Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              18    1482
XP_005262424                                                           18    1482
NP_001185863                                                           16    7355
NP_258261                                                              16    7355
NP_002068                                                              16    7355
NP_036237                                                              16    7355
NP_060827                                                              16    7355
NP_001273608                                                           16    7355
NP_775919                                                              16    7355
NP_620477                                                              16    7355
NP_620476                                                              16    7355
XP_005276185                                                           16    7355
XP_006717126                                                           16    7355
XP_005251986                                                           16    7355
XP_006717125                                                           16    7355
XP_006715303                                                           16    7355
XP_006712503                                                           16    7355
XP_005275932                                                           16    7355
NP_055791                                                              15    9605
NP_075561                                                              15    9605
NP_001020365                                                           15    9605
NP_001257                                                              15    9605
NP_001020366                                                           15    9605
NP_001296                                                              15    9605
NP_001242953                                                           15    9605
NP_001093252                                                           15    9605
NP_001093251                                                           15    9605
NP_004112                                                              15    9605
NP_067049                                                              15    9605
NP_001242955                                                           15    9605
NP_001242954                                                           15    9605
XP_005276924                                                           15    9605
XP_005261616                                                           15    9605
XP_005261615                                                           15    9605
XP_005261614                                                           15    9605
XP_005255831                                                           15    9605
XP_006717997                                                           15    9605
XP_005270071                                                           15    9605
XP_005269704                                                           15    9605
XP_006717206                                                           15    9605
XP_005252108                                                           15    9605
XP_006714553                                                           15    9605
XP_005248407                                                           15    9605
XP_005248406                                                           15    9605
XP_005248404                                                           15    9605
XP_005248403                                                           15    9605
XP_006714552                                                           15    9605
XP_005248402                                                           15    9605
NP_005383                                                              15    9605
>NP_722576
          Length = 3080

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    GLALAVLR 9
            GLALAVLR
Sbjct: 2563 GLALAVLR 2570
>XP_005262424
          Length = 2875

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    GLALAVLR 9
            GLALAVLR
Sbjct: 2358 GLALAVLR 2365
>NP_001185863
          Length = 1492

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GLALAVL 8
           GLALA+L
Sbjct: 883 GLALAIL 889
>NP_258261
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GLALAVL 8
           GLALA+L
Sbjct: 855 GLALAIL 861
>NP_002068
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DGLALAVLR 9
           +GLALA+ R
Sbjct: 122 EGLALALAR 130
>NP_036237
          Length = 518

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  DGLALAV 7
          DGLALA+
Sbjct: 58 DGLALAL 64
>NP_060827
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DGLALAVLR 9
           DGL + VLR
Sbjct: 462 DGLPVGVLR 470
>NP_001273608
          Length = 307

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DGLALAVLR 9
           DGL + VLR
Sbjct: 278 DGLPVGVLR 286
>NP_775919
          Length = 1530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DGLALAVL 8
           +GL+LAVL
Sbjct: 382 EGLSLAVL 389
>NP_620477
          Length = 396

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  DGLALAV 7
          DGLALA+
Sbjct: 58 DGLALAL 64
>NP_620476
          Length = 468

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  DGLALAV 7
          DGLALA+
Sbjct: 58 DGLALAL 64
>XP_005276185
          Length = 116

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  GLALAVLR 9
          G+AL VLR
Sbjct: 32 GMALTVLR 39
>XP_006717126
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DGLALAVLR 9
           +GLALA+ R
Sbjct: 122 EGLALALAR 130
>XP_005251986
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DGLALAVLR 9
           +GLALA+ R
Sbjct: 122 EGLALALAR 130
>XP_006717125
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DGLALAVLR 9
           +GLALA+ R
Sbjct: 122 EGLALALAR 130
>XP_006715303
          Length = 1463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GLALAVL 8
           GLALA+L
Sbjct: 883 GLALAIL 889
>XP_006712503
          Length = 1470

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DGLALAVL 8
           +GL+LAVL
Sbjct: 382 EGLSLAVL 389
>XP_005275932
          Length = 116

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  GLALAVLR 9
          G+AL VLR
Sbjct: 32 GMALTVLR 39
>NP_055791
          Length = 1871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DGLALAVL 8
           DGL +AVL
Sbjct: 649 DGLEVAVL 656
>NP_075561
          Length = 3197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DGLALAV 7
           DGL LAV
Sbjct: 264 DGLTLAV 270
>NP_001020365
          Length = 567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DGLALA 6
           DGLALA
Sbjct: 153 DGLALA 158
>NP_001257
          Length = 566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DGLALA 6
           DGLALA
Sbjct: 153 DGLALA 158
>NP_001020366
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DGLALA 6
           DGLALA
Sbjct: 154 DGLALA 159
>NP_001296
          Length = 209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  GLALAVL 8
          G+ALAVL
Sbjct: 10 GIALAVL 16
>NP_001242953
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DGLALAVL 8
           DG A+AVL
Sbjct: 413 DGAAVAVL 420
>NP_001093252
          Length = 554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  GLALAVL 8
          GLALAV+
Sbjct: 17 GLALAVI 23
>NP_001093251
          Length = 587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  GLALAVL 8
          GLALAV+
Sbjct: 17 GLALAVI 23
>NP_004112
          Length = 586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  GLALAVL 8
          GLALAV+
Sbjct: 17 GLALAVI 23
>NP_067049
          Length = 698

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DGLALAVL 8
           DG A+AVL
Sbjct: 397 DGAAVAVL 404
>NP_001242955
          Length = 608

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DGLALAVL 8
           DG A+AVL
Sbjct: 307 DGAAVAVL 314
>NP_001242954
          Length = 704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DGLALAVL 8
           DG A+AVL
Sbjct: 403 DGAAVAVL 410
>XP_005276924
          Length = 567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DGLALA 6
           DGLALA
Sbjct: 154 DGLALA 159
>XP_005261616
          Length = 586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  GLALAVL 8
          GLALAV+
Sbjct: 17 GLALAVI 23
>XP_005261615
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  GLALAVL 8
          GLALAV+
Sbjct: 17 GLALAVI 23
>XP_005261614
          Length = 618

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  GLALAVL 8
          GLALAV+
Sbjct: 17 GLALAVI 23
>XP_005255831
          Length = 567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DGLALA 6
           DGLALA
Sbjct: 154 DGLALA 159
>XP_006717997
          Length = 608

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DGLALAVL 8
           DG A+AVL
Sbjct: 307 DGAAVAVL 314
>XP_005270071
          Length = 624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DGLALAVL 8
           DG A+AVL
Sbjct: 323 DGAAVAVL 330
>XP_005269704
          Length = 1872

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DGLALAVL 8
           DGL +AVL
Sbjct: 649 DGLEVAVL 656
>XP_006717206
          Length = 1062

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DGLALAV 7
           DGL LAV
Sbjct: 133 DGLGLAV 139
>XP_005252108
          Length = 1097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DGLALAV 7
           DGL LAV
Sbjct: 133 DGLGLAV 139
>XP_006714553
          Length = 2792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DGLALAV 7
           DGL LAV
Sbjct: 264 DGLTLAV 270
>XP_005248407
          Length = 3208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DGLALAV 7
           DGL LAV
Sbjct: 264 DGLTLAV 270
>XP_005248406
          Length = 3214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DGLALAV 7
           DGL LAV
Sbjct: 264 DGLTLAV 270
>XP_005248404
          Length = 3250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DGLALAV 7
           DGL LAV
Sbjct: 264 DGLTLAV 270
>XP_005248403
          Length = 3250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DGLALAV 7
           DGL LAV
Sbjct: 264 DGLTLAV 270
>XP_006714552
          Length = 3251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DGLALAV 7
           DGL LAV
Sbjct: 264 DGLTLAV 270
>XP_005248402
          Length = 3251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DGLALAV 7
           DGL LAV
Sbjct: 264 DGLTLAV 270
>NP_005383
          Length = 1096

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DGLALAV 7
           DGL LAV
Sbjct: 133 DGLGLAV 139
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.149    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 309,684
Number of extensions: 649
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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