Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000207                                                              18    1482
XP_005274558                                                           18    1482
NP_001245210                                                           17    2528
NP_000242                                                              17    2528
XP_005264389                                                           17    2528
NP_001138462                                                           16    7355
NP_001007189                                                           15    9605
NP_001229825                                                           15    9605
NP_443104                                                              15    9605
NP_060142                                                              15    9605
NP_001229826                                                           15    9605
NP_055477                                                              15    9605
NP_001129501                                                           15    9605
NP_060132                                                              15    9605
NP_060664                                                              15    9605
NP_001164059                                                           15    9605
NP_001116306                                                           15    9605
NP_001164035                                                           15    9605
NP_001164051                                                           15    9605
NP_057652                                                              15    9605
NP_835368                                                              15    9605
NP_001170781                                                           15    9605
NP_835369                                                              15    9605
NP_004471                                                              15    9605
NP_150286                                                              15    9605
NP_056968                                                              15    9605
NP_001164058                                                           15    9605
XP_005261924                                                           15    9605
XP_006724450                                                           15    9605
XP_006724449                                                           15    9605
XP_005261923                                                           15    9605
XP_006724448                                                           15    9605
XP_006724447                                                           15    9605
XP_005261922                                                           15    9605
XP_005261921                                                           15    9605
XP_005261920                                                           15    9605
XP_005261919                                                           15    9605
XP_005254546                                                           15    9605
XP_005254545                                                           15    9605
XP_005254544                                                           15    9605
XP_005254543                                                           15    9605
XP_006720160                                                           15    9605
XP_006720159                                                           15    9605
XP_005252502                                                           15    9605
XP_006717022                                                           15    9605
XP_006711504                                                           15    9605
NP_001170782                                                           15    9605
NP_004499                                                              15    9605
>NP_000207
          Length = 680

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   FVKYLLLVR 9
           F+KY+LLV+
Sbjct: 122 FLKYILLVK 130
>XP_005274558
          Length = 420

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   FVKYLLLVR 9
           F+KY+LLV+
Sbjct: 122 FLKYILLVK 130
>NP_001245210
          Length = 868

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  FVKYLLLVR 9
          FVK LLLVR
Sbjct: 22 FVKDLLLVR 30
>NP_000242
          Length = 934

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  FVKYLLLVR 9
          FVK LLLVR
Sbjct: 88 FVKDLLLVR 96
>XP_005264389
          Length = 921

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  FVKYLLLVR 9
          FVK LLLVR
Sbjct: 88 FVKDLLLVR 96
>NP_001138462
          Length = 1742

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    FVKYLLLV 8
            FVK+LL++
Sbjct: 1144 FVKFLLIL 1151
>NP_001007189
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FVKYLLLVR 9
           F++Y +LVR
Sbjct: 278 FIQYPVLVR 286
>NP_001229825
          Length = 1603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FVKYLLLVR 9
           F++Y +LVR
Sbjct: 278 FIQYPVLVR 286
>NP_443104
          Length = 163

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  VKYLLL 7
          VKYLLL
Sbjct: 12 VKYLLL 17
>NP_060142
          Length = 1865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    FVKYLLLV 8
            FV+Y+++V
Sbjct: 1082 FVQYIIMV 1089
>NP_001229826
          Length = 1503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FVKYLLLVR 9
           F++Y +LVR
Sbjct: 278 FIQYPVLVR 286
>NP_055477
          Length = 1572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FVKYLLLVR 9
           F++Y +LVR
Sbjct: 278 FIQYPVLVR 286
>NP_001129501
          Length = 1594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FVKYLLLVR 9
           F++Y +LVR
Sbjct: 278 FIQYPVLVR 286
>NP_060132
          Length = 2022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    FVKYLLLV 8
            FV+Y+++V
Sbjct: 1055 FVQYIIMV 1062
>NP_060664
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FVKYLLL 7
           +VKYL+L
Sbjct: 297 YVKYLVL 303
>NP_001164059
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FVKYLLL 7
           +VKYL+L
Sbjct: 232 YVKYLVL 238
>NP_001116306
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FVKYLLL 7
           +VKYL+L
Sbjct: 297 YVKYLVL 303
>NP_001164035
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FVKYLLL 7
           +VKYL+L
Sbjct: 160 YVKYLVL 166
>NP_001164051
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FVKYLLL 7
           +VKYL+L
Sbjct: 297 YVKYLVL 303
>NP_057652
          Length = 469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   YLLLVR 9
           YLLLVR
Sbjct: 287 YLLLVR 292
>NP_835368
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FVKYLL 6
           FVKYL+
Sbjct: 331 FVKYLI 336
>NP_001170781
          Length = 2017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    FVKYLLLV 8
            FV+Y+++V
Sbjct: 1050 FVQYIIMV 1057
>NP_835369
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FVKYLL 6
           FVKYL+
Sbjct: 331 FVKYLI 336
>NP_004471
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FVKYLL 6
           FVKYL+
Sbjct: 168 FVKYLI 173
>NP_150286
          Length = 227

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   YLLLVR 9
           YLLLVR
Sbjct: 151 YLLLVR 156
>NP_056968
          Length = 519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FVKYLL 6
           FVKYL+
Sbjct: 444 FVKYLI 449
>NP_001164058
          Length = 494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FVKYLLL 7
           +VKYL+L
Sbjct: 298 YVKYLVL 304
>XP_005261924
          Length = 1176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FVKYLLLVR 9
           F++Y +LVR
Sbjct: 278 FIQYPVLVR 286
>XP_006724450
          Length = 1187

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FVKYLLLVR 9
           F++Y +LVR
Sbjct: 278 FIQYPVLVR 286
>XP_006724449
          Length = 1198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FVKYLLLVR 9
           F++Y +LVR
Sbjct: 278 FIQYPVLVR 286
>XP_005261923
          Length = 1307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FVKYLLLVR 9
           F++Y +LVR
Sbjct: 278 FIQYPVLVR 286
>XP_006724448
          Length = 1490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FVKYLLLVR 9
           F++Y +LVR
Sbjct: 165 FIQYPVLVR 173
>XP_006724447
          Length = 1516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FVKYLLLVR 9
           F++Y +LVR
Sbjct: 278 FIQYPVLVR 286
>XP_005261922
          Length = 1525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FVKYLLLVR 9
           F++Y +LVR
Sbjct: 278 FIQYPVLVR 286
>XP_005261921
          Length = 1581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FVKYLLLVR 9
           F++Y +LVR
Sbjct: 278 FIQYPVLVR 286
>XP_005261920
          Length = 1594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FVKYLLLVR 9
           F++Y +LVR
Sbjct: 278 FIQYPVLVR 286
>XP_005261919
          Length = 1603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FVKYLLLVR 9
           F++Y +LVR
Sbjct: 278 FIQYPVLVR 286
>XP_005254546
          Length = 1443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   FVKYLLLV 8
           FV+Y+++V
Sbjct: 640 FVQYIIMV 647
>XP_005254545
          Length = 1864

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    FVKYLLLV 8
            FV+Y+++V
Sbjct: 1082 FVQYIIMV 1089
>XP_005254544
          Length = 1884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    FVKYLLLV 8
            FV+Y+++V
Sbjct: 1082 FVQYIIMV 1089
>XP_005254543
          Length = 1885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    FVKYLLLV 8
            FV+Y+++V
Sbjct: 1082 FVQYIIMV 1089
>XP_006720160
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FVKYLL 6
           FVKYL+
Sbjct: 331 FVKYLI 336
>XP_006720159
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FVKYLL 6
           FVKYL+
Sbjct: 331 FVKYLI 336
>XP_005252502
          Length = 228

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VKYLLLVR 9
           + Y+LLVR
Sbjct: 150 IDYILLVR 157
>XP_006717022
          Length = 1054

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  FVKYLLLV 8
          FV+Y+++V
Sbjct: 87 FVQYIIMV 94
>XP_006711504
          Length = 527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FVKYLLL 7
           +VKYL+L
Sbjct: 331 YVKYLVL 337
>NP_001170782
          Length = 2017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    FVKYLLLV 8
            FV+Y+++V
Sbjct: 1050 FVQYIIMV 1057
>NP_004499
          Length = 284

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VKYLLLVR 9
           + Y+LLVR
Sbjct: 206 IDYILLVR 213
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.353    0.168    0.475 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 415,842
Number of extensions: 590
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.8 bits)
S2: 28 (15.4 bits)

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