Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              18    1935
NP_001035957                                                           18    1935
XP_006721990                                                           18    1935
XP_006721989                                                           18    1935
XP_005258041                                                           18    1935
XP_006721988                                                           18    1935
XP_006721987                                                           18    1935
XP_006721986                                                           18    1935
XP_005258040                                                           18    1935
XP_006721985                                                           18    1935
NP_003881                                                              17    4312
NP_940849                                                              17    4312
NP_079236                                                              16    5631
NP_705902                                                              16    5631
NP_705904                                                              16    5631
NP_001257449                                                           16    5631
NP_055807                                                              16    5631
NP_683878                                                              16    5631
NP_683879                                                              16    5631
NP_001096654                                                           16    5631
NP_001264242                                                           16    5631
NP_835260                                                              16    5631
NP_919278                                                              16    5631
NP_078870                                                              16    5631
XP_006723694                                                           16    5631
XP_005260892                                                           16    5631
XP_005260893                                                           16    5631
XP_005267488                                                           16    5631
XP_005267487                                                           16    5631
XP_006714522                                                           16    5631
XP_006714521                                                           16    5631
XP_006714520                                                           16    5631
XP_005248327                                                           16    5631
XP_005248326                                                           16    5631
XP_006714519                                                           16    5631
XP_006712459                                                           16    5631
NP_002145                                                              16    7355
NP_003477                                                              16    7355
NP_001264044                                                           16    7355
NP_055093                                                              16    7355
NP_001138868                                                           16    7355
NP_699160                                                              16    7355
NP_005883                                                              16    7355
XP_006722133                                                           16    7355
XP_006722132                                                           16    7355
XP_006722131                                                           16    7355
XP_006722130                                                           16    7355
XP_006722129                                                           16    7355
XP_006722128                                                           16    7355
XP_006722127                                                           16    7355
XP_006722126                                                           16    7355
XP_006722125                                                           16    7355
XP_006721350                                                           16    7355
XP_006721349                                                           16    7355
XP_006714203                                                           16    7355
NP_055495                                                              15    9605
NP_001399                                                              15    9605
XP_005258130                                                           15    9605
XP_006710468                                                           15    9605
XP_005270637                                                           15    9605
>NP_000258
          Length = 2818

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AVALAFGNV 9
            AVALA GNV
Sbjct: 2014 AVALASGNV 2022
>NP_001035957
          Length = 2839

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AVALAFGNV 9
            AVALA GNV
Sbjct: 2035 AVALASGNV 2043
>XP_006721990
          Length = 2823

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AVALAFGNV 9
            AVALA GNV
Sbjct: 2045 AVALASGNV 2053
>XP_006721989
          Length = 2823

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AVALAFGNV 9
            AVALA GNV
Sbjct: 2045 AVALASGNV 2053
>XP_005258041
          Length = 2836

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AVALAFGNV 9
            AVALA GNV
Sbjct: 2014 AVALASGNV 2022
>XP_006721988
          Length = 2846

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AVALAFGNV 9
            AVALA GNV
Sbjct: 2024 AVALASGNV 2032
>XP_006721987
          Length = 2849

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AVALAFGNV 9
            AVALA GNV
Sbjct: 2045 AVALASGNV 2053
>XP_006721986
          Length = 2854

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AVALAFGNV 9
            AVALA GNV
Sbjct: 2032 AVALASGNV 2040
>XP_005258040
          Length = 2857

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AVALAFGNV 9
            AVALA GNV
Sbjct: 2035 AVALASGNV 2043
>XP_006721985
          Length = 2867

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    AVALAFGNV 9
            AVALA GNV
Sbjct: 2045 AVALASGNV 2053
>NP_003881
          Length = 5405

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    AVALAFGN 8
            A ALAFGN
Sbjct: 1023 ANALAFGN 1030
>NP_940849
          Length = 132

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AVALAFGNV 9
          +V LAFGN+
Sbjct: 32 SVLLAFGNL 40
>NP_079236
          Length = 279

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVALAFGNV 9
           AVA +FGN+
Sbjct: 176 AVASSFGNM 184
>NP_705902
          Length = 570

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVALAFGNV 9
           AVA +FGN+
Sbjct: 467 AVASSFGNM 475
>NP_705904
          Length = 279

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVALAFGNV 9
           AVA +FGN+
Sbjct: 176 AVASSFGNM 184
>NP_001257449
          Length = 1068

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VALAFGN 8
           V LAFGN
Sbjct: 806 VVLAFGN 812
>NP_055807
          Length = 1078

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VALAFGN 8
           V LAFGN
Sbjct: 816 VVLAFGN 822
>NP_683878
          Length = 598

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVALAFGNV 9
           AVA +FGN+
Sbjct: 492 AVASSFGNM 500
>NP_683879
          Length = 373

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVALAFGNV 9
           AVA +FGN+
Sbjct: 267 AVASSFGNM 275
>NP_001096654
          Length = 1196

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AVALAFGN 8
           A+ LAFGN
Sbjct: 959 ALILAFGN 966
>NP_001264242
          Length = 1419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    AVALAFGN 8
            A+ LAFGN
Sbjct: 1182 ALILAFGN 1189
>NP_835260
          Length = 2839

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VALAFGNV 9
          V L+FGN+
Sbjct: 83 VGLSFGNI 90
>NP_919278
          Length = 1925

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LAFGNV 9
            LAFGNV
Sbjct: 999  LAFGNV 1004
>NP_078870
          Length = 370

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVALAFGNV 9
           AVA +FGN+
Sbjct: 267 AVASSFGNM 275
>XP_006723694
          Length = 279

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVALAFGNV 9
           AVA +FGN+
Sbjct: 176 AVASSFGNM 184
>XP_005260892
          Length = 365

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVALAFGNV 9
           AVA +FGN+
Sbjct: 262 AVASSFGNM 270
>XP_005260893
          Length = 420

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   AVALAFGNV 9
           AVA +FGN+
Sbjct: 317 AVASSFGNM 325
>XP_005267488
          Length = 1078

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VALAFGN 8
           V LAFGN
Sbjct: 816 VVLAFGN 822
>XP_005267487
          Length = 1078

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VALAFGN 8
           V LAFGN
Sbjct: 816 VVLAFGN 822
>XP_006714522
          Length = 2719

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VALAFGNV 9
          V L+FGN+
Sbjct: 83 VGLSFGNI 90
>XP_006714521
          Length = 2781

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VALAFGNV 9
          V L+FGN+
Sbjct: 83 VGLSFGNI 90
>XP_006714520
          Length = 2802

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VALAFGNV 9
          V L+FGN+
Sbjct: 83 VGLSFGNI 90
>XP_005248327
          Length = 2839

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VALAFGNV 9
          V L+FGN+
Sbjct: 83 VGLSFGNI 90
>XP_005248326
          Length = 2873

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VALAFGNV 9
          V L+FGN+
Sbjct: 83 VGLSFGNI 90
>XP_006714519
          Length = 2873

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VALAFGNV 9
          V L+FGN+
Sbjct: 83 VGLSFGNI 90
>XP_006712459
          Length = 1914

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LAFGNV 9
           LAFGNV
Sbjct: 988 LAFGNV 993
>NP_002145
          Length = 840

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AVALAFG 7
           AVALA+G
Sbjct: 176 AVALAYG 182
>NP_003477
          Length = 507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AVALAFGN 8
           AVA+ FGN
Sbjct: 310 AVAVDFGN 317
>NP_001264044
          Length = 4516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ALAFGNV 9
            ALAFG+V
Sbjct: 3531 ALAFGDV 3537
>NP_055093
          Length = 839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AVALAFG 7
           AVALA+G
Sbjct: 176 AVALAYG 182
>NP_001138868
          Length = 751

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AVALAFGN 8
           A ALA+GN
Sbjct: 631 APALAYGN 638
>NP_699160
          Length = 802

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AVALAFGN 8
           A ALA+GN
Sbjct: 682 APALAYGN 689
>NP_005883
          Length = 1100

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VALAFGN 8
           + LAFGN
Sbjct: 840 IVLAFGN 846
>XP_006722133
          Length = 1104

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VALAFGN 8
           + LAFGN
Sbjct: 840 IVLAFGN 846
>XP_006722132
          Length = 1076

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VALAFGN 8
           + LAFGN
Sbjct: 846 IVLAFGN 852
>XP_006722131
          Length = 1100

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VALAFGN 8
           + LAFGN
Sbjct: 840 IVLAFGN 846
>XP_006722130
          Length = 1106

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VALAFGN 8
           + LAFGN
Sbjct: 846 IVLAFGN 852
>XP_006722129
          Length = 1110

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VALAFGN 8
           + LAFGN
Sbjct: 846 IVLAFGN 852
>XP_006722128
          Length = 1148

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VALAFGN 8
           + LAFGN
Sbjct: 830 IVLAFGN 836
>XP_006722127
          Length = 1154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VALAFGN 8
           + LAFGN
Sbjct: 836 IVLAFGN 842
>XP_006722126
          Length = 1158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VALAFGN 8
           + LAFGN
Sbjct: 840 IVLAFGN 846
>XP_006722125
          Length = 1164

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VALAFGN 8
           + LAFGN
Sbjct: 846 IVLAFGN 852
>XP_006721350
          Length = 241

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AVALAFGN 8
          AVA+ FGN
Sbjct: 44 AVAVDFGN 51
>XP_006721349
          Length = 334

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AVALAFGN 8
           AVA+ FGN
Sbjct: 137 AVAVDFGN 144
>XP_006714203
          Length = 543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AVALAFG 7
           AVALA+G
Sbjct: 176 AVALAYG 182
>NP_055495
          Length = 2235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  VALAFGNV 9
          VAL FG V
Sbjct: 86 VALCFGEV 93
>NP_001399
          Length = 2923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    VALAFGNV 9
            VAL FG+V
Sbjct: 1491 VALRFGSV 1498
>XP_005258130
          Length = 2234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  VALAFGNV 9
          VAL FG V
Sbjct: 86 VALCFGEV 93
>XP_006710468
          Length = 2916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    VALAFGNV 9
            VAL FG+V
Sbjct: 1491 VALRFGSV 1498
>XP_005270637
          Length = 2921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    VALAFGNV 9
            VAL FG+V
Sbjct: 1491 VALRFGSV 1498
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.137    0.375 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 374,316
Number of extensions: 394
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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