Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              19     869
XP_005266703                                                           19     869
NP_001245344                                                           17    3301
NP_065860                                                              17    3301
NP_001245347                                                           17    3301
NP_001245346                                                           17    3301
NP_001245345                                                           17    3301
NP_001166101                                                           17    3301
XP_006723066                                                           17    3301
XP_006723065                                                           17    3301
XP_005258546                                                           17    3301
XP_006723064                                                           17    3301
XP_005258545                                                           17    3301
XP_005258544                                                           17    3301
XP_006723063                                                           17    3301
XP_006723062                                                           17    3301
XP_005271685                                                           17    3301
XP_006718956                                                           17    3301
NP_001140155                                                           17    4312
NP_004835                                                              17    4312
NP_001018009                                                           17    4312
XP_006720296                                                           17    4312
XP_006713483                                                           17    4312
NP_055572                                                              16    5631
NP_061744                                                              16    5631
NP_114478                                                              16    5631
NP_001165599                                                           16    7355
NP_757366                                                              16    7355
XP_005254400                                                           16    7355
XP_005254399                                                           16    7355
NP_065805                                                              15    9605
NP_002408                                                              15    9605
NP_001139438                                                           15    9605
NP_057636                                                              15    9605
NP_001269710                                                           15    9605
NP_001269700                                                           15    9605
XP_006717927                                                           15    9605
XP_005247728                                                           15    9605
XP_006713777                                                           15    9605
XP_006712635                                                           15    9605
XP_006712634                                                           15    9605
XP_006712633                                                           15    9605
XP_005247077                                                           15    9605
XP_006712631                                                           15    9605
XP_006712630                                                           15    9605
NP_115271                                                              15    9605
NP_116175                                                              15    9605
NP_061749                                                              15    9605
>NP_443179
          Length = 2170

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EPLAVSVAS 9
           EP+AVSVAS
Sbjct: 770 EPVAVSVAS 778
>XP_005266703
          Length = 1501

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EPLAVSVAS 9
           EP+AVSVAS
Sbjct: 101 EPVAVSVAS 109
>NP_001245344
          Length = 1168

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   EPLAVSVAS 9
           +P+A+SVAS
Sbjct: 774 KPVAISVAS 782
>NP_065860
          Length = 1191

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   EPLAVSVAS 9
           +P+A+SVAS
Sbjct: 797 KPVAISVAS 805
>NP_001245347
          Length = 1155

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   EPLAVSVAS 9
           +P+A+SVAS
Sbjct: 761 KPVAISVAS 769
>NP_001245346
          Length = 1155

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   EPLAVSVAS 9
           +P+A+SVAS
Sbjct: 761 KPVAISVAS 769
>NP_001245345
          Length = 1165

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   EPLAVSVAS 9
           +P+A+SVAS
Sbjct: 771 KPVAISVAS 779
>NP_001166101
          Length = 1123

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   EPLAVSV 7
           EPLAVSV
Sbjct: 661 EPLAVSV 667
>XP_006723066
          Length = 818

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   EPLAVSV 7
           EPLAVSV
Sbjct: 328 EPLAVSV 334
>XP_006723065
          Length = 1162

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   EPLAVSV 7
           EPLAVSV
Sbjct: 672 EPLAVSV 678
>XP_005258546
          Length = 1259

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   EPLAVSV 7
           EPLAVSV
Sbjct: 797 EPLAVSV 803
>XP_006723064
          Length = 1270

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   EPLAVSV 7
           EPLAVSV
Sbjct: 808 EPLAVSV 814
>XP_005258545
          Length = 1287

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   EPLAVSV 7
           EPLAVSV
Sbjct: 797 EPLAVSV 803
>XP_005258544
          Length = 1288

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   EPLAVSV 7
           EPLAVSV
Sbjct: 798 EPLAVSV 804
>XP_006723063
          Length = 1297

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   EPLAVSV 7
           EPLAVSV
Sbjct: 807 EPLAVSV 813
>XP_006723062
          Length = 1298

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   EPLAVSV 7
           EPLAVSV
Sbjct: 808 EPLAVSV 814
>XP_005271685
          Length = 734

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   EPLAVSVAS 9
           +P+A+SVAS
Sbjct: 340 KPVAISVAS 348
>XP_006718956
          Length = 1191

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   EPLAVSVAS 9
           +P+A+SVAS
Sbjct: 797 KPVAISVAS 805
>NP_001140155
          Length = 217

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2  PLAVSVA 8
          PLAVSVA
Sbjct: 48 PLAVSVA 54
>NP_004835
          Length = 455

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EPLAVSVAS 9
           EP A+SVAS
Sbjct: 291 EPDAISVAS 299
>NP_001018009
          Length = 298

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EPLAVSVAS 9
           EP A+SVAS
Sbjct: 134 EPDAISVAS 142
>XP_006720296
          Length = 217

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2  PLAVSVA 8
          PLAVSVA
Sbjct: 48 PLAVSVA 54
>XP_006713483
          Length = 298

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EPLAVSVAS 9
           EP A+SVAS
Sbjct: 134 EPDAISVAS 142
>NP_055572
          Length = 1016

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EPLAVSVAS 9
           +P AVSVAS
Sbjct: 596 QPPAVSVAS 604
>NP_061744
          Length = 932

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   EPLAVSVAS 9
           EPL VSV S
Sbjct: 789 EPLCVSVDS 797
>NP_114478
          Length = 828

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   EPLAVSVAS 9
           EPL VSV S
Sbjct: 789 EPLCVSVDS 797
>NP_001165599
          Length = 1331

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EPLAVSVAS 9
           EP+ +S+AS
Sbjct: 551 EPVVLSIAS 559
>NP_757366
          Length = 1332

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EPLAVSVAS 9
           EP+ +S+AS
Sbjct: 551 EPVVLSIAS 559
>XP_005254400
          Length = 1378

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EPLAVSVAS 9
           EP+ +S+AS
Sbjct: 598 EPVVLSIAS 606
>XP_005254399
          Length = 1379

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EPLAVSVAS 9
           EP+ +S+AS
Sbjct: 598 EPVVLSIAS 606
>NP_065805
          Length = 1444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   EPLAVSV 7
           EP AVSV
Sbjct: 488 EPFAVSV 494
>NP_002408
          Length = 3256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    EPLAVS 6
            EPLAVS
Sbjct: 2494 EPLAVS 2499
>NP_001139438
          Length = 2896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    EPLAVS 6
            EPLAVS
Sbjct: 2134 EPLAVS 2139
>NP_057636
          Length = 941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PLAVSVAS 9
           PL++S+AS
Sbjct: 698 PLSLSIAS 705
>NP_001269710
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PLAVSVAS 9
           PL++S+AS
Sbjct: 459 PLSLSIAS 466
>NP_001269700
          Length = 1030

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PLAVSVAS 9
           PL++S+AS
Sbjct: 787 PLSLSIAS 794
>XP_006717927
          Length = 2406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    EPLAVS 6
            EPLAVS
Sbjct: 1644 EPLAVS 1649
>XP_005247728
          Length = 1413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   EPLAVSV 7
           EP AVSV
Sbjct: 457 EPFAVSV 463
>XP_006713777
          Length = 1424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   EPLAVSV 7
           EP AVSV
Sbjct: 468 EPFAVSV 474
>XP_006712635
          Length = 610

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PLAVSVAS 9
           PL++S+AS
Sbjct: 367 PLSLSIAS 374
>XP_006712634
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PLAVSVAS 9
           PL++S+AS
Sbjct: 460 PLSLSIAS 467
>XP_006712633
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PLAVSVAS 9
           PL++S+AS
Sbjct: 468 PLSLSIAS 475
>XP_005247077
          Length = 778

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PLAVSVAS 9
           PL++S+AS
Sbjct: 535 PLSLSIAS 542
>XP_006712631
          Length = 800

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PLAVSVAS 9
           PL++S+AS
Sbjct: 557 PLSLSIAS 564
>XP_006712630
          Length = 941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PLAVSVAS 9
           PL++S+AS
Sbjct: 698 PLSLSIAS 705
>NP_115271
          Length = 820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EPLAVS 6
           EPLAVS
Sbjct: 497 EPLAVS 502
>NP_116175
          Length = 434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   PLAVSVA 8
           P+AVSVA
Sbjct: 386 PVAVSVA 392
>NP_061749
          Length = 930

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EPLAVS 6
           EPLAVS
Sbjct: 497 EPLAVS 502
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.300    0.113    0.269 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 407,359
Number of extensions: 608
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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