Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004809                                                              18    1135
XP_006719762                                                           18    1135
NP_776175                                                              17    2528
XP_005254367                                                           17    2528
XP_006720536                                                           17    2528
NP_001017969                                                           16    5631
NP_116279                                                              16    5631
NP_002421                                                              16    5631
XP_006716793                                                           16    5631
XP_005251442                                                           16    5631
XP_006711658                                                           16    5631
XP_005273393                                                           16    5631
XP_006711657                                                           16    5631
XP_006711656                                                           16    5631
XP_005273392                                                           16    5631
XP_006711655                                                           16    5631
NP_055646                                                              16    7355
NP_001139745                                                           16    7355
XP_006723242                                                           16    7355
XP_005258889                                                           16    7355
XP_006713495                                                           16    7355
NP_976219                                                              16    7355
NP_001008495                                                           16    7355
NP_037500                                                              16    7355
NP_001108086                                                           15    9605
NP_005919                                                              15    9605
NP_000444                                                              15    9605
NP_037528                                                              15    9605
NP_001269970                                                           15    9605
NP_001269971                                                           15    9605
NP_065937                                                              15    9605
NP_001121                                                              15    9605
NP_945321                                                              15    9605
NP_945320                                                              15    9605
XP_006722727                                                           15    9605
XP_005254978                                                           15    9605
XP_005254977                                                           15    9605
XP_005271698                                                           15    9605
XP_005271696                                                           15    9605
XP_005271695                                                           15    9605
XP_005271694                                                           15    9605
XP_005271693                                                           15    9605
XP_005271690                                                           15    9605
XP_005271689                                                           15    9605
XP_005271688                                                           15    9605
XP_005271687                                                           15    9605
>NP_004809
          Length = 820

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AMPVGLQN 8
           A+P+GLQN
Sbjct: 421 AIPIGLQN 428
>XP_006719762
          Length = 602

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   AMPVGLQN 8
           A+P+GLQN
Sbjct: 421 AIPIGLQN 428
>NP_776175
          Length = 1150

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   PVGLQNS 9
           PVGLQN+
Sbjct: 761 PVGLQNA 767
>XP_005254367
          Length = 1031

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   PVGLQNS 9
           PVGLQN+
Sbjct: 642 PVGLQNA 648
>XP_006720536
          Length = 1072

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   PVGLQNS 9
           PVGLQN+
Sbjct: 683 PVGLQNA 689
>NP_001017969
          Length = 2103

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    MPVGLQNS 9
            +P+ LQNS
Sbjct: 1074 LPIDLQNS 1081
>NP_116279
          Length = 1524

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    PVGLQNS 9
            P G+QNS
Sbjct: 1344 PAGMQNS 1350
>NP_002421
          Length = 1320

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MPVGLQNS 9
           MPVGL+ S
Sbjct: 323 MPVGLEPS 330
>XP_006716793
          Length = 1317

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MPVGLQNS 9
           +P+ LQNS
Sbjct: 288 LPIDLQNS 295
>XP_005251442
          Length = 2073

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    MPVGLQNS 9
            +P+ LQNS
Sbjct: 1044 LPIDLQNS 1051
>XP_006711658
          Length = 1235

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    PVGLQNS 9
            P G+QNS
Sbjct: 1055 PAGMQNS 1061
>XP_005273393
          Length = 1330

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    PVGLQNS 9
            P G+QNS
Sbjct: 1150 PAGMQNS 1156
>XP_006711657
          Length = 1330

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    PVGLQNS 9
            P G+QNS
Sbjct: 1150 PAGMQNS 1156
>XP_006711656
          Length = 1524

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    PVGLQNS 9
            P G+QNS
Sbjct: 1344 PAGMQNS 1350
>XP_005273392
          Length = 1524

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    PVGLQNS 9
            P G+QNS
Sbjct: 1344 PAGMQNS 1350
>XP_006711655
          Length = 1524

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    PVGLQNS 9
            P G+QNS
Sbjct: 1344 PAGMQNS 1350
>NP_055646
          Length = 2925

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AMPVGLQNS 9
           A+P GLQ S
Sbjct: 455 ALPDGLQES 463
>NP_001139745
          Length = 328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MPVGLQNS 9
           +P GLQN+
Sbjct: 255 IPFGLQNA 262
>XP_006723242
          Length = 196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   PVGLQN 8
           P+GLQN
Sbjct: 118 PLGLQN 123
>XP_005258889
          Length = 196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   PVGLQN 8
           P+GLQN
Sbjct: 118 PLGLQN 123
>XP_006713495
          Length = 2969

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AMPVGLQNS 9
           A+P GLQ S
Sbjct: 499 ALPDGLQES 507
>NP_976219
          Length = 196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   PVGLQN 8
           P+GLQN
Sbjct: 118 PLGLQN 123
>NP_001008495
          Length = 380

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MPVGLQNS 9
           +P GLQN+
Sbjct: 255 IPFGLQNA 262
>NP_037500
          Length = 196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   PVGLQN 8
           P+GLQN
Sbjct: 118 PLGLQN 123
>NP_001108086
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AMPVGLQNS 9
           A P+GL+N+
Sbjct: 231 ANPLGLKNN 239
>NP_005919
          Length = 387

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AMPVGLQNS 9
           A P+GL+N+
Sbjct: 231 ANPLGLKNN 239
>NP_000444
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  AMPVGLQNS 9
          A+PVGL  S
Sbjct: 56 ALPVGLSLS 64
>NP_037528
          Length = 1055

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   PVGLQN 8
           PVGL+N
Sbjct: 168 PVGLKN 173
>NP_001269970
          Length = 1125

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   PVGLQN 8
           PVGL+N
Sbjct: 168 PVGLKN 173
>NP_001269971
          Length = 1087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   PVGLQN 8
           PVGL+N
Sbjct: 168 PVGLKN 173
>NP_065937
          Length = 1077

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   PVGLQN 8
           PVGL+N
Sbjct: 161 PVGLKN 166
>NP_001121
          Length = 197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MPVGLQ 7
           +PVGLQ
Sbjct: 145 LPVGLQ 150
>NP_945321
          Length = 196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MPVGLQ 7
           +PVGLQ
Sbjct: 144 LPVGLQ 149
>NP_945320
          Length = 264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MPVGLQ 7
           +PVGLQ
Sbjct: 212 LPVGLQ 217
>XP_006722727
          Length = 263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MPVGLQ 7
           +PVGLQ
Sbjct: 211 LPVGLQ 216
>XP_005254978
          Length = 275

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AMPVGLQNS 9
           A P+GL+N+
Sbjct: 119 ANPLGLKNN 127
>XP_005254977
          Length = 303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AMPVGLQNS 9
           A P+GL+N+
Sbjct: 231 ANPLGLKNN 239
>XP_005271698
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  PVGLQN 8
          PVGL+N
Sbjct: 36 PVGLKN 41
>XP_005271696
          Length = 1045

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   PVGLQN 8
           PVGL+N
Sbjct: 161 PVGLKN 166
>XP_005271695
          Length = 1046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   PVGLQN 8
           PVGL+N
Sbjct: 161 PVGLKN 166
>XP_005271694
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   PVGLQN 8
           PVGL+N
Sbjct: 161 PVGLKN 166
>XP_005271693
          Length = 1080

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   PVGLQN 8
           PVGL+N
Sbjct: 161 PVGLKN 166
>XP_005271690
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   PVGLQN 8
           PVGL+N
Sbjct: 139 PVGLKN 144
>XP_005271689
          Length = 1137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   PVGLQN 8
           PVGL+N
Sbjct: 158 PVGLKN 163
>XP_005271688
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   PVGLQN 8
           PVGL+N
Sbjct: 161 PVGLKN 166
>XP_005271687
          Length = 1140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   PVGLQN 8
           PVGL+N
Sbjct: 161 PVGLKN 166
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.125    0.346 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 679,259
Number of extensions: 1068
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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