Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              21     175
NP_001263689                                                           21     175
NP_001119584                                                           21     175
NP_001119586                                                           21     175
NP_001263625                                                           21     175
NP_001119590                                                           21     175
NP_001263690                                                           21     175
NP_001119585                                                           21     175
NP_001263624                                                           21     175
NP_001138597                                                           18    1482
NP_038474                                                              18    1482
NP_054879                                                              18    1935
NP_073564                                                              18    1935
NP_001244923                                                           18    1935
NP_892029                                                              18    1935
XP_005261291                                                           18    1935
NP_001278014                                                           17    4312
NP_001077378                                                           17    4312
NP_064508                                                              17    4312
NP_001152765                                                           17    4312
XP_006722662                                                           17    4312
XP_006722661                                                           17    4312
XP_005259757                                                           17    4312
XP_005259756                                                           17    4312
XP_005259755                                                           17    4312
XP_006722660                                                           17    4312
XP_005259754                                                           17    4312
XP_005252752                                                           17    4312
NP_060941                                                              17    4312
NP_060115                                                              16    5631
NP_000867                                                              16    5631
NP_001257819                                                           16    5631
NP_443132                                                              16    5631
NP_937757                                                              16    5631
NP_937756                                                              16    5631
NP_919274                                                              16    5631
XP_005247408                                                           16    5631
XP_005247407                                                           16    5631
NP_055190                                                              16    5631
NP_060624                                                              16    7355
NP_003406                                                              16    7355
NP_001159354                                                           16    7355
NP_001159353                                                           16    7355
NP_898884                                                              16    7355
XP_006719322                                                           16    7355
XP_006719321                                                           16    7355
XP_006713666                                                           16    7355
XP_006713665                                                           16    7355
NP_940980                                                              15    9605
NP_056019                                                              15    9605
NP_001269633                                                           15    9605
NP_001269634                                                           15    9605
NP_001269635                                                           15    9605
NP_001091068                                                           15    9605
NP_005733                                                              15    9605
NP_079522                                                              15    9605
NP_001269636                                                           15    9605
XP_005254703                                                           15    9605
XP_005268686                                                           15    9605
XP_006715725                                                           15    9605
XP_006715724                                                           15    9605
XP_006715723                                                           15    9605
XP_006715722                                                           15    9605
XP_006713837                                                           15    9605
XP_006713836                                                           15    9605
XP_005246202                                                           15    9605
XP_006711919                                                           15    9605
NP_001091069                                                           15    9605
>NP_000537
          Length = 393

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AKSVTCTY 8
           AKSVTCTY
Sbjct: 119 AKSVTCTY 126
>NP_001263689
          Length = 354

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  AKSVTCTY 8
          AKSVTCTY
Sbjct: 80 AKSVTCTY 87
>NP_001119584
          Length = 393

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AKSVTCTY 8
           AKSVTCTY
Sbjct: 119 AKSVTCTY 126
>NP_001119586
          Length = 341

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AKSVTCTY 8
           AKSVTCTY
Sbjct: 119 AKSVTCTY 126
>NP_001263625
          Length = 302

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  AKSVTCTY 8
          AKSVTCTY
Sbjct: 80 AKSVTCTY 87
>NP_001119590
          Length = 354

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  AKSVTCTY 8
          AKSVTCTY
Sbjct: 80 AKSVTCTY 87
>NP_001263690
          Length = 354

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  AKSVTCTY 8
          AKSVTCTY
Sbjct: 80 AKSVTCTY 87
>NP_001119585
          Length = 346

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   AKSVTCTY 8
           AKSVTCTY
Sbjct: 119 AKSVTCTY 126
>NP_001263624
          Length = 307

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  AKSVTCTY 8
          AKSVTCTY
Sbjct: 80 AKSVTCTY 87
>NP_001138597
          Length = 329

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  KSVTCTYF 9
          K VTC YF
Sbjct: 57 KQVTCRYF 64

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3  SVTCTYF 9
          SV C YF
Sbjct: 87 SVVCKYF 93
>NP_038474
          Length = 482

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  KSVTCTYF 9
          K VTC YF
Sbjct: 57 KQVTCRYF 64

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3  SVTCTYF 9
          SV C YF
Sbjct: 87 SVVCKYF 93
>NP_054879
          Length = 416

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  KSVTCTYF 9
          K +TC YF
Sbjct: 4  KQITCRYF 11
>NP_073564
          Length = 625

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   AKSVTCTYF 9
           A  VTC YF
Sbjct: 360 ASGVTCLYF 368
>NP_001244923
          Length = 562

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   AKSVTCTYF 9
           A  VTC YF
Sbjct: 360 ASGVTCLYF 368
>NP_892029
          Length = 625

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   AKSVTCTYF 9
           A  VTC YF
Sbjct: 360 ASGVTCLYF 368
>XP_005261291
          Length = 586

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   AKSVTCTYF 9
           A  VTC YF
Sbjct: 360 ASGVTCLYF 368
>NP_001278014
          Length = 463

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  VTCTYF 9
          VTC YF
Sbjct: 92 VTCVYF 97
>NP_001077378
          Length = 560

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   VTCTYF 9
           VTC YF
Sbjct: 189 VTCVYF 194
>NP_064508
          Length = 589

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   SVTCTYF 9
           ++ CTYF
Sbjct: 499 TIVCTYF 505
>NP_001152765
          Length = 536

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SVTCTYF 9
          SVTC++F
Sbjct: 75 SVTCSHF 81
>XP_006722662
          Length = 439

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SVTCTYF 9
          SVTC++F
Sbjct: 75 SVTCSHF 81
>XP_006722661
          Length = 495

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SVTCTYF 9
          SVTC++F
Sbjct: 75 SVTCSHF 81
>XP_005259757
          Length = 523

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SVTCTYF 9
          SVTC++F
Sbjct: 75 SVTCSHF 81
>XP_005259756
          Length = 523

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SVTCTYF 9
          SVTC++F
Sbjct: 75 SVTCSHF 81
>XP_005259755
          Length = 523

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SVTCTYF 9
          SVTC++F
Sbjct: 75 SVTCSHF 81
>XP_006722660
          Length = 550

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SVTCTYF 9
          SVTC++F
Sbjct: 75 SVTCSHF 81
>XP_005259754
          Length = 551

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SVTCTYF 9
          SVTC++F
Sbjct: 75 SVTCSHF 81
>XP_005252752
          Length = 1279

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   VTCTYF 9
           VTC YF
Sbjct: 908 VTCVYF 913
>NP_060941
          Length = 426

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KSVTCTYF 9
           KSV C +F
Sbjct: 101 KSVVCAFF 108
>NP_060115
          Length = 955

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   AKSVTCTY 8
           AKS+ C Y
Sbjct: 419 AKSILCQY 426
>NP_000867
          Length = 2491

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   VTCTYF 9
           V CTYF
Sbjct: 452 VDCTYF 457
>NP_001257819
          Length = 920

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   AKSVTCTY 8
           AKS+ C Y
Sbjct: 384 AKSILCQY 391
>NP_443132
          Length = 3538

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   AKSVTC 6
           AKS+TC
Sbjct: 417 AKSITC 422
>NP_937757
          Length = 3667

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   AKSVTC 6
           AKS+TC
Sbjct: 481 AKSITC 486
>NP_937756
          Length = 3707

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   AKSVTC 6
           AKS+TC
Sbjct: 521 AKSITC 526
>NP_919274
          Length = 509

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   SVTCTYF 9
           ++TC YF
Sbjct: 126 TITCQYF 132
>XP_005247408
          Length = 234

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SVTCTYF 9
           SVTC +F
Sbjct: 103 SVTCDFF 109
>XP_005247407
          Length = 317

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SVTCTYF 9
           SVTC +F
Sbjct: 186 SVTCDFF 192
>NP_055190
          Length = 382

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SVTCTYF 9
           SVTC +F
Sbjct: 251 SVTCDFF 257
>NP_060624
          Length = 202

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 4   VTCTY 8
           +TCTY
Sbjct: 97  ITCTY 101
>NP_003406
          Length = 947

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   AKSVTCTYF 9
           AKS  CT F
Sbjct: 176 AKSFECTTF 184
>NP_001159354
          Length = 864

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   AKSVTCTYF 9
           AKS  CT F
Sbjct: 93  AKSFECTTF 101
>NP_001159353
          Length = 947

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   AKSVTCTYF 9
           AKS  CT F
Sbjct: 176 AKSFECTTF 184
>NP_898884
          Length = 1177

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KSVTCTY 8
           KSV CT+
Sbjct: 437 KSVCCTF 443
>XP_006719322
          Length = 243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   KSVTCTYF 9
           K V C YF
Sbjct: 106 KQVICIYF 113
>XP_006719321
          Length = 243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   KSVTCTYF 9
           K V C YF
Sbjct: 106 KQVICIYF 113
>XP_006713666
          Length = 1104

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KSVTCTY 8
           KSV CT+
Sbjct: 364 KSVCCTF 370
>XP_006713665
          Length = 1175

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KSVTCTY 8
           KSV CT+
Sbjct: 437 KSVCCTF 443
>NP_940980
          Length = 2527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    SVTCTY 8
            SVTC Y
Sbjct: 2244 SVTCLY 2249
>NP_056019
          Length = 1657

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   AKSVTCTYF 9
           A+ + C YF
Sbjct: 169 AEDIICEYF 177
>NP_001269633
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  VTCTYF 9
          V+CT+F
Sbjct: 61 VSCTFF 66
>NP_001269634
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  VTCTYF 9
          V+CT+F
Sbjct: 57 VSCTFF 62
>NP_001269635
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  VTCTYF 9
          V+CT+F
Sbjct: 14 VSCTFF 19
>NP_001091068
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 3   SVTCTY 8
           S+TC Y
Sbjct: 178 SITCAY 183
>NP_005733
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  VTCTYF 9
          V+CT+F
Sbjct: 9  VSCTFF 14
>NP_079522
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 3   SVTCTY 8
           S+TC Y
Sbjct: 178 SITCAY 183
>NP_001269636
          Length = 437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  VTCTYF 9
          V+CT+F
Sbjct: 6  VSCTFF 11
>XP_005254703
          Length = 275

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 5   TCTYF 9
           TCT+F
Sbjct: 257 TCTFF 261
>XP_005268686
          Length = 2521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    SVTCTY 8
            SVTC Y
Sbjct: 2244 SVTCLY 2249
>XP_006715725
          Length = 1516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   AKSVTCTYF 9
           A+ + C YF
Sbjct: 169 AEDIICEYF 177
>XP_006715724
          Length = 1533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   AKSVTCTYF 9
           A+ + C YF
Sbjct: 169 AEDIICEYF 177
>XP_006715723
          Length = 1559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   AKSVTCTYF 9
           A+ + C YF
Sbjct: 169 AEDIICEYF 177
>XP_006715722
          Length = 1614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   AKSVTCTYF 9
           A+ + C YF
Sbjct: 169 AEDIICEYF 177
>XP_006713837
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 3   SVTCTY 8
           S+TC Y
Sbjct: 178 SITCAY 183
>XP_006713836
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 3   SVTCTY 8
           S+TC Y
Sbjct: 178 SITCAY 183
>XP_005246202
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  VTCTYF 9
          V+CT+F
Sbjct: 9  VSCTFF 14
>XP_006711919
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  VTCTYF 9
          V+CT+F
Sbjct: 9  VSCTFF 14
>NP_001091069
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 3   SVTCTY 8
           S+TC Y
Sbjct: 178 SITCAY 183
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.127    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 521,009
Number of extensions: 521
Number of successful extensions: 70
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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