Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              17    2528
NP_005913                                                              17    2528
XP_005267046                                                           17    2528
XP_005267045                                                           17    2528
NP_001286                                                              16    5631
NP_002051                                                              16    7355
XP_005270807                                                           16    7355
NP_006741                                                              16    7355
NP_005017                                                              15    9605
NP_620581                                                              15    9605
NP_620583                                                              15    9605
NP_620582                                                              15    9605
NP_001273988                                                           15    9605
NP_001186308                                                           15    9605
NP_055867                                                              15    9605
NP_056227                                                              15    9605
NP_001186307                                                           15    9605
NP_004184                                                              15    9605
XP_005261547                                                           15    9605
XP_006718114                                                           15    9605
XP_005270318                                                           15    9605
XP_006718113                                                           15    9605
XP_006718112                                                           15    9605
XP_006718111                                                           15    9605
XP_006718110                                                           15    9605
XP_006715736                                                           15    9605
XP_006715735                                                           15    9605
XP_005249722                                                           15    9605
XP_006715734                                                           15    9605
XP_006715733                                                           15    9605
XP_006715061                                                           15    9605
XP_005247333                                                           15    9605
XP_006710753                                                           15    9605
XP_005263530                                                           15    9605
XP_006710752                                                           15    9605
XP_006710751                                                           15    9605
XP_006710750                                                           15    9605
XP_006710749                                                           15    9605
NP_056185                                                              15    9605
>NP_006715
          Length = 1558

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GLIKLILRL 9
           GL KLILRL
Sbjct: 538 GLRKLILRL 546
>NP_005913
          Length = 1608

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GLIKLILRL 9
           GL KLILRL
Sbjct: 538 GLRKLILRL 546
>XP_005267046
          Length = 1554

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GLIKLILRL 9
           GL KLILRL
Sbjct: 538 GLRKLILRL 546
>XP_005267045
          Length = 1604

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GLIKLILRL 9
           GL KLILRL
Sbjct: 538 GLRKLILRL 546
>NP_001286
          Length = 355

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GLIKLILR 8
           G+IK++LR
Sbjct: 221 GIIKILLR 228
>NP_002051
          Length = 333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GLIKLILRL 9
           GLI L+L L
Sbjct: 217 GLISLVLNL 225
>XP_005270807
          Length = 333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GLIKLILRL 9
           GLI L+L L
Sbjct: 217 GLISLVLNL 225
>NP_006741
          Length = 540

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  GLIKLILR 8
          GL++L+LR
Sbjct: 26 GLVELLLR 33
>NP_005017
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GLIKLILR 8
           GLI+++LR
Sbjct: 823 GLIEVVLR 830
>NP_620581
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IKLILRL 9
           +KLILRL
Sbjct: 232 LKLILRL 238
>NP_620583
          Length = 307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IKLILRL 9
           +KLILRL
Sbjct: 232 LKLILRL 238
>NP_620582
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IKLILRL 9
           +KLILRL
Sbjct: 232 LKLILRL 238
>NP_001273988
          Length = 1572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GLIKLILR 8
            G IKLI+R
Sbjct: 1214 GKIKLIIR 1221
>NP_001186308
          Length = 1855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GLIKLILRL 9
            GL++L +RL
Sbjct: 1202 GLLRLAIRL 1210
>NP_055867
          Length = 1606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GLIKLILR 8
            G IKLI+R
Sbjct: 1248 GKIKLIIR 1255
>NP_056227
          Length = 567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GLIKLILRL 9
           G  KL+LRL
Sbjct: 141 GACKLLLRL 149
>NP_001186307
          Length = 1856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GLIKLILRL 9
            GL++L +RL
Sbjct: 1203 GLLRLAIRL 1211
>NP_004184
          Length = 1859

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GLIKLILRL 9
            GL++L +RL
Sbjct: 1202 GLLRLAIRL 1210
>XP_005261547
          Length = 249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LIKLILR 8
          L+KL+LR
Sbjct: 35 LVKLVLR 41
>XP_006718114
          Length = 1850

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GLIKLILRL 9
            GL++L +RL
Sbjct: 1236 GLLRLAIRL 1244
>XP_005270318
          Length = 1860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GLIKLILRL 9
            GL++L +RL
Sbjct: 1203 GLLRLAIRL 1211
>XP_006718113
          Length = 1881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GLIKLILRL 9
            GL++L +RL
Sbjct: 1224 GLLRLAIRL 1232
>XP_006718112
          Length = 1889

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GLIKLILRL 9
            GL++L +RL
Sbjct: 1236 GLLRLAIRL 1244
>XP_006718111
          Length = 1892

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GLIKLILRL 9
            GL++L +RL
Sbjct: 1235 GLLRLAIRL 1243
>XP_006718110
          Length = 1893

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GLIKLILRL 9
            GL++L +RL
Sbjct: 1236 GLLRLAIRL 1244
>XP_006715736
          Length = 1573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GLIKLILR 8
            G IKLI+R
Sbjct: 1215 GKIKLIIR 1222
>XP_006715735
          Length = 1606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GLIKLILR 8
            G IKLI+R
Sbjct: 1248 GKIKLIIR 1255
>XP_005249722
          Length = 1607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GLIKLILR 8
            G IKLI+R
Sbjct: 1249 GKIKLIIR 1256
>XP_006715734
          Length = 1607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GLIKLILR 8
            G IKLI+R
Sbjct: 1249 GKIKLIIR 1256
>XP_006715733
          Length = 1608

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GLIKLILR 8
            G IKLI+R
Sbjct: 1250 GKIKLIIR 1257
>XP_006715061
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IKLILRL 9
           +KLILRL
Sbjct: 155 LKLILRL 161
>XP_005247333
          Length = 431

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GLIKLILRL 9
          G  KL+LRL
Sbjct: 5  GACKLLLRL 13
>XP_006710753
          Length = 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GLIKLILR 8
           GLI+++LR
Sbjct: 794 GLIEVVLR 801
>XP_005263530
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GLIKLILR 8
           GLI+++LR
Sbjct: 822 GLIEVVLR 829
>XP_006710752
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GLIKLILR 8
           GLI+++LR
Sbjct: 823 GLIEVVLR 830
>XP_006710751
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GLIKLILR 8
           GLI+++LR
Sbjct: 823 GLIEVVLR 830
>XP_006710750
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GLIKLILR 8
           GLI+++LR
Sbjct: 823 GLIEVVLR 830
>XP_006710749
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GLIKLILR 8
           GLI+++LR
Sbjct: 823 GLIEVVLR 830
>NP_056185
          Length = 290

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LIKLILR 8
          L+KL+LR
Sbjct: 76 LVKLVLR 82
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.345    0.174    0.453 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 404,119
Number of extensions: 761
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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