Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001013433                                                           20     509
NP_060785                                                              20     509
NP_361014                                                              20     509
NP_055761                                                              17    2528
NP_955468                                                              17    2528
NP_004243                                                              17    2528
XP_005264573                                                           17    2528
NP_057270                                                              17    3301
NP_001094077                                                           17    3301
XP_006725227                                                           17    3301
XP_006725226                                                           17    3301
XP_005267790                                                           17    3301
XP_006720222                                                           17    3301
NP_001093869                                                           16    5631
XP_005262709                                                           16    5631
NP_036336                                                              16    5631
NP_941374                                                              16    7355
NP_065682                                                              16    7355
NP_001036128                                                           16    7355
NP_001036130                                                           16    7355
NP_060193                                                              16    7355
NP_001036129                                                           16    7355
NP_001252522                                                           16    7355
NP_001252521                                                           16    7355
NP_001252523                                                           16    7355
NP_065827                                                              16    7355
XP_005258378                                                           16    7355
XP_005258376                                                           16    7355
XP_005258375                                                           16    7355
XP_005258374                                                           16    7355
XP_006722574                                                           16    7355
XP_006722573                                                           16    7355
XP_005258372                                                           16    7355
NP_005693                                                              16    7355
NP_149117                                                              16    7355
NP_004987                                                              15    9605
NP_001161384                                                           15    9605
NP_001161383                                                           15    9605
NP_002438                                                              15    9605
NP_001231866                                                           15    9605
NP_003671                                                              15    9605
NP_997634                                                              15    9605
NP_001268                                                              15    9605
NP_078897                                                              15    9605
NP_055554                                                              15    9605
NP_997364                                                              15    9605
NP_862820                                                              15    9605
NP_001184188                                                           15    9605
NP_036513                                                              15    9605
XP_006720948                                                           15    9605
XP_005255386                                                           15    9605
XP_005255385                                                           15    9605
XP_005255384                                                           15    9605
XP_005267295                                                           15    9605
XP_005267294                                                           15    9605
XP_005267293                                                           15    9605
XP_005248763                                                           15    9605
XP_005248762                                                           15    9605
XP_005248761                                                           15    9605
XP_005265227                                                           15    9605
XP_006712554                                                           15    9605
XP_005263717                                                           15    9605
XP_005263716                                                           15    9605
XP_006712553                                                           15    9605
NP_001070908                                                           15    9605
NP_997246                                                              15    9605
>NP_001013433
          Length = 589

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EETKLLLLD 9
           EETKLL+LD
Sbjct: 575 EETKLLVLD 583
>NP_060785
          Length = 627

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EETKLLLLD 9
           EETKLL+LD
Sbjct: 613 EETKLLVLD 621
>NP_361014
          Length = 707

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EETKLLLLD 9
           EETKLL+LD
Sbjct: 693 EETKLLVLD 701
>NP_055761
          Length = 616

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   EETKLLLL 8
           EET+LLLL
Sbjct: 511 EETRLLLL 518
>NP_955468
          Length = 584

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   EETKLLLL 8
           EET+LLLL
Sbjct: 479 EETRLLLL 486
>NP_004243
          Length = 358

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   EETKLLLLD 9
           +ETKLL++D
Sbjct: 224 DETKLLVVD 232
>XP_005264573
          Length = 615

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   EETKLLLL 8
           EET+LLLL
Sbjct: 510 EETRLLLL 517
>NP_057270
          Length = 444

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ETKLLLLD 9
           ETKL+L+D
Sbjct: 227 ETKLILVD 234
>NP_001094077
          Length = 444

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ETKLLLLD 9
           ETKL+L+D
Sbjct: 227 ETKLILVD 234
>XP_006725227
          Length = 444

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ETKLLLLD 9
           ETKL+L+D
Sbjct: 227 ETKLILVD 234
>XP_006725226
          Length = 484

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ETKLLLLD 9
           ETKL+L+D
Sbjct: 267 ETKLILVD 274
>XP_005267790
          Length = 444

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ETKLLLLD 9
           ETKL+L+D
Sbjct: 227 ETKLILVD 234
>XP_006720222
          Length = 484

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ETKLLLLD 9
           ETKL+L+D
Sbjct: 267 ETKLILVD 274
>NP_001093869
          Length = 1337

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    EETKLLLL 8
            EET++LLL
Sbjct: 1124 EETRVLLL 1131
>XP_005262709
          Length = 1337

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    EETKLLLL 8
            EET++LLL
Sbjct: 1124 EETRVLLL 1131
>NP_036336
          Length = 822

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   EETKLLLLD 9
           E++K+LL+D
Sbjct: 602 EDSKILLVD 610
>NP_941374
          Length = 1083

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EETKLLLLD 9
           EET+ LLL+
Sbjct: 657 EETRQLLLE 665
>NP_065682
          Length = 1006

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EETKLLLLD 9
           EET+ LLL+
Sbjct: 580 EETRQLLLE 588
>NP_001036128
          Length = 1062

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EETKLLLLD 9
           EET+ LLL+
Sbjct: 636 EETRQLLLE 644
>NP_001036130
          Length = 1006

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EETKLLLLD 9
           EET+ LLL+
Sbjct: 580 EETRQLLLE 588
>NP_060193
          Length = 423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EETKLLLLD 9
           E+T LL+LD
Sbjct: 258 EKTPLLVLD 266
>NP_001036129
          Length = 1006

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EETKLLLLD 9
           EET+ LLL+
Sbjct: 580 EETRQLLLE 588
>NP_001252522
          Length = 1075

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EETKLLLLD 9
           EET+ LLL+
Sbjct: 649 EETRQLLLE 657
>NP_001252521
          Length = 1085

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EETKLLLLD 9
           EET+ LLL+
Sbjct: 659 EETRQLLLE 667
>NP_001252523
          Length = 930

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EETKLLLLD 9
           EET+ LLL+
Sbjct: 580 EETRQLLLE 588
>NP_065827
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EETKLLL 7
           +ETKLLL
Sbjct: 391 QETKLLL 397
>XP_005258378
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EETKLLL 7
           +ETKLLL
Sbjct: 107 QETKLLL 113
>XP_005258376
          Length = 505

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EETKLLL 7
           +ETKLLL
Sbjct: 283 QETKLLL 289
>XP_005258375
          Length = 568

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EETKLLL 7
           +ETKLLL
Sbjct: 346 QETKLLL 352
>XP_005258374
          Length = 573

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EETKLLL 7
           +ETKLLL
Sbjct: 387 QETKLLL 393
>XP_006722574
          Length = 594

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EETKLLL 7
           +ETKLLL
Sbjct: 391 QETKLLL 397
>XP_006722573
          Length = 609

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EETKLLL 7
           +ETKLLL
Sbjct: 387 QETKLLL 393
>XP_005258372
          Length = 613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EETKLLL 7
           +ETKLLL
Sbjct: 391 QETKLLL 397
>NP_005693
          Length = 437

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   EETKLLLLD 9
           +ET+++LLD
Sbjct: 159 KETQVILLD 167
>NP_149117
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EETKLLLLD 9
           EE+K+L+ D
Sbjct: 196 EESKILITD 204
>NP_004987
          Length = 1531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ETKLLLLD 9
            +TK+L+LD
Sbjct: 1447 KTKILVLD 1454
>NP_001161384
          Length = 833

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EETKLLLLD 9
           EETKL++ +
Sbjct: 390 EETKLIVTE 398
>NP_001161383
          Length = 788

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EETKLLLLD 9
           EETKL++ +
Sbjct: 390 EETKLIVTE 398
>NP_002438
          Length = 1400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ETKLLLLD 9
           +TK+L+LD
Sbjct: 119 DTKVLVLD 126
>NP_001231866
          Length = 1351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ETKLLLLD 9
           +TK+L+LD
Sbjct: 119 DTKVLVLD 126
>NP_003671
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EETKLLLLD 9
           EE+K+ LLD
Sbjct: 228 EESKIDLLD 236
>NP_997634
          Length = 439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EETKLLLLD 9
           E+ KL+L+D
Sbjct: 304 EKQKLMLID 312
>NP_001268
          Length = 457

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EETKLLLLD 9
           E+ KL+L+D
Sbjct: 322 EKQKLMLID 330
>NP_078897
          Length = 833

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EETKLLLLD 9
           EETKL++ +
Sbjct: 390 EETKLIVTE 398
>NP_055554
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EETKLLLLD 9
           EE+++ LLD
Sbjct: 343 EESRVFLLD 351
>NP_997364
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EETKLLL 7
           E+TKLLL
Sbjct: 180 EKTKLLL 186
>NP_862820
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EETKLLL 7
           EET+LLL
Sbjct: 396 EETQLLL 402
>NP_001184188
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EETKLLL 7
           EET+LLL
Sbjct: 253 EETQLLL 259
>NP_036513
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EETKLLL 7
           EET+LLL
Sbjct: 396 EETQLLL 402
>XP_006720948
          Length = 1401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ETKLLLLD 9
            +TK+L+LD
Sbjct: 1317 KTKILVLD 1324
>XP_005255386
          Length = 1472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ETKLLLLD 9
            +TK+L+LD
Sbjct: 1388 KTKILVLD 1395
>XP_005255385
          Length = 1485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ETKLLLLD 9
            +TK+L+LD
Sbjct: 1401 KTKILVLD 1408
>XP_005255384
          Length = 1489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ETKLLLLD 9
            +TK+L+LD
Sbjct: 1405 KTKILVLD 1412
>XP_005267295
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EETKLLLLD 9
           EE+++ LLD
Sbjct: 343 EESRVFLLD 351
>XP_005267294
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EETKLLLLD 9
           EE+++ LLD
Sbjct: 343 EESRVFLLD 351
>XP_005267293
          Length = 918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EETKLLLLD 9
           EE+++ LLD
Sbjct: 341 EESRVFLLD 349
>XP_005248763
          Length = 659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EETKLLL 7
           EET+LLL
Sbjct: 343 EETQLLL 349
>XP_005248762
          Length = 659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EETKLLL 7
           EET+LLL
Sbjct: 343 EETQLLL 349
>XP_005248761
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EETKLLL 7
           EET+LLL
Sbjct: 396 EETQLLL 402
>XP_005265227
          Length = 1401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ETKLLLLD 9
           +TK+L+LD
Sbjct: 119 DTKVLVLD 126
>XP_006712554
          Length = 1885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EETKLLL 7
           E+TKLLL
Sbjct: 112 EKTKLLL 118
>XP_005263717
          Length = 1953

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EETKLLL 7
           E+TKLLL
Sbjct: 180 EKTKLLL 186
>XP_005263716
          Length = 1953

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EETKLLL 7
           E+TKLLL
Sbjct: 180 EKTKLLL 186
>XP_006712553
          Length = 1953

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EETKLLL 7
           E+TKLLL
Sbjct: 180 EKTKLLL 186
>NP_001070908
          Length = 869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EETKLLLLD 9
           EE+++ LLD
Sbjct: 341 EESRVFLLD 349
>NP_997246
          Length = 1909

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EETKLLL 7
           E+TKLLL
Sbjct: 180 EKTKLLL 186
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.139    0.334 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 451,557
Number of extensions: 891
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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