Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              18    1135
XP_006716142                                                           18    1135
XP_005250088                                                           18    1135
XP_006716141                                                           18    1135
XP_005250085                                                           18    1135
XP_006716140                                                           18    1135
XP_005250084                                                           18    1135
XP_005250083                                                           18    1135
XP_005250082                                                           18    1135
NP_848695                                                              17    3301
NP_848696                                                              17    3301
NP_110416                                                              17    3301
XP_005260619                                                           17    3301
XP_006714616                                                           17    3301
NP_056261                                                              16    5631
NP_001299                                                              16    5631
XP_006711822                                                           16    5631
XP_006711821                                                           16    5631
NP_065883                                                              16    7355
NP_775960                                                              16    7355
NP_079229                                                              16    7355
NP_001136438                                                           16    7355
XP_006722611                                                           16    7355
XP_006722610                                                           16    7355
XP_005253995                                                           16    7355
XP_006719669                                                           16    7355
XP_005253988                                                           16    7355
XP_005251991                                                           16    7355
XP_005245423                                                           16    7355
XP_005245425                                                           16    7355
NP_899231                                                              16    7355
NP_001243643                                                           15    9605
NP_001164434                                                           15    9605
NP_002832                                                              15    9605
NP_005493                                                              15    9605
NP_001276932                                                           15    9605
NP_001271254                                                           15    9605
NP_001181                                                              15    9605
NP_001158245                                                           15    9605
NP_001160158                                                           15    9605
NP_113666                                                              15    9605
NP_065692                                                              15    9605
NP_001155057                                                           15    9605
NP_991402                                                              15    9605
NP_001245219                                                           15    9605
NP_775773                                                              15    9605
NP_001245220                                                           15    9605
NP_000280                                                              15    9605
NP_001160160                                                           15    9605
XP_006719527                                                           15    9605
XP_006719526                                                           15    9605
XP_005269037                                                           15    9605
XP_005269036                                                           15    9605
XP_005269035                                                           15    9605
XP_005269034                                                           15    9605
XP_005269033                                                           15    9605
XP_005269032                                                           15    9605
XP_005269031                                                           15    9605
XP_005251837                                                           15    9605
XP_005251835                                                           15    9605
XP_006717058                                                           15    9605
XP_005251833                                                           15    9605
XP_005251831                                                           15    9605
XP_005251830                                                           15    9605
XP_005247794                                                           15    9605
XP_006713802                                                           15    9605
XP_006713801                                                           15    9605
XP_005265410                                                           15    9605
XP_005265409                                                           15    9605
NP_001160159                                                           15    9605
>NP_733751
          Length = 4911

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AVVLPGVFT 9
           AVVLPGV T
Sbjct: 918 AVVLPGVST 926
>XP_006716142
          Length = 4927

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AVVLPGVFT 9
           AVVLPGV T
Sbjct: 919 AVVLPGVST 927
>XP_005250088
          Length = 4928

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AVVLPGVFT 9
           AVVLPGV T
Sbjct: 919 AVVLPGVST 927
>XP_006716141
          Length = 4959

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AVVLPGVFT 9
           AVVLPGV T
Sbjct: 919 AVVLPGVST 927
>XP_005250085
          Length = 4979

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AVVLPGVFT 9
           AVVLPGV T
Sbjct: 919 AVVLPGVST 927
>XP_006716140
          Length = 4982

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AVVLPGVFT 9
           AVVLPGV T
Sbjct: 919 AVVLPGVST 927
>XP_005250084
          Length = 4982

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AVVLPGVFT 9
           AVVLPGV T
Sbjct: 919 AVVLPGVST 927
>XP_005250083
          Length = 4982

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AVVLPGVFT 9
           AVVLPGV T
Sbjct: 918 AVVLPGVST 926
>XP_005250082
          Length = 4983

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   AVVLPGVFT 9
           AVVLPGV T
Sbjct: 919 AVVLPGVST 927
>NP_848695
          Length = 394

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VVLPGVF 8
           VV+PG+F
Sbjct: 266 VVIPGIF 272
>NP_848696
          Length = 426

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VVLPGVF 8
           VV+PG+F
Sbjct: 266 VVIPGIF 272
>NP_110416
          Length = 377

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VVLPGVF 8
           VV+PG+F
Sbjct: 266 VVIPGIF 272
>XP_005260619
          Length = 317

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VVLPGVF 8
           VV+PG+F
Sbjct: 266 VVIPGIF 272
>XP_006714616
          Length = 399

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VVLPGVF 8
           V++PGVF
Sbjct: 364 VIIPGVF 370
>NP_056261
          Length = 2275

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   AVVLPGVFT 9
           AVVLPG  T
Sbjct: 128 AVVLPGRVT 136
>NP_001299
          Length = 458

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VVLPGVFT 9
           ++LPG++T
Sbjct: 379 LLLPGIYT 386
>XP_006711822
          Length = 2266

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   AVVLPGVFT 9
           AVVLPG  T
Sbjct: 119 AVVLPGRVT 127
>XP_006711821
          Length = 2301

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   AVVLPGVFT 9
           AVVLPG  T
Sbjct: 154 AVVLPGRVT 162
>NP_065883
          Length = 1237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   AVVLPG 6
           AVVLPG
Sbjct: 423 AVVLPG 428
>NP_775960
          Length = 1285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   AVVLPG 6
           AVVLPG
Sbjct: 714 AVVLPG 719
>NP_079229
          Length = 972

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AVVLPGVFT 9
           ++++P VFT
Sbjct: 880 SIIMPPVFT 888
>NP_001136438
          Length = 1923

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VVLPGVF 8
            +VLPG+F
Sbjct: 1567 LVLPGMF 1573
>XP_006722611
          Length = 1034

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VVLPGVF 8
           +VLPG+F
Sbjct: 678 LVLPGMF 684
>XP_006722610
          Length = 1967

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VVLPGVF 8
            +VLPG+F
Sbjct: 1611 LVLPGMF 1617
>XP_005253995
          Length = 836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AVVLPGVFT 9
           ++++P VFT
Sbjct: 744 SIIMPPVFT 752
>XP_006719669
          Length = 944

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AVVLPGVFT 9
           ++++P VFT
Sbjct: 852 SIIMPPVFT 860
>XP_005253988
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVVLPGVFT 9
           A +LP VFT
Sbjct: 567 AALLPQVFT 575
>XP_005251991
          Length = 953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   AVVLPG 6
           AVVLPG
Sbjct: 382 AVVLPG 387
>XP_005245423
          Length = 1246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   AVVLPG 6
           AVVLPG
Sbjct: 432 AVVLPG 437
>XP_005245425
          Length = 1299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   AVVLPG 6
           AVVLPG
Sbjct: 485 AVVLPG 490
>NP_899231
          Length = 328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LPGVFT 9
           LPGV+T
Sbjct: 248 LPGVYT 253
>NP_001243643
          Length = 608

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  AVVLPG 6
          AV+LPG
Sbjct: 92 AVILPG 97
>NP_001164434
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   AVVLPGV 7
           A+V+PG+
Sbjct: 233 AIVVPGI 239
>NP_002832
          Length = 1445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5    PGVFT 9
            PGVFT
Sbjct: 1391 PGVFT 1395
>NP_005493
          Length = 2261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    VVLPGVF 8
            +VLP VF
Sbjct: 1351 IVLPAVF 1357
>NP_001276932
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  LPGVFT 9
          LPG FT
Sbjct: 32 LPGAFT 37
>NP_001271254
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VVLPGV 7
           V+LPGV
Sbjct: 251 VILPGV 256
>NP_001181
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VVLPGV 7
           V+LPGV
Sbjct: 291 VILPGV 296
>NP_001158245
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VVLPGV 7
           V+LPGV
Sbjct: 199 VILPGV 204
>NP_001160158
          Length = 851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVVLPGVFT 9
           AVV  G+FT
Sbjct: 107 AVVRVGIFT 115
>NP_113666
          Length = 274

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  VVLPGVF 8
          VV PG+F
Sbjct: 10 VVFPGLF 16
>NP_065692
          Length = 294

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  VVLPGVFT 9
          + +PGVF+
Sbjct: 7  IFIPGVFS 14
>NP_001155057
          Length = 265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  VVLPGVFT 9
          + +PGVF+
Sbjct: 7  IFIPGVFS 14
>NP_991402
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   AVVLPGV 7
           A+V+PG+
Sbjct: 233 AIVVPGI 239
>NP_001245219
          Length = 850

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   PGVFT 9
           PGVFT
Sbjct: 273 PGVFT 277
>NP_775773
          Length = 855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   PGVFT 9
           PGVFT
Sbjct: 273 PGVFT 277
>NP_001245220
          Length = 752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   PGVFT 9
           PGVFT
Sbjct: 273 PGVFT 277
>NP_000280
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AVVLPGVFT 9
          AVV  G+FT
Sbjct: 36 AVVRVGIFT 44
>NP_001160160
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AVVLPGVFT 9
          AVV  G+FT
Sbjct: 36 AVVRVGIFT 44
>XP_006719527
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AVVLPGVFT 9
          AVV  G+FT
Sbjct: 36 AVVRVGIFT 44
>XP_006719526
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AVVLPGVFT 9
          AVV  G+FT
Sbjct: 36 AVVRVGIFT 44
>XP_005269037
          Length = 811

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AVVLPGVFT 9
          AVV  G+FT
Sbjct: 67 AVVRVGIFT 75
>XP_005269036
          Length = 851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVVLPGVFT 9
           AVV  G+FT
Sbjct: 107 AVVRVGIFT 115
>XP_005269035
          Length = 851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVVLPGVFT 9
           AVV  G+FT
Sbjct: 107 AVVRVGIFT 115
>XP_005269034
          Length = 851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVVLPGVFT 9
           AVV  G+FT
Sbjct: 107 AVVRVGIFT 115
>XP_005269033
          Length = 883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVVLPGVFT 9
           AVV  G+FT
Sbjct: 139 AVVRVGIFT 147
>XP_005269032
          Length = 883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVVLPGVFT 9
           AVV  G+FT
Sbjct: 139 AVVRVGIFT 147
>XP_005269031
          Length = 883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AVVLPGVFT 9
           AVV  G+FT
Sbjct: 139 AVVRVGIFT 147
>XP_005251837
          Length = 1659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    VVLPGVF 8
            +VLP VF
Sbjct: 1353 IVLPAVF 1359
>XP_005251835
          Length = 2074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    VVLPGVF 8
            +VLP VF
Sbjct: 1353 IVLPAVF 1359
>XP_006717058
          Length = 2100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    VVLPGVF 8
            +VLP VF
Sbjct: 1353 IVLPAVF 1359
>XP_005251833
          Length = 2203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    VVLPGVF 8
            +VLP VF
Sbjct: 1293 IVLPAVF 1299
>XP_005251831
          Length = 2263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    VVLPGVF 8
            +VLP VF
Sbjct: 1353 IVLPAVF 1359
>XP_005251830
          Length = 2263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    VVLPGVF 8
            +VLP VF
Sbjct: 1353 IVLPAVF 1359
>XP_005247794
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  LPGVFT 9
          LPG FT
Sbjct: 57 LPGAFT 62
>XP_006713802
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  LPGVFT 9
          LPG FT
Sbjct: 59 LPGAFT 64
>XP_006713801
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  LPGVFT 9
          LPG FT
Sbjct: 59 LPGAFT 64
>XP_005265410
          Length = 1416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5    PGVFT 9
            PGVFT
Sbjct: 1362 PGVFT 1366
>XP_005265409
          Length = 1431

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5    PGVFT 9
            PGVFT
Sbjct: 1377 PGVFT 1381
>NP_001160159
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AVVLPGVFT 9
          AVV  G+FT
Sbjct: 36 AVVRVGIFT 44
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.149    0.446 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 737,930
Number of extensions: 944
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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