Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005148                                                              20     509
NP_009297                                                              20     509
NP_001103224                                                           19     869
NP_848652                                                              19     869
XP_006719593                                                           19     869
XP_006719591                                                           19     869
XP_006710219                                                           19     869
NP_001186127                                                           18    1935
NP_060779                                                              18    1935
NP_659491                                                              18    1935
XP_006726780                                                           17    2528
XP_006721690                                                           17    2528
XP_006710091                                                           17    2528
NP_064629                                                              17    2528
NP_789787                                                              17    4312
NP_001019831                                                           16    5631
NP_009049                                                              16    5631
NP_002536                                                              16    5631
NP_001012393                                                           16    5631
NP_001122312                                                           16    5631
NP_001122311                                                           16    5631
XP_005271636                                                           16    5631
XP_005271635                                                           16    5631
XP_005271632                                                           16    5631
XP_006718909                                                           16    5631
XP_005271631                                                           16    5631
XP_006714558                                                           16    5631
XP_006713877                                                           16    5631
XP_006713876                                                           16    5631
XP_006713875                                                           16    5631
XP_006713874                                                           16    5631
XP_006713873                                                           16    5631
XP_005265505                                                           16    5631
NP_064610                                                              16    7355
NP_116117                                                              16    7355
NP_002477                                                              16    7355
XP_006723284                                                           16    7355
XP_006717182                                                           16    7355
XP_006717181                                                           16    7355
XP_005252054                                                           16    7355
XP_005263199                                                           16    7355
NP_115512                                                              16    7355
NP_001094842                                                           16    7355
NP_062545                                                              16    7355
NP_057658                                                              15    9605
NP_000786                                                              15    9605
NP_006500                                                              15    9605
NP_066363                                                              15    9605
NP_001158001                                                           15    9605
NP_062826                                                              15    9605
NP_001275631                                                           15    9605
NP_001275632                                                           15    9605
NP_001116362                                                           15    9605
XP_006723899                                                           15    9605
XP_005259268                                                           15    9605
XP_005259185                                                           15    9605
XP_005259184                                                           15    9605
XP_006718837                                                           15    9605
XP_005271482                                                           15    9605
XP_005249232                                                           15    9605
NP_060426                                                              15    9605
NP_001158002                                                           15    9605
NP_001157999                                                           15    9605
NP_009065                                                              15    9605
>NP_005148
          Length = 1130

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ALCLAISRS 9
            ALCLAISR+
Sbjct: 1038 ALCLAISRN 1046
>NP_009297
          Length = 1149

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ALCLAISRS 9
            ALCLAISR+
Sbjct: 1057 ALCLAISRN 1065
>NP_001103224
          Length = 2215

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  ALCLAISRS 9
          ALCLAIS S
Sbjct: 66 ALCLAISNS 74
>NP_848652
          Length = 302

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ALCLAISRS 9
           ALC A+SRS
Sbjct: 126 ALCFAVSRS 134
>XP_006719593
          Length = 1304

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  ALCLAISRS 9
          ALCLAIS S
Sbjct: 66 ALCLAISNS 74
>XP_006719591
          Length = 2230

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  ALCLAISRS 9
          ALCLAIS S
Sbjct: 66 ALCLAISNS 74
>XP_006710219
          Length = 218

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  ALCLAISRS 9
          ALC A+SRS
Sbjct: 42 ALCFAVSRS 50
>NP_001186127
          Length = 699

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ALCLAISRS 9
           ALCLAIS S
Sbjct: 315 ALCLAISVS 323
>NP_060779
          Length = 684

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ALCLAISRS 9
           ALCLAIS S
Sbjct: 315 ALCLAISVS 323
>NP_659491
          Length = 620

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3  CLAISRS 9
          CLAISRS
Sbjct: 69 CLAISRS 75
>XP_006726780
          Length = 293

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ALCLAISRS 9
           ALCLA+S S
Sbjct: 215 ALCLAVSVS 223
>XP_006721690
          Length = 293

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ALCLAISRS 9
           ALCLA+S S
Sbjct: 215 ALCLAVSVS 223
>XP_006710091
          Length = 293

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ALCLAISRS 9
           ALCLA+S S
Sbjct: 215 ALCLAVSVS 223
>NP_064629
          Length = 406

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ALCLAISR 8
           ALCL ISR
Sbjct: 368 ALCLQISR 375
>NP_789787
          Length = 333

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LCLAISR 8
          LCL+ISR
Sbjct: 58 LCLSISR 64
>NP_001019831
          Length = 2986

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ALCLAISRS 9
            ALC++ SRS
Sbjct: 1705 ALCISHSRS 1713
>NP_009049
          Length = 3097

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ALCLAISRS 9
            +LC+A SRS
Sbjct: 1715 SLCIAHSRS 1723
>NP_002536
          Length = 345

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LCLAISR 8
           LCLAI R
Sbjct: 156 LCLAIGR 162
>NP_001012393
          Length = 338

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LCLAISR 8
           LCLAI R
Sbjct: 149 LCLAIGR 155
>NP_001122312
          Length = 2161

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALCLAISRS 9
           +LC AIS+S
Sbjct: 491 SLCQAISKS 499
>NP_001122311
          Length = 2137

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALCLAISRS 9
           +LC AIS+S
Sbjct: 491 SLCQAISKS 499
>XP_005271636
          Length = 207

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  LCLAISR 8
          LCLAI R
Sbjct: 18 LCLAIGR 24
>XP_005271635
          Length = 245

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  LCLAISR 8
          LCLAI R
Sbjct: 56 LCLAIGR 62
>XP_005271632
          Length = 326

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LCLAISR 8
           LCLAI R
Sbjct: 156 LCLAIGR 162
>XP_006718909
          Length = 337

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LCLAISR 8
           LCLAI R
Sbjct: 149 LCLAIGR 155
>XP_005271631
          Length = 344

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LCLAISR 8
           LCLAI R
Sbjct: 156 LCLAIGR 162
>XP_006714558
          Length = 2612

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ALCLAISRS 9
            +LC+A SRS
Sbjct: 1230 SLCIAHSRS 1238
>XP_006713877
          Length = 2956

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ALCLAISRS 9
            ALC++ SRS
Sbjct: 1707 ALCISHSRS 1715
>XP_006713876
          Length = 2966

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ALCLAISRS 9
            ALC++ SRS
Sbjct: 1685 ALCISHSRS 1693
>XP_006713875
          Length = 2975

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ALCLAISRS 9
            ALC++ SRS
Sbjct: 1694 ALCISHSRS 1702
>XP_006713874
          Length = 2979

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ALCLAISRS 9
            ALC++ SRS
Sbjct: 1698 ALCISHSRS 1706
>XP_006713873
          Length = 2988

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ALCLAISRS 9
            ALC++ SRS
Sbjct: 1707 ALCISHSRS 1715
>XP_005265505
          Length = 2146

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ALCLAISRS 9
           +LC AIS+S
Sbjct: 491 SLCQAISKS 499
>NP_064610
          Length = 926

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  LCLAIS 7
          LCLAIS
Sbjct: 78 LCLAIS 83
>NP_116117
          Length = 271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ALCLAISR 8
           ALC+ +SR
Sbjct: 222 ALCVGLSR 229
>NP_002477
          Length = 790

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ALCLAIS 7
           ALCLA++
Sbjct: 501 ALCLAVA 507
>XP_006723284
          Length = 354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LCLAISR 8
           LCLA+ R
Sbjct: 171 LCLAVGR 177
>XP_006717182
          Length = 600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ALCLAIS 7
           ALCLA++
Sbjct: 311 ALCLAVA 317
>XP_006717181
          Length = 600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ALCLAIS 7
           ALCLA++
Sbjct: 311 ALCLAVA 317
>XP_005252054
          Length = 723

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ALCLAIS 7
           ALCLA++
Sbjct: 434 ALCLAVA 440
>XP_005263199
          Length = 863

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  LCLAIS 7
          LCLAIS
Sbjct: 78 LCLAIS 83
>NP_115512
          Length = 626

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ALCLAISR 8
           A+C A+SR
Sbjct: 575 AVCAAVSR 582
>NP_001094842
          Length = 336

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LCLAISR 8
           LCLA+ R
Sbjct: 153 LCLAVGR 159
>NP_062545
          Length = 299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  CLAISR 8
          CLA+SR
Sbjct: 50 CLAVSR 55
>NP_057658
          Length = 414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  LCLAISR 8
          +C+A+SR
Sbjct: 55 VCMAVSR 61
>NP_000786
          Length = 443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  LCLAISR 8
          +C+A+SR
Sbjct: 55 VCMAVSR 61
>NP_006500
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  ALCLAISRS 9
          +L LA+SRS
Sbjct: 42 SLSLAVSRS 50
>NP_066363
          Length = 1918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    LCLAISRS 9
            +C+A+SR+
Sbjct: 1217 ICVALSRA 1224
>NP_001158001
          Length = 115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  LCLAISR 8
          LCLA+ R
Sbjct: 17 LCLAVRR 23
>NP_062826
          Length = 580

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ALCLAIS 7
           ++CLAIS
Sbjct: 99  SICLAIS 105
>NP_001275631
          Length = 499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ALCLAI 6
           ALCLA+
Sbjct: 139 ALCLAV 144
>NP_001275632
          Length = 198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ALCLAI 6
           ALCLA+
Sbjct: 133 ALCLAV 138
>NP_001116362
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ALCLAI 6
           ALCLA+
Sbjct: 133 ALCLAV 138
>XP_006723899
          Length = 1918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    LCLAISRS 9
            +C+A+SR+
Sbjct: 1217 ICVALSRA 1224
>XP_005259268
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  LCLAISR 8
          LCLA+ R
Sbjct: 17 LCLAVRR 23
>XP_005259185
          Length = 507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  ALCLAISRS 9
          +L LA+SRS
Sbjct: 42 SLSLAVSRS 50
>XP_005259184
          Length = 576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  ALCLAISRS 9
          +L LA+SRS
Sbjct: 42 SLSLAVSRS 50
>XP_006718837
          Length = 414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  LCLAISR 8
          +C+A+SR
Sbjct: 55 VCMAVSR 61
>XP_005271482
          Length = 443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  LCLAISR 8
          +C+A+SR
Sbjct: 55 VCMAVSR 61
>XP_005249232
          Length = 189

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LCLAIS 7
           LCLA+S
Sbjct: 97  LCLAVS 102
>NP_060426
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LCLAISR 8
           LCL +SR
Sbjct: 107 LCLEVSR 113
>NP_001158002
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  LCLAISR 8
          LCLA+ R
Sbjct: 17 LCLAVRR 23
>NP_001157999
          Length = 123

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  LCLAISR 8
          LCLA+ R
Sbjct: 17 LCLAVRR 23
>NP_009065
          Length = 682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  LCLAISR 8
          LCLA+ R
Sbjct: 17 LCLAVRR 23
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.334    0.131    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 579,499
Number of extensions: 641
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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