Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_444256                                                              18    1935
NP_444254                                                              18    1935
NP_444253                                                              18    1935
NP_444255                                                              18    1935
XP_005247551                                                           18    1935
XP_005247550                                                           18    1935
XP_006713712                                                           18    1935
XP_005247549                                                           18    1935
NP_065816                                                              17    4312
NP_114119                                                              17    4312
XP_006713840                                                           17    4312
XP_006713839                                                           17    4312
XP_006710573                                                           17    4312
XP_006710572                                                           17    4312
XP_006710571                                                           17    4312
XP_006710570                                                           17    4312
XP_006710569                                                           17    4312
XP_006710568                                                           17    4312
XP_006710567                                                           17    4312
XP_006710566                                                           17    4312
XP_005245859                                                           17    4312
NP_001153514                                                           16    7355
NP_060604                                                              16    7355
NP_004844                                                              16    7355
NP_079490                                                              15    9605
NP_001137301                                                           15    9605
NP_001248359                                                           15    9605
NP_001136126                                                           15    9605
NP_001136125                                                           15    9605
NP_001129514                                                           15    9605
NP_079543                                                              15    9605
NP_001103444                                                           15    9605
NP_001159681                                                           15    9605
NP_001159680                                                           15    9605
NP_009217                                                              15    9605
XP_006722615                                                           15    9605
XP_005268428                                                           15    9605
XP_005268427                                                           15    9605
XP_005268426                                                           15    9605
XP_006714818                                                           15    9605
XP_005264132                                                           15    9605
NP_056988                                                              15    9605
>NP_444256
          Length = 1794

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DLLVKKVST 9
           DLL KKVST
Sbjct: 830 DLLGKKVST 838
>NP_444254
          Length = 1845

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DLLVKKVST 9
           DLL KKVST
Sbjct: 830 DLLGKKVST 838
>NP_444253
          Length = 1914

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DLLVKKVST 9
           DLL KKVST
Sbjct: 899 DLLGKKVST 907
>NP_444255
          Length = 1863

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DLLVKKVST 9
           DLL KKVST
Sbjct: 899 DLLGKKVST 907
>XP_005247551
          Length = 1855

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DLLVKKVST 9
           DLL KKVST
Sbjct: 840 DLLGKKVST 848
>XP_005247550
          Length = 1856

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DLLVKKVST 9
           DLL KKVST
Sbjct: 909 DLLGKKVST 917
>XP_006713712
          Length = 1923

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DLLVKKVST 9
           DLL KKVST
Sbjct: 909 DLLGKKVST 917
>XP_005247549
          Length = 1924

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DLLVKKVST 9
           DLL KKVST
Sbjct: 909 DLLGKKVST 917
>NP_065816
          Length = 5183

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    DLLVKKVST 9
            DL++ KVST
Sbjct: 3945 DLIIGKVST 3953
>NP_114119
          Length = 886

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LLVKKVST 9
           LL+KKV+T
Sbjct: 604 LLIKKVAT 611
>XP_006713840
          Length = 817

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LLVKKVST 9
           LL+KKV+T
Sbjct: 604 LLIKKVAT 611
>XP_006713839
          Length = 874

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LLVKKVST 9
           LL+KKV+T
Sbjct: 604 LLIKKVAT 611
>XP_006710573
          Length = 5177

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    DLLVKKVST 9
            DL++ KVST
Sbjct: 3939 DLIIGKVST 3947
>XP_006710572
          Length = 5188

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    DLLVKKVST 9
            DL++ KVST
Sbjct: 3950 DLIIGKVST 3958
>XP_006710571
          Length = 5194

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    DLLVKKVST 9
            DL++ KVST
Sbjct: 3956 DLIIGKVST 3964
>XP_006710570
          Length = 5195

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    DLLVKKVST 9
            DL++ KVST
Sbjct: 3957 DLIIGKVST 3965
>XP_006710569
          Length = 5212

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    DLLVKKVST 9
            DL++ KVST
Sbjct: 3974 DLIIGKVST 3982
>XP_006710568
          Length = 5221

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    DLLVKKVST 9
            DL++ KVST
Sbjct: 3983 DLIIGKVST 3991
>XP_006710567
          Length = 5222

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    DLLVKKVST 9
            DL++ KVST
Sbjct: 3984 DLIIGKVST 3992
>XP_006710566
          Length = 5222

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    DLLVKKVST 9
            DL++ KVST
Sbjct: 3984 DLIIGKVST 3992
>XP_005245859
          Length = 5223

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    DLLVKKVST 9
            DL++ KVST
Sbjct: 3985 DLIIGKVST 3993
>NP_001153514
          Length = 546

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  DLLVKKVS 8
          +LLV+KVS
Sbjct: 4  ELLVRKVS 11
>NP_060604
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  DLLVKKVS 8
          +LLV+KVS
Sbjct: 4  ELLVRKVS 11
>NP_004844
          Length = 236

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  DLLVKKVST 9
          DLL++ VST
Sbjct: 60 DLLLRAVST 68
>NP_079490
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  DLLVKKV 7
          DLL+KK+
Sbjct: 89 DLLMKKI 95
>NP_001137301
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  DLLVKKV 7
          DLL+KK+
Sbjct: 89 DLLMKKI 95
>NP_001248359
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LVKKVST 9
           L+KKVST
Sbjct: 170 LLKKVST 176
>NP_001136126
          Length = 161

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LVKKVST 9
           L+KKVST
Sbjct: 132 LLKKVST 138
>NP_001136125
          Length = 166

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LVKKVST 9
           L+KKVST
Sbjct: 137 LLKKVST 143
>NP_001129514
          Length = 586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LVKKVST 9
           L+KKVST
Sbjct: 170 LLKKVST 176
>NP_079543
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LVKKVST 9
           L+KKVST
Sbjct: 109 LLKKVST 115
>NP_001103444
          Length = 685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLVKKVST 9
           LL+ KVST
Sbjct: 155 LLIDKVST 162
>NP_001159681
          Length = 929

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLVKKVST 9
           LL+ KVST
Sbjct: 399 LLIDKVST 406
>NP_001159680
          Length = 929

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLVKKVST 9
           LL+ KVST
Sbjct: 399 LLIDKVST 406
>NP_009217
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLVKKVST 9
           LL+ KVST
Sbjct: 155 LLIDKVST 162
>XP_006722615
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  DLLVKKV 7
          DLL+KK+
Sbjct: 89 DLLMKKI 95
>XP_005268428
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLVKKVST 9
           LL+ KVST
Sbjct: 155 LLIDKVST 162
>XP_005268427
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLVKKVST 9
           LL+ KVST
Sbjct: 155 LLIDKVST 162
>XP_005268426
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLVKKVST 9
           LL+ KVST
Sbjct: 155 LLIDKVST 162
>XP_006714818
          Length = 1147

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLVKKVST 9
           LL+ KVST
Sbjct: 399 LLIDKVST 406
>XP_005264132
          Length = 1219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DLLVKKVS 8
            D+LV K+S
Sbjct: 1179 DILVSKIS 1186
>NP_056988
          Length = 1220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DLLVKKVS 8
            D+LV K+S
Sbjct: 1180 DILVSKIS 1187
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.129    0.306 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 330,074
Number of extensions: 467
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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