Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001008487                                                           17    2528
NP_001008486                                                           17    2528
NP_001008485                                                           17    2528
NP_060306                                                              17    2528
NP_001157947                                                           17    2528
XP_005247622                                                           17    2528
XP_005247621                                                           17    2528
XP_006713744                                                           17    2528
XP_005247620                                                           17    2528
XP_005247619                                                           17    2528
XP_005247618                                                           17    2528
XP_005247617                                                           17    2528
XP_005247616                                                           17    2528
NP_006197                                                              17    4312
NP_776253                                                              17    4312
XP_006714104                                                           17    4312
XP_005265800                                                           17    4312
XP_006714103                                                           17    4312
XP_006714102                                                           17    4312
XP_005245126                                                           17    4312
NP_003092                                                              15    9605
NP_001239441                                                           15    9605
NP_001239440                                                           15    9605
XP_005271680                                                           15    9605
XP_005271679                                                           15    9605
XP_005271678                                                           15    9605
XP_005271676                                                           15    9605
XP_005271681                                                           15    9605
XP_006718955                                                           15    9605
XP_006718954                                                           15    9605
XP_006718953                                                           15    9605
XP_006718950                                                           15    9605
XP_005273894                                                           15    9605
NP_878253                                                              15    9605

>NP_001008487
          Length = 461

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ARVLVLLVI 9
           ARVL+LLV+
Sbjct: 349 ARVLLLLVV 357



>NP_001008486
          Length = 471

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ARVLVLLVI 9
           ARVL+LLV+
Sbjct: 339 ARVLLLLVV 347



>NP_001008485
          Length = 507

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ARVLVLLVI 9
           ARVL+LLV+
Sbjct: 375 ARVLLLLVV 383



>NP_060306
          Length = 487

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ARVLVLLVI 9
           ARVL+LLV+
Sbjct: 375 ARVLLLLVV 383



>NP_001157947
          Length = 370

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ARVLVLLVI 9
           ARVL+LLV+
Sbjct: 258 ARVLLLLVV 266



>XP_005247622
          Length = 481

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ARVLVLLVI 9
           ARVL+LLV+
Sbjct: 349 ARVLLLLVV 357



>XP_005247621
          Length = 502

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ARVLVLLVI 9
           ARVL+LLV+
Sbjct: 390 ARVLLLLVV 398



>XP_006713744
          Length = 507

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ARVLVLLVI 9
           ARVL+LLV+
Sbjct: 375 ARVLLLLVV 383



>XP_005247620
          Length = 507

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ARVLVLLVI 9
           ARVL+LLV+
Sbjct: 375 ARVLLLLVV 383



>XP_005247619
          Length = 507

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ARVLVLLVI 9
           ARVL+LLV+
Sbjct: 375 ARVLLLLVV 383



>XP_005247618
          Length = 507

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ARVLVLLVI 9
           ARVL+LLV+
Sbjct: 375 ARVLLLLVV 383



>XP_005247617
          Length = 522

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ARVLVLLVI 9
           ARVL+LLV+
Sbjct: 390 ARVLLLLVV 398



>XP_005247616
          Length = 522

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   ARVLVLLVI 9
           ARVL+LLV+
Sbjct: 390 ARVLLLLVV 398



>NP_006197
          Length = 1089

 Score = 16.5 bits (31), Expect =  4312
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ARVLVLLVI 9
           A VLVLLVI
Sbjct: 529 AAVLVLLVI 537



>NP_776253
          Length = 513

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ARVLVLLVI 9
           ARVL LLV+
Sbjct: 409 ARVLFLLVV 417



>XP_006714104
          Length = 832

 Score = 16.5 bits (31), Expect =  4312
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ARVLVLLVI 9
           A VLVLLVI
Sbjct: 554 AAVLVLLVI 562



>XP_005265800
          Length = 1089

 Score = 16.5 bits (31), Expect =  4312
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ARVLVLLVI 9
           A VLVLLVI
Sbjct: 529 AAVLVLLVI 537



>XP_006714103
          Length = 1111

 Score = 16.5 bits (31), Expect =  4312
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ARVLVLLVI 9
           A VLVLLVI
Sbjct: 551 AAVLVLLVI 559



>XP_006714102
          Length = 1114

 Score = 16.5 bits (31), Expect =  4312
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ARVLVLLVI 9
           A VLVLLVI
Sbjct: 554 AAVLVLLVI 562



>XP_005245126
          Length = 513

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ARVLVLLVI 9
           ARVL LLV+
Sbjct: 409 ARVLFLLVV 417



>NP_003092
          Length = 550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ARVLVLLV 8
           ARVLVL V
Sbjct: 359 ARVLVLCV 366



>NP_001239441
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ARVLVLLV 8
           ARVLVL V
Sbjct: 294 ARVLVLCV 301



>NP_001239440
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ARVLVLLV 8
           ARVLVL V
Sbjct: 301 ARVLVLCV 308



>XP_005271680
          Length = 713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   VLVLLVI 9
           VLVLLVI
Sbjct: 590 VLVLLVI 596



>XP_005271679
          Length = 713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   VLVLLVI 9
           VLVLLVI
Sbjct: 590 VLVLLVI 596



>XP_005271678
          Length = 713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   VLVLLVI 9
           VLVLLVI
Sbjct: 590 VLVLLVI 596



>XP_005271676
          Length = 753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   VLVLLVI 9
           VLVLLVI
Sbjct: 630 VLVLLVI 636



>XP_005271681
          Length = 772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   VLVLLVI 9
           VLVLLVI
Sbjct: 649 VLVLLVI 655



>XP_006718955
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   VLVLLVI 9
           VLVLLVI
Sbjct: 673 VLVLLVI 679



>XP_006718954
          Length = 877

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   VLVLLVI 9
           VLVLLVI
Sbjct: 773 VLVLLVI 779



>XP_006718953
          Length = 881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   VLVLLVI 9
           VLVLLVI
Sbjct: 758 VLVLLVI 764



>XP_006718950
          Length = 896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   VLVLLVI 9
           VLVLLVI
Sbjct: 773 VLVLLVI 779



>XP_005273894
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  RVLVLLVI 9
          ++L+LLVI
Sbjct: 69 KILILLVI 76



>NP_878253
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  RVLVLLVI 9
          ++L+LLVI
Sbjct: 69 KILILLVI 76



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.355    0.167    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 245,196
Number of extensions: 316
Number of successful extensions: 34
Number of sequences better than 10000.0: 34
Number of HSP's gapped: 34
Number of HSP's successfully gapped: 34
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.9 bits)
S2: 28 (15.4 bits)