Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              19     869
XP_005271621                                                           19     869
XP_006718907                                                           19     869
XP_006718906                                                           19     869
XP_005271619                                                           19     869
XP_005271618                                                           19     869
NP_001170946                                                           17    4312
NP_689794                                                              17    4312
NP_001164100                                                           16    5631
NP_065971                                                              16    5631
XP_005264808                                                           16    7355
XP_005264807                                                           16    7355
XP_005264806                                                           16    7355
XP_005264805                                                           16    7355
XP_005264804                                                           16    7355
NP_000857                                                              16    7355
NP_067002                                                              15    9605
NP_714916                                                              15    9605
XP_005245441                                                           15    9605
XP_005245439                                                           15    9605
XP_005245440                                                           15    9605
XP_005245438                                                           15    9605

>NP_000042
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EKILLSLTM 9
           EKIL+SLTM
Sbjct: 609 EKILVSLTM 617



>XP_005271621
          Length = 2708

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EKILLSLTM 9
           EKIL+SLTM
Sbjct: 261 EKILVSLTM 269



>XP_006718907
          Length = 3050

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EKILLSLTM 9
           EKIL+SLTM
Sbjct: 609 EKILVSLTM 617



>XP_006718906
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EKILLSLTM 9
           EKIL+SLTM
Sbjct: 609 EKILVSLTM 617



>XP_005271619
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EKILLSLTM 9
           EKIL+SLTM
Sbjct: 609 EKILVSLTM 617



>XP_005271618
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EKILLSLTM 9
           EKIL+SLTM
Sbjct: 609 EKILVSLTM 617



>NP_001170946
          Length = 455

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   EKILLSLTM 9
           +++LLSLTM
Sbjct: 432 QQLLLSLTM 440



>NP_689794
          Length = 518

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   EKILLSLTM 9
           +++LLSLTM
Sbjct: 495 QQLLLSLTM 503



>NP_001164100
          Length = 2581

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    EKILLSLTM 9
            E+ LLSLTM
Sbjct: 2117 EESLLSLTM 2125



>NP_065971
          Length = 2302

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    EKILLSLTM 9
            E+ LLSLTM
Sbjct: 1838 EESLLSLTM 1846



>XP_005264808
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  KILLSLTM 9
          KIL+SLT+
Sbjct: 23 KILVSLTL 30



>XP_005264807
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  KILLSLTM 9
          KIL+SLT+
Sbjct: 23 KILVSLTL 30



>XP_005264806
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  KILLSLTM 9
          KIL+SLT+
Sbjct: 23 KILVSLTL 30



>XP_005264805
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  KILLSLTM 9
          KIL+SLT+
Sbjct: 23 KILVSLTL 30



>XP_005264804
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  KILLSLTM 9
          KIL+SLT+
Sbjct: 23 KILVSLTL 30



>NP_000857
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  KILLSLTM 9
          KIL+SLT+
Sbjct: 23 KILVSLTL 30



>NP_067002
          Length = 508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EKILLSLT 8
           E +LLSLT
Sbjct: 198 EDVLLSLT 205



>NP_714916
          Length = 507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   EKILLSLT 8
           ++ILLSLT
Sbjct: 219 DEILLSLT 226



>XP_005245441
          Length = 508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EKILLSLT 8
           E +LLSLT
Sbjct: 198 EDVLLSLT 205



>XP_005245439
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EKILLSLT 8
           E +LLSLT
Sbjct: 198 EDVLLSLT 205



>XP_005245440
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EKILLSLT 8
           E +LLSLT
Sbjct: 198 EDVLLSLT 205



>XP_005245438
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EKILLSLT 8
           E +LLSLT
Sbjct: 198 EDVLLSLT 205



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.136    0.310 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 336,990
Number of extensions: 420
Number of successful extensions: 22
Number of sequences better than 10000.0: 22
Number of HSP's gapped: 22
Number of HSP's successfully gapped: 22
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)