Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_361014                                                              19     869
NP_001243998                                                           19     869
NP_659473                                                              16    5631
NP_001186094                                                           16    5631
XP_005257183                                                           16    5631
XP_005257182                                                           16    5631
XP_006721806                                                           16    5631
XP_006721805                                                           16    5631
XP_006721804                                                           16    5631
XP_005257179                                                           16    5631
XP_006721803                                                           16    5631
XP_005257176                                                           16    5631
NP_714922                                                              16    5631
NP_612433                                                              16    7355
NP_659570                                                              16    7355
XP_005251744                                                           16    7355
XP_005251742                                                           16    7355
XP_006717010                                                           16    7355
XP_005251741                                                           16    7355
XP_005251740                                                           16    7355
XP_006715976                                                           16    7355
XP_006715975                                                           16    7355
NP_849150                                                              16    7355
NP_055384                                                              16    7355
NP_000278                                                              15    9605
NP_002308                                                              15    9605
NP_115690                                                              15    9605
NP_694979                                                              15    9605
NP_037491                                                              15    9605
NP_079303                                                              15    9605
NP_065166                                                              15    9605
XP_006723895                                                           15    9605
XP_005259334                                                           15    9605
XP_005259333                                                           15    9605
XP_005259263                                                           15    9605
XP_006719702                                                           15    9605
XP_005249715                                                           15    9605
XP_005249714                                                           15    9605
XP_006715730                                                           15    9605
XP_005249237                                                           15    9605
NP_001956                                                              15    9605
NP_001035751                                                           15    9605
>NP_361014
          Length = 707

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  ELLSVGSQR 9
          ELLSVGS+R
Sbjct: 4  ELLSVGSKR 12
>NP_001243998
          Length = 176

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  ELLSVGSQR 9
          ELLSVGS+R
Sbjct: 4  ELLSVGSKR 12
>NP_659473
          Length = 955

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ELLSVGSQR 9
           EL++V SQR
Sbjct: 736 ELINVNSQR 744
>NP_001186094
          Length = 955

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ELLSVGSQR 9
           EL++V SQR
Sbjct: 736 ELINVNSQR 744
>XP_005257183
          Length = 547

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ELLSVGSQR 9
           EL++V SQR
Sbjct: 328 ELINVNSQR 336
>XP_005257182
          Length = 648

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ELLSVGSQR 9
           EL++V SQR
Sbjct: 429 ELINVNSQR 437
>XP_006721806
          Length = 838

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ELLSVGSQR 9
           EL++V SQR
Sbjct: 737 ELINVNSQR 745
>XP_006721805
          Length = 874

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ELLSVGSQR 9
           EL++V SQR
Sbjct: 737 ELINVNSQR 745
>XP_006721804
          Length = 908

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ELLSVGSQR 9
           EL++V SQR
Sbjct: 689 ELINVNSQR 697
>XP_005257179
          Length = 913

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ELLSVGSQR 9
           EL++V SQR
Sbjct: 694 ELINVNSQR 702
>XP_006721803
          Length = 956

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ELLSVGSQR 9
           EL++V SQR
Sbjct: 737 ELINVNSQR 745
>XP_005257176
          Length = 956

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ELLSVGSQR 9
           EL++V SQR
Sbjct: 737 ELINVNSQR 745
>NP_714922
          Length = 309

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  LLSVGSQR 9
          LL+VGS+R
Sbjct: 25 LLTVGSER 32
>NP_612433
          Length = 513

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  ELLSVGSQR 9
          +LLS+GS R
Sbjct: 35 DLLSLGSPR 43
>NP_659570
          Length = 839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLSVGSQR 9
           LLS GSQ+
Sbjct: 206 LLSTGSQK 213
>XP_005251744
          Length = 379

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ELLSVGSQR 9
           +LLS+GS R
Sbjct: 173 DLLSLGSPR 181
>XP_005251742
          Length = 542

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ELLSVGSQR 9
           +LLS+GS R
Sbjct: 173 DLLSLGSPR 181
>XP_006717010
          Length = 635

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ELLSVGSQR 9
           +LLS+GS R
Sbjct: 139 DLLSLGSPR 147
>XP_005251741
          Length = 651

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ELLSVGSQR 9
           +LLS+GS R
Sbjct: 173 DLLSLGSPR 181
>XP_005251740
          Length = 669

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ELLSVGSQR 9
           +LLS+GS R
Sbjct: 173 DLLSLGSPR 181
>XP_006715976
          Length = 839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLSVGSQR 9
           LLS GSQ+
Sbjct: 206 LLSTGSQK 213
>XP_006715975
          Length = 839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLSVGSQR 9
           LLS GSQ+
Sbjct: 206 LLSTGSQK 213
>NP_849150
          Length = 1445

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    ELLSVGSQ 8
            ++LS+GSQ
Sbjct: 1018 QVLSIGSQ 1025
>NP_055384
          Length = 839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLSVGSQR 9
           LLS GSQ+
Sbjct: 206 LLSTGSQK 213
>NP_000278
          Length = 980

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ELLSVGSQR 9
           ELLS+G +R
Sbjct: 729 ELLSLGLRR 737
>NP_002308
          Length = 417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LLSVGSQ 8
          LLS+GSQ
Sbjct: 57 LLSLGSQ 63
>NP_115690
          Length = 327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ELLSVGSQR 9
           E+L VG Q+
Sbjct: 175 EMLKVGKQK 183
>NP_694979
          Length = 530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 SVGSQR 9
         SVGSQR
Sbjct: 3 SVGSQR 8
>NP_037491
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LLSVGSQ 8
          LLSVG+Q
Sbjct: 66 LLSVGNQ 72
>NP_079303
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LLSVGSQ 8
           LLSVG+Q
Sbjct: 98  LLSVGNQ 104
>NP_065166
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SVGSQR 9
           SVGSQR
Sbjct: 238 SVGSQR 243
>XP_006723895
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SVGSQR 9
           SVGSQR
Sbjct: 238 SVGSQR 243
>XP_005259334
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LLSVGSQ 8
          LLSVG+Q
Sbjct: 8  LLSVGNQ 14
>XP_005259333
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LLSVGSQ 8
           LLSVG+Q
Sbjct: 98  LLSVGNQ 104
>XP_005259263
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LLSVGSQ 8
          LLSVG+Q
Sbjct: 66 LLSVGNQ 72
>XP_006719702
          Length = 246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ELLSVGSQR 9
           E+L VG Q+
Sbjct: 94  EMLKVGKQK 102
>XP_005249715
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 SVGSQR 9
         SVGSQR
Sbjct: 3 SVGSQR 8
>XP_005249714
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 SVGSQR 9
         SVGSQR
Sbjct: 3 SVGSQR 8
>XP_006715730
          Length = 530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 SVGSQR 9
         SVGSQR
Sbjct: 3 SVGSQR 8
>XP_005249237
          Length = 892

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ELLSVGSQR 9
           ELLS+G +R
Sbjct: 641 ELLSLGLRR 649
>NP_001956
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ELLSVGS 7
           ELLSVG+
Sbjct: 312 ELLSVGA 318
>NP_001035751
          Length = 530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 SVGSQR 9
         SVGSQR
Sbjct: 3 SVGSQR 8
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.127    0.304 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 466,777
Number of extensions: 743
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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