Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              17    3301
XP_005271621                                                           17    3301
XP_006718907                                                           17    3301
XP_006718906                                                           17    3301
XP_005271619                                                           17    3301
XP_005271618                                                           17    3301
NP_000799                                                              17    4312
XP_006724874                                                           17    4312
XP_005274716                                                           17    4312
XP_005254225                                                           17    4312
NP_689666                                                              17    4312
NP_006138                                                              16    5631
NP_001193625                                                           16    5631
NP_001121697                                                           16    5631
NP_689477                                                              16    5631
XP_005253279                                                           16    5631
XP_006718446                                                           16    5631
XP_006718445                                                           16    5631
XP_005253278                                                           16    5631
XP_006718444                                                           16    5631
NP_004786                                                              16    7355
NP_006706                                                              16    7355
NP_277053                                                              16    7355
NP_001243424                                                           16    7355
NP_001243425                                                           16    7355
NP_001243423                                                           16    7355
XP_006724633                                                           16    7355
XP_005272755                                                           16    7355
XP_006724632                                                           16    7355
XP_005272754                                                           16    7355
XP_005272753                                                           16    7355
XP_005272752                                                           16    7355
XP_005272751                                                           16    7355
XP_006720571                                                           16    7355
XP_005254441                                                           16    7355
XP_006719958                                                           16    7355
NP_060918                                                              16    7355
NP_001245361                                                           15    9605
NP_001245362                                                           15    9605
NP_006087                                                              15    9605
NP_001128714                                                           15    9605
>NP_000042
          Length = 3056

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ILVNVLP 9
            ILVN+LP
Sbjct: 1290 ILVNILP 1296
>XP_005271621
          Length = 2708

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ILVNVLP 9
           ILVN+LP
Sbjct: 942 ILVNILP 948
>XP_006718907
          Length = 3050

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ILVNVLP 9
            ILVN+LP
Sbjct: 1284 ILVNILP 1290
>XP_006718906
          Length = 3056

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ILVNVLP 9
            ILVN+LP
Sbjct: 1290 ILVNILP 1296
>XP_005271619
          Length = 3056

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ILVNVLP 9
            ILVN+LP
Sbjct: 1290 ILVNILP 1296
>XP_005271618
          Length = 3056

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ILVNVLP 9
            ILVN+LP
Sbjct: 1290 ILVNILP 1296
>NP_000799
          Length = 492

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LILVNVLP 9
          L L+N+LP
Sbjct: 17 LFLINILP 24
>XP_006724874
          Length = 340

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LILVNVLP 9
          L L+N+LP
Sbjct: 17 LFLINILP 24
>XP_005274716
          Length = 491

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LILVNVLP 9
          L L+N+LP
Sbjct: 17 LFLINILP 24
>XP_005254225
          Length = 288

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ILVNVLP 9
           +LVNVLP
Sbjct: 253 LLVNVLP 259
>NP_689666
          Length = 288

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ILVNVLP 9
           +LVNVLP
Sbjct: 253 LLVNVLP 259
>NP_006138
          Length = 467

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ELILVNVLP 9
           +LILV V+P
Sbjct: 388 KLILVQVIP 396
>NP_001193625
          Length = 372

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ELILVNVLP 9
           +LILV V+P
Sbjct: 293 KLILVQVIP 301
>NP_001121697
          Length = 371

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LILVNVLP 9
           + LVNVLP
Sbjct: 331 IALVNVLP 338
>NP_689477
          Length = 364

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LILVNVLP 9
           + LVNVLP
Sbjct: 324 IALVNVLP 331
>XP_005253279
          Length = 328

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LILVNVLP 9
           + LVNVLP
Sbjct: 288 IALVNVLP 295
>XP_006718446
          Length = 343

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LILVNVLP 9
           + LVNVLP
Sbjct: 303 IALVNVLP 310
>XP_006718445
          Length = 364

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LILVNVLP 9
           + LVNVLP
Sbjct: 324 IALVNVLP 331
>XP_005253278
          Length = 364

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LILVNVLP 9
           + LVNVLP
Sbjct: 324 IALVNVLP 331
>XP_006718444
          Length = 379

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LILVNVLP 9
           + LVNVLP
Sbjct: 339 IALVNVLP 346
>NP_004786
          Length = 1012

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ELILVNVLP 9
           EL+ VN+ P
Sbjct: 625 ELVRVNITP 633
>NP_006706
          Length = 1040

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LILVNVLP 9
           L++VN LP
Sbjct: 624 LLIVNTLP 631
>NP_277053
          Length = 472

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LILVNVL 8
           L+LVNVL
Sbjct: 384 LVLVNVL 390
>NP_001243424
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LILVNVLP 9
           L++VN LP
Sbjct: 624 LLIVNTLP 631
>NP_001243425
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LILVNVLP 9
           L++VN LP
Sbjct: 525 LLIVNTLP 532
>NP_001243423
          Length = 1057

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LILVNVLP 9
           L++VN LP
Sbjct: 624 LLIVNTLP 631
>XP_006724633
          Length = 441

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LILVNVL 8
           L+LVNVL
Sbjct: 333 LVLVNVL 339
>XP_005272755
          Length = 492

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LILVNVL 8
           L+LVNVL
Sbjct: 384 LVLVNVL 390
>XP_006724632
          Length = 492

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LILVNVL 8
           L+LVNVL
Sbjct: 384 LVLVNVL 390
>XP_005272754
          Length = 498

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LILVNVL 8
           L+LVNVL
Sbjct: 390 LVLVNVL 396
>XP_005272753
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LILVNVL 8
           L+LVNVL
Sbjct: 431 LVLVNVL 437
>XP_005272752
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LILVNVL 8
           L+LVNVL
Sbjct: 431 LVLVNVL 437
>XP_005272751
          Length = 539

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LILVNVL 8
           L+LVNVL
Sbjct: 431 LVLVNVL 437
>XP_006720571
          Length = 949

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LILVNVLP 9
           L++VN LP
Sbjct: 525 LLIVNTLP 532
>XP_005254441
          Length = 1048

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LILVNVLP 9
           L++VN LP
Sbjct: 624 LLIVNTLP 631
>XP_006719958
          Length = 705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ELILVNVLP 9
           EL+ VN+ P
Sbjct: 318 ELVRVNITP 326
>NP_060918
          Length = 1230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LVNVLP 9
           LVNVLP
Sbjct: 461 LVNVLP 466
>NP_001245361
          Length = 328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LILVNVLP 9
           L+L+NV P
Sbjct: 94  LVLINVNP 101
>NP_001245362
          Length = 313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LILVNVLP 9
          L+L+NV P
Sbjct: 79 LVLINVNP 86
>NP_006087
          Length = 394

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LILVNVLP 9
           L+L+NV P
Sbjct: 160 LVLINVNP 167
>NP_001128714
          Length = 394

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LILVNVLP 9
           L+L+NV P
Sbjct: 160 LVLINVNP 167
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.154    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 439,955
Number of extensions: 951
Number of successful extensions: 41
Number of sequences better than 10000.0: 41
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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