Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001185761                                                           20     299
NP_001185763                                                           20     299
NP_055459                                                              20     299
NP_001002811                                                           20     299
NP_001002812                                                           20     299
XP_006726410                                                           20     299
XP_006711719                                                           20     299
XP_006711717                                                           20     299
XP_006711716                                                           20     299
XP_006711715                                                           20     299
XP_006711714                                                           20     299
XP_006711713                                                           20     299
XP_006711712                                                           20     299
XP_006711711                                                           20     299
XP_006711710                                                           20     299
XP_006711709                                                           20     299
XP_005277503                                                           20     299
XP_005273038                                                           20     299
XP_006711708                                                           20     299
XP_005277500                                                           20     299
XP_006711707                                                           20     299
XP_005277499                                                           20     299
XP_006711706                                                           20     299
XP_006711705                                                           20     299
XP_006711164                                                           20     299
XP_006710144                                                           20     299
NP_005221                                                              19     869
XP_006719338                                                           19     869
NP_004258                                                              17    3301
NP_078832                                                              17    4312
XP_005271723                                                           17    4312
XP_005271722                                                           17    4312
NP_071378                                                              16    5631
NP_060798                                                              16    5631
XP_005260563                                                           16    5631
XP_005260561                                                           16    5631
XP_005263769                                                           16    5631
XP_005263768                                                           16    5631
NP_056142                                                              16    7355
XP_006711311                                                           16    7355
XP_005245106                                                           16    7355
NP_001033729                                                           16    7355
NP_955523                                                              15    9605
NP_055766                                                              15    9605
NP_955522                                                              15    9605
NP_072097                                                              15    9605
>NP_001185761
          Length = 2240

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 444 FVEAAAHES 452
>NP_001185763
          Length = 2362

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 378 FVEAAAHES 386
>NP_055459
          Length = 2346

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 378 FVEAAAHES 386
>NP_001002811
          Length = 1132

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 541 FVEAAAHES 549
>NP_001002812
          Length = 969

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 378 FVEAAAHES 386
>XP_006726410
          Length = 2087

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 453 FVEAAAHES 461
>XP_006711719
          Length = 2302

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 444 FVEAAAHES 452
>XP_006711717
          Length = 2385

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 444 FVEAAAHES 452
>XP_006711716
          Length = 2411

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 444 FVEAAAHES 452
>XP_006711715
          Length = 2428

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 378 FVEAAAHES 386
>XP_006711714
          Length = 2429

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 378 FVEAAAHES 386
>XP_006711713
          Length = 2432

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 381 FVEAAAHES 389
>XP_006711712
          Length = 2473

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 541 FVEAAAHES 549
>XP_006711711
          Length = 2482

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 541 FVEAAAHES 549
>XP_006711710
          Length = 2494

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 444 FVEAAAHES 452
>XP_006711709
          Length = 2495

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 444 FVEAAAHES 452
>XP_005277503
          Length = 2498

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 541 FVEAAAHES 549
>XP_005273038
          Length = 2509

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 541 FVEAAAHES 549
>XP_006711708
          Length = 2512

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 541 FVEAAAHES 549
>XP_005277500
          Length = 2525

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 541 FVEAAAHES 549
>XP_006711707
          Length = 2553

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 541 FVEAAAHES 549
>XP_005277499
          Length = 2561

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 541 FVEAAAHES 549
>XP_006711706
          Length = 2591

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 541 FVEAAAHES 549
>XP_006711705
          Length = 2592

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 541 FVEAAAHES 549
>XP_006711164
          Length = 2087

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 453 FVEAAAHES 461
>XP_006710144
          Length = 564

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FLEAAAHES 9
           F+EAAAHES
Sbjct: 541 FVEAAAHES 549
>NP_005221
          Length = 407

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   FLEAAAHES 9
           FLEAA H+S
Sbjct: 260 FLEAACHDS 268
>XP_006719338
          Length = 407

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   FLEAAAHES 9
           FLEAA H+S
Sbjct: 260 FLEAACHDS 268
>NP_004258
          Length = 530

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   FLEAAAHE 8
           FLEAA H+
Sbjct: 368 FLEAAGHK 375
>NP_078832
          Length = 351

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FLEAAAHES 9
           FLEA  H+S
Sbjct: 262 FLEAVKHKS 270
>XP_005271723
          Length = 331

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FLEAAAHES 9
           FLEA  H+S
Sbjct: 262 FLEAVKHKS 270
>XP_005271722
          Length = 350

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FLEAAAHES 9
           FLEA  H+S
Sbjct: 262 FLEAVKHKS 270
>NP_071378
          Length = 1342

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LEAAAHES 9
            LEAAAH +
Sbjct: 1291 LEAAAHSA 1298
>NP_060798
          Length = 1494

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LEAAAHES 9
            LEAA HE+
Sbjct: 1454 LEAAIHEA 1461
>XP_005260563
          Length = 1166

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LEAAAHES 9
            LEAAAH +
Sbjct: 1115 LEAAAHSA 1122
>XP_005260561
          Length = 1341

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LEAAAHES 9
            LEAAAH +
Sbjct: 1290 LEAAAHSA 1297
>XP_005263769
          Length = 1727

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LEAAAHES 9
            LEAA HE+
Sbjct: 1687 LEAAIHEA 1694
>XP_005263768
          Length = 1727

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LEAAAHES 9
            LEAA HE+
Sbjct: 1687 LEAAIHEA 1694
>NP_056142
          Length = 1016

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LEAAAHES 9
           L+AAAH S
Sbjct: 992 LQAAAHAS 999
>XP_006711311
          Length = 950

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LEAAAHES 9
           L+AAAH S
Sbjct: 926 LQAAAHAS 933
>XP_005245106
          Length = 970

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LEAAAHES 9
           L+AAAH S
Sbjct: 946 LQAAAHAS 953
>NP_001033729
          Length = 693

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LEAAAHES 9
           LEAA+H++
Sbjct: 478 LEAASHQN 485
>NP_955523
          Length = 462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   FLEAAAHE 8
           FLEAAA +
Sbjct: 256 FLEAAAEK 263
>NP_055766
          Length = 407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   FLEAAAHE 8
           FLEAAA +
Sbjct: 256 FLEAAAEK 263
>NP_955522
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   FLEAAAHE 8
           FLEAAA +
Sbjct: 256 FLEAAAEK 263
>NP_072097
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LEAAAHE 8
           +EAA HE
Sbjct: 384 IEAAGHE 390
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.117    0.308 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 537,349
Number of extensions: 720
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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