Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000224                                                              18    1135
NP_000360                                                              18    1135
XP_005268094                                                           18    1135
XP_005264366                                                           18    1135
XP_006712078                                                           18    1135
NP_039229                                                              16    5631
NP_001005282                                                           16    5631
NP_001004743                                                           16    7355
NP_057448                                                              15    9605
NP_001193890                                                           15    9605
NP_065937                                                              15    9605
NP_068593                                                              15    9605
NP_001193889                                                           15    9605
XP_005271698                                                           15    9605
XP_005271696                                                           15    9605
XP_005271695                                                           15    9605
XP_005271694                                                           15    9605
XP_005271693                                                           15    9605
XP_005271690                                                           15    9605
XP_005271689                                                           15    9605
XP_005271688                                                           15    9605
XP_005271687                                                           15    9605
XP_005269947                                                           15    9605
XP_005269946                                                           15    9605
XP_005269945                                                           15    9605
XP_005269944                                                           15    9605
XP_005269943                                                           15    9605
XP_005269941                                                           15    9605
XP_005269940                                                           15    9605
XP_006713716                                                           15    9605
NP_001005203                                                           15    9605
NP_001007273                                                           15    9605
NP_001007274                                                           15    9605
NP_056984                                                              15    9605
>NP_000224
          Length = 699

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ELSVYMLTV 9
           ELSVY LTV
Sbjct: 451 ELSVYTLTV 459
>NP_000360
          Length = 764

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ELSVYMLTV 9
           ELSVY LTV
Sbjct: 506 ELSVYTLTV 514
>XP_005268094
          Length = 764

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ELSVYMLTV 9
           ELSVY LTV
Sbjct: 506 ELSVYTLTV 514
>XP_005264366
          Length = 380

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ELSVYMLTV 9
           ELSVY LTV
Sbjct: 132 ELSVYTLTV 140
>XP_006712078
          Length = 389

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ELSVYMLTV 9
           ELSVY LTV
Sbjct: 141 ELSVYTLTV 149
>NP_039229
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LSVYMLTV 9
          L++Y+LTV
Sbjct: 31 LTIYLLTV 38
>NP_001005282
          Length = 311

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LSVYMLTV 9
          L++YM+TV
Sbjct: 31 LAIYMVTV 38
>NP_001004743
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LSVYMLTV 9
          L+VYM+T+
Sbjct: 30 LAVYMITL 37
>NP_057448
          Length = 198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ELSVYMLTV 9
           +LSVY L V
Sbjct: 111 DLSVYFLPV 119
>NP_001193890
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ELSVYMLT 8
           E+ VY+LT
Sbjct: 150 EVKVYLLT 157
>NP_065937
          Length = 1077

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ELSVYMLT 8
           ++SVY+LT
Sbjct: 897 KVSVYLLT 904
>NP_068593
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ELSVYMLTV 9
           + +VY+LTV
Sbjct: 220 DYAVYLLTV 228
>NP_001193889
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ELSVYMLT 8
           E+ VY+LT
Sbjct: 307 EVKVYLLT 314
>XP_005271698
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ELSVYMLT 8
           ++SVY+LT
Sbjct: 740 KVSVYLLT 747
>XP_005271696
          Length = 1045

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ELSVYMLT 8
           ++SVY+LT
Sbjct: 865 KVSVYLLT 872
>XP_005271695
          Length = 1046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ELSVYMLT 8
           ++SVY+LT
Sbjct: 866 KVSVYLLT 873
>XP_005271694
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ELSVYMLT 8
           ++SVY+LT
Sbjct: 898 KVSVYLLT 905
>XP_005271693
          Length = 1080

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ELSVYMLT 8
           ++SVY+LT
Sbjct: 900 KVSVYLLT 907
>XP_005271690
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ELSVYMLT 8
           ++SVY+LT
Sbjct: 938 KVSVYLLT 945
>XP_005271689
          Length = 1137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ELSVYMLT 8
           ++SVY+LT
Sbjct: 957 KVSVYLLT 964
>XP_005271688
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ELSVYMLT 8
           ++SVY+LT
Sbjct: 959 KVSVYLLT 966
>XP_005271687
          Length = 1140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ELSVYMLT 8
           ++SVY+LT
Sbjct: 960 KVSVYLLT 967
>XP_005269947
          Length = 198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ELSVYMLTV 9
           +LSVY L V
Sbjct: 111 DLSVYFLPV 119
>XP_005269946
          Length = 198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ELSVYMLTV 9
           +LSVY L V
Sbjct: 111 DLSVYFLPV 119
>XP_005269945
          Length = 198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ELSVYMLTV 9
           +LSVY L V
Sbjct: 111 DLSVYFLPV 119
>XP_005269944
          Length = 291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ELSVYMLTV 9
           +LSVY L V
Sbjct: 204 DLSVYFLPV 212
>XP_005269943
          Length = 291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ELSVYMLTV 9
           +LSVY L V
Sbjct: 204 DLSVYFLPV 212
>XP_005269941
          Length = 316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ELSVYMLTV 9
           +LSVY L V
Sbjct: 229 DLSVYFLPV 237
>XP_005269940
          Length = 417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ELSVYMLTV 9
           +LSVY L V
Sbjct: 330 DLSVYFLPV 338
>XP_006713716
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ELSVYMLT 8
           E+ VY+LT
Sbjct: 289 EVKVYLLT 296
>NP_001005203
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  LSVYMLTV 9
          L +Y+LT+
Sbjct: 32 LGIYLLTI 39
>NP_001007273
          Length = 248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ELSVYMLTV 9
           +LSVY L V
Sbjct: 161 DLSVYFLPV 169
>NP_001007274
          Length = 291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ELSVYMLTV 9
           +LSVY L V
Sbjct: 204 DLSVYFLPV 212
>NP_056984
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ELSVYMLT 8
           E+ VY+LT
Sbjct: 323 EVKVYLLT 330
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.134    0.333 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 325,006
Number of extensions: 394
Number of successful extensions: 34
Number of sequences better than 10000.0: 34
Number of HSP's gapped: 34
Number of HSP's successfully gapped: 34
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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