Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              18    1135
XP_006718908                                                           18    1135
XP_005271621                                                           18    1135
XP_006718907                                                           18    1135
XP_006718906                                                           18    1135
XP_005271619                                                           18    1135
XP_005271618                                                           18    1135
NP_443125                                                              18    1482
NP_001165889                                                           18    1482
XP_005248898                                                           18    1482
NP_001092742                                                           18    1482
NP_689946                                                              18    1482
NP_001161288                                                           17    4312
NP_001271347                                                           17    4312
NP_001271346                                                           17    4312
NP_056400                                                              17    4312
NP_689662                                                              17    4312
NP_001271348                                                           17    4312
NP_872344                                                              17    4312
NP_001271349                                                           17    4312
XP_005260754                                                           17    4312
XP_005260752                                                           17    4312
XP_005260750                                                           17    4312
XP_005260749                                                           17    4312
XP_005260748                                                           17    4312
XP_005260747                                                           17    4312
XP_005260746                                                           17    4312
XP_005260745                                                           17    4312
XP_005257805                                                           17    4312
XP_006722205                                                           17    4312
XP_006722204                                                           17    4312
XP_005254924                                                           17    4312
XP_006720459                                                           17    4312
XP_006720458                                                           17    4312
XP_006720457                                                           17    4312
NP_003623                                                              17    4312
NP_001093326                                                           16    5631
NP_001093327                                                           16    5631
NP_003630                                                              16    5631
NP_690042                                                              16    5631
NP_056456                                                              16    5631
XP_005274821                                                           16    5631
XP_005274820                                                           16    5631
XP_005274818                                                           16    5631
XP_006724916                                                           16    5631
XP_005274817                                                           16    5631
XP_005250315                                                           16    5631
NP_005637                                                              16    7355
XP_005273291                                                           16    7355
NP_573439                                                              15    9605
NP_573438                                                              15    9605
NP_001181930                                                           15    9605
NP_005695                                                              15    9605
XP_006710336                                                           15    9605
XP_006710335                                                           15    9605
XP_006710334                                                           15    9605
XP_006710333                                                           15    9605
XP_006710332                                                           15    9605
>NP_000042
          Length = 3056

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ENHAVIMQT 9
            EN AVIMQT
Sbjct: 2351 ENPAVIMQT 2359
>XP_006718908
          Length = 1708

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ENHAVIMQT 9
            EN AVIMQT
Sbjct: 1003 ENPAVIMQT 1011
>XP_005271621
          Length = 2708

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ENHAVIMQT 9
            EN AVIMQT
Sbjct: 2003 ENPAVIMQT 2011
>XP_006718907
          Length = 3050

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ENHAVIMQT 9
            EN AVIMQT
Sbjct: 2345 ENPAVIMQT 2353
>XP_006718906
          Length = 3056

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ENHAVIMQT 9
            EN AVIMQT
Sbjct: 2351 ENPAVIMQT 2359
>XP_005271619
          Length = 3056

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ENHAVIMQT 9
            EN AVIMQT
Sbjct: 2351 ENPAVIMQT 2359
>XP_005271618
          Length = 3056

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ENHAVIMQT 9
            EN AVIMQT
Sbjct: 2351 ENPAVIMQT 2359
>NP_443125
          Length = 612

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ENHAVIMQ 8
           ENHA IMQ
Sbjct: 216 ENHAEIMQ 223
>NP_001165889
          Length = 582

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ENHAVIMQ 8
           ENHA IMQ
Sbjct: 157 ENHAEIMQ 164
>XP_005248898
          Length = 612

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ENHAVIMQ 8
           ENHA IMQ
Sbjct: 216 ENHAEIMQ 223
>NP_001092742
          Length = 612

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ENHAVIMQ 8
           ENHA IMQ
Sbjct: 216 ENHAEIMQ 223
>NP_689946
          Length = 544

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ENHAVIMQ 8
           ENHA IMQ
Sbjct: 148 ENHAEIMQ 155
>NP_001161288
          Length = 470

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ENHAVIMQ 8
           ENHAV+ +
Sbjct: 226 ENHAVVCE 233
>NP_001271347
          Length = 296

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   NHAVIMQT 9
           NH ++M+T
Sbjct: 122 NHGILMET 129
>NP_001271346
          Length = 296

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   NHAVIMQT 9
           NH ++M+T
Sbjct: 122 NHGILMET 129
>NP_056400
          Length = 1237

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ENHAVIMQ 8
           ENHAV+ +
Sbjct: 226 ENHAVVCE 233
>NP_689662
          Length = 297

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   NHAVIMQT 9
           NH ++M+T
Sbjct: 123 NHGILMET 130
>NP_001271348
          Length = 292

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   NHAVIMQT 9
           NH ++M+T
Sbjct: 118 NHGILMET 125
>NP_872344
          Length = 512

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ENHAVIMQT 9
          +NHA ++QT
Sbjct: 80 DNHAGLLQT 88
>NP_001271349
          Length = 235

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  NHAVIMQT 9
          NH ++M+T
Sbjct: 61 NHGILMET 68
>XP_005260754
          Length = 654

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ENHAVIMQ 8
           ENHAV+ +
Sbjct: 226 ENHAVVCE 233
>XP_005260752
          Length = 1046

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ENHAVIMQ 8
          ENHAV+ +
Sbjct: 30 ENHAVVCE 37
>XP_005260750
          Length = 1180

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ENHAVIMQ 8
           ENHAV+ +
Sbjct: 226 ENHAVVCE 233
>XP_005260749
          Length = 1211

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ENHAVIMQ 8
           ENHAV+ +
Sbjct: 226 ENHAVVCE 233
>XP_005260748
          Length = 1216

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ENHAVIMQ 8
           ENHAV+ +
Sbjct: 226 ENHAVVCE 233
>XP_005260747
          Length = 1217

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ENHAVIMQ 8
           ENHAV+ +
Sbjct: 226 ENHAVVCE 233
>XP_005260746
          Length = 1237

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ENHAVIMQ 8
           ENHAV+ +
Sbjct: 226 ENHAVVCE 233
>XP_005260745
          Length = 1242

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ENHAVIMQ 8
           ENHAV+ +
Sbjct: 226 ENHAVVCE 233
>XP_005257805
          Length = 1308

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ENHAVI 6
           ENHAVI
Sbjct: 377 ENHAVI 382
>XP_006722205
          Length = 1384

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ENHAVI 6
           ENHAVI
Sbjct: 453 ENHAVI 458
>XP_006722204
          Length = 1384

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ENHAVI 6
           ENHAVI
Sbjct: 453 ENHAVI 458
>XP_005254924
          Length = 203

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  NHAVIMQT 9
          NH ++M+T
Sbjct: 29 NHGILMET 36
>XP_006720459
          Length = 296

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   NHAVIMQT 9
           NH ++M+T
Sbjct: 122 NHGILMET 129
>XP_006720458
          Length = 297

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   NHAVIMQT 9
           NH ++M+T
Sbjct: 123 NHGILMET 130
>XP_006720457
          Length = 297

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   NHAVIMQT 9
           NH ++M+T
Sbjct: 123 NHGILMET 130
>NP_003623
          Length = 1384

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ENHAVI 6
           ENHAVI
Sbjct: 453 ENHAVI 458
>NP_001093326
          Length = 487

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   ENHAVIMQT 9
           E H ++M+T
Sbjct: 357 EQHKIVMET 365
>NP_001093327
          Length = 419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   ENHAVIMQT 9
           E H ++M+T
Sbjct: 289 EQHKIVMET 297
>NP_003630
          Length = 419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   ENHAVIMQT 9
           E H ++M+T
Sbjct: 289 EQHKIVMET 297
>NP_690042
          Length = 412

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ENHAVIMQ 8
           +NHAV+ Q
Sbjct: 346 KNHAVVCQ 353
>NP_056456
          Length = 421

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ENHAVIMQ 8
           +NHAV+ Q
Sbjct: 355 KNHAVVCQ 362
>XP_005274821
          Length = 418

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   ENHAVIMQT 9
           E H ++M+T
Sbjct: 288 EQHKIVMET 296
>XP_005274820
          Length = 419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   ENHAVIMQT 9
           E H ++M+T
Sbjct: 289 EQHKIVMET 297
>XP_005274818
          Length = 441

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   ENHAVIMQT 9
           E H ++M+T
Sbjct: 357 EQHKIVMET 365
>XP_006724916
          Length = 461

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   ENHAVIMQT 9
           E H ++M+T
Sbjct: 331 EQHKIVMET 339
>XP_005274817
          Length = 486

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   ENHAVIMQT 9
           E H ++M+T
Sbjct: 356 EQHKIVMET 364
>XP_005250315
          Length = 336

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ENHAVIMQ 8
           +NHAV+ Q
Sbjct: 270 KNHAVVCQ 277
>NP_005637
          Length = 1621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ENHAVIMQT 9
           EN+ +IM+T
Sbjct: 330 ENYILIMET 338
>XP_005273291
          Length = 1620

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ENHAVIMQT 9
           EN+ +IM+T
Sbjct: 330 ENYILIMET 338
>NP_573439
          Length = 1436

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ENHAVIMQT 9
           E HAV +QT
Sbjct: 333 EVHAVSLQT 341
>NP_573438
          Length = 1440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ENHAVIMQT 9
           E HAV +QT
Sbjct: 333 EVHAVSLQT 341
>NP_001181930
          Length = 1433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ENHAVIMQT 9
           E HAV +QT
Sbjct: 333 EVHAVSLQT 341
>NP_005695
          Length = 1446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ENHAVIMQT 9
           E HAV +QT
Sbjct: 333 EVHAVSLQT 341
>XP_006710336
          Length = 1177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ENHAVIMQT 9
          E HAV +QT
Sbjct: 68 EVHAVSLQT 76
>XP_006710335
          Length = 1370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ENHAVIMQT 9
           E HAV +QT
Sbjct: 261 EVHAVSLQT 269
>XP_006710334
          Length = 1292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ENHAVIMQT 9
           E HAV +QT
Sbjct: 333 EVHAVSLQT 341
>XP_006710333
          Length = 1439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ENHAVIMQT 9
           E HAV +QT
Sbjct: 333 EVHAVSLQT 341
>XP_006710332
          Length = 1442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ENHAVIMQT 9
           E HAV +QT
Sbjct: 333 EVHAVSLQT 341
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.119    0.319 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 426,581
Number of extensions: 567
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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