Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004324                                                              20     390
XP_005250103                                                           20     390
XP_005250102                                                           20     390
NP_001093156                                                           18    1935
NP_071336                                                              18    1935
NP_689607                                                              17    4312
NP_003694                                                              17    4312
NP_001026918                                                           17    4312
XP_006719421                                                           17    4312
XP_005268863                                                           17    4312
XP_006713992                                                           17    4312
XP_005247177                                                           17    4312
XP_005247176                                                           17    4312
XP_006713561                                                           17    4312
NP_055192                                                              16    7355
NP_620074                                                              16    7355
NP_001123359                                                           16    7355
NP_001124332                                                           16    7355
NP_055614                                                              16    7355
NP_665803                                                              16    7355
XP_006724785                                                           16    7355
XP_006724783                                                           16    7355
XP_006724782                                                           16    7355
XP_005250326                                                           16    7355
NP_976054                                                              15    9605
NP_001207413                                                           15    9605
NP_055742                                                              15    9605
NP_008832                                                              15    9605
NP_001162119                                                           15    9605
NP_001162120                                                           15    9605
NP_001243323                                                           15    9605
NP_031377                                                              15    9605
NP_001098714                                                           15    9605
NP_060418                                                              15    9605
XP_005274525                                                           15    9605
XP_006722401                                                           15    9605
XP_006722400                                                           15    9605
XP_006722399                                                           15    9605
XP_006722398                                                           15    9605
XP_006720604                                                           15    9605
XP_005254461                                                           15    9605
XP_006720603                                                           15    9605
XP_006720602                                                           15    9605
XP_006720206                                                           15    9605
XP_006719364                                                           15    9605
XP_006719363                                                           15    9605
XP_006717236                                                           15    9605
XP_006717235                                                           15    9605
XP_006717234                                                           15    9605
XP_006717233                                                           15    9605
XP_006717232                                                           15    9605
XP_006717231                                                           15    9605
XP_006717230                                                           15    9605
XP_006717229                                                           15    9605
XP_005262913                                                           15    9605
NP_002836                                                              15    9605
NP_001092142                                                           15    9605
>NP_004324
          Length = 766

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EDSNRMKTL 9
           ED NRMKTL
Sbjct: 433 EDRNRMKTL 441
>XP_005250103
          Length = 758

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EDSNRMKTL 9
           ED NRMKTL
Sbjct: 433 EDRNRMKTL 441
>XP_005250102
          Length = 767

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EDSNRMKTL 9
           ED NRMKTL
Sbjct: 433 EDRNRMKTL 441
>NP_001093156
          Length = 626

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   EDSNRMKTL 9
           EDS  MKTL
Sbjct: 442 EDSRNMKTL 450
>NP_071336
          Length = 626

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   EDSNRMKTL 9
           EDS  MKTL
Sbjct: 442 EDSRNMKTL 450
>NP_689607
          Length = 663

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EDSNRMKTL 9
           +DS R+KT+
Sbjct: 370 DDSKRLKTI 378
>NP_003694
          Length = 857

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EDSNRMKT 8
           + SNRMKT
Sbjct: 267 QPSNRMKT 274
>NP_001026918
          Length = 652

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EDSNRM 6
           EDSNRM
Sbjct: 511 EDSNRM 516
>XP_006719421
          Length = 575

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EDSNRM 6
           EDSNRM
Sbjct: 434 EDSNRM 439
>XP_005268863
          Length = 575

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EDSNRM 6
           EDSNRM
Sbjct: 434 EDSNRM 439
>XP_006713992
          Length = 857

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EDSNRMKT 8
           + SNRMKT
Sbjct: 267 QPSNRMKT 274
>XP_005247177
          Length = 512

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EDSNRMKTL 9
           +DS R+KT+
Sbjct: 370 DDSKRLKTI 378
>XP_005247176
          Length = 517

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EDSNRMKTL 9
           +DS R+KT+
Sbjct: 224 DDSKRLKTI 232
>XP_006713561
          Length = 616

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EDSNRMKTL 9
           +DS R+KT+
Sbjct: 323 DDSKRLKTI 331
>NP_055192
          Length = 621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EDSNRMKTL 9
           E+ NR++TL
Sbjct: 261 EEMNRIRTL 269
>NP_620074
          Length = 1212

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EDSNRMKTL 9
           +DSNRM  +
Sbjct: 669 QDSNRMHAI 677
>NP_001123359
          Length = 568

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EDSNRMKTL 9
           E+ NR++TL
Sbjct: 261 EEMNRIRTL 269
>NP_001124332
          Length = 1160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EDSNRMKTL 9
           +DSNRM  +
Sbjct: 618 QDSNRMHAI 626
>NP_055614
          Length = 891

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EDSNRMKTL 9
           +DSNRM  +
Sbjct: 348 QDSNRMHAI 356
>NP_665803
          Length = 1025

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SNRMKTL 9
           SNR KTL
Sbjct: 867 SNRFKTL 873
>XP_006724785
          Length = 1161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EDSNRMKTL 9
           +DSNRM  +
Sbjct: 618 QDSNRMHAI 626
>XP_006724783
          Length = 1049

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EDSNRMKTL 9
           +DSNRM  +
Sbjct: 618 QDSNRMHAI 626
>XP_006724782
          Length = 1050

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EDSNRMKTL 9
           +DSNRM  +
Sbjct: 618 QDSNRMHAI 626
>XP_005250326
          Length = 475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EDSNRMKTL 9
           E+ NR++TL
Sbjct: 115 EEMNRIRTL 123
>NP_976054
          Length = 1026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EDSNRMKTL 9
           E  NR+KTL
Sbjct: 871 EIKNRIKTL 879
>NP_001207413
          Length = 1026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EDSNRMKTL 9
           E  NR+KTL
Sbjct: 871 EIKNRIKTL 879
>NP_055742
          Length = 1034

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDSNRMK 7
           ED N+MK
Sbjct: 453 EDPNKMK 459
>NP_008832
          Length = 2548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    EDSNRM 6
            ED+NRM
Sbjct: 2199 EDTNRM 2204
>NP_001162119
          Length = 898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDSNRMK 7
           ED N+MK
Sbjct: 453 EDPNKMK 459
>NP_001162120
          Length = 849

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDSNRMK 7
           ED N+MK
Sbjct: 404 EDPNKMK 410
>NP_001243323
          Length = 1099

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDSNRMK 7
           +DSNR K
Sbjct: 779 DDSNRFK 785
>NP_031377
          Length = 1228

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  EDSNRMKTL 9
          ED N  KT+
Sbjct: 31 EDGNSQKTM 39
>NP_001098714
          Length = 1465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDSNRMK 7
           +D NRMK
Sbjct: 933 KDENRMK 939
>NP_060418
          Length = 1167

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDSNRMK 7
           +DSNR K
Sbjct: 847 DDSNRFK 853
>XP_005274525
          Length = 985

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDSNRMK 7
           ED N+MK
Sbjct: 404 EDPNKMK 410
>XP_006722401
          Length = 1432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDSNRMK 7
           +D NRMK
Sbjct: 883 KDENRMK 889
>XP_006722400
          Length = 1469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDSNRMK 7
           +D NRMK
Sbjct: 920 KDENRMK 926
>XP_006722399
          Length = 1477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDSNRMK 7
           +D NRMK
Sbjct: 945 KDENRMK 951
>XP_006722398
          Length = 1494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDSNRMK 7
           +D NRMK
Sbjct: 945 KDENRMK 951
>XP_006720604
          Length = 1677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    EDSNRM 6
            ED+NRM
Sbjct: 1328 EDTNRM 1333
>XP_005254461
          Length = 2600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    EDSNRM 6
            ED+NRM
Sbjct: 2251 EDTNRM 2256
>XP_006720603
          Length = 2619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    EDSNRM 6
            ED+NRM
Sbjct: 2270 EDTNRM 2275
>XP_006720602
          Length = 2619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    EDSNRM 6
            ED+NRM
Sbjct: 2270 EDTNRM 2275
>XP_006720206
          Length = 1026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EDSNRMKTL 9
           E  NR+KTL
Sbjct: 871 EIKNRIKTL 879
>XP_006719364
          Length = 924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   EDSNRMKTL 9
           +D+N +KT+
Sbjct: 159 KDANELKTI 167
>XP_006719363
          Length = 944

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   EDSNRMKTL 9
           +D+N +KT+
Sbjct: 159 KDANELKTI 167
>XP_006717236
          Length = 1041

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDSNRMK 7
           +DSNR K
Sbjct: 721 DDSNRFK 727
>XP_006717235
          Length = 1041

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDSNRMK 7
           +DSNR K
Sbjct: 721 DDSNRFK 727
>XP_006717234
          Length = 1041

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDSNRMK 7
           +DSNR K
Sbjct: 721 DDSNRFK 727
>XP_006717233
          Length = 1099

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDSNRMK 7
           +DSNR K
Sbjct: 779 DDSNRFK 785
>XP_006717232
          Length = 1099

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDSNRMK 7
           +DSNR K
Sbjct: 779 DDSNRFK 785
>XP_006717231
          Length = 1129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDSNRMK 7
           +DSNR K
Sbjct: 809 DDSNRFK 815
>XP_006717230
          Length = 1167

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDSNRMK 7
           +DSNR K
Sbjct: 847 DDSNRFK 853
>XP_006717229
          Length = 1167

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDSNRMK 7
           +DSNR K
Sbjct: 847 DDSNRFK 853
>XP_005262913
          Length = 1193

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  EDSNRMKTL 9
          ED N  KT+
Sbjct: 31 EDGNSQKTM 39
>NP_002836
          Length = 1452

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDSNRMK 7
           +D NRMK
Sbjct: 920 KDENRMK 926
>NP_001092142
          Length = 1159

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EDSNRMKTL 9
           E+SNRM  +
Sbjct: 962 EESNRMHAI 970
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.302    0.116    0.287 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 531,241
Number of extensions: 1022
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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