Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004324                                                              20     509
XP_005250103                                                           20     509
XP_005250102                                                           20     509
NP_055642                                                              17    4312
XP_005245703                                                           17    4312
XP_006711736                                                           17    4312
XP_005245701                                                           17    4312
XP_005245700                                                           17    4312
NP_006258                                                              16    5631
XP_005264064                                                           16    5631
XP_005264063                                                           16    5631
XP_005264062                                                           16    5631
XP_005264061                                                           16    5631
XP_005264060                                                           16    5631
XP_005264059                                                           16    5631
NP_776255                                                              16    5631
NP_001274745                                                           16    7355
NP_055662                                                              16    7355
NP_149043                                                              16    7355
NP_000515                                                              16    7355
NP_001073892                                                           16    7355
XP_006715500                                                           16    7355
XP_006711752                                                           16    7355
XP_006711751                                                           16    7355
XP_006711750                                                           16    7355
XP_006711749                                                           16    7355
XP_005245729                                                           16    7355
XP_005245727                                                           16    7355
XP_005245726                                                           16    7355
XP_005245725                                                           16    7355
XP_005245724                                                           16    7355
XP_005245715                                                           16    7355
XP_006711748                                                           16    7355
XP_006711747                                                           16    7355
XP_006711746                                                           16    7355
XP_006711745                                                           16    7355
XP_006711744                                                           16    7355
XP_006711743                                                           16    7355
XP_006711742                                                           16    7355
NP_803875                                                              16    7355
NP_116116                                                              15    9605
NP_997243                                                              15    9605
NP_002217                                                              15    9605
NP_660142                                                              15    9605
NP_775871                                                              15    9605
XP_005248296                                                           15    9605
XP_005248295                                                           15    9605
XP_005246847                                                           15    9605
XP_006712769                                                           15    9605
XP_006712768                                                           15    9605
XP_006712767                                                           15    9605
XP_006712766                                                           15    9605
XP_005246846                                                           15    9605
NP_005061                                                              15    9605
NP_001129705                                                           15    9605
NP_055857                                                              15    9605
NP_009208                                                              15    9605
NP_963868                                                              15    9605
>NP_004324
          Length = 766

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GSTTGLSVT 9
           GSTTGLS T
Sbjct: 393 GSTTGLSAT 401
>XP_005250103
          Length = 758

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GSTTGLSVT 9
           GSTTGLS T
Sbjct: 393 GSTTGLSAT 401
>XP_005250102
          Length = 767

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GSTTGLSVT 9
           GSTTGLS T
Sbjct: 393 GSTTGLSAT 401
>NP_055642
          Length = 810

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G TTG+ +T
Sbjct: 544 GETTGVDIT 552
>XP_005245703
          Length = 474

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G TTG+ +T
Sbjct: 208 GETTGVDIT 216
>XP_006711736
          Length = 810

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G TTG+ +T
Sbjct: 544 GETTGVDIT 552
>XP_005245701
          Length = 810

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G TTG+ +T
Sbjct: 544 GETTGVDIT 552
>XP_005245700
          Length = 810

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G TTG+ +T
Sbjct: 544 GETTGVDIT 552
>NP_006258
          Length = 3224

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    GSTTGLS 7
            GS+TGLS
Sbjct: 2843 GSSTGLS 2849
>XP_005264064
          Length = 2282

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    GSTTGLS 7
            GS+TGLS
Sbjct: 1901 GSSTGLS 1907
>XP_005264063
          Length = 3136

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    GSTTGLS 7
            GS+TGLS
Sbjct: 2755 GSSTGLS 2761
>XP_005264062
          Length = 3232

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    GSTTGLS 7
            GS+TGLS
Sbjct: 2851 GSSTGLS 2857
>XP_005264061
          Length = 3232

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    GSTTGLS 7
            GS+TGLS
Sbjct: 2851 GSSTGLS 2857
>XP_005264060
          Length = 3250

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    GSTTGLS 7
            GS+TGLS
Sbjct: 2869 GSSTGLS 2875
>XP_005264059
          Length = 3258

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    GSTTGLS 7
            GS+TGLS
Sbjct: 2877 GSSTGLS 2883
>NP_776255
          Length = 395

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  GSTTGLSV 8
          G+TTGL V
Sbjct: 43 GATTGLRV 50
>NP_001274745
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G  TG+SVT
Sbjct: 975 GYNTGVSVT 983
>NP_055662
          Length = 1087

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G  TG+SVT
Sbjct: 964 GYNTGVSVT 972
>NP_149043
          Length = 1018

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   STTGLSVT 9
           + TGLSVT
Sbjct: 915 AVTGLSVT 922
>NP_000515
          Length = 422

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  GSTTGLS 7
          G+TTG+S
Sbjct: 23 GNTTGIS 29
>NP_001073892
          Length = 1140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSTTGLSVT 9
           GST GL+++
Sbjct: 153 GSTLGLTIS 161
>XP_006715500
          Length = 246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GSTTGLSV 8
           GSTTG+ +
Sbjct: 237 GSTTGIQL 244
>XP_006711752
          Length = 1085

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G  TG+SVT
Sbjct: 964 GYNTGVSVT 972
>XP_006711751
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G  TG+SVT
Sbjct: 624 GYNTGVSVT 632
>XP_006711750
          Length = 930

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G  TG+SVT
Sbjct: 734 GYNTGVSVT 742
>XP_006711749
          Length = 965

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G  TG+SVT
Sbjct: 769 GYNTGVSVT 777
>XP_005245729
          Length = 1067

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G  TG+SVT
Sbjct: 964 GYNTGVSVT 972
>XP_005245727
          Length = 1079

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G  TG+SVT
Sbjct: 975 GYNTGVSVT 983
>XP_005245726
          Length = 1095

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G  TG+SVT
Sbjct: 975 GYNTGVSVT 983
>XP_005245725
          Length = 1096

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G  TG+SVT
Sbjct: 975 GYNTGVSVT 983
>XP_005245724
          Length = 1098

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G  TG+SVT
Sbjct: 975 GYNTGVSVT 983
>XP_005245715
          Length = 1115

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G  TG+SVT
Sbjct: 975 GYNTGVSVT 983
>XP_006711748
          Length = 1160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G  TG+SVT
Sbjct: 964 GYNTGVSVT 972
>XP_006711747
          Length = 1160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G  TG+SVT
Sbjct: 964 GYNTGVSVT 972
>XP_006711746
          Length = 1160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G  TG+SVT
Sbjct: 964 GYNTGVSVT 972
>XP_006711745
          Length = 1170

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G  TG+SVT
Sbjct: 975 GYNTGVSVT 983
>XP_006711744
          Length = 1171

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G  TG+SVT
Sbjct: 975 GYNTGVSVT 983
>XP_006711743
          Length = 1171

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G  TG+SVT
Sbjct: 975 GYNTGVSVT 983
>XP_006711742
          Length = 1171

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSTTGLSVT 9
           G  TG+SVT
Sbjct: 975 GYNTGVSVT 983
>NP_803875
          Length = 4243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    GSTTGLS 7
            GSTTG++
Sbjct: 1669 GSTTGMT 1675
>NP_116116
          Length = 499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   STTGLSVT 9
           ST+GLS++
Sbjct: 408 STSGLSIS 415
>NP_997243
          Length = 527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GSTTGLSV 8
           G+T GLSV
Sbjct: 460 GATGGLSV 467
>NP_002217
          Length = 1238

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GSTTGLSV 8
            GS+TGL V
Sbjct: 1077 GSSTGLLV 1084
>NP_660142
          Length = 1200

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GSTTGLSV 8
            GS+TGL V
Sbjct: 1039 GSSTGLLV 1046
>NP_775871
          Length = 8384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    TTGLSV 8
            TTGLSV
Sbjct: 3566 TTGLSV 3571

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    TTGLSV 8
            TTGLSV
Sbjct: 3954 TTGLSV 3959

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    TTGLSV 8
            TTGLSV
Sbjct: 5941 TTGLSV 5946
>XP_005248296
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GSTTGLS 7
           GST GLS
Sbjct: 178 GSTQGLS 184
>XP_005248295
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GSTTGLS 7
           GST GLS
Sbjct: 178 GSTQGLS 184
>XP_005246847
          Length = 1034

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TGLSVT 9
           TGLSVT
Sbjct: 760 TGLSVT 765
>XP_006712769
          Length = 1059

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TGLSVT 9
           TGLSVT
Sbjct: 785 TGLSVT 790
>XP_006712768
          Length = 1150

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TGLSVT 9
           TGLSVT
Sbjct: 876 TGLSVT 881
>XP_006712767
          Length = 1150

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TGLSVT 9
           TGLSVT
Sbjct: 876 TGLSVT 881
>XP_006712766
          Length = 1179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TGLSVT 9
           TGLSVT
Sbjct: 905 TGLSVT 910
>XP_005246846
          Length = 1259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TGLSVT 9
           TGLSVT
Sbjct: 985 TGLSVT 990
>NP_005061
          Length = 1232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TGLSVT 9
           TGLSVT
Sbjct: 958 TGLSVT 963
>NP_001129705
          Length = 817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GSTTGLS 7
           GST GLS
Sbjct: 691 GSTLGLS 697
>NP_055857
          Length = 1411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSTTGLSVT 9
           GS++GL+ T
Sbjct: 682 GSSSGLTAT 690
>NP_009208
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GSTTGLS 7
           GST GLS
Sbjct: 178 GSTQGLS 184
>NP_963868
          Length = 1259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TGLSVT 9
           TGLSVT
Sbjct: 985 TGLSVT 990
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.296    0.115    0.290 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 465,132
Number of extensions: 846
Number of successful extensions: 60
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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