Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              20     390
XP_005265800                                                           20     390
XP_006714103                                                           20     390
XP_006714102                                                           20     390
NP_787128                                                              17    4312
NP_002808                                                              17    4312
NP_060009                                                              17    4312
XP_006721125                                                           17    4312
NP_659449                                                              16    5631
NP_001157871                                                           16    5631
XP_005264132                                                           16    5631
NP_056988                                                              16    5631
NP_004056                                                              16    5631
NP_997064                                                              16    7355
NP_000263                                                              16    7355
NP_060145                                                              16    7355
NP_001165447                                                           16    7355
NP_001135772                                                           16    7355
NP_000428                                                              16    7355
XP_006726617                                                           16    7355
XP_006720409                                                           16    7355
XP_006714950                                                           16    7355
XP_006712615                                                           16    7355
XP_005263735                                                           16    7355
XP_005263732                                                           16    7355
XP_006712614                                                           16    7355
XP_005246400                                                           16    7355
XP_006710733                                                           16    7355
XP_006710732                                                           16    7355
XP_006710731                                                           16    7355
NP_689736                                                              16    7355
NP_001243143                                                           15    9605
NP_689509                                                              15    9605
NP_001243142                                                           15    9605
NP_848547                                                              15    9605
NP_005624                                                              15    9605
NP_000693                                                              15    9605
NP_001153705                                                           15    9605
NP_000692                                                              15    9605
NP_001153706                                                           15    9605
NP_078858                                                              15    9605
NP_001278232                                                           15    9605
NP_001278214                                                           15    9605
NP_002892                                                              15    9605
NP_006347                                                              15    9605
NP_001003785                                                           15    9605
NP_001155244                                                           15    9605
NP_000860                                                              15    9605
NP_998786                                                              15    9605
NP_056145                                                              15    9605
NP_055501                                                              15    9605
NP_055055                                                              15    9605
NP_149035                                                              15    9605
NP_001172014                                                           15    9605
NP_065078                                                              15    9605
NP_061736                                                              15    9605
NP_001241661                                                           15    9605
NP_000695                                                              15    9605
NP_001138940                                                           15    9605
NP_001667                                                              15    9605
XP_005259501                                                           15    9605
XP_005259010                                                           15    9605
XP_006721192                                                           15    9605
XP_005265134                                                           15    9605
XP_005265135                                                           15    9605
XP_005265133                                                           15    9605
XP_005264572                                                           15    9605
XP_006710718                                                           15    9605
NP_078785                                                              15    9605
NP_114479                                                              15    9605
>NP_006197
          Length = 1089

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETIEDINMM 9
            ETIEDI+MM
Sbjct: 1065 ETIEDIDMM 1073
>XP_005265800
          Length = 1089

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETIEDINMM 9
            ETIEDI+MM
Sbjct: 1065 ETIEDIDMM 1073
>XP_006714103
          Length = 1111

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETIEDINMM 9
            ETIEDI+MM
Sbjct: 1087 ETIEDIDMM 1095
>XP_006714102
          Length = 1114

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETIEDINMM 9
            ETIEDI+MM
Sbjct: 1090 ETIEDIDMM 1098
>NP_787128
          Length = 378

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ETIEDINMM 9
           ETIED+  M
Sbjct: 135 ETIEDVEEM 143
>NP_002808
          Length = 376

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ETIEDINMM 9
           ETIED+  M
Sbjct: 133 ETIEDVEEM 141
>NP_060009
          Length = 4116

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    IEDINMM 9
            +EDINM+
Sbjct: 2502 VEDINML 2508
>XP_006721125
          Length = 4070

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    IEDINMM 9
            +EDINM+
Sbjct: 2456 VEDINML 2462
>NP_659449
          Length = 341

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ETIEDINM 8
          E I+D+NM
Sbjct: 48 ENIDDLNM 55
>NP_001157871
          Length = 793

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ETIEDIN 7
           ET++DIN
Sbjct: 722 ETLQDIN 728
>XP_005264132
          Length = 1219

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ETIEDINMM 9
           +TIE IN++
Sbjct: 735 QTIESINLL 743
>NP_056988
          Length = 1220

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ETIEDINMM 9
           +TIE IN++
Sbjct: 736 QTIESINLL 744
>NP_004056
          Length = 262

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IEDINMM 9
          +EDIN+M
Sbjct: 40 LEDINLM 46
>NP_997064
          Length = 732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ETIEDIN 7
           ET+ED N
Sbjct: 281 ETVEDTN 287
>NP_000263
          Length = 733

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ETIEDIN 7
           ET+ED N
Sbjct: 281 ETVEDTN 287
>NP_060145
          Length = 1310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIEDIN 7
           T+EDIN
Sbjct: 684 TVEDIN 689

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIEDIN 7
           TIED+N
Sbjct: 917 TIEDVN 922
>NP_001165447
          Length = 1310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIEDIN 7
           T+EDIN
Sbjct: 684 TVEDIN 689

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIEDIN 7
           TIED+N
Sbjct: 917 TIEDVN 922
>NP_001135772
          Length = 308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TIEDINMM 9
           T+ED+N M
Sbjct: 214 TVEDMNEM 221
>NP_000428
          Length = 392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ETIEDINMM 9
           +T+E +N+M
Sbjct: 286 QTMESVNLM 294
>XP_006726617
          Length = 1688

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TIEDINMM 9
           T+EDI++M
Sbjct: 113 TMEDISLM 120
>XP_006720409
          Length = 1688

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TIEDINMM 9
           T+EDI++M
Sbjct: 113 TMEDISLM 120
>XP_006714950
          Length = 1304

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIEDIN 7
           T+EDIN
Sbjct: 684 TVEDIN 689

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIEDIN 7
           TIED+N
Sbjct: 917 TIEDVN 922
>XP_006712615
          Length = 465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ETIEDIN 7
           ET+ED N
Sbjct: 281 ETVEDTN 287
>XP_005263735
          Length = 686

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ETIEDIN 7
           ET+ED N
Sbjct: 281 ETVEDTN 287
>XP_005263732
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ETIEDIN 7
           ET+ED N
Sbjct: 281 ETVEDTN 287
>XP_006712614
          Length = 768

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ETIEDIN 7
           ET+ED N
Sbjct: 281 ETVEDTN 287
>XP_005246400
          Length = 359

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TIEDINMM 9
           T+ED+N M
Sbjct: 265 TVEDMNEM 272
>XP_006710733
          Length = 392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ETIEDINMM 9
           +T+E +N+M
Sbjct: 286 QTMESVNLM 294
>XP_006710732
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ETIEDINMM 9
           +T+E +N+M
Sbjct: 179 QTMESVNLM 187
>XP_006710731
          Length = 416

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ETIEDINMM 9
           +T+E +N+M
Sbjct: 310 QTMESVNLM 318
>NP_689736
          Length = 289

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TIEDINMM 9
           T+ED+N M
Sbjct: 195 TVEDMNEM 202
>NP_001243143
          Length = 1026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ETIEDI 6
           ET+EDI
Sbjct: 642 ETVEDI 647
>NP_689509
          Length = 1013

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ETIEDI 6
           ET+EDI
Sbjct: 629 ETVEDI 634
>NP_001243142
          Length = 1024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ETIEDI 6
           ET+EDI
Sbjct: 640 ETVEDI 645
>NP_848547
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ETIEDI 6
           ET+EDI
Sbjct: 208 ETVEDI 213
>NP_005624
          Length = 1333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ETIEDINMM 9
           + +EDIN++
Sbjct: 178 QDVEDINIL 186
>NP_000693
          Length = 1020

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ETIEDI 6
           ET+EDI
Sbjct: 636 ETVEDI 641
>NP_001153705
          Length = 1023

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ETIEDI 6
           ET+EDI
Sbjct: 639 ETVEDI 644
>NP_000692
          Length = 1023

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ETIEDI 6
           ET+EDI
Sbjct: 639 ETVEDI 644
>NP_001153706
          Length = 992

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ETIEDI 6
           ET+EDI
Sbjct: 608 ETVEDI 613
>NP_078858
          Length = 4981

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    TIEDIN 7
            T+EDIN
Sbjct: 3499 TLEDIN 3504
>NP_001278232
          Length = 4983

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    TIEDIN 7
            T+EDIN
Sbjct: 3501 TLEDIN 3506
>NP_001278214
          Length = 4982

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    TIEDIN 7
            T+EDIN
Sbjct: 3501 TLEDIN 3506
>NP_002892
          Length = 331

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ETIEDIN 7
           ET+EDI+
Sbjct: 210 ETLEDID 216
>NP_006347
          Length = 161

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIEDIN 7
           TIED+N
Sbjct: 132 TIEDLN 137
>NP_001003785
          Length = 137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIEDIN 7
           TIED+N
Sbjct: 108 TIEDLN 113
>NP_001155244
          Length = 463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIEDINM 8
           TI+DIN+
Sbjct: 166 TIQDINI 172
>NP_000860
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIEDINM 8
           TI+DIN+
Sbjct: 187 TIQDINI 193
>NP_998786
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TIEDINM 8
           TI+DIN+
Sbjct: 187 TIQDINI 193
>NP_056145
          Length = 1117

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IEDINM 8
           IED+NM
Sbjct: 662 IEDLNM 667
>NP_055501
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   TIEDIN 7
           T+ED+N
Sbjct: 962 TVEDVN 967
>NP_055055
          Length = 676

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  IEDINM 8
          IED+NM
Sbjct: 15 IEDLNM 20
>NP_149035
          Length = 550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  IEDINMM 9
          +ED+NM+
Sbjct: 8  LEDLNML 14
>NP_001172014
          Length = 1045

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ETIEDI 6
           ET+EDI
Sbjct: 660 ETVEDI 665
>NP_065078
          Length = 192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ETIEDINM 8
          ET+ED+ M
Sbjct: 37 ETMEDVYM 44
>NP_061736
          Length = 936

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   TIEDIN 7
           T+ED+N
Sbjct: 340 TVEDVN 345
>NP_001241661
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IEDINM 8
           IED+NM
Sbjct: 662 IEDLNM 667
>NP_000695
          Length = 1035

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ETIEDI 6
           ET+EDI
Sbjct: 650 ETVEDI 655
>NP_001138940
          Length = 1117

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IEDINM 8
           IED+NM
Sbjct: 662 IEDLNM 667
>NP_001667
          Length = 1039

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ETIEDI 6
           ET+EDI
Sbjct: 654 ETVEDI 659
>XP_005259501
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   TIEDIN 7
           T+ED+N
Sbjct: 962 TVEDVN 967
>XP_005259010
          Length = 1261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ETIEDI 6
           ET+EDI
Sbjct: 629 ETVEDI 634
>XP_006721192
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ETIEDI 6
           ET+EDI
Sbjct: 208 ETVEDI 213
>XP_005265134
          Length = 192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ETIEDINM 8
          ET+ED+ M
Sbjct: 37 ETMEDVYM 44
>XP_005265135
          Length = 192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ETIEDINM 8
          ET+ED+ M
Sbjct: 37 ETMEDVYM 44
>XP_005265133
          Length = 192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ETIEDINM 8
          ET+ED+ M
Sbjct: 37 ETMEDVYM 44
>XP_005264572
          Length = 1318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ETIEDINMM 9
           + +EDIN++
Sbjct: 178 QDVEDINIL 186
>XP_006710718
          Length = 992

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ETIEDI 6
           ET+EDI
Sbjct: 608 ETVEDI 613
>NP_078785
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   ETIEDINM 8
           ET+ED+++
Sbjct: 156 ETLEDLDL 163
>NP_114479
          Length = 850

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   TIEDIN 7
           T+ED+N
Sbjct: 340 TVEDVN 345
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.314    0.130    0.322 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 437,911
Number of extensions: 781
Number of successful extensions: 73
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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