775483
          Length = 582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DSIYVSKG 9
           DSI VS+G
Sbjct: 217 DSIIVSEG 224
>NP_055897
          Length = 842

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   DSIYVSK 8
           DS+Y++K
Sbjct: 304 DSLYITK 310
>NP_055789
          Length = 1556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    HDSIYV 6
            HD++YV
Sbjct: 1434 HDALYV 1439
>NP_001139588
          Length = 1567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    HDSIYV 6
            HD++YV
Sbjct: 1445 HDALYV 1450
>NP_055966
          Length = 1571

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    HDSIYV 6
            HD++YV
Sbjct: 1449 HDALYV 1454
>XP_006726297
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  HDSIYVSKG 9
          HD++ + KG
Sbjct: 77 HDNLQLQKG 85
>XP_006726296
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HDSIYVSKG 9
           HD++ + KG
Sbjct: 107 HDNLQLQKG 115
>XP_006726295
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HDSIYVSKG 9
           HD++ + KG
Sbjct: 139 HDNLQLQKG 147
>XP_006722726
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  HDSIYVSKG 9
          HD++ + KG
Sbjct: 77 HDNLQLQKG 85
>XP_006722725
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  HDSIYVSKG 9
          HD++ + KG
Sbjct: 77 HDNLQLQKG 85
>XP_005259841
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HDSIYVSKG 9
           HD++ + KG
Sbjct: 107 HDNLQLQKG 115
>XP_005259840
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HDSIYVSKG 9
           HD++ + KG
Sbjct: 139 HDNLQLQKG 147
>XP_006719585
          Length = 1459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    HDSIYV 6
            HD++YV
Sbjct: 1337 HDALYV 1342
>XP_006719584
          Length = 1515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    HDSIYV 6
            HD++YV
Sbjct: 1393 HDALYV 1398
>XP_005269101
          Length = 1577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    HDSIYV 6
            HD++YV
Sbjct: 1455 HDALYV 1460
>XP_006719583
          Length = 1586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    HDSIYV 6
            HD++YV
Sbjct: 1464 HDALYV 1469
>XP_006717878
          Length = 310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DSIYVSKG 9
           DSI VS+G
Sbjct: 217 DSIIVSEG 224
>XP_005269804
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  DSIYVSKG 9
          DSI VS+G
Sbjct: 54 DSIIVSEG 61
>XP_005269803
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DSIYVSKG 9
           DSI VS+G
Sbjct: 217 DSIIVSEG 224
>XP_005269802
          Length = 540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DSIYVSKG 9
           DSI VS+G
Sbjct: 217 DSIIVSEG 224
>XP_005269801
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DSIYVSKG 9
           DSI VS+G
Sbjct: 217 DSIIVSEG 224
>XP_005252487
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   HDSIYV 6
           HD++YV
Sbjct: 797 HDALYV 802
>XP_005252486
          Length = 1407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    HDSIYV 6
            HD++YV
Sbjct: 1285 HDALYV 1290
>XP_005252485
          Length = 1622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    HDSIYV 6
            HD++YV
Sbjct: 1500 HDALYV 1505
>XP_005252484
          Length = 1566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    HDSIYV 6
            HD++YV
Sbjct: 1444 HDALYV 1449
>XP_005252483
          Length = 1612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    HDSIYV 6
            HD++YV
Sbjct: 1490 HDALYV 1495
>XP_005251906
          Length = 1108

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HDSIYVSKG 9
           H +IY +KG
Sbjct: 872 HPTIYHAKG 880
>XP_005251905
          Length = 1226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HDSIYVSKG 9
           H +IY +KG
Sbjct: 990 HPTIYHAKG 998
>XP_005251904
          Length = 1226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HDSIYVSKG 9
           H +IY +KG
Sbjct: 990 HPTIYHAKG 998
>XP_005249754
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   HDSIYV 6
           HD IYV
Sbjct: 370 HDCIYV 375
>XP_005249753
          Length = 623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   HDSIYV 6
           HD IYV
Sbjct: 428 HDCIYV 433
>NP_066385
          Length = 499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HDSIYVSKG 9
           HD++ + KG
Sbjct: 107 HDNLQLKKG 115
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.132    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 516,071
Number of extensions: 1017
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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