Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000360                                                              19     665
XP_005268094                                                           19     665
NP_065103                                                              17    3301
XP_005267162                                                           17    3301
XP_005267161                                                           17    3301
XP_005267159                                                           17    3301
XP_006716440                                                           17    4312
NP_066918                                                              16    5631
XP_006712194                                                           16    5631
XP_006712193                                                           16    5631
XP_006712192                                                           16    5631
XP_006712191                                                           16    5631
NP_444504                                                              16    7355
NP_001158051                                                           16    7355
XP_006726675                                                           16    7355
XP_006710372                                                           16    7355
XP_005270458                                                           16    7355
XP_005270457                                                           16    7355
NP_001036014                                                           16    7355
NP_037468                                                              16    7355
NP_000677                                                              15    9605
NP_001191762                                                           15    9605
NP_001191763                                                           15    9605
NP_001191760                                                           15    9605
NP_060545                                                              15    9605
NP_001191761                                                           15    9605
NP_076985                                                              15    9605
NP_073732                                                              15    9605
NP_001243328                                                           15    9605
NP_775789                                                              15    9605
NP_065937                                                              15    9605
XP_005271698                                                           15    9605
XP_005271696                                                           15    9605
XP_005271695                                                           15    9605
XP_005271694                                                           15    9605
XP_005271693                                                           15    9605
XP_005271690                                                           15    9605
XP_005271689                                                           15    9605
XP_005271688                                                           15    9605
XP_005271687                                                           15    9605
XP_006716496                                                           15    9605
XP_006716495                                                           15    9605
XP_005251231                                                           15    9605
XP_006716493                                                           15    9605
XP_006716492                                                           15    9605
XP_006716491                                                           15    9605
XP_006716490                                                           15    9605
XP_005265322                                                           15    9605
NP_001129632                                                           15    9605
NP_071387                                                              15    9605
NP_001243330                                                           15    9605
>NP_000360
          Length = 764

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ALSYIVFVL 9
           AL+YIVFVL
Sbjct: 579 ALAYIVFVL 587
>XP_005268094
          Length = 764

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ALSYIVFVL 9
           AL+YIVFVL
Sbjct: 579 ALAYIVFVL 587
>NP_065103
          Length = 396

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ALSYIVFVL 9
           ALSYI F+L
Sbjct: 329 ALSYIPFLL 337
>XP_005267162
          Length = 418

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ALSYIVFVL 9
           ALSY VF L
Sbjct: 380 ALSYFVFFL 388
>XP_005267161
          Length = 418

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ALSYIVFVL 9
           ALSY VF L
Sbjct: 380 ALSYFVFFL 388
>XP_005267159
          Length = 610

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ALSYIVFVL 9
           ALSY VF L
Sbjct: 572 ALSYFVFFL 580
>XP_006716440
          Length = 171

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ALSYIVFV 8
           A+SYI+F+
Sbjct: 156 AMSYIIFL 163
>NP_066918
          Length = 635

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LSYIVFVL 9
          + Y+VFVL
Sbjct: 27 MDYVVFVL 34
>XP_006712194
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LSYIVFVL 9
          + Y+VFVL
Sbjct: 27 MDYVVFVL 34
>XP_006712193
          Length = 635

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LSYIVFVL 9
          + Y+VFVL
Sbjct: 27 MDYVVFVL 34
>XP_006712192
          Length = 635

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LSYIVFVL 9
          + Y+VFVL
Sbjct: 27 MDYVVFVL 34
>XP_006712191
          Length = 635

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LSYIVFVL 9
          + Y+VFVL
Sbjct: 27 MDYVVFVL 34
>NP_444504
          Length = 594

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ALSYIVFV 8
           +L+Y+VFV
Sbjct: 288 SLAYLVFV 295
>NP_001158051
          Length = 167

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SYIVFVL 9
           SY++FVL
Sbjct: 142 SYVLFVL 148
>XP_006726675
          Length = 167

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SYIVFVL 9
           SY++FVL
Sbjct: 142 SYVLFVL 148
>XP_006710372
          Length = 427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ALSYIVFV 8
           +L+Y+VFV
Sbjct: 121 SLAYLVFV 128
>XP_005270458
          Length = 552

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ALSYIVFV 8
           +L+Y+VFV
Sbjct: 246 SLAYLVFV 253
>XP_005270457
          Length = 580

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ALSYIVFV 8
           +L+Y+VFV
Sbjct: 288 SLAYLVFV 295
>NP_001036014
          Length = 213

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LSYIVFV 8
           LSY+VF+
Sbjct: 186 LSYMVFI 192
>NP_037468
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALSYIVFVL 9
           A+ YIVF+L
Sbjct: 361 AVVYIVFML 369
>NP_000677
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LSYIVFVL 9
          L YI+FV+
Sbjct: 50 LYYIIFVI 57
>NP_001191762
          Length = 549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ALSYIVFVL 9
           +L YI FVL
Sbjct: 304 SLFYIAFVL 312
>NP_001191763
          Length = 470

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ALSYIVFVL 9
           +L YI FVL
Sbjct: 225 SLFYIAFVL 233
>NP_001191760
          Length = 627

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ALSYIVFVL 9
           +L YI FVL
Sbjct: 415 SLFYIAFVL 423
>NP_060545
          Length = 660

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ALSYIVFVL 9
           +L YI FVL
Sbjct: 415 SLFYIAFVL 423
>NP_001191761
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ALSYIVFVL 9
           +L YI FVL
Sbjct: 349 SLFYIAFVL 357
>NP_076985
          Length = 1104

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LSYIVFVL 9
           L YI+F L
Sbjct: 834 LDYIIFTL 841
>NP_073732
          Length = 279

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LSYIVFVL 9
          L+Y+ FVL
Sbjct: 36 LTYVYFVL 43
>NP_001243328
          Length = 279

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LSYIVFVL 9
          L+Y+ FVL
Sbjct: 36 LTYVYFVL 43
>NP_775789
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ALSYIVFV 8
           AL Y+VF+
Sbjct: 586 ALKYLVFL 593
>NP_065937
          Length = 1077

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ALSYIVF 7
           ALSY+V+
Sbjct: 917 ALSYLVY 923
>XP_005271698
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ALSYIVF 7
           ALSY+V+
Sbjct: 760 ALSYLVY 766
>XP_005271696
          Length = 1045

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ALSYIVF 7
           ALSY+V+
Sbjct: 885 ALSYLVY 891
>XP_005271695
          Length = 1046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ALSYIVF 7
           ALSY+V+
Sbjct: 886 ALSYLVY 892
>XP_005271694
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ALSYIVF 7
           ALSY+V+
Sbjct: 918 ALSYLVY 924
>XP_005271693
          Length = 1080

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ALSYIVF 7
           ALSY+V+
Sbjct: 920 ALSYLVY 926
>XP_005271690
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ALSYIVF 7
           ALSY+V+
Sbjct: 958 ALSYLVY 964
>XP_005271689
          Length = 1137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ALSYIVF 7
           ALSY+V+
Sbjct: 977 ALSYLVY 983
>XP_005271688
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ALSYIVF 7
           ALSY+V+
Sbjct: 979 ALSYLVY 985
>XP_005271687
          Length = 1140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ALSYIVF 7
           ALSY+V+
Sbjct: 980 ALSYLVY 986
>XP_006716496
          Length = 439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ALSYIVFV 8
           AL Y+VF+
Sbjct: 344 ALKYLVFL 351
>XP_006716495
          Length = 439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ALSYIVFV 8
           AL Y+VF+
Sbjct: 344 ALKYLVFL 351
>XP_005251231
          Length = 618

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ALSYIVFV 8
           AL Y+VF+
Sbjct: 523 ALKYLVFL 530
>XP_006716493
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ALSYIVFV 8
           AL Y+VF+
Sbjct: 586 ALKYLVFL 593
>XP_006716492
          Length = 654

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ALSYIVFV 8
           AL Y+VF+
Sbjct: 559 ALKYLVFL 566
>XP_006716491
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ALSYIVFV 8
           AL Y+VF+
Sbjct: 566 ALKYLVFL 573
>XP_006716490
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ALSYIVFV 8
           AL Y+VF+
Sbjct: 568 ALKYLVFL 575
>XP_005265322
          Length = 621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ALSYIVFVL 9
           +L YI FVL
Sbjct: 415 SLFYIAFVL 423
>NP_001129632
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ALSYIVFV 8
           AL Y+VF+
Sbjct: 586 ALKYLVFL 593
>NP_071387
          Length = 704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LSYIVFV 8
           LS+IVF+
Sbjct: 579 LSFIVFI 585
>NP_001243330
          Length = 252

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LSYIVFVL 9
          L+Y+ FVL
Sbjct: 36 LTYVYFVL 43
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.348    0.157    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 385,934
Number of extensions: 571
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

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