Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001276866                                                           18    1935
NP_004439                                                              18    1935
NP_001276865                                                           18    1935
NP_001005862                                                           18    1935
XP_005257197                                                           18    1935
XP_006721828                                                           18    1935
NP_057617                                                              17    4312
XP_006719047                                                           17    4312
XP_005253746                                                           17    4312
NP_055628                                                              15    9605
NP_066010                                                              15    9605
NP_115613                                                              15    9605
NP_001264900                                                           15    9605
NP_001296                                                              15    9605
NP_001116078                                                           15    9605
NP_008859                                                              15    9605
NP_694560                                                              15    9605
NP_001186982                                                           15    9605
NP_001186983                                                           15    9605
XP_006719632                                                           15    9605
XP_006719631                                                           15    9605
XP_005250862                                                           15    9605
XP_006711136                                                           15    9605
XP_006711135                                                           15    9605
XP_005271426                                                           15    9605
NP_006625                                                              15    9605
>NP_001276866
          Length = 1055

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VGILLVVV 9
           VGILLVVV
Sbjct: 659 VGILLVVV 666
>NP_004439
          Length = 1255

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VGILLVVV 9
           VGILLVVV
Sbjct: 659 VGILLVVV 666
>NP_001276865
          Length = 1240

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VGILLVVV 9
           VGILLVVV
Sbjct: 644 VGILLVVV 651
>NP_001005862
          Length = 1225

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VGILLVVV 9
           VGILLVVV
Sbjct: 629 VGILLVVV 636
>XP_005257197
          Length = 1225

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VGILLVVV 9
           VGILLVVV
Sbjct: 629 VGILLVVV 636
>XP_006721828
          Length = 1336

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VGILLVVV 9
           VGILLVVV
Sbjct: 740 VGILLVVV 747
>NP_057617
          Length = 188

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VGILLVVV 9
           +G+LLVV+
Sbjct: 126 IGVLLVVI 133
>XP_006719047
          Length = 106

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VGILLVVV 9
          +G+LLVV+
Sbjct: 44 IGVLLVVI 51
>XP_005253746
          Length = 135

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VGILLVVV 9
          +G+LLVV+
Sbjct: 73 IGVLLVVI 80
>NP_055628
          Length = 1065

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VGILLVVV 9
           VGI+++VV
Sbjct: 806 VGIVIIVV 813
>NP_066010
          Length = 1232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AVGILLVVV 9
           A+G+L +VV
Sbjct: 811 AMGVLAIVV 819
>NP_115613
          Length = 350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  AVGILLVV 8
          AVG+LL++
Sbjct: 20 AVGLLLIM 27
>NP_001264900
          Length = 350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  AVGILLVV 8
          AVG+LL++
Sbjct: 20 AVGLLLIM 27
>NP_001296
          Length = 209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVGILLVVV 9
           A+G+LL VV
Sbjct: 92  ALGVLLSVV 100
>NP_001116078
          Length = 411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AVGILLVVV 9
           A+G L++VV
Sbjct: 385 ALGFLIIVV 393
>NP_008859
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VGILLVVV 9
           VGILLV++
Sbjct: 600 VGILLVLM 607
>NP_694560
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GILLVVV 9
           GILLV++
Sbjct: 188 GILLVII 194
>NP_001186982
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VGILLVVV 9
           VGILLV++
Sbjct: 514 VGILLVLM 521
>NP_001186983
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VGILLVVV 9
           VGILLV++
Sbjct: 607 VGILLVLM 614
>XP_006719632
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VGILLVVV 9
           VGILLV++
Sbjct: 600 VGILLVLM 607
>XP_006719631
          Length = 664

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VGILLVVV 9
           VGILLV++
Sbjct: 603 VGILLVLM 610
>XP_005250862
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GILLVVV 9
           GILLV++
Sbjct: 188 GILLVII 194
>XP_006711136
          Length = 553

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VGILLVVV 9
           VGI+++VV
Sbjct: 294 VGIVIIVV 301
>XP_006711135
          Length = 553

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VGILLVVV 9
           VGI+++VV
Sbjct: 294 VGIVIIVV 301
>XP_005271426
          Length = 958

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VGILLVVV 9
           VGI+++VV
Sbjct: 699 VGIVIIVV 706
>NP_006625
          Length = 116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  VGILLVVV 9
          VG+LL+++
Sbjct: 78 VGVLLIIL 85
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.341    0.161    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 360,877
Number of extensions: 571
Number of successful extensions: 26
Number of sequences better than 10000.0: 26
Number of HSP's gapped: 26
Number of HSP's successfully gapped: 26
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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