Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              19     665
XP_006718908                                                           19     665
XP_005271621                                                           19     665
XP_006718907                                                           19     665
XP_006718906                                                           19     665
XP_005271619                                                           19     665
XP_005271618                                                           19     665
NP_573439                                                              17    2528
NP_573438                                                              17    2528
NP_001181930                                                           17    2528
NP_005695                                                              17    2528
XP_006710336                                                           17    2528
XP_006710335                                                           17    2528
XP_006710334                                                           17    2528
XP_006710333                                                           17    2528
XP_006710332                                                           17    2528
NP_597677                                                              17    3301
NP_056199                                                              17    3301
XP_005248340                                                           17    3301
XP_005248339                                                           17    3301
XP_005248337                                                           17    3301
XP_006714531                                                           17    3301
XP_006714530                                                           17    3301
NP_776165                                                              17    4312
NP_005350                                                              16    5631
NP_001123633                                                           16    5631
XP_006717757                                                           16    5631
XP_006717756                                                           16    5631
NP_689922                                                              16    5631
NP_057422                                                              16    7355
NP_001032203                                                           16    7355
NP_068579                                                              16    7355
XP_005250580                                                           16    7355
NP_001128251                                                           16    7355
NP_001006618                                                           15    9605
NP_001006620                                                           15    9605
NP_077022                                                              15    9605
NP_001006621                                                           15    9605
NP_001006622                                                           15    9605
NP_001004751                                                           15    9605
NP_055524                                                              15    9605
NP_066282                                                              15    9605
NP_065908                                                              15    9605
>NP_000042
          Length = 3056

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AVIMQTYL 9
            AVIMQTYL
Sbjct: 2354 AVIMQTYL 2361
>XP_006718908
          Length = 1708

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AVIMQTYL 9
            AVIMQTYL
Sbjct: 1006 AVIMQTYL 1013
>XP_005271621
          Length = 2708

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AVIMQTYL 9
            AVIMQTYL
Sbjct: 2006 AVIMQTYL 2013
>XP_006718907
          Length = 3050

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AVIMQTYL 9
            AVIMQTYL
Sbjct: 2348 AVIMQTYL 2355
>XP_006718906
          Length = 3056

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AVIMQTYL 9
            AVIMQTYL
Sbjct: 2354 AVIMQTYL 2361
>XP_005271619
          Length = 3056

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AVIMQTYL 9
            AVIMQTYL
Sbjct: 2354 AVIMQTYL 2361
>XP_005271618
          Length = 3056

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    AVIMQTYL 9
            AVIMQTYL
Sbjct: 2354 AVIMQTYL 2361
>NP_573439
          Length = 1436

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HAVIMQTY 8
           HAV +QTY
Sbjct: 335 HAVSLQTY 342
>NP_573438
          Length = 1440

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HAVIMQTY 8
           HAV +QTY
Sbjct: 335 HAVSLQTY 342
>NP_001181930
          Length = 1433

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HAVIMQTY 8
           HAV +QTY
Sbjct: 335 HAVSLQTY 342
>NP_005695
          Length = 1446

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HAVIMQTY 8
           HAV +QTY
Sbjct: 335 HAVSLQTY 342
>XP_006710336
          Length = 1177

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  HAVIMQTY 8
          HAV +QTY
Sbjct: 70 HAVSLQTY 77
>XP_006710335
          Length = 1370

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HAVIMQTY 8
           HAV +QTY
Sbjct: 263 HAVSLQTY 270
>XP_006710334
          Length = 1292

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HAVIMQTY 8
           HAV +QTY
Sbjct: 335 HAVSLQTY 342
>XP_006710333
          Length = 1439

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HAVIMQTY 8
           HAV +QTY
Sbjct: 335 HAVSLQTY 342
>XP_006710332
          Length = 1442

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HAVIMQTY 8
           HAV +QTY
Sbjct: 335 HAVSLQTY 342
>NP_597677
          Length = 2804

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    HAVIMQTYL 9
            HA+ MQ YL
Sbjct: 2023 HAMTMQPYL 2031
>NP_056199
          Length = 2697

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    HAVIMQTYL 9
            HA+ MQ YL
Sbjct: 2023 HAMTMQPYL 2031
>XP_005248340
          Length = 2265

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    HAVIMQTYL 9
            HA+ MQ YL
Sbjct: 1484 HAMTMQPYL 1492
>XP_005248339
          Length = 2584

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    HAVIMQTYL 9
            HA+ MQ YL
Sbjct: 1803 HAMTMQPYL 1811
>XP_005248337
          Length = 2698

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    HAVIMQTYL 9
            HA+ MQ YL
Sbjct: 2023 HAMTMQPYL 2031
>XP_006714531
          Length = 2738

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    HAVIMQTYL 9
            HA+ MQ YL
Sbjct: 1957 HAMTMQPYL 1965
>XP_006714530
          Length = 2755

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    HAVIMQTYL 9
            HA+ MQ YL
Sbjct: 2023 HAMTMQPYL 2031
>NP_776165
          Length = 226

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HAVIMQTY 8
           H VIM TY
Sbjct: 199 HLVIMTTY 206
>NP_005350
          Length = 552

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HAVIMQTY 8
           HAV +Q+Y
Sbjct: 405 HAVFVQSY 412
>NP_001123633
          Length = 989

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HAVIMQTY 8
           H V+MQ Y
Sbjct: 377 HTVLMQKY 384
>XP_006717757
          Length = 879

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HAVIMQTY 8
           H V+MQ Y
Sbjct: 267 HTVLMQKY 274
>XP_006717756
          Length = 879

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HAVIMQTY 8
           H V+MQ Y
Sbjct: 267 HTVLMQKY 274
>NP_689922
          Length = 989

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HAVIMQTY 8
           H V+MQ Y
Sbjct: 377 HTVLMQKY 384
>NP_057422
          Length = 975

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HAVIMQTYL 9
           + V+M TYL
Sbjct: 784 YPVVMSTYL 792
>NP_001032203
          Length = 473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HAVIMQTYL 9
           HA+ M  YL
Sbjct: 449 HAISMSAYL 457
>NP_068579
          Length = 974

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HAVIMQTYL 9
           HA+ M  YL
Sbjct: 449 HAISMSAYL 457
>XP_005250580
          Length = 485

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HAVIMQTYL 9
           HA+ M  YL
Sbjct: 449 HAISMSAYL 457
>NP_001128251
          Length = 1015

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HAVIMQTYL 9
           + V+M TYL
Sbjct: 824 YPVVMSTYL 832
>NP_001006618
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HAVIMQTYL 9
           HA+   TYL
Sbjct: 450 HAIFKLTYL 458
>NP_001006620
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HAVIMQTYL 9
           HA+   TYL
Sbjct: 403 HAIFKLTYL 411
>NP_077022
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HAVIMQTYL 9
           HA+   TYL
Sbjct: 414 HAIFKLTYL 422
>NP_001006621
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HAVIMQTYL 9
           HA+   TYL
Sbjct: 258 HAIFKLTYL 266
>NP_001006622
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HAVIMQTYL 9
           HA+   TYL
Sbjct: 258 HAIFKLTYL 266
>NP_001004751
          Length = 324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HAVIMQTYL 9
           H V+  TYL
Sbjct: 285 HVVMANTYL 293
>NP_055524
          Length = 3546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    HAVIMQTY 8
            HA+ M+TY
Sbjct: 1042 HAMGMETY 1049
>NP_066282
          Length = 189

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  HAVIMQTY 8
          H VI QT+
Sbjct: 81 HEVIQQTF 88
>NP_065908
          Length = 973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   AVIMQTY 8
           AVIMQ Y
Sbjct: 560 AVIMQDY 566
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.338    0.136    0.398 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 371,859
Number of extensions: 679
Number of successful extensions: 43
Number of sequences better than 10000.0: 43
Number of HSP's gapped: 43
Number of HSP's successfully gapped: 43
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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