Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001161328                                                           17    2528
NP_060653                                                              17    2528
XP_005253633                                                           17    2528
XP_005253632                                                           17    2528
XP_006719537                                                           17    2528
XP_006719536                                                           17    2528
XP_005253630                                                           17    2528
XP_005253629                                                           17    2528
XP_005272668                                                           17    4312
XP_005272667                                                           17    4312
XP_006724596                                                           17    4312
NP_000069                                                              16    5631
NP_001273014                                                           16    5631
NP_653081                                                              16    5631
NP_055650                                                              16    5631
NP_001265578                                                           16    5631
NP_006725                                                              16    5631
NP_001010979                                                           16    5631
XP_005260682                                                           16    5631
XP_005267014                                                           16    5631
NP_001121054                                                           16    7355
NP_001121058                                                           16    7355
NP_057246                                                              16    7355
NP_001121057                                                           16    7355
NP_001121055                                                           16    7355
NP_001121056                                                           16    7355
NP_008937                                                              16    7355
NP_001182682                                                           16    7355
NP_001182681                                                           16    7355
XP_005253755                                                           16    7355
XP_005263589                                                           16    7355
NP_065077                                                              15    9605
NP_001180217                                                           15    9605
NP_001269340                                                           15    9605
NP_002703                                                              15    9605
NP_001269338                                                           15    9605
NP_001269343                                                           15    9605
NP_001269339                                                           15    9605
NP_001269342                                                           15    9605
NP_001269341                                                           15    9605
NP_061927                                                              15    9605
NP_003569                                                              15    9605
NP_001231681                                                           15    9605
XP_006717968                                                           15    9605
XP_006717967                                                           15    9605
XP_006717966                                                           15    9605
XP_006717965                                                           15    9605
XP_006716835                                                           15    9605
XP_006716834                                                           15    9605
XP_006716833                                                           15    9605
XP_006716832                                                           15    9605
XP_006716813                                                           15    9605
XP_005251482                                                           15    9605
XP_005251483                                                           15    9605
XP_006716812                                                           15    9605
NP_671728                                                              15    9605
>NP_001161328
          Length = 1393

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    KKKLFLV 8
            KKKLFLV
Sbjct: 1227 KKKLFLV 1233
>NP_060653
          Length = 1392

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    KKKLFLV 8
            KKKLFLV
Sbjct: 1226 KKKLFLV 1232
>XP_005253633
          Length = 1392

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    KKKLFLV 8
            KKKLFLV
Sbjct: 1226 KKKLFLV 1232
>XP_005253632
          Length = 1392

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    KKKLFLV 8
            KKKLFLV
Sbjct: 1226 KKKLFLV 1232
>XP_006719537
          Length = 1393

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    KKKLFLV 8
            KKKLFLV
Sbjct: 1227 KKKLFLV 1233
>XP_006719536
          Length = 1393

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    KKKLFLV 8
            KKKLFLV
Sbjct: 1227 KKKLFLV 1233
>XP_005253630
          Length = 1393

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    KKKLFLV 8
            KKKLFLV
Sbjct: 1227 KKKLFLV 1233
>XP_005253629
          Length = 1393

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    KKKLFLV 8
            KKKLFLV
Sbjct: 1227 KKKLFLV 1233
>XP_005272668
          Length = 504

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KKKLFLVR 9
          K KLFL+R
Sbjct: 76 KAKLFLIR 83
>XP_005272667
          Length = 539

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KKKLFLVR 9
          K KLFL+R
Sbjct: 76 KAKLFLIR 83
>XP_006724596
          Length = 562

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KKKLFLVR 9
          K KLFL+R
Sbjct: 76 KAKLFLIR 83
>NP_000069
          Length = 493

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AKKKLFL 7
           +KKKLFL
Sbjct: 393 SKKKLFL 399
>NP_001273014
          Length = 433

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   AKKKLFL 7
           +KKKLFL
Sbjct: 333 SKKKLFL 339
>NP_653081
          Length = 480

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KKKLFLV 8
           KKKLF++
Sbjct: 292 KKKLFMI 298
>NP_055650
          Length = 468

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KKKLFLV 8
           KKKLF++
Sbjct: 280 KKKLFMI 286
>NP_001265578
          Length = 370

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KKKLFLV 8
           KKKLF++
Sbjct: 200 KKKLFMI 206
>NP_006725
          Length = 2446

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KKKLFLVR 9
            +KK FLVR
Sbjct: 1075 RKKCFLVR 1082
>NP_001010979
          Length = 101

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  AKKKLFLVR 9
          AKK+L +VR
Sbjct: 62 AKKQLLMVR 70
>XP_005260682
          Length = 267

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  KKKLFLV 8
          KKKLF++
Sbjct: 79 KKKLFMI 85
>XP_005267014
          Length = 2446

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KKKLFLVR 9
            +KK FLVR
Sbjct: 1075 RKKCFLVR 1082
>NP_001121054
          Length = 249

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AKKKLFLVR 9
           A+KKL LVR
Sbjct: 158 AQKKLKLVR 166
>NP_001121058
          Length = 179

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AKKKLFLVR 9
           A+KKL LVR
Sbjct: 158 AQKKLKLVR 166
>NP_057246
          Length = 248

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AKKKLFLVR 9
           A+KKL LVR
Sbjct: 157 AQKKLKLVR 165
>NP_001121057
          Length = 225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AKKKLFLVR 9
           A+KKL LVR
Sbjct: 134 AQKKLKLVR 142
>NP_001121055
          Length = 246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AKKKLFLVR 9
           A+KKL LVR
Sbjct: 155 AQKKLKLVR 163
>NP_001121056
          Length = 245

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AKKKLFLVR 9
           A+KKL LVR
Sbjct: 154 AQKKLKLVR 162
>NP_008937
          Length = 227

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KKLFLVR 9
           KKLFLV+
Sbjct: 172 KKLFLVQ 178
>NP_001182682
          Length = 239

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KKKLFL 7
           KKKLFL
Sbjct: 189 KKKLFL 194
>NP_001182681
          Length = 238

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KKKLFL 7
           KKKLFL
Sbjct: 188 KKKLFL 193
>XP_005253755
          Length = 200

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   AKKKLFLVR 9
           A+KKL LVR
Sbjct: 109 AQKKLKLVR 117
>XP_005263589
          Length = 238

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KKKLFL 7
           KKKLFL
Sbjct: 188 KKKLFL 193
>NP_065077
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KKKLFLVR 9
          KKKL L+R
Sbjct: 31 KKKLKLIR 38
>NP_001180217
          Length = 644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KKKLFLVR 9
          KKKL L+R
Sbjct: 31 KKKLKLIR 38
>NP_001269340
          Length = 237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KKLFLV 8
           KKLFLV
Sbjct: 124 KKLFLV 129
>NP_002703
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KKLFLV 8
           KKLFLV
Sbjct: 167 KKLFLV 172
>NP_001269338
          Length = 317

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KKLFLV 8
           KKLFLV
Sbjct: 124 KKLFLV 129
>NP_001269343
          Length = 221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KKLFLV 8
           KKLFLV
Sbjct: 108 KKLFLV 113
>NP_001269339
          Length = 280

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KKLFLV 8
           KKLFLV
Sbjct: 167 KKLFLV 172
>NP_001269342
          Length = 301

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KKLFLV 8
           KKLFLV
Sbjct: 108 KKLFLV 113
>NP_001269341
          Length = 344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KKLFLV 8
           KKLFLV
Sbjct: 151 KKLFLV 156
>NP_061927
          Length = 835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KKKLFLVR 9
           KKK+FL R
Sbjct: 483 KKKVFLWR 490
>NP_003569
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   KKKLFLVR 9
           K+K+F++R
Sbjct: 100 KQKVFIIR 107
>NP_001231681
          Length = 1010

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AKKKLFLV 8
           +KKKLF V
Sbjct: 666 SKKKLFQV 673
>XP_006717968
          Length = 952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KKKLFLVR 9
           KKK+FL R
Sbjct: 483 KKKVFLWR 490
>XP_006717967
          Length = 952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KKKLFLVR 9
           KKK+FL R
Sbjct: 483 KKKVFLWR 490
>XP_006717966
          Length = 952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KKKLFLVR 9
           KKK+FL R
Sbjct: 483 KKKVFLWR 490
>XP_006717965
          Length = 958

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KKKLFLVR 9
           KKK+FL R
Sbjct: 489 KKKVFLWR 496
>XP_006716835
          Length = 1048

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AKKKLFLV 8
           +KKKLF V
Sbjct: 639 SKKKLFQV 646
>XP_006716834
          Length = 1076

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AKKKLFLV 8
           +KKKLF V
Sbjct: 667 SKKKLFQV 674
>XP_006716833
          Length = 1083

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AKKKLFLV 8
           +KKKLF V
Sbjct: 685 SKKKLFQV 692
>XP_006716832
          Length = 1093

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AKKKLFLV 8
           +KKKLF V
Sbjct: 685 SKKKLFQV 692
>XP_006716813
          Length = 644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KKKLFLVR 9
          KKKL L+R
Sbjct: 31 KKKLKLIR 38
>XP_005251482
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KKKLFLVR 9
          KKKL L+R
Sbjct: 31 KKKLKLIR 38
>XP_005251483
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KKKLFLVR 9
          KKKL L+R
Sbjct: 31 KKKLKLIR 38
>XP_006716812
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AKKKLFLV 8
           +KKKLF V
Sbjct: 676 SKKKLFQV 683
>NP_671728
          Length = 992

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   AKKKLFLV 8
           +KKKLF V
Sbjct: 658 SKKKLFQV 665
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.338    0.147    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 503,451
Number of extensions: 587
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package