Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005302                                                              17    3301
NP_001001549                                                           17    3301
NP_001001550                                                           17    3301
NP_001001555                                                           17    3301
NP_001253974                                                           17    3301
NP_005780                                                              17    3301
NP_789839                                                              17    3301
XP_005271824                                                           17    3301
XP_006715768                                                           17    3301
XP_005271823                                                           17    3301
XP_005271822                                                           17    3301
XP_006715767                                                           17    3301
XP_006715766                                                           17    3301
XP_005271818                                                           17    3301
XP_005271817                                                           17    3301
NP_665809                                                              16    5631
NP_114148                                                              16    5631
NP_060538                                                              16    5631
NP_001129193                                                           16    5631
NP_071442                                                              16    5631
XP_005273608                                                           16    5631
XP_005273607                                                           16    5631
NP_005219                                                              16    7355
NP_000104                                                              16    7355
NP_001121363                                                           16    7355
NP_004521                                                              16    7355
NP_115543                                                              16    7355
NP_004111                                                              16    7355
NP_078878                                                              16    7355
NP_001026885                                                           16    7355
NP_940862                                                              16    7355
NP_056003                                                              16    7355
XP_006721041                                                           16    7355
XP_006721040                                                           16    7355
XP_005255739                                                           16    7355
XP_006717795                                                           16    7355
XP_005270606                                                           16    7355
XP_006710456                                                           16    7355
NP_919047                                                              15    9605
NP_003555                                                              15    9605
NP_001036068                                                           15    9605
NP_001264152                                                           15    9605
NP_001264153                                                           15    9605
NP_110440                                                              15    9605
NP_001245323                                                           15    9605
NP_001245322                                                           15    9605
NP_001245321                                                           15    9605
NP_116243                                                              15    9605
XP_005258114                                                           15    9605
XP_005258113                                                           15    9605
XP_005258112                                                           15    9605
XP_005258111                                                           15    9605
XP_005258108                                                           15    9605
XP_005258106                                                           15    9605
XP_005258105                                                           15    9605
XP_005258104                                                           15    9605
XP_005274377                                                           15    9605
XP_005274129                                                           15    9605
XP_006718655                                                           15    9605
XP_005274128                                                           15    9605
XP_005274127                                                           15    9605
XP_006717679                                                           15    9605
XP_005269551                                                           15    9605
XP_005250598                                                           15    9605
NP_060327                                                              15    9605
NP_060523                                                              15    9605
NP_653188                                                              15    9605
>NP_005302
          Length = 594

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   MNFFPKR 8
           MNFFP++
Sbjct: 259 MNFFPEQ 265
>NP_001001549
          Length = 548

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   MNFFPKR 8
           MNFFP++
Sbjct: 259 MNFFPEQ 265
>NP_001001550
          Length = 536

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   MNFFPKR 8
           MNFFP++
Sbjct: 201 MNFFPEQ 207
>NP_001001555
          Length = 536

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   MNFFPKR 8
           MNFFP++
Sbjct: 201 MNFFPEQ 207
>NP_001253974
          Length = 265

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  NFFPKR 8
          NFFPK+
Sbjct: 43 NFFPKK 48
>NP_005780
          Length = 254

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  NFFPKR 8
          NFFPK+
Sbjct: 32 NFFPKK 37
>NP_789839
          Length = 267

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  NFFPKR 8
          NFFPK+
Sbjct: 32 NFFPKK 37
>XP_005271824
          Length = 407

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  MNFFPKR 8
          MNFFP++
Sbjct: 72 MNFFPEQ 78
>XP_006715768
          Length = 536

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   MNFFPKR 8
           MNFFP++
Sbjct: 201 MNFFPEQ 207
>XP_005271823
          Length = 536

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   MNFFPKR 8
           MNFFP++
Sbjct: 201 MNFFPEQ 207
>XP_005271822
          Length = 536

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   MNFFPKR 8
           MNFFP++
Sbjct: 201 MNFFPEQ 207
>XP_006715767
          Length = 588

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   MNFFPKR 8
           MNFFP++
Sbjct: 253 MNFFPEQ 259
>XP_006715766
          Length = 594

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   MNFFPKR 8
           MNFFP++
Sbjct: 259 MNFFPEQ 265
>XP_005271818
          Length = 594

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   MNFFPKR 8
           MNFFP++
Sbjct: 259 MNFFPEQ 265
>XP_005271817
          Length = 594

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   MNFFPKR 8
           MNFFP++
Sbjct: 259 MNFFPEQ 265
>NP_665809
          Length = 371

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   MNFFPKRA 9
           MNF  KRA
Sbjct: 112 MNFLEKRA 119
>NP_114148
          Length = 450

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   MNFFPKRA 9
           MNF  KRA
Sbjct: 191 MNFLEKRA 198
>NP_060538
          Length = 973

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FFPKRA 9
           F+PKRA
Sbjct: 609 FYPKRA 614
>NP_001129193
          Length = 973

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FFPKRA 9
           F+PKRA
Sbjct: 609 FYPKRA 614
>NP_071442
          Length = 690

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   MNFFPKR 8
           +N FPKR
Sbjct: 279 INIFPKR 285
>XP_005273608
          Length = 804

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FFPKRA 9
           F+PKRA
Sbjct: 609 FYPKRA 614
>XP_005273607
          Length = 937

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FFPKRA 9
           F+PKRA
Sbjct: 609 FYPKRA 614
>NP_005219
          Length = 1210

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    NFFPKRA 9
            +FFPK A
Sbjct: 1175 DFFPKEA 1181
>NP_000104
          Length = 332

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   MNFFPK 7
           M FFPK
Sbjct: 304 MTFFPK 309
>NP_001121363
          Length = 610

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3  NFFPKR 8
          NFFP++
Sbjct: 61 NFFPRK 66
>NP_004521
          Length = 660

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   NFFPKR 8
           NFFP++
Sbjct: 111 NFFPRK 116
>NP_115543
          Length = 813

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AMNFFPKRA 9
           A NF PK+A
Sbjct: 714 AYNFPPKKA 722
>NP_004111
          Length = 591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   FFPKR 8
           FFPKR
Sbjct: 227 FFPKR 231
>NP_078878
          Length = 861

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   NFFPKR 8
           NF PKR
Sbjct: 304 NFMPKR 309
>NP_001026885
          Length = 1027

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   AMNFFPK 7
           A+N FPK
Sbjct: 539 AVNIFPK 545
>NP_940862
          Length = 633

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   FFPKR 8
           FFPKR
Sbjct: 227 FFPKR 231
>NP_056003
          Length = 775

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   NFFPKR 8
           N FPKR
Sbjct: 325 NLFPKR 330
>XP_006721041
          Length = 680

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AMNFFPKRA 9
           A NF PK+A
Sbjct: 581 AYNFPPKKA 589
>XP_006721040
          Length = 661

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AMNFFPKRA 9
           A NF PK+A
Sbjct: 562 AYNFPPKKA 570
>XP_005255739
          Length = 823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   AMNFFPKRA 9
           A NF PK+A
Sbjct: 724 AYNFPPKKA 732
>XP_006717795
          Length = 841

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   NFFPKR 8
           N FPKR
Sbjct: 418 NLFPKR 423
>XP_005270606
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   FFPKR 8
           FFPKR
Sbjct: 97  FFPKR 101
>XP_006710456
          Length = 633

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   FFPKR 8
           FFPKR
Sbjct: 227 FFPKR 231
>NP_919047
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   MNFFPKRA 9
           +NF PK A
Sbjct: 188 LNFSPKEA 195
>NP_003555
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   NFFPKRA 9
           N+FPK++
Sbjct: 149 NWFPKKS 155
>NP_001036068
          Length = 1690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   MNFFPKR 8
           MN  PKR
Sbjct: 211 MNILPKR 217
>NP_001264152
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   NFFPKRA 9
           N+FPK++
Sbjct: 149 NWFPKKS 155
>NP_001264153
          Length = 220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   NFFPKRA 9
           N+FPK++
Sbjct: 170 NWFPKKS 176
>NP_110440
          Length = 707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MNFFPKRA 9
           +NF+ KRA
Sbjct: 584 LNFWAKRA 591
>NP_001245323
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MNFFPKRA 9
           +NF+ KRA
Sbjct: 539 LNFWAKRA 546
>NP_001245322
          Length = 648

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MNFFPKRA 9
           +NF+ KRA
Sbjct: 525 LNFWAKRA 532
>NP_001245321
          Length = 677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MNFFPKRA 9
           +NF+ KRA
Sbjct: 554 LNFWAKRA 561
>NP_116243
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   MNFFPKR 8
           M F PKR
Sbjct: 318 MGFMPKR 324
>XP_005258114
          Length = 237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2  MNFFPKR 8
          M F PKR
Sbjct: 84 MGFMPKR 90
>XP_005258113
          Length = 237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2  MNFFPKR 8
          M F PKR
Sbjct: 84 MGFMPKR 90
>XP_005258112
          Length = 238

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2  MNFFPKR 8
          M F PKR
Sbjct: 84 MGFMPKR 90
>XP_005258111
          Length = 238

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2  MNFFPKR 8
          M F PKR
Sbjct: 84 MGFMPKR 90
>XP_005258108
          Length = 431

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   MNFFPKR 8
           M F PKR
Sbjct: 277 MGFMPKR 283
>XP_005258106
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   MNFFPKR 8
           M F PKR
Sbjct: 318 MGFMPKR 324
>XP_005258105
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   MNFFPKR 8
           M F PKR
Sbjct: 318 MGFMPKR 324
>XP_005258104
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   MNFFPKR 8
           M F PKR
Sbjct: 318 MGFMPKR 324
>XP_005274377
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MNFFPKRA 9
           +NF+ KRA
Sbjct: 555 LNFWAKRA 562
>XP_005274129
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   NFFPKR 8
           NF+P+R
Sbjct: 276 NFYPER 281
>XP_006718655
          Length = 596

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   NFFPKR 8
           NF+P+R
Sbjct: 304 NFYPER 309
>XP_005274128
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   NFFPKR 8
           NF+P+R
Sbjct: 313 NFYPER 318
>XP_005274127
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   NFFPKR 8
           NF+P+R
Sbjct: 376 NFYPER 381
>XP_006717679
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   MNFFPK 7
           +NFFP+
Sbjct: 176 LNFFPE 181
>XP_005269551
          Length = 439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   MNFFPK 7
           +NFFP+
Sbjct: 277 LNFFPE 282
>XP_005250598
          Length = 457

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   MNFFPKRA 9
           +NF PK A
Sbjct: 125 LNFSPKEA 132
>NP_060327
          Length = 659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   NFFPKR 8
           NF+P+R
Sbjct: 367 NFYPER 372
>NP_060523
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   AMNFFPK 7
           A  FFPK
Sbjct: 378 AQKFFPK 384
>NP_653188
          Length = 506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   MNFFPK 7
           +NFFP+
Sbjct: 344 LNFFPE 349
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.339    0.139    0.447 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 652,076
Number of extensions: 1030
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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