Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004251                                                              20     509
NP_055904                                                              17    3301
XP_006715095                                                           17    3301
XP_006715094                                                           17    3301
XP_006715093                                                           17    3301
XP_006715092                                                           17    3301
NP_775794                                                              16    5631
NP_001073847                                                           16    7355
NP_001073848                                                           16    7355
NP_689623                                                              16    7355
XP_005266883                                                           16    7355
XP_006715408                                                           16    7355
XP_005266882                                                           16    7355
XP_006715407                                                           16    7355
XP_005266881                                                           16    7355
XP_006715406                                                           16    7355
NP_115582                                                              15    9605
NP_001078816                                                           15    9605
NP_001127902                                                           15    9605
NP_569726                                                              15    9605
NP_115746                                                              15    9605
NP_775919                                                              15    9605
XP_006722985                                                           15    9605
XP_005256255                                                           15    9605
XP_006721362                                                           15    9605
XP_006721361                                                           15    9605
XP_005256254                                                           15    9605
XP_005256253                                                           15    9605
XP_005256252                                                           15    9605
XP_005256251                                                           15    9605
XP_006721360                                                           15    9605
XP_005256250                                                           15    9605
XP_006712503                                                           15    9605
NP_001139647                                                           15    9605
NP_001001694                                                           15    9605
>NP_004251
          Length = 1208

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DVAQHLVVA 9
           DVAQHL VA
Sbjct: 651 DVAQHLAVA 659
>NP_055904
          Length = 2517

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    DVAQHLV 7
            DVAQHL+
Sbjct: 2022 DVAQHLL 2028
>XP_006715095
          Length = 2046

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    DVAQHLV 7
            DVAQHL+
Sbjct: 1551 DVAQHLL 1557
>XP_006715094
          Length = 2407

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    DVAQHLV 7
            DVAQHL+
Sbjct: 1912 DVAQHLL 1918
>XP_006715093
          Length = 2459

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    DVAQHLV 7
            DVAQHL+
Sbjct: 1964 DVAQHLL 1970
>XP_006715092
          Length = 2490

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    DVAQHLV 7
            DVAQHL+
Sbjct: 1995 DVAQHLL 2001
>NP_775794
          Length = 407

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AQHLVVA 9
           +QHLVVA
Sbjct: 241 SQHLVVA 247
>NP_001073847
          Length = 257

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VAQHLVVA 9
           V QHLVV+
Sbjct: 171 VLQHLVVS 178
>NP_001073848
          Length = 257

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VAQHLVVA 9
           V QHLVV+
Sbjct: 171 VLQHLVVS 178
>NP_689623
          Length = 296

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VAQHLVVA 9
           V QHLVV+
Sbjct: 171 VLQHLVVS 178
>XP_005266883
          Length = 211

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VAQHLVVA 9
           V QHLVV+
Sbjct: 171 VLQHLVVS 178
>XP_006715408
          Length = 212

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VAQHLVVA 9
           V QHLVV+
Sbjct: 171 VLQHLVVS 178
>XP_005266882
          Length = 214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VAQHLVVA 9
           V QHLVV+
Sbjct: 171 VLQHLVVS 178
>XP_006715407
          Length = 221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VAQHLVVA 9
           V QHLVV+
Sbjct: 171 VLQHLVVS 178
>XP_005266881
          Length = 221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VAQHLVVA 9
           V QHLVV+
Sbjct: 171 VLQHLVVS 178
>XP_006715406
          Length = 257

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VAQHLVVA 9
           V QHLVV+
Sbjct: 171 VLQHLVVS 178
>NP_115582
          Length = 1866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DVAQHL 6
            D+AQHL
Sbjct: 1839 DMAQHL 1844
>NP_001078816
          Length = 321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  DVAQHL 6
          D+AQHL
Sbjct: 55 DLAQHL 60
>NP_001127902
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  DVAQHL 6
          D+AQHL
Sbjct: 55 DLAQHL 60
>NP_569726
          Length = 253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  DVAQHL 6
          D+AQHL
Sbjct: 55 DLAQHL 60
>NP_115746
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DVAQHL 6
           D+AQHL
Sbjct: 125 DLAQHL 130
>NP_775919
          Length = 1530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DVAQHL 6
            D+AQHL
Sbjct: 1075 DLAQHL 1080
>XP_006722985
          Length = 410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DVAQHL 6
           D+AQHL
Sbjct: 145 DLAQHL 150
>XP_005256255
          Length = 1809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DVAQHL 6
            D+AQHL
Sbjct: 1782 DMAQHL 1787
>XP_006721362
          Length = 1810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DVAQHL 6
            D+AQHL
Sbjct: 1783 DMAQHL 1788
>XP_006721361
          Length = 1836

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DVAQHL 6
            D+AQHL
Sbjct: 1809 DMAQHL 1814
>XP_005256254
          Length = 1837

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DVAQHL 6
            D+AQHL
Sbjct: 1810 DMAQHL 1815
>XP_005256253
          Length = 1838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DVAQHL 6
            D+AQHL
Sbjct: 1811 DMAQHL 1816
>XP_005256252
          Length = 1865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DVAQHL 6
            D+AQHL
Sbjct: 1838 DMAQHL 1843
>XP_005256251
          Length = 1866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DVAQHL 6
            D+AQHL
Sbjct: 1839 DMAQHL 1844
>XP_006721360
          Length = 1866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DVAQHL 6
            D+AQHL
Sbjct: 1839 DMAQHL 1844
>XP_005256250
          Length = 1866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DVAQHL 6
            D+AQHL
Sbjct: 1839 DMAQHL 1844
>XP_006712503
          Length = 1470

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DVAQHL 6
            D+AQHL
Sbjct: 1015 DLAQHL 1020
>NP_001139647
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DVAQHL 6
           D+AQHL
Sbjct: 125 DLAQHL 130
>NP_001001694
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  VAQHLVV 8
          VAQHL V
Sbjct: 85 VAQHLYV 91
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.327    0.132    0.356 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 494,064
Number of extensions: 550
Number of successful extensions: 35
Number of sequences better than 10000.0: 35
Number of HSP's gapped: 35
Number of HSP's successfully gapped: 35
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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