Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000542                                                              20     299
NP_996531                                                              18    1935
XP_005254088                                                           18    1935
XP_006719978                                                           18    1935
XP_005254087                                                           18    1935
NP_001004441                                                           17    3301
XP_006714662                                                           17    3301
NP_078853                                                              17    4312
NP_001167539                                                           17    4312
NP_001123368                                                           17    4312
NP_008832                                                              17    4312
NP_542775                                                              17    4312
NP_115641                                                              17    4312
XP_005262286                                                           17    4312
XP_006724781                                                           17    4312
XP_006724780                                                           17    4312
XP_005262283                                                           17    4312
XP_006720604                                                           17    4312
XP_005254461                                                           17    4312
XP_006720603                                                           17    4312
XP_006720602                                                           17    4312
NP_006062                                                              17    4312
NP_060626                                                              16    5631
NP_056193                                                              16    5631
NP_000015                                                              16    5631
NP_005233                                                              16    5631
NP_001004319                                                           16    5631
NP_055111                                                              16    5631
NP_055535                                                              16    5631
XP_005270358                                                           16    5631
XP_005265065                                                           16    5631
XP_006713143                                                           16    5631
NP_001120                                                              16    7355
NP_001230675                                                           16    7355
NP_005495                                                              16    7355
NP_001171564                                                           16    7355
NP_001171565                                                           16    7355
NP_060035                                                              16    7355
NP_001186704                                                           16    7355
NP_001295                                                              16    7355
XP_006722023                                                           16    7355
XP_006722022                                                           16    7355
XP_006722021                                                           16    7355
XP_005253517                                                           16    7355
XP_005248296                                                           16    7355
XP_005248295                                                           16    7355
NP_009208                                                              16    7355
NP_001275927                                                           15    9605
NP_001275928                                                           15    9605
NP_057657                                                              15    9605
NP_001209                                                              15    9605
NP_065169                                                              15    9605
NP_996808                                                              15    9605
NP_055935                                                              15    9605
NP_001139813                                                           15    9605
NP_006314                                                              15    9605
NP_001036199                                                           15    9605
NP_064581                                                              15    9605
NP_067045                                                              15    9605
XP_006724037                                                           15    9605
XP_006723898                                                           15    9605
XP_006723897                                                           15    9605
XP_005260524                                                           15    9605
XP_005259984                                                           15    9605
XP_005262748                                                           15    9605
XP_005262746                                                           15    9605
XP_005262745                                                           15    9605
XP_006713075                                                           15    9605
XP_005245451                                                           15    9605
NP_001073913                                                           15    9605
>NP_000542
          Length = 213

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   FVPSLNVD 8
           FVPSLNVD
Sbjct: 136 FVPSLNVD 143
>NP_996531
          Length = 340

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  VPSLNVD 8
          +PSLNVD
Sbjct: 62 IPSLNVD 68
>XP_005254088
          Length = 306

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  VPSLNVD 8
          +PSLNVD
Sbjct: 62 IPSLNVD 68
>XP_006719978
          Length = 340

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  VPSLNVD 8
          +PSLNVD
Sbjct: 62 IPSLNVD 68
>XP_005254087
          Length = 340

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  VPSLNVD 8
          +PSLNVD
Sbjct: 62 IPSLNVD 68
>NP_001004441
          Length = 514

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   FVPSLNVDS 9
           F+P LNV+S
Sbjct: 448 FLPPLNVNS 456
>XP_006714662
          Length = 514

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   FVPSLNVDS 9
           F+P LNV+S
Sbjct: 448 FLPPLNVNS 456
>NP_078853
          Length = 1288

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FVPSLNVD 8
           FVP+ N+D
Sbjct: 320 FVPTRNID 327
>NP_001167539
          Length = 671

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VPSLNVD 8
           VP LNVD
Sbjct: 297 VPGLNVD 303
>NP_001123368
          Length = 671

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VPSLNVD 8
           VP LNVD
Sbjct: 297 VPGLNVD 303
>NP_008832
          Length = 2548

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    VPSLNVDS 9
            VPSLN +S
Sbjct: 1475 VPSLNTES 1482
>NP_542775
          Length = 671

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VPSLNVD 8
           VP LNVD
Sbjct: 297 VPGLNVD 303
>NP_115641
          Length = 703

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FVPSLNVDS 9
           FVP LN+ +
Sbjct: 459 FVPELNIQN 467
>XP_005262286
          Length = 671

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VPSLNVD 8
           VP LNVD
Sbjct: 297 VPGLNVD 303
>XP_006724781
          Length = 671

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VPSLNVD 8
           VP LNVD
Sbjct: 297 VPGLNVD 303
>XP_006724780
          Length = 671

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VPSLNVD 8
           VP LNVD
Sbjct: 297 VPGLNVD 303
>XP_005262283
          Length = 671

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VPSLNVD 8
           VP LNVD
Sbjct: 297 VPGLNVD 303
>XP_006720604
          Length = 1677

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VPSLNVDS 9
           VPSLN +S
Sbjct: 533 VPSLNTES 540
>XP_005254461
          Length = 2600

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    VPSLNVDS 9
            VPSLN +S
Sbjct: 1456 VPSLNTES 1463
>XP_006720603
          Length = 2619

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    VPSLNVDS 9
            VPSLN +S
Sbjct: 1475 VPSLNTES 1482
>XP_006720602
          Length = 2619

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    VPSLNVDS 9
            VPSLN +S
Sbjct: 1475 VPSLNTES 1482
>NP_006062
          Length = 2253

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FVPSLNVDS 9
           F P+LNV S
Sbjct: 885 FYPTLNVSS 893
>NP_060626
          Length = 4363

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PSLNVDS 9
            PS+N+DS
Sbjct: 1092 PSMNLDS 1098
>NP_056193
          Length = 4388

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PSLNVDS 9
            PS+N+DS
Sbjct: 1092 PSMNLDS 1098
>NP_000015
          Length = 413

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VPSLNVDS 9
           VPS N+DS
Sbjct: 394 VPSDNIDS 401
>NP_005233
          Length = 397

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   FVPSLNV 7
           F+P+LN+
Sbjct: 217 FIPALNI 223
>NP_001004319
          Length = 139

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   FVPSLNVD 8
           FVPS NV+
Sbjct: 118 FVPSSNVN 125
>NP_055111
          Length = 813

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FVPSLNVD 8
           +VP +NVD
Sbjct: 223 YVPFMNVD 230
>NP_055535
          Length = 1235

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VPSLNVDS 9
           +PS+N++S
Sbjct: 710 IPSININS 717
>XP_005270358
          Length = 1204

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VPSLNVDS 9
           +PS+N++S
Sbjct: 710 IPSININS 717
>XP_005265065
          Length = 719

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FVPSLNVD 8
           +VP +NVD
Sbjct: 223 YVPFMNVD 230
>XP_006713143
          Length = 769

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FVPSLNVD 8
           +VP +NVD
Sbjct: 179 YVPFMNVD 186
>NP_001120
          Length = 1158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VPSLNVD 8
           VPSLN D
Sbjct: 665 VPSLNPD 671
>NP_001230675
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FVPSLNV 7
           F+PSLN+
Sbjct: 205 FLPSLNL 211
>NP_005495
          Length = 386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FVPSLNVD 8
           F P+LN+D
Sbjct: 111 FQPNLNMD 118
>NP_001171564
          Length = 398

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FVPSLNVD 8
           F P+LN+D
Sbjct: 123 FQPNLNMD 130
>NP_001171565
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FVPSLNVD 8
           F P+LN+D
Sbjct: 110 FQPNLNMD 117
>NP_060035
          Length = 541

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FVPSLNV 7
           F+PSLN+
Sbjct: 343 FLPSLNL 349
>NP_001186704
          Length = 1133

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VPSLNVD 8
           VPSLN D
Sbjct: 786 VPSLNPD 792
>NP_001295
          Length = 1380

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    VPSLNVD 8
            VPSLN D
Sbjct: 1033 VPSLNPD 1039
>XP_006722023
          Length = 386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FVPSLNV 7
           F+PSLN+
Sbjct: 343 FLPSLNL 349
>XP_006722022
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FVPSLNV 7
           F+PSLN+
Sbjct: 205 FLPSLNL 211
>XP_006722021
          Length = 418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FVPSLNV 7
           F+PSLN+
Sbjct: 343 FLPSLNL 349
>XP_005253517
          Length = 320

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FVPSLNVD 8
           F P+LN+D
Sbjct: 110 FQPNLNMD 117
>XP_005248296
          Length = 630

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VPSLNV 7
           VPSLNV
Sbjct: 620 VPSLNV 625
>XP_005248295
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VPSLNV 7
           VPSLNV
Sbjct: 735 VPSLNV 740
>NP_009208
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VPSLNV 7
           VPSLNV
Sbjct: 735 VPSLNV 740
>NP_001275927
          Length = 941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FVPSLN 6
           F+PSLN
Sbjct: 369 FLPSLN 374
>NP_001275928
          Length = 944

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FVPSLN 6
           F+PSLN
Sbjct: 369 FLPSLN 374
>NP_057657
          Length = 970

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FVPSLN 6
           F+PSLN
Sbjct: 369 FLPSLN 374
>NP_001209
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   FVPSLNVD 8
           FVP  N++
Sbjct: 201 FVPGFNIE 208
>NP_065169
          Length = 1053

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   PSLNVD 8
           PS+NVD
Sbjct: 960 PSVNVD 965
>NP_996808
          Length = 343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   FVPSLNVD 8
           FVP  N++
Sbjct: 201 FVPGFNIE 208
>NP_055935
          Length = 4169

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    FVPSLNVDS 9
            FVP  NV+S
Sbjct: 3963 FVPVENVES 3971
>NP_001139813
          Length = 535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FVPSLNVD 8
           F+P LNV+
Sbjct: 462 FLPPLNVN 469
>NP_006314
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VPSLNVD 8
           VP+LN D
Sbjct: 543 VPNLNAD 549
>NP_001036199
          Length = 1233

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VPSLNVD 8
           VP+LN D
Sbjct: 508 VPNLNAD 514
>NP_064581
          Length = 855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VPSLNVDS 9
           V SLNVD+
Sbjct: 235 VQSLNVDA 242
>NP_067045
          Length = 453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  FVPSLNV 7
          FVP LN+
Sbjct: 52 FVPVLNI 58
>XP_006724037
          Length = 407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   FVPSLNV 7
           F+PS+N+
Sbjct: 145 FIPSVNL 151
>XP_006723898
          Length = 951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   PSLNVD 8
           PS+NVD
Sbjct: 858 PSVNVD 863
>XP_006723897
          Length = 951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   PSLNVD 8
           PS+NVD
Sbjct: 858 PSVNVD 863
>XP_005260524
          Length = 951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   PSLNVD 8
           PS+NVD
Sbjct: 858 PSVNVD 863
>XP_005259984
          Length = 967

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FVPSLN 6
           F+PSLN
Sbjct: 369 FLPSLN 374
>XP_005262748
          Length = 1263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VPSLNVD 8
           VP+LN D
Sbjct: 538 VPNLNAD 544
>XP_005262746
          Length = 1298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VPSLNVD 8
           VP+LN D
Sbjct: 573 VPNLNAD 579
>XP_005262745
          Length = 1299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VPSLNVD 8
           VP+LN D
Sbjct: 574 VPNLNAD 580
>XP_006713075
          Length = 1019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FVPSLN 6
           F+PSLN
Sbjct: 989 FLPSLN 994
>XP_005245451
          Length = 400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  FVPSLNV 7
          FVP LN+
Sbjct: 52 FVPVLNI 58
>NP_001073913
          Length = 407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   FVPSLNV 7
           F+PS+N+
Sbjct: 145 FIPSVNL 151
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.134    0.380 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 721,054
Number of extensions: 1441
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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