Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001277114                                                           17    3301
NP_068375                                                              17    3301
XP_005254804                                                           17    4312
XP_006720791                                                           17    4312
XP_005254803                                                           17    4312
XP_005254800                                                           17    4312
XP_005254799                                                           17    4312
NP_003913                                                              17    4312
NP_000537                                                              16    5631
NP_001263689                                                           16    5631
NP_001119584                                                           16    5631
NP_001119586                                                           16    5631
NP_001263625                                                           16    5631
NP_001119590                                                           16    5631
NP_001263690                                                           16    5631
NP_001119585                                                           16    5631
NP_001263624                                                           16    5631
NP_001119588                                                           16    5631
NP_001119587                                                           16    5631
NP_001119589                                                           16    5631
NP_001263627                                                           16    5631
NP_001263628                                                           16    5631
NP_001263626                                                           16    5631
XP_006713927                                                           16    5631
NP_660334                                                              16    5631
NP_001167639                                                           16    7355
NP_001167638                                                           16    7355
NP_001128524                                                           16    7355
NP_003168                                                              16    7355
NP_001131136                                                           16    7355
NP_057322                                                              16    7355
XP_005253960                                                           16    7355
XP_006719513                                                           16    7355
XP_005252204                                                           16    7355
NP_000278                                                              15    9605
NP_004000                                                              15    9605
NP_004001                                                              15    9605
NP_003997                                                              15    9605
NP_000100                                                              15    9605
NP_060356                                                              15    9605
NP_001239077                                                           15    9605
XP_006724538                                                           15    9605
XP_006724537                                                           15    9605
XP_006724536                                                           15    9605
XP_006724535                                                           15    9605
XP_006724534                                                           15    9605
XP_006724533                                                           15    9605
XP_006724532                                                           15    9605
XP_006724531                                                           15    9605
XP_006713278                                                           15    9605
XP_005265318                                                           15    9605
>NP_001277114
          Length = 931

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   DSDGLALI 8
           DSDGLA I
Sbjct: 373 DSDGLAQI 380
>NP_068375
          Length = 941

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   DSDGLALI 8
           DSDGLA I
Sbjct: 383 DSDGLAQI 390
>XP_005254804
          Length = 4796

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SDGLALI 8
            SDGLAL+
Sbjct: 3692 SDGLALV 3698
>XP_006720791
          Length = 4853

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SDGLALI 8
            SDGLAL+
Sbjct: 3749 SDGLALV 3755
>XP_005254803
          Length = 4854

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SDGLALI 8
            SDGLAL+
Sbjct: 3750 SDGLALV 3756
>XP_005254800
          Length = 4861

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SDGLALI 8
            SDGLAL+
Sbjct: 3757 SDGLALV 3763
>XP_005254799
          Length = 4861

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SDGLALI 8
            SDGLAL+
Sbjct: 3757 SDGLALV 3763
>NP_003913
          Length = 4861

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SDGLALI 8
            SDGLAL+
Sbjct: 3757 SDGLALV 3763
>NP_000537
          Length = 393

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DSDGLA 6
           DSDGLA
Sbjct: 184 DSDGLA 189
>NP_001263689
          Length = 354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DSDGLA 6
           DSDGLA
Sbjct: 145 DSDGLA 150
>NP_001119584
          Length = 393

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DSDGLA 6
           DSDGLA
Sbjct: 184 DSDGLA 189
>NP_001119586
          Length = 341

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DSDGLA 6
           DSDGLA
Sbjct: 184 DSDGLA 189
>NP_001263625
          Length = 302

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DSDGLA 6
           DSDGLA
Sbjct: 145 DSDGLA 150
>NP_001119590
          Length = 354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DSDGLA 6
           DSDGLA
Sbjct: 145 DSDGLA 150
>NP_001263690
          Length = 354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DSDGLA 6
           DSDGLA
Sbjct: 145 DSDGLA 150
>NP_001119585
          Length = 346

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DSDGLA 6
           DSDGLA
Sbjct: 184 DSDGLA 189
>NP_001263624
          Length = 307

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DSDGLA 6
           DSDGLA
Sbjct: 145 DSDGLA 150
>NP_001119588
          Length = 209

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  DSDGLA 6
          DSDGLA
Sbjct: 52 DSDGLA 57
>NP_001119587
          Length = 261

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  DSDGLA 6
          DSDGLA
Sbjct: 52 DSDGLA 57
>NP_001119589
          Length = 214

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  DSDGLA 6
          DSDGLA
Sbjct: 52 DSDGLA 57
>NP_001263627
          Length = 182

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  DSDGLA 6
          DSDGLA
Sbjct: 25 DSDGLA 30
>NP_001263628
          Length = 187

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  DSDGLA 6
          DSDGLA
Sbjct: 25 DSDGLA 30
>NP_001263626
          Length = 234

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  DSDGLA 6
          DSDGLA
Sbjct: 25 DSDGLA 30
>XP_006713927
          Length = 765

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SDGLALIR 9
           +DG+A+IR
Sbjct: 706 ADGMAMIR 713
>NP_660334
          Length = 765

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SDGLALIR 9
           +DG+A+IR
Sbjct: 706 ADGMAMIR 713
>NP_001167639
          Length = 612

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SDGLALIR 9
          SDGL L+R
Sbjct: 35 SDGLYLLR 42
>NP_001167638
          Length = 635

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SDGLALIR 9
          SDGL L+R
Sbjct: 35 SDGLYLLR 42
>NP_001128524
          Length = 612

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SDGLALIR 9
          SDGL L+R
Sbjct: 35 SDGLYLLR 42
>NP_003168
          Length = 635

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SDGLALIR 9
          SDGL L+R
Sbjct: 35 SDGLYLLR 42
>NP_001131136
          Length = 537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DGLALIR 9
           DG+AL+R
Sbjct: 494 DGIALLR 500
>NP_057322
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DGLALIR 9
           DG+AL+R
Sbjct: 494 DGIALLR 500
>XP_005253960
          Length = 378

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DGLALIR 9
           DG+AL+R
Sbjct: 273 DGIALLR 279
>XP_006719513
          Length = 552

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DGLALIR 9
           DG+AL+R
Sbjct: 447 DGIALLR 453
>XP_005252204
          Length = 635

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SDGLALIR 9
          SDGL L+R
Sbjct: 35 SDGLYLLR 42
>NP_000278
          Length = 980

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SDGLALI 8
           +DGLAL+
Sbjct: 267 ADGLALV 273
>NP_004000
          Length = 3681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SDGLAL 7
           SDGLAL
Sbjct: 160 SDGLAL 165
>NP_004001
          Length = 3562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  SDGLAL 7
          SDGLAL
Sbjct: 41 SDGLAL 46
>NP_003997
          Length = 3685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SDGLAL 7
           SDGLAL
Sbjct: 164 SDGLAL 169
>NP_000100
          Length = 3677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SDGLAL 7
           SDGLAL
Sbjct: 156 SDGLAL 161
>NP_060356
          Length = 1275

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DSDGLALIR 9
           DS+ LALIR
Sbjct: 979 DSNLLALIR 987
>NP_001239077
          Length = 284

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DSDGLAL 7
           D+DG+AL
Sbjct: 134 DADGVAL 140
>XP_006724538
          Length = 3575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SDGLAL 7
           SDGLAL
Sbjct: 164 SDGLAL 169
>XP_006724537
          Length = 3593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SDGLAL 7
           SDGLAL
Sbjct: 164 SDGLAL 169
>XP_006724536
          Length = 3657

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SDGLAL 7
           SDGLAL
Sbjct: 164 SDGLAL 169
>XP_006724535
          Length = 3660

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SDGLAL 7
           SDGLAL
Sbjct: 164 SDGLAL 169
>XP_006724534
          Length = 3668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SDGLAL 7
           SDGLAL
Sbjct: 164 SDGLAL 169
>XP_006724533
          Length = 3690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SDGLAL 7
           SDGLAL
Sbjct: 164 SDGLAL 169
>XP_006724532
          Length = 3695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SDGLAL 7
           SDGLAL
Sbjct: 156 SDGLAL 161
>XP_006724531
          Length = 3703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SDGLAL 7
           SDGLAL
Sbjct: 164 SDGLAL 169
>XP_006713278
          Length = 1156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DSDGLALIR 9
           DS+ LALIR
Sbjct: 860 DSNLLALIR 868
>XP_005265318
          Length = 1274

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DSDGLALIR 9
           DS+ LALIR
Sbjct: 978 DSNLLALIR 986
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.146    0.391 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 549,661
Number of extensions: 837
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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