Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001167558                                                           20     509
NP_858045                                                              20     509
NP_006525                                                              20     509
NP_001167559                                                           20     509
NP_001367                                                              17    4312
NP_001148                                                              16    5631
NP_665875                                                              16    5631
NP_001265336                                                           16    5631
NP_001265337                                                           16    5631
NP_001265338                                                           16    5631
NP_665876                                                              16    5631
NP_001014811                                                           16    5631
NP_006671                                                              16    5631
NP_001155058                                                           16    5631
NP_001171992                                                           16    5631
XP_006718486                                                           16    5631
XP_005273774                                                           16    5631
XP_006717877                                                           16    5631
XP_006717876                                                           16    5631
XP_005269799                                                           16    5631
XP_005269798                                                           16    5631
NP_085128                                                              16    7355
NP_036265                                                              16    7355
NP_001276962                                                           16    7355
NP_997244                                                              15    9605
NP_001273304                                                           15    9605
NP_000878                                                              15    9605
NP_001127958                                                           15    9605
NP_443174                                                              15    9605
NP_006142                                                              15    9605
NP_001265441                                                           15    9605
NP_001265440                                                           15    9605
NP_004635                                                              15    9605
NP_001153574                                                           15    9605
NP_060239                                                              15    9605
NP_777573                                                              15    9605
XP_005258606                                                           15    9605
XP_006723100                                                           15    9605
XP_006720769                                                           15    9605
XP_006720768                                                           15    9605
XP_006720767                                                           15    9605
XP_005267442                                                           15    9605
NP_653289                                                              15    9605
>NP_001167558
          Length = 1423

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GTQNRSLLR 9
            GTQNR LLR
Sbjct: 1023 GTQNRPLLR 1031
>NP_858045
          Length = 1424

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GTQNRSLLR 9
            GTQNR LLR
Sbjct: 1023 GTQNRPLLR 1031
>NP_006525
          Length = 1420

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GTQNRSLLR 9
            GTQNR LLR
Sbjct: 1023 GTQNRPLLR 1031
>NP_001167559
          Length = 1415

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GTQNRSLLR 9
            GTQNR LLR
Sbjct: 1018 GTQNRPLLR 1026
>NP_001367
          Length = 4646

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GTQNRSLLR 9
            GT NR++LR
Sbjct: 2749 GTFNRAMLR 2757
>NP_001148
          Length = 505

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GTQNRSLLR 9
           GT++R+L+R
Sbjct: 448 GTKDRTLIR 456
>NP_665875
          Length = 505

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GTQNRSLLR 9
           GT++R+L+R
Sbjct: 448 GTKDRTLIR 456
>NP_001265336
          Length = 505

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GTQNRSLLR 9
           GT++R+L+R
Sbjct: 448 GTKDRTLIR 456
>NP_001265337
          Length = 505

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GTQNRSLLR 9
           GT++R+L+R
Sbjct: 448 GTKDRTLIR 456
>NP_001265338
          Length = 472

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GTQNRSLLR 9
           GT++R+L+R
Sbjct: 415 GTKDRTLIR 423
>NP_665876
          Length = 505

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GTQNRSLLR 9
           GT++R+L+R
Sbjct: 448 GTKDRTLIR 456
>NP_001014811
          Length = 604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GTQNRSLLR 9
           GT N  LLR
Sbjct: 231 GTNNEELLR 239
>NP_006671
          Length = 604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GTQNRSLLR 9
           GT N  LLR
Sbjct: 231 GTNNEELLR 239
>NP_001155058
          Length = 604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GTQNRSLLR 9
           GT N  LLR
Sbjct: 231 GTNNEELLR 239
>NP_001171992
          Length = 415

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GTQNRSLL 8
           GT+N SLL
Sbjct: 133 GTKNESLL 140
>XP_006718486
          Length = 313

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GTQNRSLLR 9
           GT N  LLR
Sbjct: 231 GTNNEELLR 239
>XP_005273774
          Length = 604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GTQNRSLLR 9
           GT N  LLR
Sbjct: 231 GTNNEELLR 239
>XP_006717877
          Length = 542

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GTQNRSLLR 9
           GT++R+L+R
Sbjct: 448 GTKDRTLIR 456
>XP_006717876
          Length = 542

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GTQNRSLLR 9
           GT++R+L+R
Sbjct: 448 GTKDRTLIR 456
>XP_005269799
          Length = 542

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GTQNRSLLR 9
           GT++R+L+R
Sbjct: 448 GTKDRTLIR 456
>XP_005269798
          Length = 605

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GTQNRSLLR 9
           GT++R+L+R
Sbjct: 548 GTKDRTLIR 556
>NP_085128
          Length = 2136

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GTQNRSLLR 9
           G QN SLL+
Sbjct: 174 GVQNPSLLK 182
>NP_036265
          Length = 871

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GTQNRSLL 8
           G QN SLL
Sbjct: 499 GAQNESLL 506
>NP_001276962
          Length = 726

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GTQNRSLL 8
           G QN SLL
Sbjct: 499 GAQNESLL 506
>NP_997244
          Length = 3169

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GTQNRSLLR 9
            G QN +L+R
Sbjct: 2233 GEQNETLIR 2241
>NP_001273304
          Length = 1169

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TQNRSLLR 9
           T+NRSL R
Sbjct: 695 TKNRSLSR 702
>NP_000878
          Length = 1163

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TQNRSLLR 9
           T+NRSL R
Sbjct: 695 TKNRSLSR 702
>NP_001127958
          Length = 586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   QNRSLL 8
           QNRSLL
Sbjct: 562 QNRSLL 567
>NP_443174
          Length = 586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   QNRSLL 8
           QNRSLL
Sbjct: 562 QNRSLL 567
>NP_006142
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   QNRSLL 8
           QNRSLL
Sbjct: 211 QNRSLL 216
>NP_001265441
          Length = 1101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TQNRSLL 8
           TQN SLL
Sbjct: 255 TQNESLL 261
>NP_001265440
          Length = 1050

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TQNRSLL 8
           TQN SLL
Sbjct: 223 TQNESLL 229
>NP_004635
          Length = 1082

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TQNRSLL 8
           TQN SLL
Sbjct: 255 TQNESLL 261
>NP_001153574
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   QNRSLL 8
           QNRSLL
Sbjct: 128 QNRSLL 133
>NP_060239
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GTQNRSLLR 9
           G+Q++ LLR
Sbjct: 329 GSQSKDLLR 337
>NP_777573
          Length = 636

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GTQNRSLLR 9
           G QN+ L+R
Sbjct: 585 GEQNQELIR 593
>XP_005258606
          Length = 554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   QNRSLL 8
           QNRSLL
Sbjct: 238 QNRSLL 243
>XP_006723100
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   QNRSLL 8
           QNRSLL
Sbjct: 238 QNRSLL 243
>XP_006720769
          Length = 1038

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TQNRSLL 8
           TQN SLL
Sbjct: 211 TQNESLL 217
>XP_006720768
          Length = 1038

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TQNRSLL 8
           TQN SLL
Sbjct: 211 TQNESLL 217
>XP_006720767
          Length = 1052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TQNRSLL 8
           TQN SLL
Sbjct: 225 TQNESLL 231
>XP_005267442
          Length = 650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GTQNRSLLR 9
           G QN+ L+R
Sbjct: 599 GEQNQELIR 607
>NP_653289
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   QNRSLL 8
           QNRSLL
Sbjct: 238 QNRSLL 243
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.131    0.345 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 443,511
Number of extensions: 860
Number of successful extensions: 43
Number of sequences better than 10000.0: 43
Number of HSP's gapped: 43
Number of HSP's successfully gapped: 43
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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