Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001136098                                                           20     390
NP_000360                                                              20     390
NP_001018046                                                           20     390
XP_005268096                                                           20     390
XP_006720308                                                           20     390
XP_005268094                                                           20     390
NP_705838                                                              18    1935
NP_001138501                                                           18    1935
XP_006722388                                                           18    1935
NP_001132                                                              17    3301
NP_001034219                                                           17    3301
NP_001034220                                                           17    3301
NP_000615                                                              17    4312
NP_002842                                                              17    4312
XP_006716139                                                           17    4312
XP_005250576                                                           17    4312
NP_002909                                                              16    5631
NP_149079                                                              16    5631
NP_001257697                                                           16    5631
XP_006722894                                                           16    5631
XP_006722893                                                           16    5631
XP_006722892                                                           16    5631
XP_006711057                                                           16    5631
NP_115599                                                              16    7355
NP_004514                                                              16    7355
NP_002010                                                              16    7355
NP_055690                                                              16    7355
XP_006718613                                                           16    7355
XP_006718612                                                           16    7355
XP_005274044                                                           16    7355
XP_005274045                                                           16    7355
NP_001171506                                                           15    9605
NP_001035940                                                           15    9605
NP_009049                                                              15    9605
NP_689914                                                              15    9605
NP_996804                                                              15    9605
NP_683878                                                              15    9605
NP_683879                                                              15    9605
NP_612189                                                              15    9605
NP_001263408                                                           15    9605
NP_001263409                                                           15    9605
NP_004784                                                              15    9605
NP_653320                                                              15    9605
NP_001091990                                                           15    9605
NP_001091993                                                           15    9605
NP_001091992                                                           15    9605
NP_006401                                                              15    9605
NP_001091991                                                           15    9605
NP_001001794                                                           15    9605
NP_787098                                                              15    9605
NP_064522                                                              15    9605
NP_078924                                                              15    9605
XP_005272685                                                           15    9605
XP_005261972                                                           15    9605
XP_005261971                                                           15    9605
XP_005269959                                                           15    9605
XP_006715538                                                           15    9605
XP_005267028                                                           15    9605
XP_005267027                                                           15    9605
XP_005266930                                                           15    9605
XP_006714558                                                           15    9605
XP_005264955                                                           15    9605
NP_006568                                                              15    9605
>NP_001136098
          Length = 274

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  EEDFRVTSK 9
          EEDFRVT K
Sbjct: 34 EEDFRVTCK 42
>NP_000360
          Length = 764

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  EEDFRVTSK 9
          EEDFRVT K
Sbjct: 34 EEDFRVTCK 42
>NP_001018046
          Length = 253

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  EEDFRVTSK 9
          EEDFRVT K
Sbjct: 34 EEDFRVTCK 42
>XP_005268096
          Length = 253

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  EEDFRVTSK 9
          EEDFRVT K
Sbjct: 34 EEDFRVTCK 42
>XP_006720308
          Length = 274

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  EEDFRVTSK 9
          EEDFRVT K
Sbjct: 34 EEDFRVTCK 42
>XP_005268094
          Length = 764

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  EEDFRVTSK 9
          EEDFRVT K
Sbjct: 34 EEDFRVTCK 42
>NP_705838
          Length = 4069

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    EDFRVTSK 9
            EDF VTSK
Sbjct: 2925 EDFTVTSK 2932
>NP_001138501
          Length = 1392

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EEDFRVTSK 9
           EEDF +T+K
Sbjct: 822 EEDFNLTTK 830
>XP_006722388
          Length = 1511

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EEDFRVTSK 9
           EEDF +T+K
Sbjct: 941 EEDFNLTTK 949
>NP_001132
          Length = 676

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  EEDFRVT 7
          EEDF+VT
Sbjct: 50 EEDFQVT 56
>NP_001034219
          Length = 647

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  EEDFRVT 7
          EEDF+VT
Sbjct: 50 EEDFQVT 56
>NP_001034220
          Length = 602

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  EEDFRVT 7
          EEDF+VT
Sbjct: 50 EEDFQVT 56
>NP_000615
          Length = 406

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EEDFRVTSK 9
           E+DF VTS+
Sbjct: 220 EQDFYVTSE 228
>NP_002842
          Length = 2315

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    EEDFRVTS 8
            EED RVTS
Sbjct: 1482 EEDNRVTS 1489
>XP_006716139
          Length = 1869

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    EEDFRVTS 8
            EED RVTS
Sbjct: 1036 EEDNRVTS 1043
>XP_005250576
          Length = 2308

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    EEDFRVTS 8
            EED RVTS
Sbjct: 1482 EEDNRVTS 1489
>NP_002909
          Length = 979

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EEDFRVT 7
           E+DF+VT
Sbjct: 805 EQDFKVT 811
>NP_149079
          Length = 837

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EEDFRV 6
           EEDFR+
Sbjct: 102 EEDFRI 107
>NP_001257697
          Length = 742

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  EEDFRV 6
          EEDFR+
Sbjct: 7  EEDFRI 12
>XP_006722894
          Length = 870

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EEDFRVT 7
           E+DF+VT
Sbjct: 696 EQDFKVT 702
>XP_006722893
          Length = 870

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EEDFRVT 7
           E+DF+VT
Sbjct: 696 EQDFKVT 702
>XP_006722892
          Length = 979

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EEDFRVT 7
           E+DF+VT
Sbjct: 805 EQDFKVT 811
>XP_006711057
          Length = 838

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EEDFRV 6
           EEDFR+
Sbjct: 103 EEDFRI 108
>NP_115599
          Length = 2034

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    DFRVTS 8
            DFR+TS
Sbjct: 1617 DFRITS 1622
>NP_004514
          Length = 1056

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EEDFRVTS 8
           EE+FRV S
Sbjct: 402 EENFRVMS 409
>NP_002010
          Length = 1338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    DFRVTSK 9
            D RVTSK
Sbjct: 1272 DLRVTSK 1278
>NP_055690
          Length = 1648

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EEDFRVTSK 9
           E D R+TS+
Sbjct: 590 EHDHRITSR 598
>XP_006718613
          Length = 1946

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    DFRVTS 8
            DFR+TS
Sbjct: 1529 DFRITS 1534
>XP_006718612
          Length = 2041

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    DFRVTS 8
            DFR+TS
Sbjct: 1624 DFRITS 1629
>XP_005274044
          Length = 2046

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    DFRVTS 8
            DFR+TS
Sbjct: 1629 DFRITS 1634
>XP_005274045
          Length = 2047

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    DFRVTS 8
            DFR+TS
Sbjct: 1630 DFRITS 1635
>NP_001171506
          Length = 808

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EEDFRVTS 8
           +EDFR +S
Sbjct: 240 KEDFRASS 247
>NP_001035940
          Length = 805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EEDFRVTS 8
           +EDFR +S
Sbjct: 237 KEDFRASS 244
>NP_009049
          Length = 3097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    EDFRVTSK 9
            E+F++T+K
Sbjct: 1183 EEFQITAK 1190
>NP_689914
          Length = 5058

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    EEDFRVT 7
            +EDFR++
Sbjct: 1072 DEDFRIS 1078
>NP_996804
          Length = 496

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EEDFRVTS 8
           +EDFR +S
Sbjct: 237 KEDFRASS 244
>NP_683878
          Length = 598

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EEDFRV 6
           EEDFR+
Sbjct: 347 EEDFRM 352
>NP_683879
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EEDFRV 6
           EEDFR+
Sbjct: 122 EEDFRM 127
>NP_612189
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EEDFRV 6
           EEDFR+
Sbjct: 122 EEDFRM 127
>NP_001263408
          Length = 895

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EDFRVTSK 9
           EDF+VT +
Sbjct: 217 EDFQVTEE 224
>NP_001263409
          Length = 763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  EDFRVTSK 9
          EDF+VT +
Sbjct: 85 EDFQVTEE 92
>NP_004784
          Length = 959

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EDFRVTSK 9
           EDF+VT +
Sbjct: 281 EDFQVTEE 288
>NP_653320
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EEDFRV 6
           EEDFR+
Sbjct: 686 EEDFRM 691
>NP_001091990
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  EDFRVTSK 9
          EDFR+ +K
Sbjct: 46 EDFRMQNK 53
>NP_001091993
          Length = 133

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  EDFRVTSK 9
          EDFR+ +K
Sbjct: 12 EDFRMQNK 19
>NP_001091992
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  EDFRVTSK 9
          EDFR+ +K
Sbjct: 12 EDFRMQNK 19
>NP_006401
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  EDFRVTSK 9
          EDFR+ +K
Sbjct: 12 EDFRMQNK 19
>NP_001091991
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  EDFRVTSK 9
          EDFR+ +K
Sbjct: 12 EDFRMQNK 19
>NP_001001794
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DFRVTSK 9
          DFR+T K
Sbjct: 65 DFRLTDK 71
>NP_787098
          Length = 331

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EEDFRV 6
           EEDFR+
Sbjct: 175 EEDFRL 180
>NP_064522
          Length = 841

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  EEDFRV 6
          EEDFR+
Sbjct: 86 EEDFRL 91
>NP_078924
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EEDFRV 6
           EEDFR+
Sbjct: 175 EEDFRL 180
>XP_005272685
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  EEDFRV 6
          EEDFR+
Sbjct: 86 EEDFRL 91
>XP_005261972
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DFRVTSK 9
          DFR+T K
Sbjct: 65 DFRLTDK 71
>XP_005261971
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DFRVTSK 9
          DFR+T K
Sbjct: 65 DFRLTDK 71
>XP_005269959
          Length = 539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EEDFRV 6
           EEDFR+
Sbjct: 347 EEDFRM 352
>XP_006715538
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EEDFRVTS 8
           +EDFR +S
Sbjct: 135 KEDFRASS 142
>XP_005267028
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EEDFRVTS 8
           +EDFR +S
Sbjct: 135 KEDFRASS 142
>XP_005267027
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EEDFRVTS 8
           +EDFR +S
Sbjct: 135 KEDFRASS 142
>XP_005266930
          Length = 316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EEDFRVTSK 9
           ++DFR T+K
Sbjct: 280 QKDFRRTTK 288
>XP_006714558
          Length = 2612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   EDFRVTSK 9
           E+F++T+K
Sbjct: 698 EEFQITAK 705
>XP_005264955
          Length = 674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EEDFRV 6
           EEDFR+
Sbjct: 645 EEDFRM 650
>NP_006568
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   EEDFRVTS 8
           E D RVTS
Sbjct: 97  EPDLRVTS 104
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.306    0.124    0.313 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 627,337
Number of extensions: 932
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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