Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005350                                                              20     390
NP_005718                                                              17    3301
NP_001269973                                                           17    3301
NP_055805                                                              17    3301
NP_001269972                                                           17    3301
NP_919277                                                              17    3301
XP_006720167                                                           17    3301
XP_006720166                                                           17    3301
XP_005267550                                                           17    3301
XP_005267549                                                           17    3301
XP_005267548                                                           17    3301
XP_006720165                                                           17    3301
XP_006720164                                                           17    3301
XP_006720163                                                           17    3301
XP_006720162                                                           17    3301
XP_006720161                                                           17    3301
NP_006024                                                              17    4312
NP_039256                                                              17    4312
NP_001153473                                                           17    4312
NP_001153479                                                           17    4312
NP_001153477                                                           17    4312
XP_005258447                                                           17    4312
NP_065853                                                              16    5631
NP_689526                                                              16    5631
NP_001273068                                                           16    5631
XP_005271684                                                           16    5631
XP_006718826                                                           16    5631
XP_006718825                                                           16    5631
NP_003153                                                              16    7355
NP_620414                                                              16    7355
XP_005264576                                                           16    7355
NP_001123308                                                           15    9605
NP_001123306                                                           15    9605
NP_001123312                                                           15    9605
NP_001123307                                                           15    9605
NP_001123316                                                           15    9605
NP_001123304                                                           15    9605
NP_001123305                                                           15    9605
NP_001123309                                                           15    9605
NP_001123299                                                           15    9605
NP_001123313                                                           15    9605
NP_000710                                                              15    9605
NP_001123314                                                           15    9605
NP_001123311                                                           15    9605
NP_001123310                                                           15    9605
NP_001123318                                                           15    9605
NP_001123301                                                           15    9605
NP_001123303                                                           15    9605
NP_001123315                                                           15    9605
NP_001123302                                                           15    9605
NP_001161095                                                           15    9605
NP_955630                                                              15    9605
NP_001161096                                                           15    9605
NP_001161097                                                           15    9605
XP_006723005                                                           15    9605
XP_006719080                                                           15    9605
>NP_005350
          Length = 552

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ESNATNTAN 9
           ESNAT+TAN
Sbjct: 205 ESNATSTAN 213
>NP_005718
          Length = 241

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   NATNTAN 9
           N TNTAN
Sbjct: 178 NVTNTAN 184
>NP_001269973
          Length = 2083

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESNATNTAN 9
           E N TNTA+
Sbjct: 483 EENGTNTAD 491
>NP_055805
          Length = 2036

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESNATNTAN 9
           E N TNTA+
Sbjct: 483 EENGTNTAD 491
>NP_001269972
          Length = 2049

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESNATNTAN 9
           E N TNTA+
Sbjct: 483 EENGTNTAD 491
>NP_919277
          Length = 2083

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESNATNTAN 9
           E N TNTA+
Sbjct: 483 EENGTNTAD 491
>XP_006720167
          Length = 1607

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESNATNTAN 9
           E N TNTA+
Sbjct: 483 EENGTNTAD 491
>XP_006720166
          Length = 2083

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESNATNTAN 9
           E N TNTA+
Sbjct: 483 EENGTNTAD 491
>XP_005267550
          Length = 2084

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESNATNTAN 9
           E N TNTA+
Sbjct: 483 EENGTNTAD 491
>XP_005267549
          Length = 2130

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESNATNTAN 9
           E N TNTA+
Sbjct: 483 EENGTNTAD 491
>XP_005267548
          Length = 2131

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESNATNTAN 9
           E N TNTA+
Sbjct: 483 EENGTNTAD 491
>XP_006720165
          Length = 2542

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESNATNTAN 9
           E N TNTA+
Sbjct: 483 EENGTNTAD 491
>XP_006720164
          Length = 2542

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESNATNTAN 9
           E N TNTA+
Sbjct: 483 EENGTNTAD 491
>XP_006720163
          Length = 2543

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESNATNTAN 9
           E N TNTA+
Sbjct: 483 EENGTNTAD 491
>XP_006720162
          Length = 2589

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESNATNTAN 9
           E N TNTA+
Sbjct: 483 EENGTNTAD 491
>XP_006720161
          Length = 2590

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESNATNTAN 9
           E N TNTA+
Sbjct: 483 EENGTNTAD 491
>NP_006024
          Length = 500

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ESNATNT 7
           E NATNT
Sbjct: 391 EQNATNT 397
>NP_039256
          Length = 422

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   ESNATNTA 8
           ESNAT+T+
Sbjct: 346 ESNATSTS 353
>NP_001153473
          Length = 590

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   ESNATNTA 8
           ESNAT+T+
Sbjct: 110 ESNATSTS 117
>NP_001153479
          Length = 177

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   ESNATNTA 8
           ESNAT+T+
Sbjct: 131 ESNATSTS 138
>NP_001153477
          Length = 207

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   ESNATNTA 8
           ESNAT+T+
Sbjct: 131 ESNATSTS 138
>XP_005258447
          Length = 536

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ESNATNT 7
           E NATNT
Sbjct: 427 EQNATNT 433
>NP_065853
          Length = 1117

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ATNTAN 9
           ATNTAN
Sbjct: 360 ATNTAN 365
>NP_689526
          Length = 504

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SNATNTAN 9
           SN+TN++N
Sbjct: 193 SNSTNSSN 200
>NP_001273068
          Length = 369

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SNATNTAN 9
          SN+TN++N
Sbjct: 58 SNSTNSSN 65
>XP_005271684
          Length = 1081

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ATNTAN 9
           ATNTAN
Sbjct: 360 ATNTAN 365
>XP_006718826
          Length = 345

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SNATNTAN 9
           SN+TN++N
Sbjct: 193 SNSTNSSN 200
>XP_006718825
          Length = 398

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SNATNTAN 9
          SN+TN++N
Sbjct: 87 SNSTNSSN 94
>NP_003153
          Length = 780

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ESNATNTAN 9
           ESN   TAN
Sbjct: 654 ESNVDTTAN 662
>NP_620414
          Length = 393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ESNATNTA 8
          + NATNT+
Sbjct: 9  DDNATNTS 16
>XP_005264576
          Length = 743

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ESNATNTAN 9
           ESN   TAN
Sbjct: 617 ESNVDTTAN 625
>NP_001123308
          Length = 2155

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_001123306
          Length = 2157

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_001123312
          Length = 2138

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_001123307
          Length = 2157

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_001123316
          Length = 2135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_001123304
          Length = 2158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_001123305
          Length = 2157

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_001123309
          Length = 2146

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_001123299
          Length = 2186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_001123313
          Length = 2138

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_000710
          Length = 2138

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_001123314
          Length = 2138

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_001123311
          Length = 2144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_001123310
          Length = 2146

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_001123318
          Length = 2127

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_001123301
          Length = 2179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_001123303
          Length = 2166

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_001123315
          Length = 2138

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_001123302
          Length = 2173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_001161095
          Length = 2138

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_955630
          Length = 2221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_001161096
          Length = 2173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>NP_001161097
          Length = 2198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 151 DSNATNS 157
>XP_006723005
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   ESNATNTAN 9
           E N+TN  N
Sbjct: 213 EENSTNVKN 221
>XP_006719080
          Length = 2168

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESNATNT 7
           +SNATN+
Sbjct: 181 DSNATNS 187
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.270   0.0861    0.199 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 351,994
Number of extensions: 681
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.5 bits)
S2: 28 (15.4 bits)

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