Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              21     229
NP_001075109                                                           21     229
NP_055178                                                              17    3301
NP_001264984                                                           17    3301
NP_001092879                                                           17    3301
XP_005266395                                                           17    3301
XP_005273927                                                           17    3301
XP_005273926                                                           17    3301
XP_005273925                                                           17    3301
XP_005273924                                                           17    3301
XP_006718549                                                           17    3301
XP_006712095                                                           17    3301
XP_006712094                                                           17    3301
XP_006712093                                                           17    3301
XP_005264429                                                           17    3301
NP_060022                                                              17    3301
NP_001229267                                                           17    3301
NP_004787                                                              17    4312
NP_236914                                                              17    4312
NP_114416                                                              17    4312
NP_001074                                                              17    4312
NP_246273                                                              17    4312
XP_006720386                                                           17    4312
XP_006720385                                                           17    4312
XP_005268275                                                           17    4312
XP_005271307                                                           17    4312
NP_003433                                                              16    5631
NP_056041                                                              16    5631
NP_001269586                                                           16    5631
NP_001269585                                                           16    5631
NP_003963                                                              16    5631
NP_001230332                                                           16    5631
XP_006720933                                                           16    5631
XP_005255273                                                           16    5631
XP_005255272                                                           16    5631
XP_005255271                                                           16    5631
XP_005255270                                                           16    5631
XP_005255268                                                           16    5631
XP_005255267                                                           16    5631
XP_005253183                                                           16    5631
XP_005253179                                                           16    5631
XP_005253178                                                           16    5631
XP_005270323                                                           16    5631
XP_005270322                                                           16    5631
NP_002987                                                              16    7355
NP_001004360                                                           16    7355
NP_001171507                                                           16    7355
NP_065689                                                              16    7355
NP_001171505                                                           16    7355
NP_065919                                                              16    7355
NP_001171508                                                           16    7355
NP_077007                                                              16    7355
NP_009032                                                              16    7355
NP_001128179                                                           16    7355
XP_006717054                                                           16    7355
XP_006717053                                                           16    7355
XP_005272227                                                           16    7355
XP_005263775                                                           16    7355
XP_006712713                                                           16    7355
NP_115866                                                              16    7355
NP_078966                                                              15    9605
NP_055446                                                              15    9605
NP_001784                                                              15    9605
NP_065145                                                              15    9605
NP_004566                                                              15    9605
NP_061153                                                              15    9605
XP_005270354                                                           15    9605
XP_005270352                                                           15    9605
XP_005270351                                                           15    9605
XP_006718142                                                           15    9605
XP_006715049                                                           15    9605
XP_006715047                                                           15    9605
NP_008989                                                              15    9605
>NP_008835
          Length = 4128

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    DATMDPMNI 9
            DA MDPMNI
Sbjct: 3170 DAKMDPMNI 3178
>NP_001075109
          Length = 4097

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    DATMDPMNI 9
            DA MDPMNI
Sbjct: 3170 DAKMDPMNI 3178
>NP_055178
          Length = 4579

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    MDPMNI 9
            MDPMN+
Sbjct: 4170 MDPMNV 4175
>NP_001264984
          Length = 4432

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    MDPMNI 9
            MDPMN+
Sbjct: 4023 MDPMNV 4028
>NP_001092879
          Length = 1523

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ATMDPMNI 9
            A++DP+NI
Sbjct: 1087 ASLDPLNI 1094
>XP_005266395
          Length = 4588

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    MDPMNI 9
            MDPMN+
Sbjct: 4179 MDPMNV 4184
>XP_005273927
          Length = 777

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ATMDPMNI 9
           A++DP+NI
Sbjct: 341 ASLDPLNI 348
>XP_005273926
          Length = 835

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ATMDPMNI 9
           A++DP+NI
Sbjct: 399 ASLDPLNI 406
>XP_005273925
          Length = 935

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ATMDPMNI 9
           A++DP+NI
Sbjct: 499 ASLDPLNI 506
>XP_005273924
          Length = 993

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ATMDPMNI 9
           A++DP+NI
Sbjct: 557 ASLDPLNI 564
>XP_006718549
          Length = 1535

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ATMDPMNI 9
            A++DP+NI
Sbjct: 1099 ASLDPLNI 1106
>XP_006712095
          Length = 849

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ATMDPMNI 9
           A +DPMNI
Sbjct: 400 ADVDPMNI 407
>XP_006712094
          Length = 1067

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ATMDPMNI 9
           A +DPMNI
Sbjct: 400 ADVDPMNI 407
>XP_006712093
          Length = 1460

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ATMDPMNI 9
           A +DPMNI
Sbjct: 400 ADVDPMNI 407
>XP_005264429
          Length = 1472

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ATMDPMNI 9
           A +DPMNI
Sbjct: 400 ADVDPMNI 407
>NP_060022
          Length = 1458

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ATMDPMNI 9
           A +DPMNI
Sbjct: 386 ADVDPMNI 393
>NP_001229267
          Length = 1453

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ATMDPMNI 9
           A +DPMNI
Sbjct: 386 ADVDPMNI 393
>NP_004787
          Length = 1061

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  ATMDPMN 8
          AT+DP+N
Sbjct: 71 ATLDPIN 77
>NP_236914
          Length = 833

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TMDPMNI 9
           TM+P+NI
Sbjct: 376 TMEPLNI 382
>NP_114416
          Length = 207

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DATMDPMN 8
          DAT +P+N
Sbjct: 65 DATQEPVN 72
>NP_001074
          Length = 875

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TMDPMNI 9
           TM+P+NI
Sbjct: 418 TMEPLNI 424
>NP_246273
          Length = 823

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TMDPMNI 9
           TM+P+NI
Sbjct: 366 TMEPLNI 372
>XP_006720386
          Length = 1571

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ATMDPMN 8
           AT+DP+N
Sbjct: 444 ATLDPIN 450
>XP_006720385
          Length = 1683

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ATMDPMN 8
           AT+DP+N
Sbjct: 452 ATLDPIN 458
>XP_005268275
          Length = 1684

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ATMDPMN 8
           AT+DP+N
Sbjct: 456 ATLDPIN 462
>XP_005271307
          Length = 154

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DATMDPMN 8
          DAT +P+N
Sbjct: 65 DATQEPVN 72
>NP_003433
          Length = 638

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DATMDPMNI 9
           DAT+DP  I
Sbjct: 173 DATIDPDTI 181
>NP_056041
          Length = 1053

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   TMDPMNI 9
           TM PMN+
Sbjct: 622 TMKPMNV 628
>NP_001269586
          Length = 607

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DATMDPMNI 9
           DAT+DP  I
Sbjct: 142 DATIDPDTI 150
>NP_001269585
          Length = 637

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DATMDPMNI 9
           DAT+DP  I
Sbjct: 172 DATIDPDTI 180
>NP_003963
          Length = 1849

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    ATMDPMNI 9
            ATM+ MNI
Sbjct: 1137 ATMETMNI 1144
>NP_001230332
          Length = 906

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   TMDPMNI 9
           TM PMN+
Sbjct: 604 TMKPMNV 610
>XP_006720933
          Length = 690

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   TMDPMNI 9
           TM PMN+
Sbjct: 622 TMKPMNV 628
>XP_005255273
          Length = 884

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   TMDPMNI 9
           TM PMN+
Sbjct: 622 TMKPMNV 628
>XP_005255272
          Length = 925

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   TMDPMNI 9
           TM PMN+
Sbjct: 622 TMKPMNV 628
>XP_005255271
          Length = 998

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   TMDPMNI 9
           TM PMN+
Sbjct: 622 TMKPMNV 628
>XP_005255270
          Length = 1035

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   TMDPMNI 9
           TM PMN+
Sbjct: 604 TMKPMNV 610
>XP_005255268
          Length = 1037

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   TMDPMNI 9
           TM PMN+
Sbjct: 606 TMKPMNV 612
>XP_005255267
          Length = 1051

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   TMDPMNI 9
           TM PMN+
Sbjct: 620 TMKPMNV 626
>XP_005253183
          Length = 593

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DATMDPMNI 9
           DAT+DP  I
Sbjct: 188 DATIDPDTI 196
>XP_005253179
          Length = 652

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DATMDPMNI 9
           DAT+DP  I
Sbjct: 187 DATIDPDTI 195
>XP_005253178
          Length = 653

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DATMDPMNI 9
           DAT+DP  I
Sbjct: 188 DATIDPDTI 196
>XP_005270323
          Length = 1519

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ATMDPMNI 9
           ATM+ MNI
Sbjct: 807 ATMETMNI 814
>XP_005270322
          Length = 1646

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ATMDPMNI 9
           ATM+ MNI
Sbjct: 934 ATMETMNI 941
>NP_002987
          Length = 397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ATMDPMNI 9
           ATMDP  +
Sbjct: 317 ATMDPQRL 324
>NP_001004360
          Length = 789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DATMDPMN 8
           DA+  PMN
Sbjct: 472 DASFSPMN 479
>NP_001171507
          Length = 746

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DATMDPMN 8
           DA+  PMN
Sbjct: 429 DASFSPMN 436
>NP_065689
          Length = 251

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   DATMDPMNI 9
           D+  DP+N+
Sbjct: 184 DSERDPLNV 192
>NP_001171505
          Length = 800

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DATMDPMN 8
           DA+  PMN
Sbjct: 483 DASFSPMN 490
>NP_065919
          Length = 796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DATMDPMN 8
           DA+  PMN
Sbjct: 479 DASFSPMN 486
>NP_001171508
          Length = 792

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DATMDPMN 8
           DA+  PMN
Sbjct: 475 DASFSPMN 482
>NP_077007
          Length = 342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DATMDPMN 8
           DAT  P+N
Sbjct: 302 DATWSPLN 309
>NP_009032
          Length = 918

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   DATMDP 6
           D TMDP
Sbjct: 208 DGTMDP 213
>NP_001128179
          Length = 918

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   DATMDP 6
           D TMDP
Sbjct: 208 DGTMDP 213
>XP_006717054
          Length = 918

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   DATMDP 6
           D TMDP
Sbjct: 208 DGTMDP 213
>XP_006717053
          Length = 918

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   DATMDP 6
           D TMDP
Sbjct: 208 DGTMDP 213
>XP_005272227
          Length = 918

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   DATMDP 6
           D TMDP
Sbjct: 208 DGTMDP 213
>XP_005263775
          Length = 500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DATMDPMN 8
           DA+  PMN
Sbjct: 183 DASFSPMN 190
>XP_006712713
          Length = 786

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DATMDPMN 8
           DA+  PMN
Sbjct: 479 DASFSPMN 486
>NP_115866
          Length = 137

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DATMDPMNI 9
           D T DP N+
Sbjct: 106 DGTFDPDNL 114
>NP_078966
          Length = 14507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    TMDPMN 8
            TMDP N
Sbjct: 4990 TMDPSN 4995
>NP_055446
          Length = 1105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DATMDPM 7
           DAT +PM
Sbjct: 160 DATAEPM 166
>NP_001784
          Length = 829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   DPMNI 9
           DPMNI
Sbjct: 197 DPMNI 201
>NP_065145
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DATMDPMNI 9
           DAT+  MN+
Sbjct: 100 DATLKTMNL 108
>NP_004566
          Length = 409

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ATMDPMN 8
           ATM+PM+
Sbjct: 223 ATMNPMH 229
>NP_061153
          Length = 228

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   DATMDPMNI 9
           DA++ P N+
Sbjct: 127 DASLQPRNV 135
>XP_005270354
          Length = 1014

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  DATMDPM 7
          DAT +PM
Sbjct: 41 DATAEPM 47
>XP_005270352
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DATMDPM 7
           DAT +PM
Sbjct: 145 DATAEPM 151
>XP_005270351
          Length = 1133

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DATMDPM 7
           DAT +PM
Sbjct: 160 DATAEPM 166
>XP_006718142
          Length = 1164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DATMDPM 7
           DAT +PM
Sbjct: 160 DATAEPM 166
>XP_006715049
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   TMDPMN 8
           TMDP N
Sbjct: 692 TMDPKN 697
>XP_006715047
          Length = 740

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   TMDPMN 8
           TMDP N
Sbjct: 717 TMDPKN 722
>NP_008989
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   TMDPMN 8
           TMDP N
Sbjct: 716 TMDPKN 721
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.129    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 590,928
Number of extensions: 767
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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