Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001155973                                                           20     390
NP_055903                                                              20     390
NP_065107                                                              17    3301
NP_001140168                                                           17    3301
NP_001140167                                                           17    3301
NP_055876                                                              17    3301
NP_001140166                                                           17    3301
XP_006719055                                                           17    3301
XP_005253773                                                           17    3301
XP_006716804                                                           17    3301
NP_001193976                                                           17    4312
NP_647537                                                              17    4312
NP_647538                                                              17    4312
NP_060899                                                              17    4312
XP_006725524                                                           17    4312
XP_006725523                                                           17    4312
XP_005276828                                                           17    4312
XP_006726279                                                           17    4312
XP_005260918                                                           17    4312
XP_005260917                                                           17    4312
XP_006714722                                                           17    4312
XP_006714721                                                           17    4312
NP_001153682                                                           16    5631
NP_055066                                                              16    5631
NP_001263347                                                           16    5631
NP_055681                                                              16    5631
NP_690597                                                              16    5631
NP_004897                                                              16    5631
NP_690596                                                              16    5631
NP_001257461                                                           16    5631
NP_001257460                                                           16    5631
NP_001257462                                                           16    5631
XP_005266194                                                           16    5631
XP_005266193                                                           16    5631
XP_005266191                                                           16    5631
XP_005266190                                                           16    5631
XP_005266189                                                           16    5631
XP_006715896                                                           16    5631
XP_006715894                                                           16    5631
XP_006715893                                                           16    5631
NP_787071                                                              16    7355
NP_071899                                                              15    9605
NP_001177779                                                           15    9605
NP_001177776                                                           15    9605
NP_037448                                                              15    9605
NP_001008226                                                           15    9605
NP_001177778                                                           15    9605
NP_001177777                                                           15    9605
NP_689594                                                              15    9605
NP_001035502                                                           15    9605
NP_001035501                                                           15    9605
NP_004679                                                              15    9605
NP_065880                                                              15    9605
NP_037375                                                              15    9605
NP_001129392                                                           15    9605
NP_976044                                                              15    9605
NP_001274320                                                           15    9605
NP_001035500                                                           15    9605
NP_001193486                                                           15    9605
XP_005251580                                                           15    9605
XP_005246998                                                           15    9605
XP_006712319                                                           15    9605
XP_005271295                                                           15    9605
XP_005275822                                                           15    9605
NP_001186073                                                           15    9605
NP_112227                                                              15    9605
NP_078799                                                              15    9605
>NP_001155973
          Length = 1833

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GGEVDQTKN 9
           G EVDQTKN
Sbjct: 750 GEEVDQTKN 758
>NP_055903
          Length = 1723

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GGEVDQTKN 9
           G EVDQTKN
Sbjct: 750 GEEVDQTKN 758
>NP_065107
          Length = 552

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GGEVDQTKN 9
           GG  D+TKN
Sbjct: 394 GGNDDKTKN 402
>NP_001140168
          Length = 835

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GGEVDQTKN 9
           GG + QTKN
Sbjct: 784 GGALKQTKN 792
>NP_001140167
          Length = 813

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GGEVDQTKN 9
           GG + QTKN
Sbjct: 762 GGALKQTKN 770
>NP_055876
          Length = 1056

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GGEVDQTKN 9
           GG + QTKN
Sbjct: 762 GGALKQTKN 770
>NP_001140166
          Length = 1047

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GGEVDQTKN 9
           GG + QTKN
Sbjct: 762 GGALKQTKN 770
>XP_006719055
          Length = 419

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GGEVDQTKN 9
           GG  D+TKN
Sbjct: 394 GGNDDKTKN 402
>XP_005253773
          Length = 509

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GGEVDQTKN 9
           GG  D+TKN
Sbjct: 351 GGNDDKTKN 359
>XP_006716804
          Length = 1089

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GGEVDQTKN 9
           GG + QTKN
Sbjct: 762 GGALKQTKN 770
>NP_001193976
          Length = 1156

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GGEVDQTKN 9
           GG++D T N
Sbjct: 292 GGKIDSTGN 300
>NP_647537
          Length = 1429

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GGEVDQTKN 9
           GG++D T N
Sbjct: 408 GGKIDSTGN 416
>NP_647538
          Length = 1272

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GGEVDQTKN 9
           GG++D T N
Sbjct: 408 GGKIDSTGN 416
>NP_060899
          Length = 2624

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EVDQTKN 9
           E+DQT+N
Sbjct: 601 EIDQTEN 607
>XP_006725524
          Length = 2584

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EVDQTKN 9
           E+DQT+N
Sbjct: 601 EIDQTEN 607
>XP_006725523
          Length = 2623

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EVDQTKN 9
           E+DQT+N
Sbjct: 601 EIDQTEN 607
>XP_005276828
          Length = 2584

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EVDQTKN 9
           E+DQT+N
Sbjct: 601 EIDQTEN 607
>XP_006726279
          Length = 2623

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EVDQTKN 9
           E+DQT+N
Sbjct: 601 EIDQTEN 607
>XP_005260918
          Length = 1111

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GGEVDQTKN 9
           GG++D T N
Sbjct: 408 GGKIDSTGN 416
>XP_005260917
          Length = 1289

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GGEVDQTKN 9
           GG++D T N
Sbjct: 408 GGKIDSTGN 416
>XP_006714722
          Length = 2584

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EVDQTKN 9
           E+DQT+N
Sbjct: 601 EIDQTEN 607
>XP_006714721
          Length = 2623

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EVDQTKN 9
           E+DQT+N
Sbjct: 601 EIDQTEN 607
>NP_001153682
          Length = 676

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  GEVDQTKN 9
          G VDQTK+
Sbjct: 63 GVVDQTKD 70
>NP_055066
          Length = 675

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  GEVDQTKN 9
          G VDQTK+
Sbjct: 63 GVVDQTKD 70
>NP_001263347
          Length = 2334

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GGEVDQT 7
           GGE D+T
Sbjct: 572 GGETDET 578
>NP_055681
          Length = 2357

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GGEVDQT 7
           GGE D+T
Sbjct: 572 GGETDET 578
>NP_690597
          Length = 151

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   GEVDQTKN 9
           GE++QTK+
Sbjct: 126 GELEQTKD 133
>NP_004897
          Length = 396

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   GEVDQTKN 9
           GE++QTK+
Sbjct: 126 GELEQTKD 133
>NP_690596
          Length = 151

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   GEVDQTKN 9
           GE++QTK+
Sbjct: 126 GELEQTKD 133
>NP_001257461
          Length = 170

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   GEVDQTKN 9
           GE++QTK+
Sbjct: 126 GELEQTKD 133
>NP_001257460
          Length = 396

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   GEVDQTKN 9
           GE++QTK+
Sbjct: 126 GELEQTKD 133
>NP_001257462
          Length = 170

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   GEVDQTKN 9
           GE++QTK+
Sbjct: 126 GELEQTKD 133
>XP_005266194
          Length = 2379

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GGEVDQT 7
           GGE D+T
Sbjct: 572 GGETDET 578
>XP_005266193
          Length = 2248

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GGEVDQT 7
           GGE D+T
Sbjct: 720 GGETDET 726
>XP_005266191
          Length = 2379

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GGEVDQT 7
           GGE D+T
Sbjct: 572 GGETDET 578
>XP_005266190
          Length = 2485

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GGEVDQT 7
           GGE D+T
Sbjct: 720 GGETDET 726
>XP_005266189
          Length = 2505

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GGEVDQT 7
           GGE D+T
Sbjct: 720 GGETDET 726
>XP_006715896
          Length = 457

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  GEVDQTKN 9
          G VDQTK+
Sbjct: 74 GVVDQTKD 81
>XP_006715894
          Length = 686

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  GEVDQTKN 9
          G VDQTK+
Sbjct: 74 GVVDQTKD 81
>XP_006715893
          Length = 687

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  GEVDQTKN 9
          G VDQTK+
Sbjct: 74 GVVDQTKD 81
>NP_787071
          Length = 739

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GGEVDQ 6
           GGEVD+
Sbjct: 711 GGEVDE 716
>NP_071899
          Length = 414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GEVDQTK 8
           GEVD+T+
Sbjct: 356 GEVDRTE 362
>NP_001177779
          Length = 713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GEVDQTKN 9
           G VD+ KN
Sbjct: 257 GSVDKNKN 264
>NP_001177776
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GEVDQTKN 9
           G VD+ KN
Sbjct: 257 GSVDKNKN 264
>NP_037448
          Length = 639

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GEVDQTKN 9
           G VD+ KN
Sbjct: 257 GSVDKNKN 264
>NP_001008226
          Length = 572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GEVDQTKN 9
           G VD+ KN
Sbjct: 257 GSVDKNKN 264
>NP_001177778
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GEVDQTKN 9
           G VD+ KN
Sbjct: 257 GSVDKNKN 264
>NP_001177777
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GEVDQTKN 9
           G VD+ KN
Sbjct: 257 GSVDKNKN 264
>NP_689594
          Length = 3549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GGEVDQTKN 9
           GG+V  TK+
Sbjct: 869 GGDVQTTKH 877
>NP_001035502
          Length = 1031

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   GEVDQTKN 9
           G++ +TKN
Sbjct: 541 GDIQKTKN 548
>NP_001035501
          Length = 1006

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   GEVDQTKN 9
           G++ +TKN
Sbjct: 516 GDIQKTKN 523
>NP_004679
          Length = 307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GGEVDQ 6
           GGEVD+
Sbjct: 188 GGEVDR 193
>NP_065880
          Length = 1423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GEVDQTKN 9
           GE  QT+N
Sbjct: 435 GEASQTQN 442
>NP_037375
          Length = 468

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   EVDQTKN 9
           +VD TKN
Sbjct: 107 DVDSTKN 113
>NP_001129392
          Length = 1165

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GEVDQTKN 9
           GE  QT+N
Sbjct: 435 GEASQTQN 442
>NP_976044
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   GEVDQTKN 9
           G++ +TKN
Sbjct: 589 GDIQKTKN 596
>NP_001274320
          Length = 1006

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   GEVDQTKN 9
           G++ +TKN
Sbjct: 516 GDIQKTKN 523
>NP_001035500
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   GEVDQTKN 9
           G++ +TKN
Sbjct: 554 GDIQKTKN 561
>NP_001193486
          Length = 1386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GEVDQTKN 9
           GE  QT+N
Sbjct: 435 GEASQTQN 442
>XP_005251580
          Length = 1422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GEVDQTKN 9
           GE  QT+N
Sbjct: 434 GEASQTQN 441
>XP_005246998
          Length = 307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GGEVDQ 6
           GGEVD+
Sbjct: 188 GGEVDR 193
>XP_006712319
          Length = 3308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GGEVDQTKN 9
           GG+V  TK+
Sbjct: 628 GGDVQTTKH 636
>XP_005271295
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   GGEVDQTK 8
           G ++DQT+
Sbjct: 111 GSQIDQTE 118
>XP_005275822
          Length = 800

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  GEVDQT 7
          G+VDQT
Sbjct: 34 GDVDQT 39
>NP_001186073
          Length = 3327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GGEVDQTKN 9
           GG+V  TK+
Sbjct: 647 GGDVQTTKH 655
>NP_112227
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   GGEVDQTK 8
           G ++DQT+
Sbjct: 111 GSQIDQTE 118
>NP_078799
          Length = 775

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GGEVDQ 6
           GGEVD+
Sbjct: 151 GGEVDK 156
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.294    0.125    0.338 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 692,213
Number of extensions: 1686
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

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