Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001242953                                                           19     665
NP_067049                                                              19     665
NP_001242955                                                           19     665
NP_001242954                                                           19     665
XP_006717997                                                           19     665
XP_005270071                                                           19     665
NP_001138498                                                           18    1482
NP_055365                                                              18    1482
NP_109593                                                              17    4312
NP_109595                                                              17    4312
NP_109596                                                              17    4312
NP_109592                                                              17    4312
NP_109594                                                              17    4312
NP_002839                                                              17    4312
NP_001139281                                                           17    4312
NP_001070654                                                           17    4312
NP_079005                                                              17    4312
XP_006723449                                                           17    4312
NP_078966                                                              16    5631
XP_005273759                                                           16    5631
XP_006718820                                                           16    5631
NP_005458                                                              16    5631
NP_056126                                                              16    7355
NP_005109                                                              16    7355
NP_955806                                                              16    7355
NP_955805                                                              16    7355
XP_005247192                                                           16    7355
XP_005246482                                                           16    7355
XP_005246481                                                           16    7355
XP_006712450                                                           16    7355
XP_005246480                                                           16    7355
XP_006712449                                                           16    7355
XP_005246478                                                           16    7355
NP_001161210                                                           15    9605
NP_065176                                                              15    9605
NP_055573                                                              15    9605
NP_055324                                                              15    9605
NP_940999                                                              15    9605
XP_006724285                                                           15    9605
XP_005271603                                                           15    9605
XP_005271602                                                           15    9605
XP_006711674                                                           15    9605
XP_006711673                                                           15    9605
XP_006711672                                                           15    9605
XP_006711671                                                           15    9605
XP_006711670                                                           15    9605
XP_005245629                                                           15    9605
NP_004913                                                              15    9605
NP_004751                                                              15    9605
>NP_001242953
          Length = 714

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   GLVSELRAE 9
           GLV+ELRAE
Sbjct: 617 GLVTELRAE 625
>NP_067049
          Length = 698

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   GLVSELRAE 9
           GLV+ELRAE
Sbjct: 601 GLVTELRAE 609
>NP_001242955
          Length = 608

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   GLVSELRAE 9
           GLV+ELRAE
Sbjct: 511 GLVTELRAE 519
>NP_001242954
          Length = 704

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   GLVSELRAE 9
           GLV+ELRAE
Sbjct: 607 GLVTELRAE 615
>XP_006717997
          Length = 608

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   GLVSELRAE 9
           GLV+ELRAE
Sbjct: 511 GLVTELRAE 519
>XP_005270071
          Length = 624

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   GLVSELRAE 9
           GLV+ELRAE
Sbjct: 527 GLVTELRAE 535
>NP_001138498
          Length = 2299

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    GLVSELRAE 9
            GLV+ELR+E
Sbjct: 2230 GLVAELRSE 2238
>NP_055365
          Length = 1032

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LVSELRAE 9
           LVSELRAE
Sbjct: 279 LVSELRAE 286
>NP_109593
          Length = 377

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   GLVSELRA 8
           GLVSE+R+
Sbjct: 327 GLVSEMRS 334
>NP_109595
          Length = 377

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   GLVSELRA 8
           GLVSE+R+
Sbjct: 327 GLVSEMRS 334
>NP_109596
          Length = 405

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   GLVSELRA 8
           GLVSE+R+
Sbjct: 355 GLVSEMRS 362
>NP_109592
          Length = 1216

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    GLVSELRA 8
            GLVSE+R+
Sbjct: 1166 GLVSEMRS 1173
>NP_109594
          Length = 405

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   GLVSELRA 8
           GLVSE+R+
Sbjct: 355 GLVSEMRS 362
>NP_002839
          Length = 1188

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    GLVSELRA 8
            GLVSE+R+
Sbjct: 1138 GLVSEMRS 1145
>NP_001139281
          Length = 2036

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    VSELRAE 9
            VSELRAE
Sbjct: 1291 VSELRAE 1297
>NP_001070654
          Length = 2003

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    VSELRAE 9
            VSELRAE
Sbjct: 1258 VSELRAE 1264
>NP_079005
          Length = 1995

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    VSELRAE 9
            VSELRAE
Sbjct: 1250 VSELRAE 1256
>XP_006723449
          Length = 2003

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    VSELRAE 9
            VSELRAE
Sbjct: 1258 VSELRAE 1264
>NP_078966
          Length = 14507

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   LVSELRA 8
           LVSELRA
Sbjct: 916 LVSELRA 922
>XP_005273759
          Length = 451

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  LVSELRAE 9
          LVSE++AE
Sbjct: 51 LVSEMKAE 58
>XP_006718820
          Length = 707

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  LVSELRAE 9
          LVSE++AE
Sbjct: 51 LVSEMKAE 58
>NP_005458
          Length = 740

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  LVSELRAE 9
          LVSE++AE
Sbjct: 51 LVSEMKAE 58
>NP_056126
          Length = 1896

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    LVSELRAE 9
            ++SELRAE
Sbjct: 1776 VLSELRAE 1783
>NP_005109
          Length = 251

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  LVSELRAE 9
          LVS+LRA+
Sbjct: 55 LVSQLRAQ 62
>NP_955806
          Length = 950

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LVSELRAE 9
           L+SELR E
Sbjct: 697 LISELRKE 704
>NP_955805
          Length = 950

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LVSELRAE 9
           L+SELR E
Sbjct: 697 LISELRKE 704
>XP_005247192
          Length = 961

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LVSELRAE 9
           L+SELR E
Sbjct: 708 LISELRKE 715
>XP_005246482
          Length = 1724

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    LVSELRAE 9
            ++SELRAE
Sbjct: 1592 VLSELRAE 1599
>XP_005246481
          Length = 1804

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    LVSELRAE 9
            ++SELRAE
Sbjct: 1684 VLSELRAE 1691
>XP_006712450
          Length = 1816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    LVSELRAE 9
            ++SELRAE
Sbjct: 1684 VLSELRAE 1691
>XP_005246480
          Length = 1816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    LVSELRAE 9
            ++SELRAE
Sbjct: 1684 VLSELRAE 1691
>XP_006712449
          Length = 1908

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    LVSELRAE 9
            ++SELRAE
Sbjct: 1776 VLSELRAE 1783
>XP_005246478
          Length = 1908

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    LVSELRAE 9
            ++SELRAE
Sbjct: 1776 VLSELRAE 1783
>NP_001161210
          Length = 1483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VSELRAE 9
           VSELR+E
Sbjct: 913 VSELRSE 919
>NP_065176
          Length = 1877

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VSELRAE 9
            VSELR+E
Sbjct: 1307 VSELRSE 1313
>NP_055573
          Length = 992

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GLVSELR 7
           GLV ELR
Sbjct: 137 GLVQELR 143
>NP_055324
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  GLVSELR 7
          GL+SEL+
Sbjct: 8  GLISELK 14
>NP_940999
          Length = 1094

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GLVSELRAE 9
            GL+  LRA+
Sbjct: 1034 GLIDSLRAQ 1042
>XP_006724285
          Length = 313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  GLVSELR 7
          GL+SEL+
Sbjct: 8  GLISELK 14
>XP_005271603
          Length = 907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GLVSELR 7
           GLV ELR
Sbjct: 137 GLVQELR 143
>XP_005271602
          Length = 915

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GLVSELR 7
           GLV ELR
Sbjct: 137 GLVQELR 143
>XP_006711674
          Length = 1385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VSELRAE 9
           VSELR+E
Sbjct: 815 VSELRSE 821
>XP_006711673
          Length = 1549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VSELRAE 9
           VSELR+E
Sbjct: 979 VSELRSE 985
>XP_006711672
          Length = 1557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VSELRAE 9
           VSELR+E
Sbjct: 987 VSELRSE 993
>XP_006711671
          Length = 2153

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VSELRAE 9
            VSELR+E
Sbjct: 1583 VSELRSE 1589
>XP_006711670
          Length = 2161

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VSELRAE 9
            VSELR+E
Sbjct: 1591 VSELRSE 1597
>XP_005245629
          Length = 2164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VSELRAE 9
            VSELR+E
Sbjct: 1594 VSELRSE 1600
>NP_004913
          Length = 1094

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GLVSELRAE 9
            GL+  LRA+
Sbjct: 1034 GLIDSLRAQ 1042
>NP_004751
          Length = 414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  GLVSELRA 8
          GL++E+RA
Sbjct: 41 GLLTEIRA 48
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.131    0.316 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 356,506
Number of extensions: 496
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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