Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_056052                                                              17    2528
NP_003651                                                              16    7355
NP_003471                                                              16    7355
NP_057279                                                              16    7355
NP_001271188                                                           16    7355
NP_003617                                                              16    7355
NP_803172                                                              16    7355
XP_006723513                                                           16    7355
XP_006721765                                                           16    7355
XP_006721764                                                           16    7355
XP_006719217                                                           16    7355
XP_006718787                                                           16    7355
XP_006718786                                                           16    7355
XP_006718785                                                           16    7355
XP_006718784                                                           16    7355
XP_006718783                                                           16    7355
XP_006718782                                                           16    7355
XP_006718781                                                           16    7355
XP_006718780                                                           16    7355
XP_006718779                                                           16    7355
XP_006718778                                                           16    7355
NP_149124                                                              16    7355
NP_001188258                                                           15    9605
NP_078883                                                              15    9605
NP_006351                                                              15    9605
NP_079184                                                              15    9605
NP_001161413                                                           15    9605
NP_705618                                                              15    9605
NP_006176                                                              15    9605
NP_004289                                                              15    9605
NP_001273490                                                           15    9605
NP_001265241                                                           15    9605
XP_005254738                                                           15    9605
XP_005254737                                                           15    9605
XP_006718633                                                           15    9605
XP_006718632                                                           15    9605
XP_006718631                                                           15    9605
XP_006718630                                                           15    9605
XP_006718629                                                           15    9605
XP_006718628                                                           15    9605
XP_006718627                                                           15    9605
XP_006718626                                                           15    9605
XP_006718625                                                           15    9605
XP_006716317                                                           15    9605
XP_006716316                                                           15    9605
>NP_056052
          Length = 1354

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   QLSEKNS 8
           QLSEKNS
Sbjct: 767 QLSEKNS 773
>NP_003651
          Length = 1194

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AQLSEKN 7
           AQL EKN
Sbjct: 404 AQLEEKN 410
>NP_003471
          Length = 173

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AQLSEKNS 8
          A LSEKN+
Sbjct: 73 ASLSEKNT 80
>NP_057279
          Length = 1780

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    AQLSEKNS 8
            AQL+EK+S
Sbjct: 1466 AQLTEKDS 1473
>NP_001271188
          Length = 1820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    AQLSEKNS 8
            AQL+EK+S
Sbjct: 1506 AQLTEKDS 1513
>NP_003617
          Length = 1202

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AQLSEKN 7
           AQL EKN
Sbjct: 421 AQLEEKN 427
>NP_803172
          Length = 1185

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AQLSEKN 7
           AQL EKN
Sbjct: 421 AQLEEKN 427
>XP_006723513
          Length = 1185

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AQLSEKN 7
           AQL EKN
Sbjct: 404 AQLEEKN 410
>XP_006721765
          Length = 401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AQLSEKN 7
           AQL EKN
Sbjct: 139 AQLKEKN 145
>XP_006721764
          Length = 401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AQLSEKN 7
           AQL EKN
Sbjct: 139 AQLKEKN 145
>XP_006719217
          Length = 161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  AQLSEKNS 8
          A LSEKN+
Sbjct: 61 ASLSEKNT 68
>XP_006718787
          Length = 1263

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AQLSEKN 7
           AQL EKN
Sbjct: 451 AQLEEKN 457
>XP_006718786
          Length = 1207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AQLSEKN 7
           AQL EKN
Sbjct: 426 AQLEEKN 432
>XP_006718785
          Length = 1232

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AQLSEKN 7
           AQL EKN
Sbjct: 451 AQLEEKN 457
>XP_006718784
          Length = 1242

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AQLSEKN 7
           AQL EKN
Sbjct: 451 AQLEEKN 457
>XP_006718783
          Length = 1247

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AQLSEKN 7
           AQL EKN
Sbjct: 426 AQLEEKN 432
>XP_006718782
          Length = 1262

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AQLSEKN 7
           AQL EKN
Sbjct: 451 AQLEEKN 457
>XP_006718781
          Length = 1272

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AQLSEKN 7
           AQL EKN
Sbjct: 451 AQLEEKN 457
>XP_006718780
          Length = 1281

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AQLSEKN 7
           AQL EKN
Sbjct: 451 AQLEEKN 457
>XP_006718779
          Length = 1306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AQLSEKN 7
           AQL EKN
Sbjct: 446 AQLEEKN 452
>XP_006718778
          Length = 1311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AQLSEKN 7
           AQL EKN
Sbjct: 451 AQLEEKN 457
>NP_149124
          Length = 421

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   AQLSEKN 7
           AQL EKN
Sbjct: 159 AQLKEKN 165
>NP_001188258
          Length = 285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  QLSEKNSA 9
          QLS KN A
Sbjct: 39 QLSSKNEA 46
>NP_078883
          Length = 285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  QLSEKNSA 9
          QLS KN A
Sbjct: 39 QLSSKNEA 46
>NP_006351
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  AQLSEKNS 8
          A++SE+NS
Sbjct: 27 AEISEENS 34
>NP_079184
          Length = 626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  LSEKNS 8
          LSEKNS
Sbjct: 70 LSEKNS 75
>NP_001161413
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  LSEKNS 8
          LSEKNS
Sbjct: 6  LSEKNS 11
>NP_705618
          Length = 1391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   AQLSEKNS 8
           AQLSEK S
Sbjct: 770 AQLSEKIS 777
>NP_006176
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AQLSEKNSA 9
            AQLS+K  A
Sbjct: 1598 AQLSQKEQA 1606
>NP_004289
          Length = 1332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   AQLSEKNS 8
           AQLSEK S
Sbjct: 711 AQLSEKIS 718
>NP_001273490
          Length = 2101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AQLSEKNSA 9
            AQLS+K  A
Sbjct: 1584 AQLSQKEQA 1592
>NP_001265241
          Length = 1327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   AQLSEKNS 8
           AQLSEK S
Sbjct: 770 AQLSEKIS 777
>XP_005254738
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  LSEKNS 8
          LSEKNS
Sbjct: 70 LSEKNS 75
>XP_005254737
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  LSEKNS 8
          LSEKNS
Sbjct: 6  LSEKNS 11
>XP_006718633
          Length = 2101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AQLSEKNSA 9
            AQLS+K  A
Sbjct: 1584 AQLSQKEQA 1592
>XP_006718632
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AQLSEKNSA 9
            AQLS+K  A
Sbjct: 1598 AQLSQKEQA 1606
>XP_006718631
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AQLSEKNSA 9
            AQLS+K  A
Sbjct: 1598 AQLSQKEQA 1606
>XP_006718630
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AQLSEKNSA 9
            AQLS+K  A
Sbjct: 1598 AQLSQKEQA 1606
>XP_006718629
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AQLSEKNSA 9
            AQLS+K  A
Sbjct: 1598 AQLSQKEQA 1606
>XP_006718628
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AQLSEKNSA 9
            AQLS+K  A
Sbjct: 1598 AQLSQKEQA 1606
>XP_006718627
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AQLSEKNSA 9
            AQLS+K  A
Sbjct: 1598 AQLSQKEQA 1606
>XP_006718626
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AQLSEKNSA 9
            AQLS+K  A
Sbjct: 1598 AQLSQKEQA 1606
>XP_006718625
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    AQLSEKNSA 9
            AQLS+K  A
Sbjct: 1598 AQLSQKEQA 1606
>XP_006716317
          Length = 285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  QLSEKNSA 9
          QLS KN A
Sbjct: 39 QLSSKNEA 46
>XP_006716316
          Length = 285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  QLSEKNSA 9
          QLS KN A
Sbjct: 39 QLSSKNEA 46
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.279   0.0933    0.199 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 424,676
Number of extensions: 480
Number of successful extensions: 45
Number of sequences better than 10000.0: 45
Number of HSP's gapped: 45
Number of HSP's successfully gapped: 45
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.7 bits)
S2: 28 (15.4 bits)

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