Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_066124                                                              21     229
XP_006717999                                                           21     229
NP_037375                                                              17    3301
NP_001268357                                                           16    7355
NP_036276                                                              16    7355
NP_000030                                                              16    7355
NP_612388                                                              16    7355
NP_001140198                                                           16    7355
NP_115813                                                              16    7355
NP_068570                                                              16    7355
NP_851564                                                              16    7355
NP_851565                                                              16    7355
NP_057573                                                              16    7355
NP_055454                                                              16    7355
NP_065798                                                              16    7355
NP_001159590                                                           16    7355
NP_001002010                                                           16    7355
NP_001002009                                                           16    7355
XP_005271597                                                           16    7355
XP_005271596                                                           16    7355
XP_006716821                                                           16    7355
XP_006716820                                                           16    7355
XP_006716819                                                           16    7355
XP_006716818                                                           16    7355
XP_005272096                                                           16    7355
XP_006714725                                                           16    7355
XP_005272095                                                           16    7355
XP_005272094                                                           16    7355
XP_005271331                                                           16    7355
XP_006711040                                                           16    7355
XP_006711039                                                           16    7355
NP_001005199                                                           16    7355
NP_055559                                                              15    9605
NP_001127853                                                           15    9605
NP_002444                                                              15    9605
NP_001005369                                                           15    9605
NP_940876                                                              15    9605
NP_620591                                                              15    9605
XP_005252935                                                           15    9605
XP_005252905                                                           15    9605
XP_005252904                                                           15    9605
XP_006718180                                                           15    9605
XP_005252777                                                           15    9605
XP_005252776                                                           15    9605
XP_005265673                                                           15    9605
XP_005265672                                                           15    9605
XP_005265671                                                           15    9605
XP_005265670                                                           15    9605
XP_005265669                                                           15    9605
XP_006713493                                                           15    9605
XP_006713492                                                           15    9605
XP_005265668                                                           15    9605
XP_006712087                                                           15    9605
XP_005264392                                                           15    9605
XP_006712086                                                           15    9605
NP_036326                                                              15    9605
>NP_066124
          Length = 1114

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    AKLMDTYDS 9
            AKLMDT+DS
Sbjct: 1106 AKLMDTFDS 1114
>XP_006717999
          Length = 1207

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    AKLMDTYDS 9
            AKLMDT+DS
Sbjct: 1199 AKLMDTFDS 1207
>NP_037375
          Length = 468

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KLMDTYDS 9
           KL+D YDS
Sbjct: 115 KLIDDYDS 122
>NP_001268357
          Length = 703

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AKLMDTYDS 9
           ++ +DTYD+
Sbjct: 534 SQFLDTYDA 542
>NP_036276
          Length = 699

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AKLMDTYDS 9
           ++ +DTYD+
Sbjct: 530 SQFLDTYDA 538
>NP_000030
          Length = 267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KLMDTYDS 9
          KL+D +DS
Sbjct: 69 KLLDNWDS 76
>NP_612388
          Length = 378

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KLMDTYDS 9
           KLM+TY S
Sbjct: 339 KLMETYCS 346
>NP_001140198
          Length = 350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KLMDTYDS 9
           KLM+TY S
Sbjct: 311 KLMETYCS 318
>NP_115813
          Length = 629

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AKLMDTYDS 9
           AK+MD Y++
Sbjct: 542 AKVMDGYEN 550
>NP_068570
          Length = 538

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MDTYDS 9
           MDT+DS
Sbjct: 487 MDTFDS 492
>NP_851564
          Length = 538

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MDTYDS 9
           MDT+DS
Sbjct: 487 MDTFDS 492
>NP_851565
          Length = 560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MDTYDS 9
           MDT+DS
Sbjct: 509 MDTFDS 514
>NP_057573
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KLMDTYD 8
           K MD+YD
Sbjct: 271 KYMDSYD 277
>NP_055454
          Length = 1564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KLMDTYDS 9
           KL+D Y+S
Sbjct: 102 KLLDLYES 109
>NP_065798
          Length = 1512

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  MDTYDS 9
          +DTYDS
Sbjct: 17 VDTYDS 22
>NP_001159590
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KLMDTYD 8
           K MD+YD
Sbjct: 259 KYMDSYD 265
>NP_001002010
          Length = 336

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KLMDTYD 8
           K MD+YD
Sbjct: 310 KYMDSYD 316
>NP_001002009
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KLMDTYD 8
           K MD+YD
Sbjct: 271 KYMDSYD 277
>XP_005271597
          Length = 267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KLMDTYDS 9
          KL+D +DS
Sbjct: 69 KLLDNWDS 76
>XP_005271596
          Length = 267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KLMDTYDS 9
          KL+D +DS
Sbjct: 69 KLLDNWDS 76
>XP_006716821
          Length = 522

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AKLMDTYDS 9
           ++ +DTYD+
Sbjct: 353 SQFLDTYDA 361
>XP_006716820
          Length = 673

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AKLMDTYDS 9
           ++ +DTYD+
Sbjct: 565 SQFLDTYDA 573
>XP_006716819
          Length = 730

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AKLMDTYDS 9
           ++ +DTYD+
Sbjct: 561 SQFLDTYDA 569
>XP_006716818
          Length = 734

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   AKLMDTYDS 9
           ++ +DTYD+
Sbjct: 565 SQFLDTYDA 573
>XP_005272096
          Length = 1511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  MDTYDS 9
          +DTYDS
Sbjct: 17 VDTYDS 22
>XP_006714725
          Length = 1512

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  MDTYDS 9
          +DTYDS
Sbjct: 17 VDTYDS 22
>XP_005272095
          Length = 1512

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  MDTYDS 9
          +DTYDS
Sbjct: 17 VDTYDS 22
>XP_005272094
          Length = 1512

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  MDTYDS 9
          +DTYDS
Sbjct: 17 VDTYDS 22
>XP_005271331
          Length = 606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AKLMDTYDS 9
           AK+MD Y++
Sbjct: 542 AKVMDGYEN 550
>XP_006711040
          Length = 629

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AKLMDTYDS 9
           AK+MD Y++
Sbjct: 542 AKVMDGYEN 550
>XP_006711039
          Length = 642

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   AKLMDTYDS 9
           AK+MD Y++
Sbjct: 555 AKVMDGYEN 563
>NP_001005199
          Length = 311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   MDTYD 8
           MDTYD
Sbjct: 189 MDTYD 193
>NP_055559
          Length = 795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   AKLMDTY 7
           AK+MDT+
Sbjct: 610 AKVMDTH 616
>NP_001127853
          Length = 817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   AKLMDTY 7
           AK+MDT+
Sbjct: 632 AKVMDTH 638
>NP_002444
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LMDTYDS 9
           ++DTYD+
Sbjct: 534 IIDTYDA 540
>NP_001005369
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LMDTYDS 9
           ++DTYD+
Sbjct: 534 IIDTYDA 540
>NP_940876
          Length = 402

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KLMDTYDS 9
           K+MDT+ S
Sbjct: 156 KMMDTHGS 163
>NP_620591
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   LMDTYD 8
           ++DTYD
Sbjct: 123 MLDTYD 128
>XP_005252935
          Length = 402

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KLMDTYDS 9
           K+MDT+ S
Sbjct: 156 KMMDTHGS 163
>XP_005252905
          Length = 1854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   MDTYDS 9
           MD YDS
Sbjct: 379 MDVYDS 384
>XP_005252904
          Length = 1855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   MDTYDS 9
           MD YDS
Sbjct: 379 MDVYDS 384
>XP_006718180
          Length = 189

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   LMDTYD 8
           ++DTYD
Sbjct: 158 MLDTYD 163
>XP_005252777
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   LMDTYD 8
           ++DTYD
Sbjct: 158 MLDTYD 163
>XP_005252776
          Length = 378

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   LMDTYD 8
           ++DTYD
Sbjct: 158 MLDTYD 163
>XP_005265673
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   AKLMDTY 7
           AK+MDT+
Sbjct: 496 AKVMDTH 502
>XP_005265672
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   AKLMDTY 7
           AK+MDT+
Sbjct: 496 AKVMDTH 502
>XP_005265671
          Length = 795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   AKLMDTY 7
           AK+MDT+
Sbjct: 610 AKVMDTH 616
>XP_005265670
          Length = 817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   AKLMDTY 7
           AK+MDT+
Sbjct: 632 AKVMDTH 638
>XP_005265669
          Length = 817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   AKLMDTY 7
           AK+MDT+
Sbjct: 632 AKVMDTH 638
>XP_006713493
          Length = 817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   AKLMDTY 7
           AK+MDT+
Sbjct: 632 AKVMDTH 638
>XP_006713492
          Length = 817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   AKLMDTY 7
           AK+MDT+
Sbjct: 632 AKVMDTH 638
>XP_005265668
          Length = 817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   AKLMDTY 7
           AK+MDT+
Sbjct: 632 AKVMDTH 638
>XP_006712087
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LMDTYDS 9
           ++DTYD+
Sbjct: 291 IIDTYDA 297
>XP_005264392
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LMDTYDS 9
           ++DTYD+
Sbjct: 534 IIDTYDA 540
>XP_006712086
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LMDTYDS 9
           ++DTYD+
Sbjct: 534 IIDTYDA 540
>NP_036326
          Length = 1849

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   MDTYDS 9
           MD YDS
Sbjct: 379 MDVYDS 384
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.122    0.326 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 477,254
Number of extensions: 628
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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