Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006333                                                              18    1935
XP_005247987                                                           18    1935
XP_006713918                                                           18    1935
XP_005247986                                                           18    1935
NP_068752                                                              17    4312
XP_005263544                                                           17    4312
NP_068765                                                              16    5631
NP_003289                                                              16    5631
XP_005262513                                                           16    5631
XP_006724842                                                           16    5631
XP_006724841                                                           16    5631
XP_006724840                                                           16    5631
XP_005262512                                                           16    5631
XP_005262511                                                           16    5631
XP_006724839                                                           16    5631
XP_005262510                                                           16    5631
XP_005262509                                                           16    5631
XP_006713383                                                           16    5631
XP_005265485                                                           16    5631
NP_001243369                                                           16    7355
NP_003194                                                              16    7355
NP_001188263                                                           16    7355
NP_112181                                                              16    7355
XP_005258578                                                           16    7355
XP_005258577                                                           16    7355
XP_005264578                                                           16    7355
XP_005264577                                                           16    7355
NP_997239                                                              15    9605
NP_001274691                                                           15    9605
NP_001274690                                                           15    9605
NP_004204                                                              15    9605
NP_076996                                                              15    9605
XP_005255050                                                           15    9605
XP_005255048                                                           15    9605
XP_005255046                                                           15    9605
XP_006714561                                                           15    9605
NP_004203                                                              15    9605
>NP_006333
          Length = 838

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ASTSLVTAC 9
           ASTSL T+C
Sbjct: 494 ASTSLPTSC 502
>XP_005247987
          Length = 482

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ASTSLVTAC 9
           ASTSL T+C
Sbjct: 134 ASTSLPTSC 142
>XP_006713918
          Length = 830

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ASTSLVTAC 9
           ASTSL T+C
Sbjct: 482 ASTSLPTSC 490
>XP_005247986
          Length = 842

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ASTSLVTAC 9
           ASTSL T+C
Sbjct: 494 ASTSLPTSC 502
>NP_068752
          Length = 388

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  ASTSLVTAC 9
          +STSL T+C
Sbjct: 58 SSTSLSTSC 66
>XP_005263544
          Length = 366

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  ASTSLVTAC 9
          +STSL T+C
Sbjct: 58 SSTSLSTSC 66
>NP_068765
          Length = 1711

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ASTSLVTA 8
           A TSLVTA
Sbjct: 549 ADTSLVTA 556
>NP_003289
          Length = 615

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   STSLVTAC 9
           +TSLV AC
Sbjct: 434 NTSLVRAC 441
>XP_005262513
          Length = 1655

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ASTSLVTA 8
           A TSLVTA
Sbjct: 549 ADTSLVTA 556
>XP_006724842
          Length = 1687

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ASTSLVTA 8
           A TSLVTA
Sbjct: 451 ADTSLVTA 458
>XP_006724841
          Length = 1687

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ASTSLVTA 8
           A TSLVTA
Sbjct: 451 ADTSLVTA 458
>XP_006724840
          Length = 1785

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ASTSLVTA 8
           A TSLVTA
Sbjct: 549 ADTSLVTA 556
>XP_005262512
          Length = 1785

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ASTSLVTA 8
           A TSLVTA
Sbjct: 549 ADTSLVTA 556
>XP_005262511
          Length = 1785

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ASTSLVTA 8
           A TSLVTA
Sbjct: 549 ADTSLVTA 556
>XP_006724839
          Length = 1785

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ASTSLVTA 8
           A TSLVTA
Sbjct: 549 ADTSLVTA 556
>XP_005262510
          Length = 1785

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ASTSLVTA 8
           A TSLVTA
Sbjct: 549 ADTSLVTA 556
>XP_005262509
          Length = 1785

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ASTSLVTA 8
           A TSLVTA
Sbjct: 549 ADTSLVTA 556
>XP_006713383
          Length = 615

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   STSLVTAC 9
           +TSLV AC
Sbjct: 434 NTSLVRAC 441
>XP_005265485
          Length = 596

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   STSLVTAC 9
           +TSLV AC
Sbjct: 415 NTSLVRAC 422
>NP_001243369
          Length = 422

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ASTSLVTAC 9
          A+ SLV AC
Sbjct: 4  AALSLVAAC 12
>NP_003194
          Length = 781

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   STSLVTAC 9
           +TSL+T C
Sbjct: 578 TTSLITHC 585
>NP_001188263
          Length = 612

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   STSLVTAC 9
           +TSL+T C
Sbjct: 409 TTSLITHC 416
>NP_112181
          Length = 615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   TSLVTAC 9
           TS+ TAC
Sbjct: 441 TSITTAC 447
>XP_005258578
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ASTSLVTAC 9
          A+ SLV AC
Sbjct: 4  AALSLVAAC 12
>XP_005258577
          Length = 421

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ASTSLVTAC 9
          A+ SLV AC
Sbjct: 4  AALSLVAAC 12
>XP_005264578
          Length = 710

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   STSLVTAC 9
           +TSL+T C
Sbjct: 586 TTSLITHC 593
>XP_005264577
          Length = 789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   STSLVTAC 9
           +TSL+T C
Sbjct: 586 TTSLITHC 593
>NP_997239
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  STSLVTAC 9
          STS  TAC
Sbjct: 35 STSAKTAC 42
>NP_001274691
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ASTSLVTAC 9
           A  SLV AC
Sbjct: 577 ACVSLVNAC 585
>NP_001274690
          Length = 483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ASTSLVTAC 9
           A  SLV AC
Sbjct: 411 ACVSLVNAC 419
>NP_004204
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ASTSLVTAC 9
           A  SLV AC
Sbjct: 577 ACVSLVNAC 585
>NP_076996
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   ASTSLVTA 8
           ++TSLVTA
Sbjct: 174 SNTSLVTA 181
>XP_005255050
          Length = 623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ASTSLVTAC 9
           A  SLV AC
Sbjct: 551 ACVSLVNAC 559
>XP_005255048
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ASTSLVTAC 9
           A  SLV AC
Sbjct: 577 ACVSLVNAC 585
>XP_005255046
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ASTSLVTAC 9
           A  SLV AC
Sbjct: 577 ACVSLVNAC 585
>XP_006714561
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   ASTSLVTA 8
           ++TSLVTA
Sbjct: 174 SNTSLVTA 181
>NP_004203
          Length = 658

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ASTSLVTAC 9
           A  SL++AC
Sbjct: 572 ACVSLISAC 580
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.107    0.295 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 274,302
Number of extensions: 360
Number of successful extensions: 37
Number of sequences better than 10000.0: 37
Number of HSP's gapped: 37
Number of HSP's successfully gapped: 37
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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